Hiperplasia linfóide angiofolicular – Doença de Castleman – do mediastino: Apresentação de um caso clínico
Mediastinal angiofolicular lymphoid hyperplasia – Castleman's disease – Case report
* Assistente Hospitalar e Assistente Estagiário de Anatomia Patológica, Hospitais da Universidade de Coimbra
** Chefe de Serviço e Professora Associada de Anatomia Patológica, Hospitais da Universidade de Coimbra
*** Hospitais da Universidade de Coimbra. Serviço de Anatomia Patológica (Directora: Dra. Fernanda Xavier da Cunha)
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"nombre" => "Fernanda" "apellidos" => "Xavier da Cunha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Assistente Hospitalar e Assistente Estagiário de Anatomia Patológica, Hospitais da Universidade de Coimbra" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Chefe de Serviço e Professora Associada de Anatomia Patológica, Hospitais da Universidade de Coimbra" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospitais da Universidade de Coimbra. Serviço de Anatomia Patológica (Directora: Dra. Fernanda Xavier da Cunha)" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Mediastinal angiofolicular lymphoid hyperplasia – Castleman's disease – Case report" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-03-02" "fechaAceptado" => "2006-03-09" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec158691" "palabras" => array:3 [ 0 => "Doença de Castleman" 1 => "hiperplasia linfóide angiofolicular do medistino" 2 => "doenças do mediastino" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec158692" "palabras" => array:3 [ 0 => "Castleman's disease" 1 => "mediastinal angiofolicular lymphoid hyperplasia" 2 => "mediastinal disease" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A hiperplasia linfóide angiofolicular foi inicialmente descrita por Castleman como uma hiperplasia do gânglio linfático, caracterizada por folículos anormais, com centros germinativos pequenos e marcada proliferação capilar.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Os autores apresentam o caso de um homem de 37 anos com toracalgia e massa mediastínica com 4<span class="elsevierStyleHsp" style=""></span>cm de diâmetro, constituída por tecido vermelho-escuro e carnudo, com pequena área central branca. Foi diagnosticada a variante plasmocitária da hiperplasia linfóide angiofolicular em gânglio linfático mediastínico. Apresentava mais dois gânglios “diafragmáticos” envolvidos pela mesma doença.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A hiperplasia linfóide angiofolicular, ou doença de Castleman, é uma doença linfoproliferativa rara que atinge frequentemente o mediastino ou os gânglios linfáticos do hilo pulmonar. Pode ter, no entanto, outras localizações, na forma multisistémica. Estão descritas duas variantes morfológicas: a vascular hialina e a plasmocitária. A IL-6 parece ter um papel importante na sua patogenia, quando se trata da variante plasmocitária. A doença de Castleman deve ser considerada no diagnóstico diferencial de massas mediastínicas, nomeadamente com linfomas.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Angiofolicular lymphoid hyperplasia was first described by Castleman as a lymph node hyperplasia characterized by abnormal follicles with small germinal centres and high capillary proliferation.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The authors present a case of a 37 year old man with thoracalgy and a mediastinal mass of 4<span class="elsevierStyleHsp" style=""></span>cm diameter, fleshy and red with a white central area. The diagnosis of plasma cell type of angiofolicular lymphoid hyperplasia in an mediastinal lymph node was made. He also had involvement of two “diaphragmatic” lymph nodes.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Angiofolicular lymphoid hyperplasia – Castleman's disease - is a rare lymphoproliferative disease that involves the mediastine or the pulmonary hilus when of solitary form but it can also have other localizations (multicentric or systemic form). Two histological variants are described, the hyaline vascular type and the plasma cell type. IL-6 seems to be in the plasma cell type, due to plasma cells proliferation. Castleman's Disease must be considered in the differential diagnosis of mediastinal masses, namely lymphomas.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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ISSN: 21735115Original language: Portuguese
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