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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A hiperplasia linf&#243;ide angiofolicular foi inicialmente descrita por Castleman como uma hiperplasia do g&#226;nglio linf&#225;tico&#44; caracterizada por fol&#237;culos anormais&#44; com centros germinativos pequenos e marcada prolifera&#231;&#227;o capilar&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Os autores apresentam o caso de um homem de 37 anos com toracalgia e massa mediast&#237;nica com 4<span class="elsevierStyleHsp" style=""></span>cm de di&#226;metro&#44; constitu&#237;da por tecido vermelho-escuro e carnudo&#44; com pequena &#225;rea central branca&#46; Foi diagnosticada a variante plasmocit&#225;ria da hiperplasia linf&#243;ide angiofolicular em g&#226;nglio linf&#225;tico mediast&#237;nico&#46; Apresentava mais dois g&#226;nglios &#8220;diafragm&#225;ticos&#8221; envolvidos pela mesma doen&#231;a&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A hiperplasia linf&#243;ide angiofolicular&#44; ou doen&#231;a de Castleman&#44; &#233; uma doen&#231;a linfoproliferativa rara que atinge frequentemente o mediastino ou os g&#226;nglios linf&#225;ticos do hilo pulmonar&#46; Pode ter&#44; no entanto&#44; outras localiza&#231;&#245;es&#44; na forma multisist&#233;mica&#46; Est&#227;o descritas duas variantes morfol&#243;gicas&#58; a vascular hialina e a plasmocit&#225;ria&#46; A IL-6 parece ter um papel importante na sua patogenia&#44; quando se trata da variante plasmocit&#225;ria&#46; A doen&#231;a de Castleman deve ser considerada no diagn&#243;stico diferencial de massas mediast&#237;nicas&#44; nomeadamente com linfomas&#46;</p>"
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        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Angiofolicular lymphoid hyperplasia was first described by Castleman as a lymph node hyperplasia characterized by abnormal follicles with small germinal centres and high capillary proliferation&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The authors present a case of a 37 year old man with thoracalgy and a mediastinal mass of 4<span class="elsevierStyleHsp" style=""></span>cm diameter&#44; fleshy and red with a white central area&#46; The diagnosis of plasma cell type of angiofolicular lymphoid hyperplasia in an mediastinal lymph node was made&#46; He also had involvement of two &#8220;diaphragmatic&#8221; lymph nodes&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Angiofolicular lymphoid hyperplasia &#8211; Castleman&#39;s disease - is a rare lymphoproliferative disease that involves the mediastine or the pulmonary hilus when of solitary form but it can also have other localizations &#40;multicentric or systemic form&#41;&#46; Two histological variants are described&#44; the hyaline vascular type and the plasma cell type&#46; IL-6 seems to be in the plasma cell type&#44; due to plasma cells proliferation&#46; Castleman&#39;s Disease must be considered in the differential diagnosis of mediastinal masses&#44; namely lymphomas&#46;</p>"
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Hiperplasia linfóide angiofolicular – Doença de Castleman – do mediastino: Apresentação de um caso clínico
Mediastinal angiofolicular lymphoid hyperplasia – Castleman's disease – Case report
Vítor Sousa*, Lina Carvalho**, Fernanda Xavier da Cunha***
* Assistente Hospitalar e Assistente Estagiário de Anatomia Patológica, Hospitais da Universidade de Coimbra
** Chefe de Serviço e Professora Associada de Anatomia Patológica, Hospitais da Universidade de Coimbra
*** Hospitais da Universidade de Coimbra. Serviço de Anatomia Patológica (Directora: Dra. Fernanda Xavier da Cunha)
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A hiperplasia linf&#243;ide angiofolicular foi inicialmente descrita por Castleman como uma hiperplasia do g&#226;nglio linf&#225;tico&#44; caracterizada por fol&#237;culos anormais&#44; com centros germinativos pequenos e marcada prolifera&#231;&#227;o capilar&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Os autores apresentam o caso de um homem de 37 anos com toracalgia e massa mediast&#237;nica com 4<span class="elsevierStyleHsp" style=""></span>cm de di&#226;metro&#44; constitu&#237;da por tecido vermelho-escuro e carnudo&#44; com pequena &#225;rea central branca&#46; Foi diagnosticada a variante plasmocit&#225;ria da hiperplasia linf&#243;ide angiofolicular em g&#226;nglio linf&#225;tico mediast&#237;nico&#46; Apresentava mais dois g&#226;nglios &#8220;diafragm&#225;ticos&#8221; envolvidos pela mesma doen&#231;a&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A hiperplasia linf&#243;ide angiofolicular&#44; ou doen&#231;a de Castleman&#44; &#233; uma doen&#231;a linfoproliferativa rara que atinge frequentemente o mediastino ou os g&#226;nglios linf&#225;ticos do hilo pulmonar&#46; Pode ter&#44; no entanto&#44; outras localiza&#231;&#245;es&#44; na forma multisist&#233;mica&#46; Est&#227;o descritas duas variantes morfol&#243;gicas&#58; a vascular hialina e a plasmocit&#225;ria&#46; A IL-6 parece ter um papel importante na sua patogenia&#44; quando se trata da variante plasmocit&#225;ria&#46; A doen&#231;a de Castleman deve ser considerada no diagn&#243;stico diferencial de massas mediast&#237;nicas&#44; nomeadamente com linfomas&#46;</p>"
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        "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Angiofolicular lymphoid hyperplasia was first described by Castleman as a lymph node hyperplasia characterized by abnormal follicles with small germinal centres and high capillary proliferation&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The authors present a case of a 37 year old man with thoracalgy and a mediastinal mass of 4<span class="elsevierStyleHsp" style=""></span>cm diameter&#44; fleshy and red with a white central area&#46; The diagnosis of plasma cell type of angiofolicular lymphoid hyperplasia in an mediastinal lymph node was made&#46; He also had involvement of two &#8220;diaphragmatic&#8221; lymph nodes&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Angiofolicular lymphoid hyperplasia &#8211; Castleman&#39;s disease - is a rare lymphoproliferative disease that involves the mediastine or the pulmonary hilus when of solitary form but it can also have other localizations &#40;multicentric or systemic form&#41;&#46; Two histological variants are described&#44; the hyaline vascular type and the plasma cell type&#46; IL-6 seems to be in the plasma cell type&#44; due to plasma cells proliferation&#46; Castleman&#39;s Disease must be considered in the differential diagnosis of mediastinal masses&#44; namely lymphomas&#46;</p>"
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