array:24 [
  "pii" => "S2173511506704195"
  "issn" => "21735115"
  "doi" => "10.1016/S2173-5115(06)70419-5"
  "estado" => "S300"
  "fechaPublicacion" => "2006-09-01"
  "aid" => "70419"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2006"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Pneumol. 2006;12:539-44"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2446
    "formatos" => array:3 [
      "EPUB" => 234
      "HTML" => 1275
      "PDF" => 937
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173511506704201"
    "issn" => "21735115"
    "doi" => "10.1016/S2173-5115(06)70420-1"
    "estado" => "S300"
    "fechaPublicacion" => "2006-09-01"
    "aid" => "70420"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "rev"
    "cita" => "Rev Port Pneumol. 2006;12:545-61"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2755
      "formatos" => array:3 [
        "EPUB" => 232
        "HTML" => 1651
        "PDF" => 872
      ]
    ]
    "pt" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Cancro do pulmão na mulher: Uma entidade diferente?"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "545"
          "paginaFinal" => "561"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Lung cancer in women: A different entity?"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Renato Sotto-Mayor"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Renato"
              "apellidos" => "Sotto-Mayor"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511506704201?idApp=UINPBA00004E"
    "url" => "/21735115/0000001200000005/v1_201305151428/S2173511506704201/v1_201305151428/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173511506704183"
    "issn" => "21735115"
    "doi" => "10.1016/S2173-5115(06)70418-3"
    "estado" => "S300"
    "fechaPublicacion" => "2006-09-01"
    "aid" => "70418"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2006;12:525-38"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2405
      "formatos" => array:3 [
        "EPUB" => 220
        "HTML" => 1286
        "PDF" => 899
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Smoking trends in Portuguese school – Aged children and aproaches for a control – An analysis based on the Health Behaviour in School – Aged Children (HBSC) data"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "525"
          "paginaFinal" => "538"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Evolu&#231;&#227;o da epidemia tab&#225;gica em adolescentes portugueses escolarizados e vias para o seu controlo &#8211; Uma an&#225;lise baseada nos dados do <span class="elsevierStyleItalic">Health Behaviour in School &#8211; Aged Children</span> &#40;HBSC&#41;"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Manuel Macedo, Jos&#233; Precioso"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Macedo"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Precioso"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511506704183?idApp=UINPBA00004E"
    "url" => "/21735115/0000001200000005/v1_201305151428/S2173511506704183/v1_201305151428/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Respiratory squamous cell carcinomas in vibroacoustic disease"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "539"
        "paginaFinal" => "544"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Jos&#233; Reis Ferreira, Carla P&#46; Mendes, Mariana Alves-Pereira, Nuno A&#46;A&#46; Castelo Branco"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Jos&#233;"
            "apellidos" => "Reis Ferreira"
            "email" => array:1 [
              0 => "vibroacoustic&#46;disease&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Carla P&#46;"
            "apellidos" => "Mendes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">2</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Mariana"
            "apellidos" => "Alves-Pereira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">3</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Nuno A&#46;A&#46;"
            "apellidos" => "Castelo Branco"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">4</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "M&#233;dico pneumologista&#44; Servi&#231;o de Pneumologia&#44; Hospital da For&#231;a A&#233;rea&#44; Lisboa &#47; Pulmonologist&#44; Pulmonology Unit&#44; Hospital da For&#231;a A&#233;rea&#44; Lisboa"
            "etiqueta" => "<span class="elsevierStyleSup">1</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "M&#233;dica pneumologista&#44; Servi&#231;o de Pneumologia&#44; Hospital da For&#231;a A&#233;rea&#44; Lisboa &#47; Pulmonologist&#44; Pulmonology Unit&#44; Hospital da For&#231;a A&#233;rea&#44; Lisboa"
            "etiqueta" => "<span class="elsevierStyleSup">2</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Engenheira biom&#233;dica&#44; ERISA&#44; Universidade Lus&#243;fona&#44; Lisboa &#47; Biomedical engineer&#44; ERISA&#44; Universidade Lus&#243;fona&#44; Lisboa"
            "etiqueta" => "<span class="elsevierStyleSup">3</span>"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "M&#233;dico anatomopatologista&#44; Presidente do Conselho Cient&#237;fico&#44; Centro da Performance Humana&#44; Alverca &#47; Anatomopathologist&#44; President&#44; Scientific Council&#44; Centro da Performance Humana&#44; Alverca"
            "etiqueta" => "<span class="elsevierStyleSup">4</span>"
            "identificador" => "aff0020"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Carcinomas epiderm&#243;ides do pulm&#227;o na doen&#231;a vibroac&#250;stica"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2006-02-28"
    "fechaAceptado" => "2006-06-09"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec158846"
          "palabras" => array:6 [
            0 => "Low frequency noise"
            1 => "infrasound"
            2 => "helicopter pilots"
            3 => "lung cancer"
            4 => "squamous cell carcinoma"
            5 => "sister chromatid exchanges"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras chave"
          "identificador" => "xpalclavsec158845"
          "palabras" => array:6 [
            0 => "Ru&#237;do de baixa frequ&#234;ncia"
            1 => "infra-sons"
            2 => "pilotos de helic&#243;ptero"
            3 => "cancro do pulm&#227;o"
            4 => "carcinoma epiderm&#243;ide"
            5 => "trocas de crom&#225;tides irm&#227;s"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In 1987&#44; the autopsy of a vibroacoustic disease &#40;VAD&#41; patient disclosed two tumours&#58; a renal cell carcinoma and a malignant glioma in the brain&#46; Since 1987&#44; malignancy in VAD patients has been under close surveillance&#46; To date&#44; in a universe of 945 individuals&#44; there are 46 cases of malignancies&#44; of which 11 are multiple&#46; Of the 11 cases of respiratory tract tumours&#44; all were squamous cell carcinomas &#40;SqCC&#41;&#46; This report focuses on the morphological features of these tumours&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Tumour fragments were collected &#40;endoscopic biopsy or surgery&#41; from 11 male VAD patients &#40;ave&#46; age&#58; 58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 years&#44; 3 non-smokers&#41;&#58; 2 in glottis and 9 in the lung&#46; In the 3 non-smokers&#44; 2 had lung tumours and 1 had a glottis tumour&#46; All were employed as or retired aircraft technicians&#44; military or commercial pilots&#46; Fragments were fixed either for light and electron microscopy&#46; Immunohistochemistry studies used chromagranine and synaptophysine staining&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">All lung tumours were located in the upper right lobe bronchi and were histologically poorly differentiated SqCC &#40;Figs&#46; 1&#44; 2&#41;&#46; The search with neuroendocrine markers was negative&#46; The average age of tumour onset in helicopter pilots was below 50 years old while for the other professional groups it was above 50&#46; Nine patients are deceased&#46; The 2 surviving patients are heavy smokers &#40;&#62; 2 packs&#47;day&#41;&#46; Smoking habits had no influence on tumour outcome and progression&#46;</p> <span class="elsevierStyleSectionTitle">Discussion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Epidemiological studies indicate that squamous cell carcinomas account for approximately 40&#37; of all lung tumours in men&#46; It seems to be highly relevant that all VAD patient respiratory tract tumours are squamous cell carcinomas&#46; It is not surprising that helicopter pilots are the ones who are affected the earliest because previous studies have shown that helicopter pilots exhibited the highest values for the frequency of sister chromatid exchanges&#46; Generally&#44; epidemiological tumor studies do not take histological tumor type into account&#44; but given the results herein&#44; it would seem of the utmost importance to begin specifiying the exact histological type of tumor in all statistical studies&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle">Enquadramento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Em 1987&#44; observou-se durante a aut&#243;psia de um doente com doen&#231;a vibroac&#250;stica &#40;VAD&#41; dois tumores&#58; Um carcinoma de c&#233;lulas renais e um glioma maligno cerebral&#46; Desde 1987&#44; tem-se vigiado o aparecimento de tumores em doentes com a VAD&#46; At&#233; &#224; data&#44; num universo de 945 indiv&#237;duos&#44; h&#225; 46 casos de tumores malignos&#44; dos quais 11 s&#227;o m&#250;ltiplos&#46; Dos 11 casos de tumores do aparelho respirat&#243;rio&#44; todos eram carcinomas epiderm&#243;ides &#40;CE&#41;&#46; O presente estudo aborda as caracter&#237;sticas morfol&#243;gicas destes tumores&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Foram recolhidos fragmentos destes tumores &#40;bi&#243;psia endosc&#243;pica ou cir&#250;rgica&#41; de 11 doentes do sexo masculino &#40;idade m&#233;dia&#58; 58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 anos&#44; 3 n&#227;o fumadores&#41;&#58; 2 na glote e 9 no pulm&#227;o&#46; Dos 3 n&#227;o fumadores&#44; 2 tinham tumores do pulm&#227;o e 1 tinha tumor da glote&#46; Todos eram trabalhadores ou reformados da ind&#250;stria aeron&#225;utica&#44; pilotos militares ou de linhas comerciais&#46; Foram fixados fragmentos para microscopia &#243;ptica e electr&#243;nica&#46; Para os estudos imuno-histoqu&#237;micos usou-se colora&#231;&#227;o com cromagranina e sinaptofisina&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Todos os tumores pulmonares se localizaram no br&#244;nquio do lobo superior direito&#44; e a sua histologia era de tumores epiderm&#243;ides pouco diferenciados&#46; A pesquisa com marcadores neuroend&#243;crinos foi negativa&#46; Nove doentes faleceram&#46; Os 2 sobreviventes s&#227;o grandes fumadores &#40;&#62; 2 ma&#231;os&#47;dia&#41;&#46; A m&#233;dia de idade de aparecimento do tumor em pilotos de helic&#243;ptero estava abaixo dos 50 anos&#44; enquanto para os outros dois grupos profissionais era superior a 50&#46; Os h&#225;bitos tab&#225;gicos n&#227;o tiveram influ&#234;ncia na progress&#227;o e desfecho dos casos&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#245;es</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">O CE constitui aproximadamente 40&#37; dos tumores pulmonares na popula&#231;&#227;o em geral&#46; Face aos actuais resultados&#44; torna-se muito importante especificar o tipo histol&#243;gico exacto do tumor em todos os estudos estat&#237;sticos&#46; N&#227;o surpreende a idade mais jovem de in&#237;cio dos tumores em pilotos de helic&#243;ptero&#44; atendendo aos resultados dos estudos de mutag&#233;nese em modelos animais e em trabalhadores expostos a RBF&#58; a frequ&#234;ncia de trocas de crom&#225;tides irm&#227;s em pilotos de helic&#243;ptero est&#225; aumentada&#44; bem como em modelos animais expostos a ru&#237;do e vibra&#231;&#245;es simult&#226;neos&#44; simulando o ambiente no <span class="elsevierStyleItalic">cockpit</span> de helic&#243;pteros&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:16 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neurological aspects of vibroacoustic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;J&#46;F&#46; Martinho Pimenta"
                            1 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A91"
                        "paginaFinal" => "A95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ERP P300 and brain magnetic resonance imaging in patients with vibroacoustic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;G&#46; Pimenta"
                            1 => "A&#46;J&#46;F&#46; Martinho Pimenta"
                            2 => "M&#46;S&#46;N&#46; Castelo Branco"
                            3 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A107"
                        "paginaFinal" => "A114"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The palmo-mental reflex in vibroacoustic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;J&#46;F&#46; Martinho Pimenta"
                            1 => "M&#46;S&#46;N&#46; Castelo Branco"
                            2 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A100"
                        "paginaFinal" => "A106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Balance disturbances in individuals with vibroacoustic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;J&#46;F&#46; Martinho Pimenta"
                            1 => "M&#46;S&#46;N&#46;A&#46; Castelo Branco"
                            2 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A96"
                        "paginaFinal" => "A99"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of occupational exposure to low frequency noise on cognition"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Gomes"
                            1 => "A&#46;J&#46;F&#46; Martinho Pimenta"
                            2 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A115"
                        "paginaFinal" => "A118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The vibroacoustic disease &#8211; An emerging pathology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;A&#46;A&#46; Castelo Branco"
                            1 => "E&#46; Rodriguez Lopez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A1"
                        "paginaFinal" => "A6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A unique case of vibroacoustic disease&#46; A tribute to an extraordinary patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A27"
                        "paginaFinal" => "A31"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The clinical stages of vibroacoustic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A32"
                        "paginaFinal" => "A39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vibroacoustic disease&#58; some forensic aspects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46;A&#46;A&#46; Castelo Branco"
                            1 => "E&#46; Rodriguez Lopez"
                            2 => "M&#46; Alves-Pereira"
                            3 => "D&#46;R&#46; Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A145"
                        "paginaFinal" => "A151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased levels of sister chromatid exchanges in military aircraft pilots"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;J&#46; Silva"
                            1 => "A&#46; Carothers"
                            2 => "N&#46;A&#46;A&#46; Castelo Branco"
                            3 => "A&#46; Dias"
                            4 => "M&#46;G&#46; Boavida"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mutation Research &#8211; Genetic Toxicolgy &#38; Environmental Mutagenesis"
                        "fecha" => "1999"
                        "volumen" => "44"
                        "numero" => "1"
                        "paginaInicial" => "129"
                        "paginaFinal" => "134"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sister chromatid exchanges workers exposed to noise and vibration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;J&#46; Silva"
                            1 => "A&#46; Carothers"
                            2 => "N&#46;A&#46;A&#46; Castelo Branco"
                            3 => "A&#46; Dias"
                            4 => "M&#46;G&#46; Boavida"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A40"
                        "paginaFinal" => "A45"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low frequency noise and wholebody vibration cause increased levels of sister chromatid exchange in splenocytes of exposed mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Silva"
                            1 => "A&#46; Dias"
                            2 => "A&#46; Barreta"
                            3 => "P&#46;J&#46; Nogueira"
                            4 => "N&#46;A&#46;A&#46; Castelo Branco"
                            5 => "M&#46;G&#46; Boavida"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.13-2804"
                      "Revista" => array:7 [
                        "tituloSerie" => "Teratogenesis Carcinogenesis &#38; Mutagenesis"
                        "fecha" => "2002"
                        "volumen" => "22"
                        "numero" => "3"
                        "paginaInicial" => "195"
                        "paginaFinal" => "203"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25451345"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Castelo Branco NAA&#44; Alves-pereira M&#44; Martins dos Santos J&#44; Monteiro E&#46; SEM and TEM study of rat respiratory epithelia exposed to low frequency noise&#46; <span class="elsevierStyleItalic">In</span> Science and Technology Education in Microscopy&#58; An Overview&#44; A&#46; Mendez- Vilas &#40;ed&#46;&#41;&#44; Formatex&#58; Badajoz&#44; Spain&#44; 2003&#59; II&#58; 505-33&#46;"
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory epithelia in Wistar rats born in low frequency noise plus varying amount of additional exposure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46;A&#46;A&#46; Castelo Branco"
                            1 => "E&#46; Monteiro"
                            2 => "E&#46; Costa"
                            3 => "A&#46; Silva"
                            4 => "J&#46; Reis Ferreira"
                            5 => "M&#46; Alves-Pereira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Port Pneumol"
                        "fecha" => "2003"
                        "volumen" => "IX"
                        "numero" => "6"
                        "paginaInicial" => "481"
                        "paginaFinal" => "492"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Skuladottir H&#46; Epidemiology of lung cancer&#46; In&#58; European Respiratory Monograph &#8211; Lung Cancer&#46; Spiro SG &#40;ed&#41;&#46; 2001&#59; 6 &#40;17&#41;&#58; 1-12&#46;"
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biological action of intense wide-band noise on animals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46;I&#46; Ponomarkov"
                            1 => "A&#46;Y&#46;U&#46; Tysik"
                            2 => "V&#46;I&#46; Kudryavtseva"
                            3 => "A&#46;S&#46; Barer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Problems of Space Biology NASA TT F-529"
                        "fecha" => "1969"
                        "volumen" => "7"
                        "paginaInicial" => "307"
                        "paginaFinal" => "309"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735115/0000001200000005/v1_201305151428/S2173511506704195/v1_201305151428/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9552"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Article&#47;Artigo Original"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001200000005/v1_201305151428/S2173511506704195/v1_201305151428/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511506704195?idApp=UINPBA00004E"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Respiratory squamous cell carcinomas in vibroacoustic disease
Carcinomas epidermóides do pulmão na doença vibroacústica
José Reis Ferreira1, Carla P. Mendes2, Mariana Alves-Pereira3, Nuno A.A. Castelo Branco4
1 Médico pneumologista, Serviço de Pneumologia, Hospital da Força Aérea, Lisboa / Pulmonologist, Pulmonology Unit, Hospital da Força Aérea, Lisboa
2 Médica pneumologista, Serviço de Pneumologia, Hospital da Força Aérea, Lisboa / Pulmonologist, Pulmonology Unit, Hospital da Força Aérea, Lisboa
3 Engenheira biomédica, ERISA, Universidade Lusófona, Lisboa / Biomedical engineer, ERISA, Universidade Lusófona, Lisboa
4 Médico anatomopatologista, Presidente do Conselho Científico, Centro da Performance Humana, Alverca / Anatomopathologist, President, Scientific Council, Centro da Performance Humana, Alverca
Read
834
Times
was read the article
454
Total PDF
380
Total HTML
Share statistics
 array:24 [
  "pii" => "S2173511506704195"
  "issn" => "21735115"
  "doi" => "10.1016/S2173-5115(06)70419-5"
  "estado" => "S300"
  "fechaPublicacion" => "2006-09-01"
  "aid" => "70419"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2006"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Pneumol. 2006;12:539-44"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2446
    "formatos" => array:3 [
      "EPUB" => 234
      "HTML" => 1275
      "PDF" => 937
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173511506704201"
    "issn" => "21735115"
    "doi" => "10.1016/S2173-5115(06)70420-1"
    "estado" => "S300"
    "fechaPublicacion" => "2006-09-01"
    "aid" => "70420"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "rev"
    "cita" => "Rev Port Pneumol. 2006;12:545-61"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2755
      "formatos" => array:3 [
        "EPUB" => 232
        "HTML" => 1651
        "PDF" => 872
      ]
    ]
    "pt" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Cancro do pulm&#227;o na mulher&#58; Uma entidade diferente&#63;"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "545"
          "paginaFinal" => "561"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Lung cancer in women&#58; A different entity&#63;"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Renato Sotto-Mayor"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Renato"
              "apellidos" => "Sotto-Mayor"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511506704201?idApp=UINPBA00004E"
    "url" => "/21735115/0000001200000005/v1_201305151428/S2173511506704201/v1_201305151428/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173511506704183"
    "issn" => "21735115"
    "doi" => "10.1016/S2173-5115(06)70418-3"
    "estado" => "S300"
    "fechaPublicacion" => "2006-09-01"
    "aid" => "70418"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2006;12:525-38"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2405
      "formatos" => array:3 [
        "EPUB" => 220
        "HTML" => 1286
        "PDF" => 899
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Smoking trends in Portuguese school &#8211; Aged children and aproaches for a control &#8211; An analysis based on the Health Behaviour in School &#8211; Aged Children &#40;HBSC&#41; data"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "525"
          "paginaFinal" => "538"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Evolu&#231;&#227;o da epidemia tab&#225;gica em adolescentes portugueses escolarizados e vias para o seu controlo &#8211; Uma an&#225;lise baseada nos dados do <span class="elsevierStyleItalic">Health Behaviour in School &#8211; Aged Children</span> &#40;HBSC&#41;"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Manuel Macedo, Jos&#233; Precioso"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Manuel"
              "apellidos" => "Macedo"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Precioso"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511506704183?idApp=UINPBA00004E"
    "url" => "/21735115/0000001200000005/v1_201305151428/S2173511506704183/v1_201305151428/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Respiratory squamous cell carcinomas in vibroacoustic disease"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "539"
        "paginaFinal" => "544"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Jos&#233; Reis Ferreira, Carla P&#46; Mendes, Mariana Alves-Pereira, Nuno A&#46;A&#46; Castelo Branco"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Jos&#233;"
            "apellidos" => "Reis Ferreira"
            "email" => array:1 [
              0 => "vibroacoustic&#46;disease&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Carla P&#46;"
            "apellidos" => "Mendes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">2</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Mariana"
            "apellidos" => "Alves-Pereira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">3</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Nuno A&#46;A&#46;"
            "apellidos" => "Castelo Branco"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">4</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "M&#233;dico pneumologista&#44; Servi&#231;o de Pneumologia&#44; Hospital da For&#231;a A&#233;rea&#44; Lisboa &#47; Pulmonologist&#44; Pulmonology Unit&#44; Hospital da For&#231;a A&#233;rea&#44; Lisboa"
            "etiqueta" => "<span class="elsevierStyleSup">1</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "M&#233;dica pneumologista&#44; Servi&#231;o de Pneumologia&#44; Hospital da For&#231;a A&#233;rea&#44; Lisboa &#47; Pulmonologist&#44; Pulmonology Unit&#44; Hospital da For&#231;a A&#233;rea&#44; Lisboa"
            "etiqueta" => "<span class="elsevierStyleSup">2</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Engenheira biom&#233;dica&#44; ERISA&#44; Universidade Lus&#243;fona&#44; Lisboa &#47; Biomedical engineer&#44; ERISA&#44; Universidade Lus&#243;fona&#44; Lisboa"
            "etiqueta" => "<span class="elsevierStyleSup">3</span>"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "M&#233;dico anatomopatologista&#44; Presidente do Conselho Cient&#237;fico&#44; Centro da Performance Humana&#44; Alverca &#47; Anatomopathologist&#44; President&#44; Scientific Council&#44; Centro da Performance Humana&#44; Alverca"
            "etiqueta" => "<span class="elsevierStyleSup">4</span>"
            "identificador" => "aff0020"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Carcinomas epiderm&#243;ides do pulm&#227;o na doen&#231;a vibroac&#250;stica"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2006-02-28"
    "fechaAceptado" => "2006-06-09"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec158846"
          "palabras" => array:6 [
            0 => "Low frequency noise"
            1 => "infrasound"
            2 => "helicopter pilots"
            3 => "lung cancer"
            4 => "squamous cell carcinoma"
            5 => "sister chromatid exchanges"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras chave"
          "identificador" => "xpalclavsec158845"
          "palabras" => array:6 [
            0 => "Ru&#237;do de baixa frequ&#234;ncia"
            1 => "infra-sons"
            2 => "pilotos de helic&#243;ptero"
            3 => "cancro do pulm&#227;o"
            4 => "carcinoma epiderm&#243;ide"
            5 => "trocas de crom&#225;tides irm&#227;s"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In 1987&#44; the autopsy of a vibroacoustic disease &#40;VAD&#41; patient disclosed two tumours&#58; a renal cell carcinoma and a malignant glioma in the brain&#46; Since 1987&#44; malignancy in VAD patients has been under close surveillance&#46; To date&#44; in a universe of 945 individuals&#44; there are 46 cases of malignancies&#44; of which 11 are multiple&#46; Of the 11 cases of respiratory tract tumours&#44; all were squamous cell carcinomas &#40;SqCC&#41;&#46; This report focuses on the morphological features of these tumours&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Tumour fragments were collected &#40;endoscopic biopsy or surgery&#41; from 11 male VAD patients &#40;ave&#46; age&#58; 58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 years&#44; 3 non-smokers&#41;&#58; 2 in glottis and 9 in the lung&#46; In the 3 non-smokers&#44; 2 had lung tumours and 1 had a glottis tumour&#46; All were employed as or retired aircraft technicians&#44; military or commercial pilots&#46; Fragments were fixed either for light and electron microscopy&#46; Immunohistochemistry studies used chromagranine and synaptophysine staining&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">All lung tumours were located in the upper right lobe bronchi and were histologically poorly differentiated SqCC &#40;Figs&#46; 1&#44; 2&#41;&#46; The search with neuroendocrine markers was negative&#46; The average age of tumour onset in helicopter pilots was below 50 years old while for the other professional groups it was above 50&#46; Nine patients are deceased&#46; The 2 surviving patients are heavy smokers &#40;&#62; 2 packs&#47;day&#41;&#46; Smoking habits had no influence on tumour outcome and progression&#46;</p> <span class="elsevierStyleSectionTitle">Discussion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Epidemiological studies indicate that squamous cell carcinomas account for approximately 40&#37; of all lung tumours in men&#46; It seems to be highly relevant that all VAD patient respiratory tract tumours are squamous cell carcinomas&#46; It is not surprising that helicopter pilots are the ones who are affected the earliest because previous studies have shown that helicopter pilots exhibited the highest values for the frequency of sister chromatid exchanges&#46; Generally&#44; epidemiological tumor studies do not take histological tumor type into account&#44; but given the results herein&#44; it would seem of the utmost importance to begin specifiying the exact histological type of tumor in all statistical studies&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle">Enquadramento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Em 1987&#44; observou-se durante a aut&#243;psia de um doente com doen&#231;a vibroac&#250;stica &#40;VAD&#41; dois tumores&#58; Um carcinoma de c&#233;lulas renais e um glioma maligno cerebral&#46; Desde 1987&#44; tem-se vigiado o aparecimento de tumores em doentes com a VAD&#46; At&#233; &#224; data&#44; num universo de 945 indiv&#237;duos&#44; h&#225; 46 casos de tumores malignos&#44; dos quais 11 s&#227;o m&#250;ltiplos&#46; Dos 11 casos de tumores do aparelho respirat&#243;rio&#44; todos eram carcinomas epiderm&#243;ides &#40;CE&#41;&#46; O presente estudo aborda as caracter&#237;sticas morfol&#243;gicas destes tumores&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Foram recolhidos fragmentos destes tumores &#40;bi&#243;psia endosc&#243;pica ou cir&#250;rgica&#41; de 11 doentes do sexo masculino &#40;idade m&#233;dia&#58; 58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 anos&#44; 3 n&#227;o fumadores&#41;&#58; 2 na glote e 9 no pulm&#227;o&#46; Dos 3 n&#227;o fumadores&#44; 2 tinham tumores do pulm&#227;o e 1 tinha tumor da glote&#46; Todos eram trabalhadores ou reformados da ind&#250;stria aeron&#225;utica&#44; pilotos militares ou de linhas comerciais&#46; Foram fixados fragmentos para microscopia &#243;ptica e electr&#243;nica&#46; Para os estudos imuno-histoqu&#237;micos usou-se colora&#231;&#227;o com cromagranina e sinaptofisina&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Todos os tumores pulmonares se localizaram no br&#244;nquio do lobo superior direito&#44; e a sua histologia era de tumores epiderm&#243;ides pouco diferenciados&#46; A pesquisa com marcadores neuroend&#243;crinos foi negativa&#46; Nove doentes faleceram&#46; Os 2 sobreviventes s&#227;o grandes fumadores &#40;&#62; 2 ma&#231;os&#47;dia&#41;&#46; A m&#233;dia de idade de aparecimento do tumor em pilotos de helic&#243;ptero estava abaixo dos 50 anos&#44; enquanto para os outros dois grupos profissionais era superior a 50&#46; Os h&#225;bitos tab&#225;gicos n&#227;o tiveram influ&#234;ncia na progress&#227;o e desfecho dos casos&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#245;es</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">O CE constitui aproximadamente 40&#37; dos tumores pulmonares na popula&#231;&#227;o em geral&#46; Face aos actuais resultados&#44; torna-se muito importante especificar o tipo histol&#243;gico exacto do tumor em todos os estudos estat&#237;sticos&#46; N&#227;o surpreende a idade mais jovem de in&#237;cio dos tumores em pilotos de helic&#243;ptero&#44; atendendo aos resultados dos estudos de mutag&#233;nese em modelos animais e em trabalhadores expostos a RBF&#58; a frequ&#234;ncia de trocas de crom&#225;tides irm&#227;s em pilotos de helic&#243;ptero est&#225; aumentada&#44; bem como em modelos animais expostos a ru&#237;do e vibra&#231;&#245;es simult&#226;neos&#44; simulando o ambiente no <span class="elsevierStyleItalic">cockpit</span> de helic&#243;pteros&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:16 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neurological aspects of vibroacoustic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;J&#46;F&#46; Martinho Pimenta"
                            1 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A91"
                        "paginaFinal" => "A95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ERP P300 and brain magnetic resonance imaging in patients with vibroacoustic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;G&#46; Pimenta"
                            1 => "A&#46;J&#46;F&#46; Martinho Pimenta"
                            2 => "M&#46;S&#46;N&#46; Castelo Branco"
                            3 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A107"
                        "paginaFinal" => "A114"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The palmo-mental reflex in vibroacoustic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;J&#46;F&#46; Martinho Pimenta"
                            1 => "M&#46;S&#46;N&#46; Castelo Branco"
                            2 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A100"
                        "paginaFinal" => "A106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Balance disturbances in individuals with vibroacoustic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;J&#46;F&#46; Martinho Pimenta"
                            1 => "M&#46;S&#46;N&#46;A&#46; Castelo Branco"
                            2 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A96"
                        "paginaFinal" => "A99"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of occupational exposure to low frequency noise on cognition"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Gomes"
                            1 => "A&#46;J&#46;F&#46; Martinho Pimenta"
                            2 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A115"
                        "paginaFinal" => "A118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The vibroacoustic disease &#8211; An emerging pathology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;A&#46;A&#46; Castelo Branco"
                            1 => "E&#46; Rodriguez Lopez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A1"
                        "paginaFinal" => "A6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A unique case of vibroacoustic disease&#46; A tribute to an extraordinary patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A27"
                        "paginaFinal" => "A31"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The clinical stages of vibroacoustic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "N&#46;A&#46;A&#46; Castelo Branco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A32"
                        "paginaFinal" => "A39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vibroacoustic disease&#58; some forensic aspects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46;A&#46;A&#46; Castelo Branco"
                            1 => "E&#46; Rodriguez Lopez"
                            2 => "M&#46; Alves-Pereira"
                            3 => "D&#46;R&#46; Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A145"
                        "paginaFinal" => "A151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased levels of sister chromatid exchanges in military aircraft pilots"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;J&#46; Silva"
                            1 => "A&#46; Carothers"
                            2 => "N&#46;A&#46;A&#46; Castelo Branco"
                            3 => "A&#46; Dias"
                            4 => "M&#46;G&#46; Boavida"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mutation Research &#8211; Genetic Toxicolgy &#38; Environmental Mutagenesis"
                        "fecha" => "1999"
                        "volumen" => "44"
                        "numero" => "1"
                        "paginaInicial" => "129"
                        "paginaFinal" => "134"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sister chromatid exchanges workers exposed to noise and vibration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;J&#46; Silva"
                            1 => "A&#46; Carothers"
                            2 => "N&#46;A&#46;A&#46; Castelo Branco"
                            3 => "A&#46; Dias"
                            4 => "M&#46;G&#46; Boavida"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fnsys.2015.00011"
                      "Revista" => array:7 [
                        "tituloSerie" => "Aviation Space &#38; Environmental Medicine"
                        "fecha" => "1999"
                        "volumen" => "70"
                        "numero" => "3&#44; Suppl"
                        "paginaInicial" => "A40"
                        "paginaFinal" => "A45"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25741249"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low frequency noise and wholebody vibration cause increased levels of sister chromatid exchange in splenocytes of exposed mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Silva"
                            1 => "A&#46; Dias"
                            2 => "A&#46; Barreta"
                            3 => "P&#46;J&#46; Nogueira"
                            4 => "N&#46;A&#46;A&#46; Castelo Branco"
                            5 => "M&#46;G&#46; Boavida"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.13-2804"
                      "Revista" => array:7 [
                        "tituloSerie" => "Teratogenesis Carcinogenesis &#38; Mutagenesis"
                        "fecha" => "2002"
                        "volumen" => "22"
                        "numero" => "3"
                        "paginaInicial" => "195"
                        "paginaFinal" => "203"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25451345"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Castelo Branco NAA&#44; Alves-pereira M&#44; Martins dos Santos J&#44; Monteiro E&#46; SEM and TEM study of rat respiratory epithelia exposed to low frequency noise&#46; <span class="elsevierStyleItalic">In</span> Science and Technology Education in Microscopy&#58; An Overview&#44; A&#46; Mendez- Vilas &#40;ed&#46;&#41;&#44; Formatex&#58; Badajoz&#44; Spain&#44; 2003&#59; II&#58; 505-33&#46;"
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory epithelia in Wistar rats born in low frequency noise plus varying amount of additional exposure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46;A&#46;A&#46; Castelo Branco"
                            1 => "E&#46; Monteiro"
                            2 => "E&#46; Costa"
                            3 => "A&#46; Silva"
                            4 => "J&#46; Reis Ferreira"
                            5 => "M&#46; Alves-Pereira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Port Pneumol"
                        "fecha" => "2003"
                        "volumen" => "IX"
                        "numero" => "6"
                        "paginaInicial" => "481"
                        "paginaFinal" => "492"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Skuladottir H&#46; Epidemiology of lung cancer&#46; In&#58; European Respiratory Monograph &#8211; Lung Cancer&#46; Spiro SG &#40;ed&#41;&#46; 2001&#59; 6 &#40;17&#41;&#58; 1-12&#46;"
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biological action of intense wide-band noise on animals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46;I&#46; Ponomarkov"
                            1 => "A&#46;Y&#46;U&#46; Tysik"
                            2 => "V&#46;I&#46; Kudryavtseva"
                            3 => "A&#46;S&#46; Barer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Problems of Space Biology NASA TT F-529"
                        "fecha" => "1969"
                        "volumen" => "7"
                        "paginaInicial" => "307"
                        "paginaFinal" => "309"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735115/0000001200000005/v1_201305151428/S2173511506704195/v1_201305151428/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9552"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Article&#47;Artigo Original"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001200000005/v1_201305151428/S2173511506704195/v1_201305151428/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511506704195?idApp=UINPBA00004E"
]
Article information
ISSN: 21735115
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 4 4 8
2024 October 23 23 46
2024 September 30 21 51
2024 August 37 34 71
2024 July 37 32 69
2024 June 15 24 39
2024 May 21 32 53
2024 April 24 25 49
2024 March 18 17 35
2024 February 19 17 36
2024 January 16 25 41
2023 December 13 22 35
2023 November 19 24 43
2023 October 9 27 36
2023 September 14 24 38
2023 August 18 20 38
2023 July 15 33 48
2023 June 18 14 32
2023 May 18 28 46
2023 April 12 8 20
Show all

Follow this link to access the full text of the article

Pulmonology

Are you a health professional able to prescribe or dispense drugs?