The evaluation of neopterin and antioxidants in long lasting asthma
Determinação da neopterina e de defesas antioxidantes na asma de evolução arrastada
A. Mota Pinto1, A. Todo-Bom2, S. Vale Pereira3, V. Alves4, M. Santos Rosa5, Doutora Anabela Mota Pinto6, Celso Chieira7, Doutor Manuel Santos Rosa8
1 Professora Associada da Faculdade de Medicina da Universidade de Coimbra. Directora do Instituto de Patologia Geral da Faculdade de Medicina de Coimbra / Associate Professor, Coimbra University Medical School. Director, General Pathology Unit, Coimbra University Medical School
2 Assistente Hospitalar Graduada de Imunoalergologia dos Hospitais da Universidade de Coimbra / Hospital Assistant, Graduate in Allergy and Clinical Immunology, Coimbra University Hospitals
3 Mestre em Biologia Celular. Técnico Superior de 2.ª Classe do Instituto de Patologia Geral da Faculdade de Medicina da Universidade de Coimbra / MSc in Cellular Biology. Senior Technician (Grade II), General Pathology Unit, Coimbra University Medical School
4 Licenciada em Bioquímica. Assistente da Disciplina Imunologia e Investigadora do Instituto de Imunologia da Faculdade de Medicina da Universidade de Coimbra / BSc in Biochemistry, Assistant, Clinical Immunology, Researcher in Clinical Immunology, Coimbra University Medical School
5 Professor Catedrático da Faculdade de Medicina da Universidade de Coimbra. Director do Instituto de Imunologia da Faculdade de Medicina de Coimbra / Cathedratic Professor, Coimbra University Medical School. Director, Clinical Immunology Unit, Coimbra University Medical School
6 Instituto de Patologia Geral, Faculdade de Medicina da Universidade de Coimbra, Rua Larga, 3004-504 Coimbra
7 Departamento de Imunoalergologia, Hospitais da Universidade de Coimbra, Praceta Mota Pinto, 3000 Coimbra
8 Instituto de Imunologia, Faculdade de Medicina da Universidade de Coimbra, Rua Larga, 3004-504 Coimbra
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Directora do Instituto de Patologia Geral da Faculdade de Medicina de Coimbra / <span class="elsevierStyleItalic">Associate Professor, Coimbra University Medical School. Director, General Pathology Unit, Coimbra University Medical School</span>" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Assistente Hospitalar Graduada de Imunoalergologia dos Hospitais da Universidade de Coimbra / <span class="elsevierStyleItalic">Hospital Assistant, Graduate in Allergy and Clinical Immunology, Coimbra University Hospitals</span>" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Mestre em Biologia Celular. Técnico Superior de 2.ª Classe do Instituto de Patologia Geral da Faculdade de Medicina da Universidade de Coimbra / <span class="elsevierStyleItalic">MSc in Cellular Biology. Senior Technician (Grade II), General Pathology Unit, Coimbra University Medical School</span>" "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Licenciada em Bioquímica. Assistente da Disciplina Imunologia e Investigadora do Instituto de Imunologia da Faculdade de Medicina da Universidade de Coimbra / <span class="elsevierStyleItalic">BSc in Biochemistry, Assistant, Clinical Immunology, Researcher in Clinical Immunology, Coimbra University Medical School</span>" "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Professor Catedrático da Faculdade de Medicina da Universidade de Coimbra. Director do Instituto de Imunologia da Faculdade de Medicina de Coimbra / <span class="elsevierStyleItalic">Cathedratic Professor, Coimbra University Medical School. Director, Clinical Immunology Unit, Coimbra University Medical School</span>" "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Instituto de Patologia Geral, Faculdade de Medicina da Universidade de Coimbra, Rua Larga, 3004-504 Coimbra" "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Departamento de Imunoalergologia, Hospitais da Universidade de Coimbra, Praceta Mota Pinto, 3000 Coimbra" "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Instituto de Imunologia, Faculdade de Medicina da Universidade de Coimbra, Rua Larga, 3004-504 Coimbra" "etiqueta" => "<span class="elsevierStyleSup">8</span>" "identificador" => "aff0045" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Determinação da neopterina e de defesas antioxidantes na asma de evolução arrastada" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-07-14" "fechaAceptado" => "2006-08-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec158912" "palabras" => array:5 [ 0 => "Neopterin" 1 => "asthma" 2 => "aging" 3 => "TAS" 4 => "SOD" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec158913" "palabras" => array:4 [ 0 => "Neopterina" 1 => "envelhecimento" 2 => "TAS" 3 => "SOD" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Asthma is a condition characterised by a chronic immunoinflammatory response to different triggers. Neopterin (NPT) is synthesised by human macrophages upon stimulation with interferon-γ and is also capable of enhancing the oxidative potential of reactive oxygen species. NPT is useful for the monitoring of cell-mediated (Th1-type) immune activation.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">This study analysed the behaviour of NPT in long lasting asthma, considering its role as a marker of Th1 environment. Allergic parameters (skin prick tests, Immunoglobin E (IgE), and eosinophil count) and NPT were evaluated in an asthmatic group and in a control group. We also analysed the C Reactive Protein (CRP) concentration, Total Antioxidant Status (TAS) and Superoxide Dismutase Enzyme (SOD) in both groups. A group of individuals aged over 65 years old was selected. It included 64 asthmatic patients (72±5 years) and 41 healthy individuals (79±7 years).</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Blood cell counts showed statistically different median values of eosinophils (5.42±4.7 <span class="elsevierStyleItalic">vs</span> 2.8±2.8;p<.04), IgE (493.2±549.8 <span class="elsevierStyleItalic">vs</span> 85.3±194.4UI/ml; p=.000) and NPT was non-statistically decreased (2.4±2.8 <span class="elsevierStyleItalic">vs</span> 4.0±4.7ng/ml) in allergic asthmatic patients when compared with non-allergic asthmatic patients. Both allergic and non-allergic asthmatic patients presented a statistically significant decreased expression of TAS (0.84±0.14/0.86±0.11 <span class="elsevierStyleItalic">vs</span> 0.91±0.10 mM) and SOD (584.8±108.7/595.6±235.9 <span class="elsevierStyleItalic">vs</span> 822.9±179.5) when compared with normal control subjects.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Our results suggest macrophage involvement in asthma pathogenesis. The deficit in antioxidant defence impacts negatively on this disease. The increase of NPT values in non-allergic asthma consolidates these affirmations and mapping this parameter should be part of the work of an analytical study panel as it may lead to allergic asthma being distinguished from nonallergic asthma.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A asma é uma doença caracterizada por uma resposta imuno-inflamatória a diferentes estímulos desencadeantes. A neopterina (NPT) é sintetizada por macrófagos após estimulação por interferon-γ produzido por linfócitos T e demonstrou-se ter capacidade de ampliar o potencial oxidativo das espécies reactivas de oxigénio. A determinação de NPT é útil para monitorizar a activação imunológica celular dos linfócitos Th1.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Este estudo tem como objectivo analisar a NPT na asma de longa evolução enquanto marcador de um ambiente citocínico do tipo Th1. Avaliaram-se, no grupo de asmáticos e no grupo-controlo, os indicadores de alergia (IgE, eosinófilos e testes cutâneos de alergia por picada). Determinou-se também a NPT, a proteína C reactiva (PCR), <span class="elsevierStyleItalic">total antioxidant status</span> (TAS) e <span class="elsevierStyleItalic">superoxide dismutase enzyme</span> (SOD).</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Seleccionaram-se idosos com mais de 65 anos. Grupo-controlo – 41 indivíduos saudáveis (79±7 anos); grupo de asmáticos – 64 indivíduos (72±5 anos).</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Os valores dos eosinófilos e de IgE estavam estatisticamente aumentados e os de NPT reduzidos entre asmáticos alérgicos e não alérgicos, respectivamente (5,42±4,7 <span class="elsevierStyleItalic">vs</span> 2,8±2,8; p<,04), (493,2±549,8 <span class="elsevierStyleItalic">vs</span> 85,3±194,4UI/ml; p=,000), (2,4±2,8 <span class="elsevierStyleItalic">vs</span> 4,0±4,7ng/ml).</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">O estudo das defesas antioxidantes (TAS, SOD) revelou no grupo-controlo valores significativamente superiores aos do dos asmáticos (p=,000) tanto de TAS (0,84±0,14/0,86±0,11<span class="elsevierStyleItalic">vs</span> 0.91±0,10mM) como de SOD (584,8±108,7/595,6±235,9 <span class="elsevierStyleItalic">vs</span> 822,9±179,5).</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Os resultados sugerem o envolvimento dos macrófagos na patogénese da asma. O défice das defesas antioxidantes é um factor de agravamento desta doença. O aumento da NPT na asma não alérgica consolida estas afirmações, sendo a determinação deste parâmetro susceptível de ser incluída no painel de estudos analíticos que permitem distinguir a asma alérgica da asma não alérgica.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography/Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
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