Os factores genéticos da asma
Asthma genetic factors
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"apellidos" => "Santos Rosa" ] 5 => array:2 [ "nombre" => "Doutora Anabela" "apellidos" => "Mota Pinto" ] 6 => array:2 [ "nombre" => "Celso" "apellidos" => "Chieira" ] 7 => array:2 [ "nombre" => "Doutor Manuel" "apellidos" => "Santos Rosa" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511506704286?idApp=UINPBA00004E" "url" => "/21735115/0000001200000006/v1_201305151431/S2173511506704286/v1_201305151431/en/main.assets" ] "pt" => array:14 [ "idiomaDefecto" => true "titulo" => "Os factores genéticos da asma" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "683" "paginaFinal" => "708" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Paula Alexandra Videira, Luís Miguel Borrego, Hélder Trindade" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Paula" "apellidos" => "Alexandra Videira" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Luís" "apellidos" => "Miguel Borrego" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] ] 2 => array:3 [ "nombre" => "Hélder" "apellidos" => "Trindade" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Assistente Convidada Doutorada" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Assistente Convidado. Assistente Hospitalar de Imunoalergologia do Hospital Dona Estefânia" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Professor Associado Convidado com Agregação" "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Faculdade de Ciências Médicas, Departamento de Imunologia, Universidade Nova de Lisboa" "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Campo dos Mártires da Pátria, n.° 130, 1169-056 Lisboa. Tel.: +351-218803045/218853000; Fax: +218853480." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Asthma genetic factors" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-06-28" "fechaAceptado" => "2006-07-30" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec158920" "palabras" => array:5 [ 0 => "Asma" 1 => "susceptibilidade genética" 2 => "<span class="elsevierStyleItalic">genome wide screen</span>" 3 => "estudos de associação" 4 => "farmacogenética" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec158921" "palabras" => array:5 [ 0 => "Asthma" 1 => "genetic susceptibility" 2 => "genome wide screen" 3 => "association studies" 4 => "pharmacogenetics" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A asma brônquica é uma doença inflamatória crónica das vias aéreas, de prevalência crescente, particularmente na infância, sendo considerado um importante problema de saúde pública.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">É reconhecidamente uma doença de transmissão familiar, sendo um desafio a descrição e potencial identificação dos genes envolvidos na sua génese.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Pretende-se com o presente artigo de revisão explicitar exaustivamente os genes associados a esta patologia, bem como esclarecer os métodos laboratoriais que permitem a sua identificação.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Asthma is a chronic inflammatory airways disease, with a rising prevalence, particularly in childhood, and is considered an important Public Health problem.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">It's familial transmission is recognised, while the description and identification of the genes implicated in this disease are a challenge.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In this revision paper the authors give a comprehensive explanation of the associated genes as well as the laboratorial methods that allow their identification.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:129 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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ISSN: 21735115Original language: Portuguese
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