Fibrose pulmonar secundária à amiodarona – A propósito de um caso clínico
Amiodarone induced pulmonary fibrosis – A clinical case report
Marta N. Silva1,
, Patrícia Bacellar1, Helena Martins1, Nélia Tinoco2, Francisco Costa3,4, Helena Rodrigues5
1 Interna Complementar de Medicina Interna
2 Assistente Hospitalar de Pneumologia
3 Director do Serviço de Pneumologia
4 Hospital de São João de Deus EPE, Serviço de Pneumologia, Apartado 31 – EC 4761-917 V. N. Famalicão
5 Hospital de São João de Deus EPE, Serviço de Medicina, Apartado 31 – EC 4761-917 V. N. Famalicão
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A toxicidade pulmonar é uma delas, relativamente rara (5 a 10% dos casos), e pode ser fatal. Há vários factores que aumentam a susceptibilidadade para esta toxicidade, tais como a idade avançada e a doença pulmonar preexistente.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Apresentamos um caso clínico de toxicidade pulmonar induzida pela amiodarona (fibrose pulmonar) num doente do sexo masculino, de 81 anos. Estava medicado com este fármaco, desde há 5 anos, com uma dose diária de 200 mg.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Após a suspensão do fármaco e tratamento com corticosteróides sistémicos, houve melhoria clínica, funcional e radiológica.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Este caso clínico realça a necessidade de uma monitorização e diagnóstico precoce dos efeitos adversos do tratamento com a amiodarona e a dificuldade no seu diagnóstico, devido à inespecificidade dos sintomas, das manifestações clínicas e dos resultados dos exames complementares de diagnóstico.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Amiodarone is an antiarrhytmic drug and it is used to treat supraventricular or ventricular rhythm disturbances. Nevertheless it is not free of side effects. Amiodarone- induced pulmonary toxicity is one of them and is relatively rare (5 to 10% of cases) and can be fatal. There are several cumulative factors that may enhance susceptibility to pulmonary toxicity, such as advanced age and pre-existing pulmonary dysfunction.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We present a case study of amiodarone-induced toxicity (pulmonary fibrosis) in an 81-year-old man. The patient had been treated with amiodarone for five years in daily dose 200 mg/day.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">After withdrawing the drug and systemic corticosteroid therapy, clinical, functional and radiological improvement was observed.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">This case confirms the needs of a vigilant monitoring and early diagnosis of the adverse effects of amiodarone therapy, and the difficulty of diagnosing it due to the nonspecificity of symptoms, clinical findings, and test results.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Zipes, Libby, Bonow, Braunwald. Therapy for Cardiac Arrhytmias. 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Steinberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Cardiovasc Electrophysiol" "fecha" => "2001" "volumen" => "12" "numero" => "4" "paginaInicial" => "431" "paginaFinal" => "436" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11332563" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/21735115/0000001200000006/v1_201305151431/S2173511506704328/v1_201305151431/pt/main.assets" "Apartado" => array:4 [ "identificador" => "9550" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Report/Caso Clínico" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001200000006/v1_201305151431/S2173511506704328/v1_201305151431/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511506704328?idApp=UINPBA00004E" ]
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ISSN: 21735115Original language: Portuguese
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