Nontuberculous mycobacteria in non-AIDS patients
Micobactérias atípicas em doentes sem síndroma de imunodeficiência adquirida
1 Serviço de Pneumologia do HSJ (Director: Prof. Dr. J. Agostinho Marques), Porto, Portugal / Pulmonology Unit, Hospital São João, Oporto, Portugal
2 Serviço de Microbiologia do HSJ (Directora: Prof.ª Dr.ª MJ Vaz), Porto, Portugal / Microbiology Unit, Hospital São João, Oporto, Portugal
3 Hospital de São João, Alameda Hernâni Monteiro, 4200-Porto
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Marinho, G. Fernandes, T. Carvalho, D. Pinheiro, I. Gomes" "autores" => array:5 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Marinho" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] 1 => array:3 [ "nombre" => "G." "apellidos" => "Fernandes" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "T." "apellidos" => "Carvalho" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "D." "apellidos" => "Pinheiro" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "I." "apellidos" => "Gomes" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Serviço de Pneumologia do HSJ (Director: Prof. Dr. J. Agostinho Marques), Porto, Portugal / Pulmonology Unit, Hospital São João, Oporto, Portugal" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Serviço de Microbiologia do HSJ (Directora: Prof.ª Dr.ª MJ Vaz), Porto, Portugal / Microbiology Unit, Hospital São João, Oporto, Portugal" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospital de São João, Alameda Hernâni Monteiro, 4200-Porto" "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Micobactérias atípicas em doentes sem síndroma de imunodeficiência adquirida" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-08-11" "fechaAceptado" => "2008-01-07" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec159557" "palabras" => array:3 [ 0 => "Nontuberculous mycobacteria" 1 => "isolation" 2 => "pulmonary disease" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec159556" "palabras" => array:3 [ 0 => "Micobactérias atípicas" 1 => "isolamento" 2 => "doença pulmonar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Nontuberculous mycobacteria (NTM) play an increasingly significant pathogenic role in HIV-positive patients, in patients with chronic lung disease, in other chronic conditions and in the elderly.</p> <span class="elsevierStyleSectionTitle">Aims</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Evaluate the importance of NTM isolation in respiratory samples in patients without HIV-infection.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Retrospective evaluation of our hospital patients with no known AIDS, with at least one NTM positive respiratory sample, from 1997-2004.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">We found 102 patients, with a median age of 63 years; 67% male. Sixty-three (62%) had underlying lung disease, mainly tuberculosis sequelae (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19). The majority (47%) of the isolations were <span class="elsevierStyleItalic">Mycobacterium avium complex</span> (MAC).</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">A diagnosis of <span class="elsevierStyleItalic">Mycobacterium</span> pulmonary disease was made in 16 patients (15.7%), 14 of which met the American Thoracic Society diagnostic criteria. Ten male and 6 female; median age 65 years. Twelve had underlying lung disease. All of them had respiratory infection complaints. Chest X-rays showed mainly pulmonary infiltrates, linear opacities and cavitation. MAC was the cause of mycobacterium respiratory disease in 12 patients (75%).</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">NTM isolation did not equal pulmonary NTM disease in the majority of cases, even in patients with underlying lung disease. MAC was the most commonly isolated agent and its relative importance was higher in the presence of NTM disease.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">As micobactérias não tuberculosas (MNT) têm um papel patogénico de importância crescente em doentes com serologia positiva para o vírus da imunodeficiência humana (VIH), em doentes com doença pulmonar crónica, em outras doencas crónicas, e ainda nos idosos.</p> <span class="elsevierStyleSectionTitle">Objectivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Avaliar a importância do isolamento de MNT em amostras respiratórias em doentes adultos sem infecção VIH.</p> <span class="elsevierStyleSectionTitle">Material e métodos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudo retrospectivo dos doentes do Hospital de São João sem infecção VIH conhecida, com pelo menos uma amostra respiratória positiva para MNT, entre 1997 e 2004.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram encontrados 102 doentes com idade mediana de 63 anos; 67% do sexo masculino. Sessenta e três doentes (62%) apresentavam patologia respiratória prévia, maioritariamente sequelas de tuberculose pulmonar (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19). O agente mais isolado (47%) foi o <span class="elsevierStyleItalic">Mycobacterium avium complex</span> (MAC).</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Foram identificados 16 casos de doenca (15,7%), 14 dos quais cumpriam os critérios definidos pela <span class="elsevierStyleItalic">American Thoracic Society.</span> Dez homens e 6 mulheres, idade mediana de 65 anos. Doze doentes tinham doenca pulmonar prévia. Todos tinham clínica de infecção respiratória. As alteraçóes mais observadas no Rx de tórax foram o infiltrado pulmonar, a opacidade linear e a cavitação. O MAC foi o causador de doenca em 75% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>12) dos casos.</p> <span class="elsevierStyleSectionTitle">Conclusão</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">O isolamento de micobactérias atípicas em amostras respiratórias, nomeadamente em doentes com patologia pulmonar prévia, não significou doença na grande maioria dos casos, mesmo em doentes com doença pulmonar prévia. O agente mais frequentemente isolado foi o MAC, tendo a sua importância relativa sido ainda maior nos casos de doença pulmonar por MNT.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography/Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
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