Evaluation of bone mineral density in cystic fibrosis patients
Avaliação da densidade mineral óssea em doentes com fibrose quística
1 Interna Complementar de Pneumologia / Resident, specialist training in Pulmonology
2 Assistente Hospitalar de Pneumologia / Pulmonolgy consultant
3 Director do Serviço de Pneumologia dos HUC / Head, Pulmonologu Unit, HUC
4 Director do Departamento de Ciências Pneumológicas e Alergológicas dos HUC / Director, Department of Pulmonology and Allergology Sciences, HUC
5 Departamento de Ciências Pneumológicas e Alergológicas dos Hospitais da Universidade de Coimbra, Av. Bissaya Barreto e Praceta Prof. Mota Pinto, 3000-075 Coimbra
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Fontes Baganha" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Jessica" "apellidos" => "Cemlyn-Jones" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] 1 => array:3 [ "nombre" => "Fernanda" "apellidos" => "Gamboa" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] 2 => array:3 [ "nombre" => "Mário" "apellidos" => "Loureiro" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] 3 => array:3 [ "nombre" => "M." "apellidos" => "Fontes Baganha" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Interna Complementar de Pneumologia / <span class="elsevierStyleItalic">Resident, specialist training in Pulmonology</span>" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Assistente Hospitalar de Pneumologia / <span class="elsevierStyleItalic">Pulmonolgy consultant</span>" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Director do Serviço de Pneumologia dos HUC / <span class="elsevierStyleItalic">Head, Pulmonologu Unit, HUC</span>" "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Director do Departamento de Ciências Pneumológicas e Alergológicas dos HUC / <span class="elsevierStyleItalic">Director, Department of Pulmonology and Allergology Sciences, HUC</span>" "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Departamento de Ciências Pneumológicas e Alergológicas dos Hospitais da Universidade de Coimbra, Av. Bissaya Barreto e Praceta Prof. Mota Pinto, 3000-075 Coimbra" "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Avaliação da densidade mineral óssea em doentes com fibrose quística" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-05-19" "fechaAceptado" => "2008-07-31" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec159732" "palabras" => array:3 [ 0 => "Cystic fibrosis" 1 => "bone mineral density" 2 => "vitamin D" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec159733" "palabras" => array:3 [ 0 => "Fibrose quística" 1 => "densidade mineral óssea" 2 => "vitamina D" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Patients with cystic fibrosis (CF) have an increasing life span and osteoporosis has become a more recognised problem in these patients. The pathogenesis of low bone mineral density (BMD) in CF seems to be multifactorial and the aim of this study was to assess the prevalence of low BMD in a group of CF outpatients and to relate the findings with the variables studied.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The study included 22 patients aged between 14 and 45 years (mean age 26.3). Two of the subjects were lung transplant patients. BMD was assessed by dualenergy X-ray absorptiometry (DEXA) at the lumbar spine (LS) and femoral neck (FN). This data was correlated with serum 25-hydroxy vitamin D (25-OHD) levels, BMI and the forced expiratory volume in one second (FEV<span class="elsevierStyleInf">1</span>).</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">BMD (Z-score and T-score) ranged from 0.6 to -6 and from 0.5 to -6.7 at LS; at FN the scores ranged from 0.6 to -3.9 and from 0.6 to -4.1. The mean serum 25-OHD concentration (12,57<span class="elsevierStyleHsp" style=""></span>ng/ml) was at the low end of the normal range (10-60<span class="elsevierStyleHsp" style=""></span>ng/ml). On average patients did not present with malnutrition, however BMI ranged from 15.2 to 33.7<span class="elsevierStyleHsp" style=""></span>kg/m<span class="elsevierStyleSup">2</span>. Lung function status was assessed by FEV<span class="elsevierStyleInf">1</span>; 64% of patients had FEV<span class="elsevierStyleInf">1</span> below 80% and within this group four patients had a FEV<span class="elsevierStyleInf">1</span> under 40%.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">There was a positive correlation between low BMD and 25-OHD concentrations and also between BMD and FEV<span class="elsevierStyleInf">1</span>. There was no linear correlation between BMD and BMI.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A esperança de vida dos doentes com fibrose quística (FQ) tem vindo a aumentar, sendo mais frequente a identificação de osteoporose. A patogénese de uma baixa densidade mineral óssea (DMO) na FQ parece ser multifactorial e o objectivo deste trabalho foi avaliar a prevalência de baixa DMO num grupo de doentes com FQ e a sua correlação com outros parâmetros avaliados.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">O estudo incluiu 22 doentes com FQ com idades compreendidas entre os 14 e os 45 anos (média 26,3), dois dos quais transplantados pulmonares. A DMO foi avaliada por densitometria óssea ao nível da coluna lombar e do colo do fémur. Estes dados foram correlacionados com os valores séricos de 25-hydroxivitamina D, o IMC e o volume expiratório máximo forçado no primeiro segundo (VEM).</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Os valores da DMO (Z-<span class="elsevierStyleItalic">score</span> e <span class="elsevierStyleItalic">T-score</span>) variaram entre 0,6 e -6 e entre 0,5 e -6,7, respectivamente, a nível da coluna lombar e entre 0,6 e -3,9 e 0,6 e -4,1 a nível do colo do fémur. A média das concentrações séricas de 25-(OH)D (12,57<span class="elsevierStyleHsp" style=""></span>ng/ml) encontrava-se no limite inferior da normalidade (10-60<span class="elsevierStyleHsp" style=""></span>ng/ml). Em média os doentes não apresentavam malnutrição mas os valores de IMC variam entre 15,2 e 33,7<span class="elsevierStyleHsp" style=""></span>kg/m<span class="elsevierStyleSup">2</span>. Relativamente à função pulmonar, 64% dos doentes apresentavam VEM inferior a 80% e, destes, quatro tinham valores inferiores a 40%. Foi encontrada uma correlação positiva entre valores baixos de DMO e VEM, assim como entre valores de DMO e 25-OHD. Não houve correlação linear entre IMC e DMO.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Elkin S, Haworth C. Cystic fibrosis related low bone mineral density. <span class="elsevierStyleItalic">In</span> Hodson M, Gedder, Bush A. Cystic fibrosis. Bush A; Hodson M; Geddes. 3rd edition. 261-267." ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." 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