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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Extensively drug-resistant tuberculosis &#40;XDR-TB&#41; is defined as a form of multidrug-resistant tuberculosis &#40;MDR-TB&#41; with additional resistance to fluoroquinolones and at least one of the injectable drugs used in tuberculosis treatment&#58; amikacin&#44; kanamycin and capreomycin&#46; It was classified by WHO as a serious threat to tuberculosis &#40;TB&#41; control&#44; with world-wide consequences&#44; taking on the proportions of a real pandemic in some regions&#46;</p> <span class="elsevierStyleSectionTitle">Aim</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To compare patients with XDR-TB <span class="elsevierStyleItalic">versus</span> other MDR-TB profiles with regard to epidemiological and demographic characteristics&#44; aetiopathogenic factors and inhospital outcomes&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Patients admitted to Pulido Valente Hospital &#40;Pulmonology Service III&#41; in the period ranging from April 1999 to June 2007 with MDR-TB diagnosis microbiologically confirmed&#46; The following variables were evaluated&#58; gender&#44; age&#44; race&#44; forms of TB presentation&#44; treatment groups&#44; resistance profile&#44; immigrant status&#44; number and duration of previous treatments&#44; WHO classification&#44; HIV co-infection&#44; alcoholism and&#47;or drug addiction&#44; average length of hospital stay and inhospital mortality&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Statistical analysis was performed using the SPSS &#40;Statistical Package for the Social Sciences&#41;&#44; version 15&#46;0&#46; In categorical variables&#44; the statistical differences between groups were evaluated by the Chisquare test and numeric variables using the T-test&#46; Logistical regression analysis was used to build the predictive model of XDR-TB existence &#40;dependent variable&#41;&#44; which included the following independent variables&#58; WHO classification&#44; HIV co-infection&#44; immigrant status&#44; alcoholism and&#47;or drug addiction and number and duration of previous treatments&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">We recorded 132 patients with MDR-TB&#44; of which 69 &#40;52&#46;3&#37;&#41; were XDR-TB&#46; Statistically significant differences were observed in the following variables&#58; race &#40;black race was associated with XDRTB in 74&#37; of cases <span class="elsevierStyleItalic">versus</span> 46&#37; of the Caucasian race&#41;&#59; WHO classification &#40;patients with retreatment for therapeutic failure&#44; stopping treatment or relapse were 69&#46;5&#37; of XDR-TB cases <span class="elsevierStyleItalic">versus</span> 44&#46;5&#37; of Not XDR-TB cases&#59; average duration of previous treatments &#40;4&#46;2 months for XDR-TB cases <span class="elsevierStyleItalic">versus</span> 2&#46;8 months for Not XDR-TB cases&#41;&#59; HIV co-infection &#40;patients with HIV co-infection constituted 65&#46;2&#37; of XDR-TB cases <span class="elsevierStyleItalic">versus</span> 42&#46;9&#37; of Not XDR-TB cases&#41;&#44; mortality &#40;33&#46;3&#37; in patients with XDR-TB <span class="elsevierStyleItalic">versus</span> 14&#46;3&#37; in Not XDR-TB patients&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The variables with predictive value for the diagnosis of XDR-TB vs&#46; Not XDR-TB were presence of HIV co-infection &#40;odds ratio &#91;OR&#93; for XDRTB 2&#46;5&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 1&#46;24&#8211;5&#46;05&#41; and increased average duration of previous treatments &#40;&#91;OR&#93; for XDR-TB 1&#46;2&#59; 95&#37; &#91;CI&#93;&#44; 1&#46;11&#8211;2&#46;30&#41;&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A tuberculose extensivamente resistente &#40;TBXDR&#41; define-se como uma forma de tuberculose multirresistente &#40;TBMR&#41; com resist&#234;ncias adicionais &#224;s fluoroquinolonas e&#44; pelo menos&#44; a um dos antibacilares inject&#225;veis seguintes&#58; amicacina&#44; canamicina e capreomicina&#46; Foi classificada pela OMS como uma amea&#231;a s&#233;ria ao controlo da tuberculose&#44; com consequ&#234;ncias &#224; escala mundial&#44; assumindo os contornos de uma aut&#234;ntica pandemia em algumas regi&#245;es do globo&#46;</p> <span class="elsevierStyleSectionTitle">Objectivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Comparar os doentes com TBXDR <span class="elsevierStyleItalic">versus</span> outros perfis de TBMR no que diz respeito &#224;s caracter&#237;sticas demogr&#225;ficas e epidemiol&#243;gicas&#44; factores etiopatog&#233;nicos e evolu&#231;&#227;o no internamento&#46;</p> <span class="elsevierStyleSectionTitle">Material e m&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Doentes internados no Servi&#231;o de Pneumologia III do Hospital de Pulido Valente no per&#237;odo compreendido entre Abril de 1999 e Junho de 2007&#44; com o diagn&#243;stico de TBMR microbiologicamente confirmado&#46; Foram analisadas as seguintes vari&#225;veis&#58; sexo&#44; distribui&#231;&#227;o et&#225;ria&#44; ra&#231;a&#44; formas de apresenta&#231;&#227;o da TB&#44; grupos de tratamento&#44; perfil de resist&#234;ncia aos antibacilares&#44; estatuto de imigrante&#44; n&#250;mero e dura&#231;&#227;o de tratamentos anteriores&#44; classifica&#231;&#227;o OMS&#44; co-infec&#231;&#227;o VIH&#44; alcoolismo e&#47;ou toxicodepend&#234;ncia&#44; demora m&#233;dia do internamento e mortalidade intra-hospitalar&#46; A an&#225;lise estat&#237;stica realizou-se no programa SPSS &#40;Statistical Package for the Social Sciences&#41;&#44; vers&#227;o 15&#46;0&#46; Nas vari&#225;veis categoriais&#44; as diferen&#231;as estat&#237;sticas entre os grupos foram avaliadas atrav&#233;s do teste qui-quadrado e as vari&#225;veis num&#233;ricas atrav&#233;s do teste t&#46; Para a constru&#231;&#227;o do modelo preditivo da presen&#231;a de TBXDR &#40;vari&#225;vel dependente&#41; foi utilizada a an&#225;lise de regress&#227;o log&#237;stica&#44; tendo sido inclu&#237;das as seguintes vari&#225;veis independentes&#58; classifica&#231;&#227;o OMS&#44; coinfec&#231;&#227;o VIH&#44; estatuto de imigrante&#44; alcoolismo e&#47;ou toxicodepend&#234;ncia e n&#250;mero e dura&#231;&#227;o de tratamentos anteriores&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram contabilizados 132 doentes com TBMR&#44; dos quais 69 &#40;52&#44;3&#37;&#41; eram TBXDR&#46; Observaram-se diferen&#231;as estatisticamente significativas nas seguintes vari&#225;veis&#58; ra&#231;a &#40;a ra&#231;a negra esteve associada a TBXDR em 74&#37; dos casos <span class="elsevierStyleItalic">versus</span> 46&#37; da ra&#231;a caucasiana&#41;&#59; classifica&#231;&#227;o OMS &#40;doentes com retratamento por insucesso terap&#234;utico&#44; interrup&#231;&#227;o do tratamento ou recidiva constitu&#237;ram 69&#44;5&#37; dos casos de TBXDR <span class="elsevierStyleItalic">versus</span> 44&#44;5&#37; dos casos n&#227;o TBXDR&#41;&#59; dura&#231;&#227;o m&#233;dia dos tratamentos anteriores &#40;4&#44;2 meses para os casos de TBXDR <span class="elsevierStyleItalic">versus</span> 2&#44;8 meses para os casos n&#227;o TBXDR&#41;&#59; coinfec&#231;&#227;o VIH&#47;SIDA &#40;doentes com coinfec&#231;&#227;o VIH constitu&#237;ram 65&#44;2&#37; dos casos de TB XDR <span class="elsevierStyleItalic">versus</span> 42&#44;9&#37; dos casos n&#227;o TBXDR&#41; e mortalidade &#40;33&#44;3&#37; nos doentes com TBXDR <span class="elsevierStyleItalic">versus</span> 14&#44;3&#37; nos doentes n&#227;o TBXDR&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#245;es</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">As vari&#225;veis com valor preditivo para o diagn&#243;stico de TBXDR <span class="elsevierStyleItalic">versus</span> n&#227;o TBXDR foram&#58; presen&#231;a de infec&#231;&#227;o VIH &#40;risco relativo &#91;RR&#93; para TBXDR de 2&#44;5&#59; intervalo de confian&#231;a &#91;IC&#93;&#44; 1&#44;24&#8211;5&#44;05&#41;&#59; maior dura&#231;&#227;o m&#233;dia dos tratamentos anteriores &#40;&#91;RR&#93; para TB XDR de 1&#44;2&#59; &#91;IC&#93;&#44; 1&#44;11&#8211;2&#44;30&#41;&#46;</p>"
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Comparative analysis of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis – Epidemiology and predictive factors
Análise comparativa entre tuberculose multirresistente e tuberculose extensivamente resistente – Epidemiologia e factores preditivos
Ana Sofia Vilariça1,
Corresponding author
anasofia.vilarica@gmail.com

Serviço de Pneumologia III Hospital de Pulido Valente, Centro Hospitalar Lisboa Norte, Lisboa Alameda das Linhas de Torres, 117 1769-001Lisboa.
, Carlos Gomes2, Jaime Pina3
1 Interna do Internato Complementar de Pneumologia / Pulmonology resident, Pulido Valente Hospital, Lisbon
2 Assistente Hospitalar Graduado de Pneumologia / Pulmonology consultant and specialist, Pulido Valente Hospital, Lisbon
3 Chefe de Serviço Hospitalar de Pneumologia e Director do Serviço de Pneumologia III do Hospital de Pulido Valente, Lisboa / Head, Hospital Pulmonology Service and Director, Hospital Pulmonology Service III, Pulido Valente Hospital, Lisbon
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            0 => "Tuberculose extensivamente resistente &#40;TBXDR&#41;"
            1 => "tuberculose multirresistente &#40;TBMR&#41;"
            2 => "epidemiologia"
            3 => "valor preditivo"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Extensively drug-resistant tuberculosis &#40;XDR-TB&#41; is defined as a form of multidrug-resistant tuberculosis &#40;MDR-TB&#41; with additional resistance to fluoroquinolones and at least one of the injectable drugs used in tuberculosis treatment&#58; amikacin&#44; kanamycin and capreomycin&#46; It was classified by WHO as a serious threat to tuberculosis &#40;TB&#41; control&#44; with world-wide consequences&#44; taking on the proportions of a real pandemic in some regions&#46;</p> <span class="elsevierStyleSectionTitle">Aim</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To compare patients with XDR-TB <span class="elsevierStyleItalic">versus</span> other MDR-TB profiles with regard to epidemiological and demographic characteristics&#44; aetiopathogenic factors and inhospital outcomes&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Patients admitted to Pulido Valente Hospital &#40;Pulmonology Service III&#41; in the period ranging from April 1999 to June 2007 with MDR-TB diagnosis microbiologically confirmed&#46; The following variables were evaluated&#58; gender&#44; age&#44; race&#44; forms of TB presentation&#44; treatment groups&#44; resistance profile&#44; immigrant status&#44; number and duration of previous treatments&#44; WHO classification&#44; HIV co-infection&#44; alcoholism and&#47;or drug addiction&#44; average length of hospital stay and inhospital mortality&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Statistical analysis was performed using the SPSS &#40;Statistical Package for the Social Sciences&#41;&#44; version 15&#46;0&#46; In categorical variables&#44; the statistical differences between groups were evaluated by the Chisquare test and numeric variables using the T-test&#46; Logistical regression analysis was used to build the predictive model of XDR-TB existence &#40;dependent variable&#41;&#44; which included the following independent variables&#58; WHO classification&#44; HIV co-infection&#44; immigrant status&#44; alcoholism and&#47;or drug addiction and number and duration of previous treatments&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">We recorded 132 patients with MDR-TB&#44; of which 69 &#40;52&#46;3&#37;&#41; were XDR-TB&#46; Statistically significant differences were observed in the following variables&#58; race &#40;black race was associated with XDRTB in 74&#37; of cases <span class="elsevierStyleItalic">versus</span> 46&#37; of the Caucasian race&#41;&#59; WHO classification &#40;patients with retreatment for therapeutic failure&#44; stopping treatment or relapse were 69&#46;5&#37; of XDR-TB cases <span class="elsevierStyleItalic">versus</span> 44&#46;5&#37; of Not XDR-TB cases&#59; average duration of previous treatments &#40;4&#46;2 months for XDR-TB cases <span class="elsevierStyleItalic">versus</span> 2&#46;8 months for Not XDR-TB cases&#41;&#59; HIV co-infection &#40;patients with HIV co-infection constituted 65&#46;2&#37; of XDR-TB cases <span class="elsevierStyleItalic">versus</span> 42&#46;9&#37; of Not XDR-TB cases&#41;&#44; mortality &#40;33&#46;3&#37; in patients with XDR-TB <span class="elsevierStyleItalic">versus</span> 14&#46;3&#37; in Not XDR-TB patients&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The variables with predictive value for the diagnosis of XDR-TB vs&#46; Not XDR-TB were presence of HIV co-infection &#40;odds ratio &#91;OR&#93; for XDRTB 2&#46;5&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 1&#46;24&#8211;5&#46;05&#41; and increased average duration of previous treatments &#40;&#91;OR&#93; for XDR-TB 1&#46;2&#59; 95&#37; &#91;CI&#93;&#44; 1&#46;11&#8211;2&#46;30&#41;&#46;</p>"
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        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A tuberculose extensivamente resistente &#40;TBXDR&#41; define-se como uma forma de tuberculose multirresistente &#40;TBMR&#41; com resist&#234;ncias adicionais &#224;s fluoroquinolonas e&#44; pelo menos&#44; a um dos antibacilares inject&#225;veis seguintes&#58; amicacina&#44; canamicina e capreomicina&#46; Foi classificada pela OMS como uma amea&#231;a s&#233;ria ao controlo da tuberculose&#44; com consequ&#234;ncias &#224; escala mundial&#44; assumindo os contornos de uma aut&#234;ntica pandemia em algumas regi&#245;es do globo&#46;</p> <span class="elsevierStyleSectionTitle">Objectivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Comparar os doentes com TBXDR <span class="elsevierStyleItalic">versus</span> outros perfis de TBMR no que diz respeito &#224;s caracter&#237;sticas demogr&#225;ficas e epidemiol&#243;gicas&#44; factores etiopatog&#233;nicos e evolu&#231;&#227;o no internamento&#46;</p> <span class="elsevierStyleSectionTitle">Material e m&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Doentes internados no Servi&#231;o de Pneumologia III do Hospital de Pulido Valente no per&#237;odo compreendido entre Abril de 1999 e Junho de 2007&#44; com o diagn&#243;stico de TBMR microbiologicamente confirmado&#46; Foram analisadas as seguintes vari&#225;veis&#58; sexo&#44; distribui&#231;&#227;o et&#225;ria&#44; ra&#231;a&#44; formas de apresenta&#231;&#227;o da TB&#44; grupos de tratamento&#44; perfil de resist&#234;ncia aos antibacilares&#44; estatuto de imigrante&#44; n&#250;mero e dura&#231;&#227;o de tratamentos anteriores&#44; classifica&#231;&#227;o OMS&#44; co-infec&#231;&#227;o VIH&#44; alcoolismo e&#47;ou toxicodepend&#234;ncia&#44; demora m&#233;dia do internamento e mortalidade intra-hospitalar&#46; A an&#225;lise estat&#237;stica realizou-se no programa SPSS &#40;Statistical Package for the Social Sciences&#41;&#44; vers&#227;o 15&#46;0&#46; Nas vari&#225;veis categoriais&#44; as diferen&#231;as estat&#237;sticas entre os grupos foram avaliadas atrav&#233;s do teste qui-quadrado e as vari&#225;veis num&#233;ricas atrav&#233;s do teste t&#46; Para a constru&#231;&#227;o do modelo preditivo da presen&#231;a de TBXDR &#40;vari&#225;vel dependente&#41; foi utilizada a an&#225;lise de regress&#227;o log&#237;stica&#44; tendo sido inclu&#237;das as seguintes vari&#225;veis independentes&#58; classifica&#231;&#227;o OMS&#44; coinfec&#231;&#227;o VIH&#44; estatuto de imigrante&#44; alcoolismo e&#47;ou toxicodepend&#234;ncia e n&#250;mero e dura&#231;&#227;o de tratamentos anteriores&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram contabilizados 132 doentes com TBMR&#44; dos quais 69 &#40;52&#44;3&#37;&#41; eram TBXDR&#46; Observaram-se diferen&#231;as estatisticamente significativas nas seguintes vari&#225;veis&#58; ra&#231;a &#40;a ra&#231;a negra esteve associada a TBXDR em 74&#37; dos casos <span class="elsevierStyleItalic">versus</span> 46&#37; da ra&#231;a caucasiana&#41;&#59; classifica&#231;&#227;o OMS &#40;doentes com retratamento por insucesso terap&#234;utico&#44; interrup&#231;&#227;o do tratamento ou recidiva constitu&#237;ram 69&#44;5&#37; dos casos de TBXDR <span class="elsevierStyleItalic">versus</span> 44&#44;5&#37; dos casos n&#227;o TBXDR&#41;&#59; dura&#231;&#227;o m&#233;dia dos tratamentos anteriores &#40;4&#44;2 meses para os casos de TBXDR <span class="elsevierStyleItalic">versus</span> 2&#44;8 meses para os casos n&#227;o TBXDR&#41;&#59; coinfec&#231;&#227;o VIH&#47;SIDA &#40;doentes com coinfec&#231;&#227;o VIH constitu&#237;ram 65&#44;2&#37; dos casos de TB XDR <span class="elsevierStyleItalic">versus</span> 42&#44;9&#37; dos casos n&#227;o TBXDR&#41; e mortalidade &#40;33&#44;3&#37; nos doentes com TBXDR <span class="elsevierStyleItalic">versus</span> 14&#44;3&#37; nos doentes n&#227;o TBXDR&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#245;es</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">As vari&#225;veis com valor preditivo para o diagn&#243;stico de TBXDR <span class="elsevierStyleItalic">versus</span> n&#227;o TBXDR foram&#58; presen&#231;a de infec&#231;&#227;o VIH &#40;risco relativo &#91;RR&#93; para TBXDR de 2&#44;5&#59; intervalo de confian&#231;a &#91;IC&#93;&#44; 1&#44;24&#8211;5&#44;05&#41;&#59; maior dura&#231;&#227;o m&#233;dia dos tratamentos anteriores &#40;&#91;RR&#93; para TB XDR de 1&#44;2&#59; &#91;IC&#93;&#44; 1&#44;11&#8211;2&#44;30&#41;&#46;</p>"
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Pulmonology

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