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    "titulo" => "Correlation of levels of obstruction in COPD with lactate and six-minute walk test"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Chronic obstructive pulmonary disease &#40;COPD&#41; is a leading cause of morbid-mortality world wide&#44; leading not only to pulmonary damage but also to multisystemic impairment&#44; with repercussions on skeletal muscles and the ability to undertake effort&#44; as measured in the six-minute walk test &#40;6-MWT&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Aims</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To correlate the level of obstruction in COPD with lactate concentration and heart rate &#40;HR&#41; at rest&#44; and distance walked&#46; To correlate distance walked with blood gas analysis and correlate desaturation in 6-MWT with post 6-MWT lactate concentration and heart rate&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">COPD patients underwent spirometry&#44; blood gas analysis and 6-MWT to evaluate distance walked&#44; heart rate&#44; capillary lactate &#40;CL&#41; concentration pre&#8211; and post 6MWT&#44; and desaturation with 6-MWT&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">91 patients with all levels of obstruction were evaluated&#46; HR and CL increased significantly post 6-MWT&#46; The decrease in peripheral saturation of haemoglobin to oxygen observed with 6-MWT was also significant&#46; The distance walked was shorter the greater the obstruction&#46; The correlation analysis was significantly positive between FEV<span class="elsevierStyleInf">1</span> and distance walked&#44; negative between FEV<span class="elsevierStyleInf">1</span> and HR at rest and negative between distance walked and PaCO<span class="elsevierStyleInf">2</span>&#44; and not significant for the other variables&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Increased obstruction in COPD and higher PaCO<span class="elsevierStyleInf">2</span> values contribute to a reduction in distance walked in 6-MWT&#46; The level of obstruction in COPD leads to a haemodynamic impairment with increased HR at rest of these patients&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Contextualiza&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A doen&#231;a pulmonar obstrutiva cr&#243;nica &#40;DPOC&#41;&#44; importante causa de morbimortalidade em todo mundo&#44; leva n&#227;o s&#243; ao comprometimento pulmonar&#44; mas tamb&#233;m a altera&#231;&#245;es sist&#233;micas&#44; com repercuss&#245;es sobre m&#250;sculos esquel&#233;ticos e a capacidade de realizar esfor&#231;os&#44; mensur&#225;vel pelo teste de caminhada de seis minutos &#40;TC6&#8217;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Objectivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">correlacionar obstru&#231;&#227;o da DPOC com lactato de repouso&#44; frequ&#234;ncia card&#237;aca de repouso&#44; bem como com dist&#226;ncia percorrida&#46; Correlacionar dist&#226;ncia percorrida com gasometria e ainda correlacionar dessatura&#231;&#227;o ao TC6&#8217; com lactato e frequ&#234;ncia card&#237;aca p&#243;s-TC6&#8217;&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Portadores de DPOC realizaram espirometria&#44; gasometria e TC6&#8217;&#44; que avaliou&#58; dist&#226;ncia percorrida&#44; frequ&#234;ncia card&#237;aca &#40;FC&#41;&#44; lactato capilar &#40;Lct&#41; pr&#233; e p&#243;s-TC6&#8217;&#44; al&#233;m de dessatura&#231;&#227;o ao TC6&#8217;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram avaliados 91 doentes abrangendo todos os graus de obstru&#231;&#227;o&#46; Os par&#226;metros p&#243;s-TC6&#8217;&#44; como FC e Lct&#44; aumentaram de maneira significativa com a realiza&#231;&#227;o do mesmo&#46; A queda da satura&#231;&#227;o da hemoglobina ao oxig&#233;nio diante do TC6&#8217; tamb&#233;m foi significativa&#46; A an&#225;lise de correla&#231;&#227;o significativa mostrou-se positiva entre VEF<span class="elsevierStyleInf">1</span> e dist&#226;ncia percorrida&#44; negativa entre VEF<span class="elsevierStyleInf">1</span> e FC de repouso e negativa entre dist&#226;ncia percorrida e PaCO<span class="elsevierStyleInf">2</span>&#44; sendo n&#227;o significante para as demais vari&#225;veis&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#245;es</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A progress&#227;o da obstru&#231;&#227;o na DPOC&#44; bem como valores maiores de PaCO<span class="elsevierStyleInf">2</span>&#44; contribuem para a redu&#231;&#227;o da dist&#226;ncia percorrida no TC6&#8217;&#46; O grau de obstru&#231;&#227;o na DPOC leva a altera&#231;&#227;o hemodin&#226;mica com o aumento da frequ&#234;ncia card&#237;aca de repouso destes doentes&#46;</p>"
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                      "titulo" => "Peripheral muscle endurance and the oxidative profile of the quadriceps in patients with COPD"
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Correlation of levels of obstruction in COPD with lactate and six-minute walk test
Correlação dos graus de obstrução na DPOC com lactato e teste de caminhada de seis minutos
Dante Brasil Santos1,
Corresponding author
dante@unb.br

Correspondence to/Endereço para correspondência: SQN 206 BLOCO J APT 503. CEP: 70844-100 – Brasília-DF – Brasil. Telefone: 061-32452503.
, Carlos Alberto de Assis Viegas2
1 Fisioterapeuta do Hospital Universitário de Brasília da Universidade de Brasília (HUB/UnB) / Physiotherapist, Hospital Universitário de Brasília da Universidade de Brasília (HUB/UnB)
2 Professor Adjunto IV da Universidade de Brasília – Departamento de Clínica Médica – Universidade de Brasília / Assistant Professor IV, Universidade de Brasília, Departamento de Clínica Médica, Universidade de Brasília
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        "resumen" => "<span class="elsevierStyleSectionTitle">Contextualiza&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A doen&#231;a pulmonar obstrutiva cr&#243;nica &#40;DPOC&#41;&#44; importante causa de morbimortalidade em todo mundo&#44; leva n&#227;o s&#243; ao comprometimento pulmonar&#44; mas tamb&#233;m a altera&#231;&#245;es sist&#233;micas&#44; com repercuss&#245;es sobre m&#250;sculos esquel&#233;ticos e a capacidade de realizar esfor&#231;os&#44; mensur&#225;vel pelo teste de caminhada de seis minutos &#40;TC6&#8217;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Objectivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">correlacionar obstru&#231;&#227;o da DPOC com lactato de repouso&#44; frequ&#234;ncia card&#237;aca de repouso&#44; bem como com dist&#226;ncia percorrida&#46; Correlacionar dist&#226;ncia percorrida com gasometria e ainda correlacionar dessatura&#231;&#227;o ao TC6&#8217; com lactato e frequ&#234;ncia card&#237;aca p&#243;s-TC6&#8217;&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Portadores de DPOC realizaram espirometria&#44; gasometria e TC6&#8217;&#44; que avaliou&#58; dist&#226;ncia percorrida&#44; frequ&#234;ncia card&#237;aca &#40;FC&#41;&#44; lactato capilar &#40;Lct&#41; pr&#233; e p&#243;s-TC6&#8217;&#44; al&#233;m de dessatura&#231;&#227;o ao TC6&#8217;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Foram avaliados 91 doentes abrangendo todos os graus de obstru&#231;&#227;o&#46; Os par&#226;metros p&#243;s-TC6&#8217;&#44; como FC e Lct&#44; aumentaram de maneira significativa com a realiza&#231;&#227;o do mesmo&#46; A queda da satura&#231;&#227;o da hemoglobina ao oxig&#233;nio diante do TC6&#8217; tamb&#233;m foi significativa&#46; A an&#225;lise de correla&#231;&#227;o significativa mostrou-se positiva entre VEF<span class="elsevierStyleInf">1</span> e dist&#226;ncia percorrida&#44; negativa entre VEF<span class="elsevierStyleInf">1</span> e FC de repouso e negativa entre dist&#226;ncia percorrida e PaCO<span class="elsevierStyleInf">2</span>&#44; sendo n&#227;o significante para as demais vari&#225;veis&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#245;es</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A progress&#227;o da obstru&#231;&#227;o na DPOC&#44; bem como valores maiores de PaCO<span class="elsevierStyleInf">2</span>&#44; contribuem para a redu&#231;&#227;o da dist&#226;ncia percorrida no TC6&#8217;&#46; O grau de obstru&#231;&#227;o na DPOC leva a altera&#231;&#227;o hemodin&#226;mica com o aumento da frequ&#234;ncia card&#237;aca de repouso destes doentes&#46;</p>"
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Pulmonology

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