C Reactive protein and disease severity in bronchiolitis
Proteína C reactiva e gravidade da bronquiolite aguda
S. Costa1,
, R. Rocha2, M. Tavares3, A. Bonito-Vítor4, L. Guedes-Vaz5, Hospital S. João6,7
Corresponding author
1 Interna Complementar de Pediatria, Serviço de Pediatria HSJ / Paediatrics resident, Paediatrics Department, HSJ
2 Interno Complementar de Pediatria, Serviço de Pediatria HSJ / Paediatrics resident, Paediatrics Department, HSJ
3 Assistente hospitalar de Pediatria, Serviço de Pediatria HSJ / Paediatrics consultant, Paediatrics Department, HSJ
4 Assistente hospitalar de Pediatria, Unidade de Pneumologia Pediátrica do Serviço de Pediatria HSJ / Paediatrics consultant, Paediatric Pulmonology Unit, Paediatrics Department, HSJ
5 Chefe de Serviço de Pediatria, Unidade de Pneumologia Pediátrica do Serviço de Pediatria HSJ / Head, Paediatrics, Paediatric Pulmonology Unit, Paediatrics Department HSJ
6 Serviço de Pediatria Médica, UAG-MC, 4200-319 Porto
7 Serviço de Pediatria, 4200-319 Porto
Read
875
Timeswas read the article
478
Total PDF
397
Total HTML
Share statistics
array:24 [ "pii" => "S2173511509700880" "issn" => "21735115" "doi" => "10.1016/S2173-5115(09)70088-0" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70088" "copyright" => "Sociedade Portuguesa de Pneumologia" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2009;15:55-65" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2775 "formatos" => array:3 [ "EPUB" => 212 "HTML" => 1583 "PDF" => 980 ] ] "itemSiguiente" => array:19 [ "pii" => "S2173511509700892" "issn" => "21735115" "doi" => "10.1016/S2173-5115(09)70089-2" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70089" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2009;15:67-76" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3508 "formatos" => array:3 [ "EPUB" => 208 "HTML" => 1981 "PDF" => 1319 ] ] "pt" => array:10 [ "idiomaDefecto" => true "titulo" => "Projecto de estadiamento do cancro do pulmão pela IASLC: Estudo comparativo entre a 6.ª edição TNM em vigor e a 7.ª edição proposta" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "67" "paginaFinal" => "76" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The IASLC lung cancer staging project. Comparing the current 6<span class="elsevierStyleSup">th</span> TNM edition with the proposed 7<span class="elsevierStyleSup">th</span> edition" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lina Carvalho, Edgar Cardoso, Henrique Nunes, Victor Baptista, Ana Gomes, Patrícia Couceiro" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Lina" "apellidos" => "Carvalho" ] 1 => array:2 [ "nombre" => "Edgar" "apellidos" => "Cardoso" ] 2 => array:2 [ "nombre" => "Henrique" "apellidos" => "Nunes" ] 3 => array:2 [ "nombre" => "Victor" "apellidos" => "Baptista" ] 4 => array:2 [ "nombre" => "Ana" "apellidos" => "Gomes" ] 5 => array:2 [ "nombre" => "Patrícia" "apellidos" => "Couceiro" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511509700892?idApp=UINPBA00004E" "url" => "/21735115/0000001500000001/v1_201305151504/S2173511509700892/v1_201305151504/pt/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173511509700879" "issn" => "21735115" "doi" => "10.1016/S2173-5115(09)70087-9" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70087" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2009;15:43-53" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2641 "formatos" => array:3 [ "EPUB" => 226 "HTML" => 1585 "PDF" => 830 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Smoking habits in secondary school students" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "43" "paginaFinal" => "53" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Avaliação de hábitos tabágicos em alunos do ensino secundário" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Damas, S. Saleiro, A. Marinho, G. Fernandes, I. Gomes" "autores" => array:5 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Damas" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Saleiro" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Marinho" ] 3 => array:2 [ "nombre" => "G." "apellidos" => "Fernandes" ] 4 => array:2 [ "nombre" => "I." "apellidos" => "Gomes" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511509700879?idApp=UINPBA00004E" "url" => "/21735115/0000001500000001/v1_201305151504/S2173511509700879/v1_201305151504/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "titulo" => "C Reactive protein and disease severity in bronchiolitis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "55" "paginaFinal" => "65" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "S. Costa, R. Rocha, M. Tavares, A. Bonito-Vítor, L. Guedes-Vaz, Hospital S. João" "autores" => array:6 [ 0 => array:4 [ "nombre" => "S." "apellidos" => "Costa" "email" => array:1 [ 0 => "sdrmcosta@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Rocha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Tavares" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Bonito-Vítor" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "L." "apellidos" => "Guedes-Vaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] 5 => array:3 [ "nombre" => "Hospital S." "apellidos" => "João" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0030" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0035" ] ] ] ] "afiliaciones" => array:7 [ 0 => array:3 [ "entidad" => "Interna Complementar de Pediatria, Serviço de Pediatria HSJ / <span class="elsevierStyleItalic">Paediatrics resident, Paediatrics Department, HSJ</span>" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Interno Complementar de Pediatria, Serviço de Pediatria HSJ / <span class="elsevierStyleItalic">Paediatrics resident, Paediatrics Department, HSJ</span>" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Assistente hospitalar de Pediatria, Serviço de Pediatria HSJ / <span class="elsevierStyleItalic">Paediatrics consultant, Paediatrics Department, HSJ</span>" "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Assistente hospitalar de Pediatria, Unidade de Pneumologia Pediátrica do Serviço de Pediatria HSJ / <span class="elsevierStyleItalic">Paediatrics consultant, Paediatric Pulmonology Unit, Paediatrics Department, HSJ</span>" "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Chefe de Serviço de Pediatria, Unidade de Pneumologia Pediátrica do Serviço de Pediatria HSJ / <span class="elsevierStyleItalic">Head, Paediatrics, Paediatric Pulmonology Unit, Paediatrics Department HSJ</span>" "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Serviço de Pediatria Médica, UAG-MC, 4200-319 Porto" "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Serviço de Pediatria, 4200-319 Porto" "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondence to/Contacto electrónico (primeiro autor)." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Proteína C reactiva e gravidade da bronquiolite aguda" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-05-21" "fechaAceptado" => "2008-09-19" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec159896" "palabras" => array:3 [ 0 => "Bronchiolitis" 1 => "diagnosis" 2 => "C reactive protein" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec159897" "palabras" => array:3 [ 0 => "Bronquiolite" 1 => "diagnóstico" 2 => "proteína C reactiva" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A diagnosis of bronchiolitis is made clinically and the use of supportive laboratory examinations, including the quantification of C reactive protein (CRP), is not well established.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to evaluate the correlation between CRP value and indirect markers of disease severity in patients with bronchiolitis.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">This study included the patients diagnosed with bronchiolitis admitted to the Pediatrics Department of S. João Hospital in 2006. A retrospective review was made through analysing clinical files.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">176 patients aged 0 to 36 months (median of 4 months) were included. 63.1% were males. CRP level was measured in 94.3% of the patients, with values ranging from zero to 256<span class="elsevierStyleHsp" style=""></span>mg/L and a median of 11<span class="elsevierStyleHsp" style=""></span>mg/L.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">CRP value in this population had a statistically significant relation with admission to Intensive Care Unit (ICU) (p=0.008), length of hospital stay (p=0.025) and need for supplementary oxygen during hospital stay (p=0.022).</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">This work raises the hypothesis that the CRP value on admission might be a marker of disease severity and have prognostic significance in patients with bronchiolitis. Further investigation is necessary to validate these results and exclude the potential confounding effect of associated infections.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">O diagnóstico de bronquiolite aguda é essencialmente clínico. A utilidade de exames laboratoriais, em particular do doseamento da proteína C reactiva (PCR), não está bem estabelecida.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">O objectivo deste trabalho foi avaliar a relação entre o valor da PCR e os marcadores indirectos de gravidade em doentes com diagnóstico de bronquiolite.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Foram incluídos no estudo todos os doentes admitidos no Serviço de Pediatria do HSJ durante o ano de 2006 e que tiveram como diagnóstico principal bronquiolite, tendo sido feita uma revisão retrospectiva do processo clínico desses doentes.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Foram incluídos 176 doentes com idades compreendidas entre zero e 36 meses (mediana de 4 meses); 63,1% eram do sexo masculino. O doseamento da PCR tinha sido efectuado em 94,3% dos doentes, com valores compreendidos entre zero e 256mg/L e com mediana de 11<span class="elsevierStyleHsp" style=""></span>mg/L.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">O valor da PCR, na população estudada, apresentou uma relação estatisticamente significativa com a admissão em unidade de cuidados intensivos (UCI) (p=0,008), a duração do internamento hospitalar (p=0,025) e a necessidade de oxigenoterapia (p=0,022).</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Desta forma, este trabalho coloca a hipótese de o valor de PCR poder ser um marcador de gravidade e ter significado prognóstico em doentes com bronquiolite. Mais estudos são necessários para validar estes resultados e esclarecer se existe uma relação real entre as variáveis estudadas ou se esta é produzida pelo efeito confundidor de outras infecções.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography/Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and management of bronchiolitis – clinical practice guideline" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Subcommittee on Diagnosis, Management of Bronchiolitis" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1542/peds.2006-2223" "Revista" => array:7 [ "tituloSerie" => "Pediatrics" "fecha" => "2006" "volumen" => "118" "numero" => "4" "paginaInicial" => "1774" "paginaFinal" => "1793" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17015575" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchiolitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Goodman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Nelson Textbook of Pediatrics" "paginaInicial" => "1415" "paginaFinal" => "1417" "serieFecha" => "2004" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and testing in bronchiolitis – a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:5 [ 0 => "W.C. Bordley" 1 => "M. Viswanathan" 2 => "V.J. King" 3 => "S.F. Sutton" 4 => "A.M. Jackman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archpedi.158.2.119" "Revista" => array:6 [ "tituloSerie" => "Arch Pediatr Adolesc Med" "fecha" => "2004" "volumen" => "158" "paginaInicial" => "119" "paginaFinal" => "126" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14757603" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of procalcitonin with C-reactive protein, interleukine 6 and interferon-alpha for differentiation of bacterial vs viral infections" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:5 [ 0 => "D. Gendrel" 1 => "J. Raymond" 2 => "J. Coste" 3 => "F. Moulin" 4 => "M. Lorrot" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "1999" "volumen" => "18" "numero" => "10" "paginaInicial" => "875" "paginaFinal" => "881" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10530583" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Procalcitonin, C-reactive protein and leukocyte count in children with lower respiratory tract infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:5 [ 0 => "C. Prat" 1 => "J. Dominguez" 2 => "C. Rodrigo" 3 => "M. Gimenez" 4 => "M. Azuara" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.inf.0000095197.72976.4f" "Revista" => array:7 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "2003" "volumen" => "22" "numero" => "11" "paginaInicial" => "963" "paginaFinal" => "967" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14614368" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between serum interleukine 6 and C-reactive protein concentration in patients with adenoviral respiratory infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Y. Kawasaki" 1 => "M. Hosoya" 2 => "M. Katayose" 3 => "H. Suzuki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "2002" "volumen" => "21" "numero" => "5" "paginaInicial" => "370" "paginaFinal" => "374" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12150170" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum procalcitonin, C-reactive protein and interleukine-6 for distinguishing bacterial and viral pneumonia in children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:5 [ 0 => "P. Toika" 1 => "K. Irjala" 2 => "T. Juven" 3 => "R. Virkki" 4 => "J. Mertsola" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "2000" "volumen" => "19" "numero" => "7" "paginaInicial" => "598" "paginaFinal" => "602" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10917215" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infecciones virales de vias respiratorias inferiores en lactantes hospitalizados: etiologia, caracteristicas clinicas y factores de riesgo" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:5 [ 0 => "G. Garcia" 1 => "M.O. Gabin" 2 => "C.C. Reya" 3 => "M.I. Avarez" 4 => "J.A. Ruiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "2001" "volumen" => "55" "paginaInicial" => "101" "paginaFinal" => "107" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11472660" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Procalcitonin, Interleukine-6, C-reactive protein and leukocyte counts in infants with bronchiolitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Resch" 1 => "W. Gusenleiner" 2 => "W. Muller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.inf.0000066196.23839.b0" "Revista" => array:7 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "2003" "volumen" => "22" "numero" => "5" "paginaInicial" => "475" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12792393" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735115/0000001500000001/v1_201305151504/S2173511509700880/v1_201305151504/en/main.assets" "Apartado" => array:4 [ "identificador" => "9552" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Article/Artigo Original" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001500000001/v1_201305151504/S2173511509700880/v1_201305151504/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511509700880?idApp=UINPBA00004E" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 1 | 6 |
| 2024 October | 32 | 22 | 54 |
| 2024 September | 27 | 24 | 51 |
| 2024 August | 49 | 35 | 84 |
| 2024 July | 24 | 29 | 53 |
| 2024 June | 20 | 27 | 47 |
| 2024 May | 22 | 34 | 56 |
| 2024 April | 18 | 25 | 43 |
| 2024 March | 26 | 20 | 46 |
| 2024 February | 21 | 31 | 52 |
| 2024 January | 19 | 23 | 42 |
| 2023 December | 13 | 25 | 38 |
| 2023 November | 18 | 25 | 43 |
| 2023 October | 13 | 31 | 44 |
| 2023 September | 17 | 33 | 50 |
| 2023 August | 15 | 19 | 34 |
| 2023 July | 16 | 25 | 41 |
| 2023 June | 11 | 18 | 29 |
| 2023 May | 20 | 24 | 44 |
| 2023 April | 11 | 7 | 18 |
Show all
