Adenocarcinoma do pulmão em doente com esclerodermia: Um caso clínico
Lung adenocarcinoma associated with systemic sclerosis: A case report
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"Serviço de Pneumologia, Hospital de São João, EPE, Porto" "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Lung adenocarcinoma associated with systemic sclerosis: A case report" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-04-21" "fechaAceptado" => "2008-09-12" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec159916" "palabras" => array:4 [ 0 => "Esclerodermia" 1 => "cancro" 2 => "pulmão" 3 => "fibrose" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec159915" "palabras" => array:4 [ 0 => "Systemic sclerosis" 1 => "cancer" 2 => "lung" 3 => "fibrosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A esclerodermia é uma doença do tecido conjuntivo de etiologia desconhecida, que tem sido associada a um risco acrescido de malignidade. O cancro do pulmão é a neoplasia mais frequente, nestes doentes.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Apresenta-se o caso clínico de uma mulher de 42 anos, não fumadora, com esclerodermia, que desenvolveu agravamento progressivo do seu estado geral e derrame pleural com características de exsudado, sem evidência de infecção ou malignidade. A TAC torácica mostrou zonas de fibrose, a broncofibroscopia, os lavados brônquico e broncoalveolar foram normais. Foi excluída neoplasia extrapulmonar. Na pleuroscopia, observaram-se formações nodulares, cujas biópsias revelaram tratar-se de adenocarcinoma pulmonar. Iniciou quimioterapia, desenvolvendo ao 48.° dia neutropenia febril e sépsis, vindo a morrer 12 dias depois.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Salientamos este caso pela relação, apesar de rara, entre a esclerodermia e o cancro do pulmão e pela importância de uma vigilância pulmonar cuidadosa, em indivíduos com esta doença reumatológica, pelo risco acrescido de neoplasia.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Systemic sclerosis (scleroderma) is a connective tissue disorder of unknown aetiology characterised by immune abnormalities, which has been related to an increased risk of malignancy. Lung cancer is the most prevalent among these patients.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We present a clinical case of a 42 years old non smoker female with systemic sclerosis. She presented progressive general health status worsening and an exudative pleural effusion, with no evidence of infection or malignancy. Chest high resolution computed tomography revealed pulmonary fibrosis. Bronchoscopy, bronchial and bronchoalveolar lavage were normal. Extrapulmonary malignancies were excluded. Pleural nodularities were found on pleuroscopy and the biopsy was compatible with lung adenocarcinoma. Chemotherapy was then started, which complicated with febrile neutropenia, sepsis and patient death 12 days after.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The purpose of this case report is to bring attention to the relationship, although rare, between systemic sclerosis and lung cancer, stressing the importance of adequate pulmonary surveillance in these patients.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence and prevalence of systemic sclerosis: a systematic literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Chifflot" 1 => "B. Fautrel" 2 => "C. Sordet" 3 => "E. Chatelus" 4 => "J. 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ISSN: 21735115Original language: Portuguese
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| 2024 September | 25 | 18 | 43 |
| 2024 August | 53 | 37 | 90 |
| 2024 July | 32 | 39 | 71 |
| 2024 June | 18 | 27 | 45 |
| 2024 May | 18 | 26 | 44 |
| 2024 April | 21 | 26 | 47 |
| 2024 March | 25 | 26 | 51 |
| 2024 February | 26 | 23 | 49 |
| 2024 January | 16 | 23 | 39 |
| 2023 December | 24 | 22 | 46 |
| 2023 November | 17 | 25 | 42 |
| 2023 October | 18 | 21 | 39 |
| 2023 September | 22 | 32 | 54 |
| 2023 August | 15 | 19 | 34 |
| 2023 July | 22 | 24 | 46 |
| 2023 June | 12 | 17 | 29 |
| 2023 May | 21 | 28 | 49 |
| 2023 April | 15 | 6 | 21 |
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