Exacerbação aguda da fibrose pulmonar idiopática
Acute exacerbation of idiopathic pulmonary fibrosis
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João" "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Serviço de Anatomia Patológica do Hospital S. João" "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Serviço de Pneumologia, Hospital de S. João, Alameda Professor Hernâni Monteiro, 4202-451 Porto. Telefone: 919371855." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Acute exacerbation of idiopathic pulmonary fibrosis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-04-11" "fechaAceptado" => "2008-11-07" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec160009" "palabras" => array:2 [ 0 => "Fibrose pulmonar idiopática" 1 => "exacerbação aguda" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec160008" "palabras" => array:2 [ 0 => "Idiopathic pulmonary fibrosis" 1 => "acute exacerbation" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Alguns doentes com fibrose pulmonar idiopática (FPI) apresentam durante a sua evolução fases de agravamento clínico sem causa conhecida, designadas como “exacerbação aguda” ou “fase acelerada” da doença (EA). Caracterizam-se pelo agravamento marcado da dispneia, hipoxemia e pelo aparecimento de novas opacidades pulmonares ou pelo agravamento das já existentes no estudo imagiológico. Os achados histológicos típicos são o dano alveolar difuso (DAD) sobreposto a alterações de pneumonia intersticial usual (UIP). Esta entidade clínica associa-se a uma mortalidade elevada, não havendo até ao momento nenhuma terapêutica de comprovada eficácia.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Os autores descrevem os casos clínicos de cinco doentes que apresentaram alterações clínicas, funcionais e radiológicas sugestivas de EA-FPI, assim como o tratamento efectuado e a evolução observada, enquadrando-os na discussão das características normalmente apresentadas por esta entidade.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Some patients with Idiopathic Pulmonary Fibrosis (IPF) have disease accelerated deterioration without identifiable cause referred as “acute exacerbation” or “accelerated stage”. It is characterized by severe worsening of dyspnea, hypoxemia and new or progressive opacities on imaging studies. The typical histological findings are diffuse alveolar damage in addition to the features of usual interstitial pneumonia pattern. Mortality in this clinical entity is very high and no efficacious therapeutic have been described.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The authors describe the clinical, functional and radiological features, treatment and evolution of five patients with IPF acute exacerbation. A discussion will be carry out concerning the IPF acute exacerbation usual features comparing with the alterations noticed in those patients.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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ISSN: 21735115Original language: Portuguese
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| 2024 November | 13 | 9 | 22 |
| 2024 October | 105 | 49 | 154 |
| 2024 September | 102 | 47 | 149 |
| 2024 August | 106 | 51 | 157 |
| 2024 July | 82 | 42 | 124 |
| 2024 June | 72 | 44 | 116 |
| 2024 May | 86 | 57 | 143 |
| 2024 April | 78 | 38 | 116 |
| 2024 March | 60 | 28 | 88 |
| 2024 February | 65 | 34 | 99 |
| 2024 January | 50 | 28 | 78 |
| 2023 December | 33 | 50 | 83 |
| 2023 November | 24 | 42 | 66 |
| 2023 October | 50 | 57 | 107 |
| 2023 September | 45 | 54 | 99 |
| 2023 August | 39 | 41 | 80 |
| 2023 July | 32 | 53 | 85 |
| 2023 June | 23 | 34 | 57 |
| 2023 May | 22 | 52 | 74 |
| 2023 April | 16 | 27 | 43 |
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