A intervenção da célula epitelial na asma
1 Professora Associada com Agregação de Fisiopatologia – Faculdade de Medicina da Universidade de Coimbra. Directora do Instituto de Patologia Geral
2 Assistente Hospitalar Graduada em Imunoalergologia nos Hospitais da Universidade de Coimbra. Doutoramento em Medicina Interna – Pneumologia pela Faculdade de Medicina da Universidade de Coimbra
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Directora do Instituto de Patologia Geral" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Assistente Hospitalar Graduada em Imunoalergologia nos Hospitais da Universidade de Coimbra. Doutoramento em Medicina Interna – Pneumologia pela Faculdade de Medicina da Universidade de Coimbra" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-11-13" "fechaAceptado" => "2008-12-30" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec160105" "palabras" => array:3 [ 0 => "Asma" 1 => "epitélio" 2 => "inflamação" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec160104" "palabras" => array:3 [ 0 => "Asthma" 1 => "epithelium" 2 => "inflammation" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Faz-se uma revisão da intervenção da célula epitelial brônquica na fisiopatologia da asma. O epitélio que reveste as vias respiratórias actua como uma barreira física, separando o meio externo do meio interno pulmonar, controla a permeabilidade intercelular e transcelular, e, deste modo, a acessibilidade dos agressores inalantes às células apresentadoras de antigénio envolvidas na resposta imunoinflamatória. As células epiteliais unidas por <span class="elsevierStyleItalic">tight junctions</span> contribuem para a integridade das vias aéreas e expressam <span class="elsevierStyleItalic">poliovirus receptor– related protein</span> (PRR), toll like receptors (TLR) e <span class="elsevierStyleItalic">protease-activated receptors</span> (PAR), que reconhecem agentes bacterianos e alergénios. A sua disfunção transforma-as em fonte de mediadores intervenientes na inflamação.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A interacção bidireccional entre, por um lado, o epitélio e os elementos constitutivos do brônquio e por outro, as partículas inaladas, tem subjacente a formação de uma unidade, com identidade própria designada EMTU – <span class="elsevierStyleItalic">epithelial mesenchymal trophic unit</span>.</p><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Esta extensa intervenção coloca a célula epitelial no centro de acção da cronicidade e remodelação do processo asmático.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">As doenças infecciosas e o <span class="elsevierStyleItalic">stress</span> ambiental são capazes de induzir alterações a nível da célula epitelial susceptíveis de modificar a sua resposta a estimulações futuras, nomeadamente a ampliar a resposta a outras agressões infecciosas por acção sinérgica das vias de sinalização.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">O epitélio brônquico tem assim funções de barreira que lhe permite exercer uma permeabilidade selectiva, a nível intracelular e transcelular, é ainda metabolicamente activo pelas capacidade de produzir mediadores quimiotácticos e citocinas envolvidos no recrutamento e na activação celular, com repercussão na broncomotricidade e na remodelação da parede brônquica.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">It is done a review of the intervention of the epithelial bronchial cell in the pathophysiology of asthma. The respiratory epithelium acts as a physical barrier that separates the external environment from the pulmonary internal environment. It controls the intercellular and trans-cellular permeability and this way the accessibility of the inhaled pathogens to the antigen presenting cells involved in the immuno-inflammatory response. Epithelial cells connected by tight junctions contribute to the barrier function of the airways. They express a poliovirus receiver – related protein (PRR), toll like receptors (TLRs) and protease-activated receptors (PARs), which recognize bacterial agents and allergens. Its dysfunction turns them into important sources of inflammatory mediators.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The bidirectional interaction between the epithelium and other bronchial wall elements with inhaled particles originates a structure with its own identity, the designated EMTU – Epithelial Mesenchymal Trophic Unit.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">These observations support a central role for the epithelial cell in chronic inflammation and in the remodelling of the asthmatic process.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Infectious diseases and environmental stress can activate different cell receptors and signalling pathways that induce changes in the cell surface modifying their response to future stimulations, namely to other infectious aggressions.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The bronchial epithelium has barrier functions with selective permeability; it has metabolic activity producing cytokines and chemokines stimulating the cell's recruitment and activation, increasing the bronchial reactivity and the remodelling of the airways.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:51 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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ISSN: 21735115Original language: Portuguese
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