Cadernos de Anatomia Patológica
Os genes ERCC1 e RRM1 no carcinoma broncopulmonar
ERCC1 and RRM1 genes in lung cancer
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class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "José Carlos" "apellidos" => "Fernandes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 6 => array:3 [ "nombre" => "Raquel" "apellidos" => "Landeiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Professora de Anatomia Patológica, Anatomia Patológica/Oncologia, Faculdade de Medicina, Universidade de Coimbra" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Disciplina de Oncologia, Anatomia Patológica/Oncologia, Faculdade de Medicina, Universidade de Coimbra" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "ERCC1 and RRM1 genes in lung cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-02-05" "fechaAceptado" => "2009-02-26" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec160214" "palabras" => array:3 [ 0 => "Carcinoma do pulmão de células não pequenas" 1 => "RRM1" 2 => "ERCC1" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec160213" "palabras" => array:3 [ 0 => "Non-small cell lung cancer" 1 => "RRM1" 2 => "ERCC1" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">No cancro do pulmão, ainda não se obteve sobrevivência expressiva dos doentes que se apresentam em estádios não cirúrgicos. Os doentes com carcinoma de não pequenas células são tratados com platina e outros fármacos, para os quais se podem caracterizar actualmente marcadores preditivos de resposta terapêutica.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Procedeu-se a uma revisão da literatura, tendo como alvo o papel dos genes <span class="elsevierStyleItalic">ERCC1</span> e <span class="elsevierStyleItalic">RRM1</span> na resposta à quimioterapia baseada na platina e na gemcitabina. Actualmente, a expressão destes genes é encarada como preditiva de resposta à quimioterapia em doentes com adenocarcinomas e carcinomas epidermóides, orientando a terapêutica personalizada.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Dados publicados demonstram a utilidade da quimioterapia individualizada, de acordo com os níveis individuais de ERCC1. Estes também são influenciados por variabilidade genética. Assim, a presença de certos polimorfismos, como são os códãos 118 C/T e C8092A, parecem estar relacionados com a carcinogénese, resistência aos citostáticos, tempo de sobrevida e até com o prognóstico.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudos clínicos e laboratoriais demonstraram também que a elevada expressão do gene <span class="elsevierStyleItalic">RRM1</span> no NSCLC tem impacto no fenótipo do tumor e na resposta variável à quimioterapia. Doentes submetidos a ressecção cirúrgica, cujos tumores apresentavam expressão aumentado do gene <span class="elsevierStyleItalic">RRM1,</span> têm maior sobrevivência do que os doentes com baixa expressão. No entanto, os doentes com NSCLC avançado sujeitos a quimioterapia com gemcitabina e cisplatina apresentam um pior prognóstico se o tumor apresentar expressão aumentada do gene <span class="elsevierStyleItalic">RRM1</span>.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">In lung cancer, expressive survival has not yet been achieved in non surgical stages. Non-small cell lung cancer (NSCLC) patients are treated with platinum and other drugs. To choose these agents we can actual ly define predictive biomarkers to preview therapeutic response.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A literature revision was done in order to define the role of <span class="elsevierStyleItalic">ERCC1</span> e <span class="elsevierStyleItalic">RRM1</span> genes in the response to chemotherapy based in platinum and gemcitabine respectively. The expression of these genes is faced as a predictive marker to the chemotherapy response in patients with adenocarcinomas and squamous cell carcinomas, providing a personalized therapy.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Published data supports this behaviour and is useful to individualize therapy accordingly to individual levels of ERCC1 which are modified by genetic mutations. Polymorphisms in codons 118 C/T and C8092A, seem to influence the carcinogenesis, cytostatic resistance, survival and even the prognosis.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Clinical and laboratorial trials showed that high expression of RRM1 gene in NSCLC has impact in the tumoral phenotype. Patients having done surgical ressection and presenting high expression of RRM1 have better survival than those with lower expression. However, patients with advanced NSCLC and treated with chemotherapy with gemcitabine and cisplatin appear to have a poor outcome if the tumor express elevated levels of <span class="elsevierStyleItalic">RRM1</span> gene.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:58 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global and regional estimates of cancer mortality and incidence by site. II. Results for the global burden of disease 2000" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Shibuya" 1 => "C.D. Mathers" 2 => "C. Boschi-Pinto" 3 => "A.D. Lopez" 4 => "C.J. Murray" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "BMC Cancer" "fecha" => "2002" "volumen" => "2" "paginaInicial" => "37" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12502432" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multidisciplinary management of lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Spira" 1 => "D.S. Ettinger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra035536" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "350" "paginaInicial" => "379" "paginaFinal" => "392" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14736930" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "RRM1-induced metastasis suppression through PTEN-regulated pathways" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Gautam" 1 => "Z.R. Li" 2 => "G. Bepler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.onc.1206232" "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "2003" "volumen" => "22" "paginaInicial" => "2135" "paginaFinal" => "2142" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12687015" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combined evaluation of Rad51 and ERCC1 expressions for sensitivy to platinum agents in non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "T. Takenaka" 1 => "I. Yoshino" 2 => "H. Kouso" 3 => "T. Ohba" 4 => "T. Yohena" 5 => "A. Osoegawa" 6 => "F. Shoji" 7 => "Y. Maehara" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.22738" "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2007" "volumen" => "121" "paginaInicial" => "895" "paginaFinal" => "900" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17417781" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]: a randomised controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:12 [ 0 => "J.Y. Douillard" 1 => "R. Rossel" 2 => "M. De Lena" 3 => "F. Carpagnamo" 4 => "R. Ramlau" 5 => "J.L. Gonzales-Larriba" 6 => "T. Grodzki" 7 => "J.R. Pereira" 8 => "A. Le Groumellec" 9 => "V. Lorusso" 10 => "C. Clary" 11 => "A.J. Torres" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2006" "volumen" => "9" "paginaInicial" => "719" "paginaFinal" => "727" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vinorelbine plus cisplatin vs. observation in ressected non-small-cell lung cancer" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "For the National Cancer Institute of Canada Clinical Trials Group and National Cancer Institute of the United States Intergroup JBR, 10 trial investigators" "etal" => true "autores" => array:12 [ 0 => "T. Winton" 1 => "R. Linvingston" 2 => "D. Johnson" 3 => "J. Rigas" 4 => "M. Johnston" 5 => "C. Butts" 6 => "Y. Cormier" 7 => "G. Goss" 8 => "R. Inculet" 9 => "E. Vallieres" 10 => "W. Fry" 11 => "D. Bethune" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa043623" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "2005" "volumen" => "352" "paginaInicial" => "2589" "paginaFinal" => "2597" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15972865" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S009082581000884X" "estado" => "S300" "issn" => "00908258" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized clinical trial of adjuvant chemotherapy with paclitaxel and carboplatin following resection in stage IB non-small-cell ling cancer: report of Cancer and Leukemia Group B protocol 9633" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "G.M. Strauss" 1 => "J. Herndon" 2 => "M.A. Maddaus" 3 => "D.W. Johnstone" 4 => "E.A. Johnson" 5 => "D.M. Watson" 6 => "D.J. Sugarbaker" 7 => "R.L. Schilsky" 8 => "M.R. Green" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2004" "volumen" => "22" "numero" => "Suppl 14" "paginaInicial" => "A7019" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Should chemotherapy combinations for advanced non-small-cell lung cancer be platinum-based? A metanalysis of phase III randomized trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.L. Pujol" 1 => "F. Barlesi" 2 => "J.P. Daures" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lung Cancer" "fecha" => "2006" "volumen" => "3" "paginaInicial" => "335" "paginaFinal" => "345" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-arm randomized study of two cisplatin-based regimens amd paclitaxel plus gemcitabine in advenced non-small-cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group-EORTC 08975" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:12 [ 0 => "E.F. Smit" 1 => "J.P. van Meerbeck" 2 => "P. Lianes" 3 => "C. Debruyne" 4 => "C. Legrand" 5 => "F. Schramel" 6 => "H. Smit" 7 => "R. Gaafar" 8 => "B. Biesma" 9 => "C. Manegold" 10 => "N. Neymark" 11 => "G. Giaconne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2003.03.195" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2003" "volumen" => "21" "paginaInicial" => "3909" "paginaFinal" => "3917" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14581415" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polimorfismos e metilação de genes na selecção da terapêutica do cancro do pulmão" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.P. Hespanhol" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Revista GECP" "fecha" => "2006" "volumen" => "1-2" "paginaInicial" => "17" "paginaFinal" => "21" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC1 as a risk stratifier in platinum-based chemotherapy for non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Olaussen" 1 => "G. Mountzios" 2 => "J. Soria" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Opin Pulm Med" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "287" "paginaFinal" => "289" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA structural elements required for ERCC1-XPF endonuclease activity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W.L. De Laat" 1 => "E. Appeldoorn" 2 => "N.G. Jaspers" 3 => "J.H. Hoeijmakers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1998" "volumen" => "273" "paginaInicial" => "7835" "paginaFinal" => "7842" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9525876" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nucleotide excision repair gene (ERCC1) deficiency causes G(2) arrest in hepatocytes and a reduction in liver binucleation:the role of p. 53 and p. 21" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F. Nunez" 1 => "M.D. Chipchase" 2 => "A.R. Clarke" 3 => "D.W. Melton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "FASEB J" "fecha" => "2000" "volumen" => "14" "paginaInicial" => "1073" "paginaFinal" => "1082" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10834928" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanism of opencomplex and dual incision formation by human nucleotide excision repair factors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E. Evans" 1 => "J.G. Moggs" 2 => "J.R. Hwang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/emboj/16.21.6559" "Revista" => array:6 [ "tituloSerie" => "EMBO J" "fecha" => "1997" "volumen" => "16" "paginaInicial" => "6559" "paginaFinal" => "6573" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9351836" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reaction mechanism of human DNA repair excision nuclease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Mu" 1 => "D.S. Hsu" 2 => "A. Sancar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1996" "volumen" => "271" "paginaInicial" => "8285" "paginaFinal" => "8294" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8626523" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nucleotide excision repair. I. From E.coli to yeast" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.H. Hoeijmakers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Trends Genet" "fecha" => "1993" "volumen" => "9" "numero" => "5" "paginaInicial" => "173" "paginaFinal" => "177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8337754" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Action of DNA repair endonuclease ERCC1/XPF in living cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.B. Houstmuller" 1 => "S. Rademarkers" 2 => "A.L. Nigg" 3 => "D. Hoogstraten" 4 => "J.H. Hoeijmakers" 5 => "W. Vermeulen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Science" "fecha" => "1999" "volumen" => "284" "numero" => "5416" "paginaInicial" => "958" "paginaFinal" => "961" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10320375" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nuclear excision repair-based personalized therapy for non-small cell lung cancer: From hypothesis to reality" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Simon" 1 => "R. Ismail-Khan" 2 => "G. Bepler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.biocel.2015.01.003" "Revista" => array:6 [ "tituloSerie" => "The International Journal of Biochemistry & Cell Biology" "fecha" => "2007" "volumen" => "39" "paginaInicial" => "1318" "paginaFinal" => "1328" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25595463" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nucleotide excision repair. II. From yeast to mammals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.H. Hoeilmakers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Trends Genet" "fecha" => "1993" "volumen" => "9" "numero" => "6" "paginaInicial" => "211" "paginaFinal" => "217" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8337762" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC1 expression as a predictor of survival in resected patients with non-small-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.R. Simon" 1 => "S. Sharma" 2 => "A. Cantor" 3 => "P. Smith" 4 => "G. Bepler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.127.3.978" "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "127" "numero" => "3" "paginaInicial" => "978" "paginaFinal" => "983" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15764785" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.A. Olaussen" 1 => "A. Dunant" 2 => "P. Fouret" 3 => "E. Brambilla" 4 => "F. Andre" 5 => "V. Haddad" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa060570" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "2006" "volumen" => "355" "numero" => "10" "paginaInicial" => "983" "paginaFinal" => "991" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16957145" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Y. Takebayashi" 1 => "K. Nakayama" 2 => "A. Kansaki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Lett" "fecha" => "2001" "volumen" => "174" "paginaInicial" => "115" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11689286" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0090825810007171" "estado" => "S300" "issn" => "00908258" ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Cheng" 1 => "M.R. Spitz" 2 => "W.K. Hong" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Carcinogenesis" "fecha" => "2000" "volumen" => "21" "paginaInicial" => "1527" "paginaFinal" => "1530" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10910954" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC1 polymorphism is associated with differencial ERCC1 gene expression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.J. Park" 1 => "J. Stoehelmacher" 2 => "W. Zhang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Proc Am Assoc Cancer" "fecha" => "2002" "paginaInicial" => "1591" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of two human ovarian carcinoma cell lines (A2780/CP70 and MCAS) that are equally resistant to platinum, but differ at codon 118 of the ERCC1 gene" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.J. Yu" 1 => "K.B. Lee" 2 => "C. Mu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Oncol" "fecha" => "2000" "volumen" => "16" "paginaInicial" => "555" "paginaFinal" => "560" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10675489" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0212656709006337" "estado" => "S300" "issn" => "02126567" ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC1 gene polymorphism as a predictor for clinical outcome in advenced colorectal cancer patients treated with platinum-based chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.J. Park" 1 => "W. Zhang" 2 => "J. Stoehlmaker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Adv Hematol Oncol" "fecha" => "2003" "volumen" => "1" "paginaInicial" => "162" "paginaFinal" => "166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16224397" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of an ERCC1 polymorphism with adul-onset glioma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Chen" 1 => "J. Wiencke" 2 => "K. Aldape" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer Epidemiol Biomark Prev" "fecha" => "2000" "volumen" => "9" "paginaInicial" => "843" "paginaFinal" => "847" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.M. Sturgis" 1 => "K.R. Dahlstrom" 2 => "M.R. Spitz" 3 => "Q. Wei" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Otolarungol Head Neck Surg" "fecha" => "2002" "volumen" => "128" "paginaInicial" => "1084" "paginaFinal" => "1088" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymorphisms of DNA repair genes and risk of non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "S. Zienolddiny" 1 => "D. Campa" 2 => "H. Lind" 3 => "D. Ryberg" 4 => "V. Skaug" 5 => "L. Stangeland" 6 => "D. Phillips" 7 => "F. Canzian" 8 => "A. Haugen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/carcin/bgi232" "Revista" => array:7 [ "tituloSerie" => "Carcinogenesis" "fecha" => "2006" "volumen" => "27" "numero" => "3" "paginaInicial" => "560" "paginaFinal" => "567" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16195237" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A nucleotide polymorphism in ERCC1 in human ovarian cancer cells lines and tumor tissues" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.J. Yu" 1 => "C. Mu" 2 => "K.B. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mutat Res" "fecha" => "1997" "volumen" => "382" "paginaInicial" => "13" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9360634" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "<a class="elsevierStyleInterRef" href="http://www.ncbi.nlm.nih.gov/sites/entrez%3Fdb=gene%26cmd=Retrieve%26dopt=Graphics%26list_uids=6240">http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6240</a>." ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.D. Davidson" 1 => "L. Ma" 2 => "M. Flagella" 3 => "S. Geeganage" 4 => "L.M. Gelbert" 5 => "C.A. Slapak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/0008-5472.CAN-03-3363" "Revista" => array:6 [ "tituloSerie" => "Cancer Research" "fecha" => "2004" "volumen" => "64" "paginaInicial" => "3761" "paginaFinal" => "3766" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15172981" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gemcitabine: Current status of phase I and II trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.B. Kaye" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1994.12.8.1527" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1994" "volumen" => "12" "paginaInicial" => "1527" "paginaFinal" => "1531" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8040662" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Z. Zheng" 1 => "T. Chen" 2 => "X. Li" 3 => "E. Haura" 4 => "A. Sharma" 5 => "G. Bepler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa065411" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "356" "paginaInicial" => "800" "paginaFinal" => "808" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17314339" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0213005X09003462" "estado" => "S300" "issn" => "0213005X" ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ribonucleotide reductase M1 gene promoter activity polymorphisms, population frequencies and clinical relevance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:13 [ 0 => "G. Bepler" 1 => "Z. Zheng" 2 => "A. Gautam" 3 => "S. Sharma" 4 => "A. Cantor" 5 => "A. Sharma" 6 => "W.D. Cress" 7 => "Y.C.K. Kim" 8 => "R. Rosell" 9 => "C. McBride" 10 => "L. Robinson" 11 => "E. Sommerers" 12 => "E. Haura" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.lungcan.2004.07.043" "Revista" => array:6 [ "tituloSerie" => "Lung Cancer" "fecha" => "2005" "volumen" => "47" "paginaInicial" => "183" "paginaFinal" => "192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15639717" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "RRM1 and PTEN as prognostic parameters for overall and disease-free survival patients with non-small-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Bepler" 1 => "S. Sharma" 2 => "A. Cantor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2004.12.002" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2004" "volumen" => "22" "paginaInicial" => "1878" "paginaFinal" => "1885" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15143080" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.K. Fukunaga" 1 => "S. Marsh" 2 => "D.J. Murry" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.tpj.6500259" "Revista" => array:6 [ "tituloSerie" => "Pharmacogenomics J" "fecha" => "2004" "volumen" => "4" "paginaInicial" => "307" "paginaFinal" => "314" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15224082" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gemcitabine: Metabolism, mechanisms of action, and self potentiation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "W. Plunkett" 1 => "P. Huang" 2 => "Y.Z. Xu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "tituloSerie" => "Semin Oncol" "fecha" => "1995" "volumen" => "22" "numero" => "suppl 11" "paginaInicial" => "3" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8604451" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0213911109003288" "estado" => "S300" "issn" => "02139111" ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vivo induction of resistance to gemcitabine resultas in increased expression of ribonucleotide reductase subunit M1 as the major determinant" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "A.M. Bergman" 1 => "P.P. Eijk" 2 => "V.W.T.R. van Haperen" 3 => "K. Smid" 4 => "G. Veerman" 5 => "I. Hubeek" 6 => "P. van den Ijssel" 7 => "B. Ylstra" 8 => "G.J. Peters" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/0008-5472.CAN-04-4557" "Revista" => array:5 [ "tituloSerie" => "Cancer Res" "fecha" => "2005" "volumen" => "65" "numero" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15994957" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemotherapy in nonsmall cell lung cancer: a meta-analysis using updated data on individual patients from 52 rendomized clinical trials" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Nonsmall Cell Lung Cancer Collaborative Group" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "1995" "volumen" => "311" "paginaInicial" => "899" "paginaFinal" => "909" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7580546" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized study of adjuvant chemotherapy for completely resected stage I, II or IIIA nonsmall-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G.V. Scagliotti" 1 => "R. Fossati" 2 => "V. Torri" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2003" "volumen" => "95" "paginaInicial" => "1453" "paginaFinal" => "1461" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14519751" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cisplatin-based adjuvant chemotherapy in patients with completely resected nonsmall-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "The International Adjuvant Lung Cancer Trial Collaborative Group" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa031644" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "350" "paginaInicial" => "351" "paginaFinal" => "360" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14736927" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Should adjuvant chemotherapy become standart treatment in all patients with resected nonsmall-cell lung cancer?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T. Le Chevalier" 1 => "R. Arriagada" 2 => "J.P. Pignon" 3 => "G.V. Scagliotti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2005" "volumen" => "6" "paginaInicial" => "182" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15759364" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Arriagada" 1 => "B. Bergman" 2 => "A. Dunant" 3 => "T. Le Chevalier" 4 => "J.P. Pignon" 5 => "J. Vansteenkiste" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "N Eng J Med" "fecha" => "2004" "volumen" => "350" "numero" => "4" "paginaInicial" => "351" "paginaFinal" => "360" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Results of the randomized adjuvant lung cancer trials (IALT): Cisplatin-based chemotherapy (CT) <span class="elsevierStyleItalic">vs</span>. noCT in 1867 patients with resected non-small cell lung cancer (NSCLC)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Le Chevalier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Proc ASCO" "fecha" => "2003" "paginaInicial" => "21" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.V. Lord" 1 => "J. Branbender" 2 => "D. Gandara" 3 => "V. Alberola" 4 => "C. Camps" 5 => "M. Domine" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clin. Cancer Res" "fecha" => "2002" "volumen" => "8" "numero" => "7" "paginaInicial" => "2286" "paginaFinal" => "2291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12114432" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.V. Lord" 1 => "J. Branbender" 2 => "D. Gandara" 3 => "V. Alberola" 4 => "C. Camps" 5 => "M. Domine" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clin. Cancer Res" "fecha" => "2002" "volumen" => "8" "numero" => "7" "paginaInicial" => "2286" "paginaFinal" => "2291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12114432" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Bepler" 1 => "I. Kusmartseva" 2 => "S. Sharma" 3 => "A. Gautam" 4 => "A. Cantor" 5 => "A. Sharma" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2006.06.1101" "Revista" => array:8 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2006" "volumen" => "24" "numero" => "29" "paginaInicial" => "4731" "paginaFinal" => "4737" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16966686" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0213005X10004763" "estado" => "S300" "issn" => "0213005X" ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase II study of sequential gemcitabine (G) and carboplatin (C) followed by docetaxel (D) as first-line chemotherapy for patients with advanced non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Chiappori" 1 => "G. Simon" 2 => "C. Rocha Lima" 3 => "C. Williams" 4 => "E. Haura" 5 => "J. Vaughn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lung Cancer" "fecha" => "2005" "volumen" => "41" "numero" => "2" "paginaInicial" => "S225" ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Customizing cisplatin based chemotherapy on quantitative excision repair cross-complementing 1 mRNA expression: a phase III randomized trial in non-small cell lung cancer. The 31st Congress of the European Society of Medical Oncology, 30 September – 3 October 2006; Istanbul, Turkey" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R. Rosell" 1 => "D. Gandara" 2 => "M. Cobo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Oncol" "fecha" => "2006" "volumen" => "17" "numero" => "suppl 9" "paginaInicial" => "1" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC 1 and RRM1 gene expressions but EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Ceppi" 1 => "M. Vollante" 2 => "S. Novello" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/annonc/mdl300" "Revista" => array:6 [ "tituloSerie" => "Ann Oncol" "fecha" => "2006" "volumen" => "17" "paginaInicial" => "1818" "paginaFinal" => "1825" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16980606" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ribonucleotide reductase M1 (RRM1) 2464G>A polymorphism shows an association with gemcitabine chemosensitivity in cancer cell lines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "W.S. Kwon" 1 => "S.Y. Rha" 2 => "Y.H. Choi" 3 => "J.O. Lee" 4 => "K.H. Park" 5 => "J.J. Jung" 6 => "T.S. Kim" 7 => "H.-C. Jeung" 8 => "H.C. Chung" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.fpc.0000204999.29924.da" "Revista" => array:7 [ "tituloSerie" => "Pharmacogenetics and Genomics" "fecha" => "2006" "volumen" => "16" "numero" => "6" "paginaInicial" => "429" "paginaFinal" => "438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16708051" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "W. Zhou" 1 => "S. Gurubhagavatula" 2 => "G. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1078-0432.CCR-04-0247" "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2004" "volumen" => "10" "paginaInicial" => "4939" "paginaFinal" => "4943" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15297394" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Single nucleotide polymorphisms and outcome in docetaxel – cisplatin – treated advanced non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D. Isla" 1 => "C. Sarries" 2 => "R. Rosell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/annonc/mdh319" "Revista" => array:6 [ "tituloSerie" => "Ann Oncol" "fecha" => "2004" "volumen" => "15" "paginaInicial" => "1194" "paginaFinal" => "1203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15277258" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Automated quantitative analysis (AQUA) of in situ protein expression, antibody concentration, and prognosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. McCabe" 1 => "M. Dolled-Filhart" 2 => "R.L. Camp" 3 => "D.L. Rimm" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jnci/dji427" "Revista" => array:7 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2005" "volumen" => "97" "numero" => "24" "paginaInicial" => "1808" "paginaFinal" => "1815" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16368942" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC1 measurements in clinical oncology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Reed" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMe068162" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2006" "volumen" => "355" "paginaInicial" => "1054" "paginaFinal" => "1055" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16957152" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA repair: a double-edged sword" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Q. Wei" 1 => "M.L. Frazier" 2 => "B. Levin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2000" "volumen" => "92" "paginaInicial" => "440" "paginaFinal" => "441" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10716953" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA repair and survival in lung cancer – the two faces of Janus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.F. Gazdar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMp068308" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "356" "paginaInicial" => "771" "paginaFinal" => "773" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17314336" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/21735115/0000001500000004/v1_201305151512/S2173511509701411/v1_201305151512/pt/main.assets" "Apartado" => array:4 [ "identificador" => "9651" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Pathology Notebooks/Cadernos de Anatomia Patológica" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001500000004/v1_201305151512/S2173511509701411/v1_201305151512/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511509701411?idApp=UINPBA00004E" ]
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ISSN: 21735115Original language: Portuguese
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