A asma e os seus diagnósticos diferenciais
Asthma and its differential diagnoses
Alexandra Bento1,
, Ana Maria Arrobas2
Corresponding author
alexitbento@gmail.com
Centro Hospitalar de Coimbra EPE, Serviço de Pneumologia, São Martinho do Bispo, 3000 Coimbra.
Centro Hospitalar de Coimbra EPE, Serviço de Pneumologia, São Martinho do Bispo, 3000 Coimbra.
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array:2 [ 0 => array:3 [ "entidad" => "Interna do Internato Complementar de Pneumologia da Unidade de Saúde Local EPE Guarda" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Assistente Hospitalar Graduada de Pneumologia do Centro Hospitalar de Coimbra, EPE" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Centro Hospitalar de Coimbra EPE, Serviço de Pneumologia, São Martinho do Bispo, 3000 Coimbra." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Asthma and its differential diagnoses" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-04-13" "fechaAceptado" => "2009-05-14" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec160483" "palabras" => array:3 [ 0 => "Asma" 1 => "aspergilose broncopulmonar alérgica" 2 => "critérios de diagnóstico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec160482" "palabras" => array:3 [ 0 => "Asthma" 1 => "allergic bronchopulmonary aspergillosis" 2 => "diagnostic guidelines" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A aspergilose broncopulmonar alérgica (ABPA) ocorre em doentes não imunocomprometidos e é uma patologia de hipersensibilidade induzida pelo <span class="elsevierStyleItalic">Aspergillus</span><span class="elsevierStyleSup">5</span>.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estima-se que esteja presente em cerca de 7–14% dos casos de asma crónica corticodependente e o no mesmo número de casos de fibrose quística. A maioria das ABPA são identificadas pela 30–50.<span class="elsevierStyleSup">a</span> décadas de vida, mas podem surgir na infância<span class="elsevierStyleSup">1</span>.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">O diagnóstico baseia-se na presença de uma combinação de critérios clínicos, biológicos e radiológicos<span class="elsevierStyleSup">5</span>. A doença apresenta-se com largo espectro de gravidade, pode ser reconhecida precocemente e tratada agressivamente, impedindo a sua progressão para um estádio de doença grave e debilitante requerendo transplante pulmonar<span class="elsevierStyleSup">1</span>.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Os autores relatam o caso de uma doente de 41 anos, com antecedentes de asma alérgica desde a infância. Uma asma grave, de difícil controlo e com recurso a corticoterapia sistémica por longos períodos.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Allergic bronchopulmonary aspergillosis (ABPA) occurs in immunocompetent patients and belongs to the <span class="elsevierStyleItalic">Aspergillus<span class="elsevierStyleSup">5</span></span> induced hypersensitivity disorders.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">It is estimated that ABPA complicates approximately 7–14% of cases of chronic steroid-dependent asthma and the same amount of cases of cystic fibrosis.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A diagnosis of ABPA is based on a combination of clinical, biological and radiology criteria4.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">There is a broad spectrum of disease severity. Early detection and aggressively management will impede progressive lung damage to a severe and debilitating disease requiring lung transplantation.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The authors describe the case of a 41 year-old female with a history of allergic asthma from childhood. It was a severe, difficult to control asthma treated with systemic corticosteroids for long periods.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fishman's pulmonary diseases and disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Alfred P. 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Collins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Alllergy Asthma Immunol" "fecha" => "2008" "volumen" => "100" "numero" => "Suppl" "paginaInicial" => "A7" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of allergic bronchopulmonary aspergillosis (ABPA) in CF with anti-IgE antibody (omalizumab)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Adaobi Kanu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.20907" "Revista" => array:7 [ "tituloSerie" => "Pediatric Pulmonology" "fecha" => "2008" "volumen" => "43" "numero" => "12" "paginaInicial" => "1249" "paginaFinal" => "1251" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19009619" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/21735115/0000001500000006/v1_201305151519/S2173511509701757/v1_201305151519/pt/main.assets" "Apartado" => array:4 [ "identificador" => "9550" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Report/Caso Clínico" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001500000006/v1_201305151519/S2173511509701757/v1_201305151519/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511509701757?idApp=UINPBA00004E" ]
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