Comparison of interferon-γ release assay and tuberculin test for screening in healthcare workers
Comparação do teste de libertação do interferão-γ e da prova de tuberculina no rastreio de profissionais de saúde
José Torres Costa1,2,3,
, Rui Silva1,2,3, Raul Sá1, Maria João Cardoso4, Carla Ribeiro1, Albert Nienhaus5
Corresponding author
zecatoco@sapo.pt
Correspondence to/Correspondência: Estrada de St.ª Luzia 269, 4900-408 Viana do Castelo.
Correspondence to/Correspondência: Estrada de St.ª Luzia 269, 4900-408 Viana do Castelo.
1 Occupational Health Division
2 Allergy and Clinical Immunology Division Hospital São João Alameda Professor Hernâni Monteiro, Porto – Portugal
3 Faculty of Medicine, Porto University Alameda Professor Hernâni Monteiro, Porto – Portugal
4 Hospital São João, Clinical Pathology Division Alameda Professor Hernâni Monteiro, Porto – Portugal
5 Accidents Insurance and Prevention in the Health and Welfare Services, Hamburg, Germany
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"palabras" => array:5 [ 0 => "Tuberculosis" 1 => "healthcare workers" 2 => "tuberculin skin test" 3 => "interferon-γ release assay" 4 => "Portugal" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec160665" "palabras" => array:5 [ 0 => "Tuberculose" 1 => "profissionais de saúde" 2 => "prova de tuberculina" 3 => "teste de libertação do interferão-γ" 4 => "Portugal" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Healthcare workers (HCWs) have an increased risk of tuberculosis (TB). Screening for latent tuberculosis infection and active TB is therefore essential in infection control programs. Tuberculin skin test (TST) and Interferon-γ Release Assay (IGRA) were used simultaneously in 1686 HCWs between May 2007 and April 2009. A chest X-ray was performed in order to exclude active TB when TST was<span class="elsevierStyleHsp" style=""></span>≥<span class="elsevierStyleHsp" style=""></span>10mm or IGRA was positive and in HCWs with TB contact or symptoms. IGRA was positive in 33.1% and TST was<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>10mm in 78.3% of the HCWs. The proportion of positive IGRA results increased with the TST diameter. In those with a TST<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>15mm, 49.2% were IGRA positive. TST was more than twice as often positive than the IGRA. Therefore, TST+/IGRA-results were more often observed than concordant negative or positive results. In none of the HCWs with a TST+/IGRA-result active TB was diagnosed during the study period. Repeated BCG vaccination increased the number of TST+/IGRA-discordance. The smaller the interval after BCG vaccination, the higher was the TST+/IGRA-discordance.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In the screened HCWs population, active TB was diagnosed in 9. At the time of diagnosis TST and IGRA were positive in all active TB cases. The study period covers 24 months, therefore the average annual incidence rate was 268/100 000.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">TB burden in HCWs in Portugal is high. Considering the limitations that TST and IGRA present, the best solution seems to be the use of both, using the IGRA higher specificity for confirming a positive TST, taking advantage of the best characteristics of each test.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Os profissionais de saúde (PS) têm um risco aumentado de tuberculose. O rastreio da tuberculose latente e da tuberculose activa é portanto essencial nos programas de controlo de infecção. Entre Maio de 2007 e Abril de 2009, foram utilizados simultaneamente a prova de tuberculina (PT) e o teste de libertação do interferão-γ (IGRA) em 1686 PS. Quando PT<span class="elsevierStyleHsp" style=""></span>≥<span class="elsevierStyleHsp" style=""></span>10mm ou IGRA positivo, e em PS com contacto com tuberculose ou sintomáticos, foi realizada uma radiografia torácica para excluir tuberculose activa. O IGRA foi positivo em 33,1% e a PT foi<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>10mm em 78.3% dos PS. A proporção de resultados IGRA positivos aumentou com o diâmetro da PT. Nos PS com PT<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>15mm, 49.2% são IGRA positivos. A PT foi positiva em mais do dobro dos casos do IGRA. Assim, foram observados mais frequentemente resultados PT+/IGRA-do que resultados concordantes negativos ou positivos. Em nenhum PS com resultado PT+/IGRA-foi diagnosticada tuberculose activa durante o período do estudo. A vacinação repetida pelo BCG aumentou o número de casos discordantes PT+/IGRA-. Quanto menor o intervalo após a vacinação pelo BCG, maior a discordância PT+/IGRA-.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Na população de PS rastreada, foram diagnosticados 9 casos de tuberculose activa, sendo todos PT e IGRA positivos na altura do diagnóstico. Este estudo durou 24 meses, pelo que a taxa de incidência anual média foi de 268/100 000.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A tuberculose é um problema importante nos PS em Portugal. Considerando as limitações que a PT e IGRA apresentam, a melhor solução parece ser o uso de ambos, utilizando a maior especificidade do IGRA para confirmar uma PT positiva, aproveitando as melhores características de cada teste.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis in hospital department health care workers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Saleiro" 1 => "A.R. Santos" 2 => "O. Vidal" 3 => "T. Carvalho" 4 => "J. Torres Costa" 5 => "J.A. Marques" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2007" "volumen" => "13" "numero" => "6" "paginaInicial" => "789" "paginaFinal" => "799" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18183330" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Review of epidemiological studies on the occupational risk of tuberculosis in low-incidence areas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Seidler" 1 => "A. Nienhaus" 2 => "R. Diel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000086261" "Revista" => array:7 [ "tituloSerie" => "Respiration" "fecha" => "2005" "volumen" => "72" "numero" => "4" "paginaInicial" => "431" "paginaFinal" => "446" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16088290" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of tuberculosis infection and disease associated with work in health care settings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Menzies" 1 => "R. Joshi" 2 => "M. Pai" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2007" "volumen" => "11" "numero" => "6" "paginaInicial" => "593" "paginaFinal" => "605" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17519089" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "CDC – Center for Disease Control and Prevention. Guidelines for Preventing the Transmission of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> in <span class="elsevierStyleItalic">Healthcare Settings,</span> 2005. MMWR 2005; 54(RR-17):1–141." ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What does tuberculin reactivity after Bacille Calmette-Guerin vaccination tell us?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Menzies" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/314075" "Revista" => array:7 [ "tituloSerie" => "Clin infect Dis" "fecha" => "2000" "volumen" => "31" "numero" => "Suppl 3" "paginaInicial" => "S71" "paginaFinal" => "S74" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11010826" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Specific immune-based diagnosis of tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Andersen" 1 => "M.E. Munk" 2 => "J.M. Pollock" 3 => "T.M. Doherty" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Lancet" "fecha" => "2000" "volumen" => "356" "numero" => "9235" "paginaInicial" => "1099" "paginaFinal" => "1104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11009160" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Advances in the diagnosis and treatment of tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Nahid" 1 => "M. Pai" 2 => "P.C. Hopewell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1513/pats.200511-119JH" "Revista" => array:6 [ "tituloSerie" => "Proc Am Thorac Soc" "fecha" => "2006" "volumen" => "3" "paginaInicial" => "103" "paginaFinal" => "110" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16493157" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Pai" 1 => "L.W. Riley" 2 => "J.M. Colford" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1473-3099(04)01206-X" "Revista" => array:6 [ "tituloSerie" => "Lancet Infect Dis" "fecha" => "2004" "volumen" => "4" "paginaInicial" => "761" "paginaFinal" => "776" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15567126" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meta-analysis: New tests for the diagnosis of latent tuberculosis infection: Areas of uncertainty and recommendations for research" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Menzies" 1 => "M. Pai" 2 => "G. Comstock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "2007" "volumen" => "146" "paginaInicial" => "340" "paginaFinal" => "352" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17339619" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictive value of a whole blood IFN-{gamma} assay for the development of active TB disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Diel" 1 => "R. Loddenkemper" 2 => "K. Meywald-Walter" 3 => "S. Niemann" 4 => "A. Nienhaus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200711-1613OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2008" "volumen" => "177" "paginaInicial" => "1164" "paginaFinal" => "1170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18276940" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Screening for tuberculosis infection using whole-blood interferon-γ and Mantoux testing among Japanese healthcare workers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N. Harada" 1 => "Y. Nakajima" 2 => "K. Higuchi" 3 => "Y. Sekiya" 4 => "J. Rothel" 5 => "T. Mori" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/504358" "Revista" => array:7 [ "tituloSerie" => "Infection Control and Hospital Epidemiology" "fecha" => "2006" "volumen" => "27" "numero" => "5" "paginaInicial" => "442" "paginaFinal" => "448" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16671023" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detecting a low prevalence of latent tuberculosis among health care workers in Denmark detected by M. tuberculosis specific INF-γ whole-blood test" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "B. Soberg" 1 => "A.B. Andersen" 2 => "H.K. Larsen" 3 => "K. Weldingh" 4 => "P. Andersen" 5 => "K. Kofoerd" 6 => "P. Ravn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/00365540601148483" "Revista" => array:6 [ "tituloSerie" => "Scandinavian Journal of Infectious Diseases" "fecha" => "2007" "volumen" => "39" "paginaInicial" => "554" "paginaFinal" => "559" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17577817" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Usefulness of QuantiFERON TB-2G, a diagnostic method for latent tuberculosis infection, in a contact investigation of health care workers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Y. Kobashi" 1 => "Y. Obase" 2 => "M. Fukuda" 3 => "K. Yoshida" 4 => "N. Miyashita" 5 => "M. Fujii" 6 => "M. Oka" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Intern Med" "fecha" => "2007" "volumen" => "46" "numero" => "18" "paginaInicial" => "1543" "paginaFinal" => "1549" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17878640" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and risk factors for latent tuberculosis infection among health care workers in Georgia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "V. Mirtskhulava" 1 => "R. Kempker" 2 => "K.L. Shields" 3 => "M.K. Leonard" 4 => "T. Tsertsvadze" 5 => "C. del Rio" 6 => "A. Salakaia" 7 => "H.M. Blumberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2008" "volumen" => "12" "numero" => "5" "paginaInicial" => "513" "paginaFinal" => "519" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18419886" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of the interferon-gamma release assay in healthcare workers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Nienhaus" 1 => "A. Schablon" 2 => "B. Siano" 3 => "C. le Bacle" 4 => "R. Diel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00420-007-0212-1" "Revista" => array:6 [ "tituloSerie" => "Int Arch Occup Environ Health" "fecha" => "2008" "volumen" => "81" "paginaInicial" => "295" "paginaFinal" => "300" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17605033" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of latent tuberculosis infection among healthcare workers in a hospital for pulmonary diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Schablon" 1 => "G. Beckmann" 2 => "M. Harling" 3 => "R. Diel" 4 => "A. Nienhaus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1745-6673-4-1" "Revista" => array:5 [ "tituloSerie" => "J Occup Med Toxicol" "fecha" => "2009" "volumen" => "4" "paginaInicial" => "1" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19134168" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of QuantiFERON-TB gold in-tube test and tuberculin skin test for identification of latent <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> infection in healthcare staff and association between positive test results and known risk factors for infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Vinton" 1 => "S. Mihrshahi" 2 => "P. Johnson" 3 => "G.A. Jenkin" 4 => "D. Jolley" 5 => "B.A. Biggs" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Infection Control and Hospital Epidemiology" "fecha" => "2009" "volumen" => "30" "numero" => "3" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Programa Nacional de Vacinação. Direcção-Geral de Saúde – Ministério da Saúde. Available at <a class="elsevierStyleInterRef" href="http://www.dgsaude.pt/upload/membro.id/ficheiros/i007442.pdf">http://www.dgsaude.pt/upload/membro.id/ficheiros/i007442.pdf</a>(accessed May 1st, 2009)" ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Applied logistic regression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Hosmer" 1 => "S. Lemeshow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2000" "editorial" => "John Wiley & Sons" "editorialLocalizacion" => "New York, NY" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Falsepositive tuberculin skin tests: what is the absolute effect of BCG and non-tuberculous mycobacteria?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Farhat" 1 => "Greenaway" 2 => "M. Pai" 3 => "D. Menzies" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2006" "volumen" => "10" "numero" => "11" "paginaInicial" => "1192" "paginaFinal" => "1204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17131776" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interferon-γ release assay for the diagnosis of latent TB infection – analysis of discordant results, when compared to the tuberculin skin test" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Nienhaus" 1 => "A. Schablon" 2 => "R. Diel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0002665" "Revista" => array:6 [ "tituloSerie" => "PLoS ONE" "fecha" => "2008" "volumen" => "3" "numero" => "7" "paginaInicial" => "e2665" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18628829" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis screening in Portuguese healthcare workers using the tuberculin skin test and the interferon-γ release assay" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "J. Torres Costa" 1 => "R. Sá" 2 => "M.J. Cardoso" 3 => "R. Silva" 4 => "J. Ferreira" 5 => "C. Ribeiro" 6 => "M. Miranda" 7 => "J.L. Plácido" 8 => "A. Nienhaus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00053809" "Revista" => array:7 [ "tituloSerie" => "Eur Respir J" "fecha" => "2009" "volumen" => "34" "numero" => "6" "paginaInicial" => "1423" "paginaFinal" => "1428" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19948911" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occupational risk of tuberculosis transmission in a low incidence area" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Diel" 1 => "A. Seidler" 2 => "A. Nienhaus" 3 => "S. Rusch-Gerdes" 4 => "S. Niemann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1465-9921-6-35" "Revista" => array:7 [ "tituloSerie" => "Respir Res" "fecha" => "2005" "volumen" => "6" "numero" => "1" "paginaInicial" => "35" "paginaFinal" => "45" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15831092" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Health-care workers with tuberculosis infected during work" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. De Vries" 1 => "M.M. Sebek" 2 => "C.S. Lambregts-van Weezenbeek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.06.00039906" "Revista" => array:7 [ "tituloSerie" => "Eur Respir J" "fecha" => "2006" "volumen" => "28" "numero" => "6" "paginaInicial" => "1216" "paginaFinal" => "1221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16807264" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of the interferon-γ release assay and the tuberculin skin test for contact investigation of tuberculosis in BCG-vaccinated health care workers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "S.-J. Lee S" 1 => "Y.-C. Liu" 2 => "T.-S. Huang" 3 => "Y.-S. Chen" 4 => "H.-C. Tsai" 5 => "S.-R. Wann" 6 => "H.-H. Lin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Scandinavian Journal of Infectious Disease" "fecha" => "2008" "volumen" => "40" "numero" => "5" "paginaInicial" => "373" "paginaFinal" => "380" "itemHostRev" => array:3 [ "pii" => "S073510970000961X" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interpretation of repeated tuberculin tests. Boosting, conversion, and reversion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Menzies" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.159.1.9801120" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1999" "volumen" => "159" "paginaInicial" => "15" "paginaFinal" => "21" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9872812" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "T-cell assay conversions and reversions among household contacts of tuberculosis patients in rural India" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:11 [ 0 => "M. Pai" 1 => "R. Joshi" 2 => "S. Dogra" 3 => "A.A. Zwerling" 4 => "D. Gajalakshmi" 5 => "K. Goswami" 6 => "M.V.R. Reddy" 7 => "S. Kalantri" 8 => "P.C. Hill" 9 => "D. Menzies" 10 => "P.C. Hopewell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2009" "volumen" => "13" "numero" => "1" "paginaInicial" => "84" "paginaFinal" => "92" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19105884" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Yoshiyama T, Harada N, Higuchi K, Nakajima Y, Ogata H. Estimation of incidence of tuberculosis infection in healthcare workers using repeated interferon-γ assays. Epidemiol Infect 2009.(ahead of print)." ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "for the TBNET. LTBI: latent tuberculosis infection or lasting immune responses to <span class="elsevierStyleItalic">M. tuberculosis?</span>. – A TBNET consensus statement" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "U. Mack" 1 => "G.B. Migliori" 2 => "M. Sester" 3 => "H.L. Rieder" 4 => "S. Ehlers" 5 => "D. Goletti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00120908" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2009" "volumen" => "33" "paginaInicial" => "956" "paginaFinal" => "973" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19407047" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Teste tuberculínico. Como optimizar?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Duarte" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2009" "volumen" => "15" "numero" => "2" "paginaInicial" => "295" "paginaFinal" => "304" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19280074" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comissão de Trabalho de Tuberculose da Sociedade Portuguesa de Pneumologia. Tratamento da tuberculose latente: Revisão das normas, 2006" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Duarte" 1 => "J. Amado" 2 => "H. Lucas" 3 => "J.M. Sapage" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2007" "volumen" => "13" "numero" => "3" "paginaInicial" => "397" "paginaFinal" => "418" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17695077" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Persistently elevated T cell interferon-γ response after treatment for latent tuberculosis infection among healthcare workers in India: a preliminary report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "M. Pai" 1 => "R. Joshi" 2 => "S. Dogra" 3 => "D.K. Mendiratta" 4 => "P. Narang" 5 => "K. Dheda" 6 => "S. Kalantri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1745-6673-1-7" "Revista" => array:6 [ "tituloSerie" => "Journal of Occupational Medicine and Toxicology" "fecha" => "2006" "volumen" => "1" "paginaInicial" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16722616" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0210570509003653" "estado" => "S300" "issn" => "02105705" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735115/0000001600000002/v1_201305151526/S2173511510700312/v1_201305151526/en/main.assets" "Apartado" => array:4 [ "identificador" => "9552" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Article/Artigo Original" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001600000002/v1_201305151526/S2173511510700312/v1_201305151526/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511510700312?idApp=UINPBA00004E" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 0 | 3 |
| 2024 October | 35 | 27 | 62 |
| 2024 September | 28 | 21 | 49 |
| 2024 August | 46 | 31 | 77 |
| 2024 July | 35 | 29 | 64 |
| 2024 June | 25 | 22 | 47 |
| 2024 May | 20 | 44 | 64 |
| 2024 April | 29 | 30 | 59 |
| 2024 March | 23 | 32 | 55 |
| 2024 February | 23 | 23 | 46 |
| 2024 January | 17 | 22 | 39 |
| 2023 December | 21 | 31 | 52 |
| 2023 November | 16 | 34 | 50 |
| 2023 October | 13 | 30 | 43 |
| 2023 September | 17 | 41 | 58 |
| 2023 August | 19 | 34 | 53 |
| 2023 July | 19 | 28 | 47 |
| 2023 June | 13 | 26 | 39 |
| 2023 May | 19 | 28 | 47 |
| 2023 April | 12 | 9 | 21 |
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