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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Com o objectivo de identificar par&#226;metros funcionais respirat&#243;rios que contribuam para o diagn&#243;stico diferencial entre asma e DPOC&#44; estud&#225;mos 20 asm&#225;ticos e 30 bronqu&#237;ticos&#44; com ou sem enfisema&#44; com os exames usuais de fun&#231;&#227;o pulmonar&#58; espirografia&#44; pletismografia e DLCO&#44; pr&#233; e p&#243;s-broncodilata&#231;&#227;o para os dois primeiros exames&#46; Os grupos apresentam diferen&#231;as significativas na sua constitui&#231;&#227;o&#46; Os asm&#225;ticos s&#227;o mais jovens&#44; m&#233;dia de 48 anos&#44; contra 59 anos no grupo com DPOC&#44; e o grupo &#233; constitu&#237;do predominantemente por mulheres&#44; 65&#37; contra 40&#37;&#44; respectivamente&#46; Os exames funcionais pulmonares&#44; realizados conforme as directrizes internacionais&#44; mostram&#44; pela espirografia&#44; que os asm&#225;ticos t&#234;m obstru&#231;&#227;o mais intensa&#44; VEF1&#47;CVF de 59 <span class="elsevierStyleItalic">versus</span> 66 e maior resposta broncodilatadora pelo VEF1&#44; quer em valor absoluto&#44; quer por varia&#231;&#227;o percentual&#44; do basal &#40;&#37;&#41; ou do valor previsto &#40;&#37;P&#41;&#46; A DLCO mostra-se&#44; em m&#233;dia&#44; normal entre os asm&#225;ticos&#44; 103&#37;P&#44; e diminu&#237;da no grupo com DPOC&#44; 69&#37;P&#46; Na pletismografia constat&#225;mos que os asm&#225;ticos t&#234;m maior volume residual &#40;&#37;P&#41; e resist&#234;ncia de vias a&#233;reas&#46; Conclu&#237;mos que v&#225;rios par&#226;metros funcionais diferenciam a asma da DPOC&#44; como um grupo&#59; na an&#225;lise individual&#44; a DLCO &#233; o par&#226;metro que melhor discrimina as duas doen&#231;as&#44; possuindo maior especificidade para o diagn&#243;stico de DPOC&#44; seguida pelas varia&#231;&#245;es de VEF1 na broncodilata&#231;&#227;o&#44; com maior sensibilidade para o diagn&#243;stico de asma&#46; Desta forma&#44; estes dois exames s&#227;o destaque no diagn&#243;stico diferencial das doen&#231;as obstrutivas&#46;</p>"
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Which functional parameters can help differentiate severe asthma from COPD?
Quais os parâmetros funcionais que permitem diferenciar asma grave de DPOC?
Ricardo Marques Dias1,5,
Corresponding author
dias.ricardomarques@gmail.com

Correspondence to/Correspondência: Dias Rua Barão da Torre 388/104, Rio de Janeiro – Brasil – 22411000.
, Fernando Hauaji Chacur2,5, Sonia Regina da Silva Carvalho3,5, Denise Duprat Neves4,5
1 Prof. Titular da Disciplina Cardiopulmonar da UNIRIO/Full Professor, Cardiopulmonary Sciences, UNIRIO
2 Médico Responsável pelo Serviço de Provas de Função Respiratória do Pró-Cardíaco/Head Physician, Respiratory Function Test Unit, Hospital Pró-Cardíaco
3 Prof.ª Adjunta da Disciplina Cardiopulmonar da UNIRIO/Assistant Professor, Cardiopulmonary Sciences, UNIRIO
4 Prof.ª Associada da Disciplina Cardiopulmonar da UNIRIO/Assistant Professor, Cardiopulmonary Sciences, UNIRIO
5 Trabalho realizado no Hospital Pró-Cardíaco e no Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro (UNIRIO)/Study undertaken at the Hospital Pró-Cardíaco and Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro (UNIRIO)
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          "clase" => "keyword"
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            0 => "Lung function test"
            1 => "asthma"
            2 => "COPD"
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            0 => "Testes de fun&#231;&#227;o pulmonar"
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            2 => "DPOC"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to identify the respiratory function parameters that help in the accurate diagnosis of asthma and COPD&#46; We studied 20 asthma and 30 COPD patients who underwent lung function tests including spirometry and plethysmography both with bronchodilator test and diffusion with carbon monoxide &#40;DLCO&#41;&#46; The tests were performed according to International Guidelines &#40;ATS&#47;ERS&#41;&#46; The asthma patients were younger &#40;mean age<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&#41; than those in the COPD group &#40;mean age<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>59&#41; and this group also had more female patients &#40;65&#37;&#41; than the COPD group &#40;40&#37;&#41;&#46; The results showed a more severe obstruction in the asthma group&#58; FEV1&#47;FVC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>59&#37; <span class="elsevierStyleItalic">versus</span> 66&#37; for COPD&#46; There was also a greater bronchodilator response as shown by changes in absolute and percentage values for FEV1 in the asthma group&#46; Average DLCO values were normal in the asthma group &#40;103&#37;P&#41; and lower in the COPD &#40;69&#37;&#41;&#46; In plethysmography the asthma group had a higher residual volume &#40;&#37;P&#41; and a higher airway resistance&#46; We concluded that many functional parameters were useful in distinguishing the asthma and COPD groups&#46; In individual analysis&#44; DLCO was the parameter which best aided in an accurate diagnosis in both groups&#44; with a higher specificity for COPD&#46; The bronchodilator response measured by changes in FEV1 showed a higher sensitivity for asthma&#46; Thus&#44; these two tests are highlighted in the differential diagnosis of obstructive diseases&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Com o objectivo de identificar par&#226;metros funcionais respirat&#243;rios que contribuam para o diagn&#243;stico diferencial entre asma e DPOC&#44; estud&#225;mos 20 asm&#225;ticos e 30 bronqu&#237;ticos&#44; com ou sem enfisema&#44; com os exames usuais de fun&#231;&#227;o pulmonar&#58; espirografia&#44; pletismografia e DLCO&#44; pr&#233; e p&#243;s-broncodilata&#231;&#227;o para os dois primeiros exames&#46; Os grupos apresentam diferen&#231;as significativas na sua constitui&#231;&#227;o&#46; Os asm&#225;ticos s&#227;o mais jovens&#44; m&#233;dia de 48 anos&#44; contra 59 anos no grupo com DPOC&#44; e o grupo &#233; constitu&#237;do predominantemente por mulheres&#44; 65&#37; contra 40&#37;&#44; respectivamente&#46; Os exames funcionais pulmonares&#44; realizados conforme as directrizes internacionais&#44; mostram&#44; pela espirografia&#44; que os asm&#225;ticos t&#234;m obstru&#231;&#227;o mais intensa&#44; VEF1&#47;CVF de 59 <span class="elsevierStyleItalic">versus</span> 66 e maior resposta broncodilatadora pelo VEF1&#44; quer em valor absoluto&#44; quer por varia&#231;&#227;o percentual&#44; do basal &#40;&#37;&#41; ou do valor previsto &#40;&#37;P&#41;&#46; A DLCO mostra-se&#44; em m&#233;dia&#44; normal entre os asm&#225;ticos&#44; 103&#37;P&#44; e diminu&#237;da no grupo com DPOC&#44; 69&#37;P&#46; Na pletismografia constat&#225;mos que os asm&#225;ticos t&#234;m maior volume residual &#40;&#37;P&#41; e resist&#234;ncia de vias a&#233;reas&#46; Conclu&#237;mos que v&#225;rios par&#226;metros funcionais diferenciam a asma da DPOC&#44; como um grupo&#59; na an&#225;lise individual&#44; a DLCO &#233; o par&#226;metro que melhor discrimina as duas doen&#231;as&#44; possuindo maior especificidade para o diagn&#243;stico de DPOC&#44; seguida pelas varia&#231;&#245;es de VEF1 na broncodilata&#231;&#227;o&#44; com maior sensibilidade para o diagn&#243;stico de asma&#46; Desta forma&#44; estes dois exames s&#227;o destaque no diagn&#243;stico diferencial das doen&#231;as obstrutivas&#46;</p>"
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                          "etal" => false
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                            0 => "G&#46; Di Lorenzo"
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                    0 => array:2 [
                      "doi" => "10.1016/j.rmed.2007.09.007"
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                      "titulo" => "Distinguishing asthma and chronic obstructive pulmonary disease&#58; why&#44; why not and how&#63;"
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                          "etal" => false
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                            2 => "P&#46;G&#46; Gibson"
                            3 => "R&#46; Wood-Baker"
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                        0 => array:2 [
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Pulmonology

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