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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Evidence suggests the INSURE strategy &#40;INtubate-SURfactant administration and Extubate to nasal continuous positive airway pressure &#91;nCPAP&#93;&#41; is superior to mechanical ventilation &#40;MV&#41; with rescue surfactant for the management of respiratory distress syndrome &#40;RDS&#41; in very low birth weight &#40;VLBW&#41; neonates&#46; There is limited data&#44; however&#44; to assess whether INSURE is superior to nCPAP alone&#46; We aimed to compare these two strategies regarding early and late outcomes&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Retrospective cohort study from Jan&#47;2002 to Aug&#47;2008&#46; We included VLBW neonateswith gestational age &#40;GA&#41; &#8804; 30 weeks registered in the Vermont Oxford Network that used either nCPAP alone &#40;nCPAP group&#44; N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#41;&#44; or with INSURE &#40;INSURE group&#44; N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>56&#41;&#46; We assessed early &#40;RDS&#44; need for rescue surfactant&#44; and CPAP failure with MV&#41; and late outcomes &#40;chronic lung disease of prematurity &#40;CLD&#41;&#44; mortality&#44; and composite outcome of mortality and&#47;or CLD&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Neonates in the INSURE group had lower mean GA&#44; while other baseline variables were comparable&#46; The proportion of RDS was significantly superior in the nCPAP group &#40;53&#37; vs&#46; 30&#37;&#59; adjusted OR &#91;95&#37; CI&#93; &#8211; 0&#46;2 &#91;0&#46;1-0&#46;6&#93;&#41;&#46; Therapeutic surfactant was administered to all cases with RDS in the nCPAP group&#44; but to none from the INSURE group&#46; MV was more frequently required in the nCPAP group &#40;11&#47; 40&#44; 28&#37; <span class="elsevierStyleItalic">vs</span>&#46; 9&#47; 56&#44; 12&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46; No statistically significant differences were found in either of the late outcomes&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The use of nCPAP alone in VLBW neonates with GA &#8804; 30 weeks may be associated with slightly poorer early outcomes than the INSURE strategy&#44; but there were no significant differences in CLD or mortality&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pretende-se determinar se a utiliza&#231;&#227;o do m&#233;todo INSURE em rec&#233;m-nascidos de muito baixo peso&#44; com idade gestacional &#40;IG&#41; &#8804; 30 semanas se associa a menor morbilidade e mortalidade quando comparado com uso de nCPAP isolado&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudo de coorte retrospectiva dos RNMBP nascidos num hospital de apoio perinatal diferenciado entre Janeiro&#47;2002-Agosto&#47;2008&#46; Inclu&#237;ram-se as crian&#231;as registadas na Vermont-Oxford Network com IG &#8804;30semanas e com uso de nCPAP logo ap&#243;s o nascimento &#40;N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>96&#41;&#46; Estabeleceu-se Grupo nCPAP &#8211; uso de nCPAP isolado &#40;N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#41; e Grupo INSURE &#40;N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>56&#41;&#46; Consideraram-se <span class="elsevierStyleItalic">outcomes</span> precoces&#58; s&#237;ndroma de dificuldade respirat&#243;ria &#40;SDR&#41;&#44; necessidade de administrar surfactante com intuito terap&#234;utico ou recurso a ventila&#231;&#227;o invasiva&#46; Compararam-se igualmente <span class="elsevierStyleItalic">outcomes</span> tardios&#58; doen&#231;a pulmonar cr&#243;nica da prematuridade &#40;DPC&#41;&#44; mortalidade e o <span class="elsevierStyleItalic">outcome</span> composto DPC-mortalidade&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">No grupo INSURE verificou-se menor IG&#44; n&#227;o se registando diferen&#231;as relativamente ao peso ao nascer e indu&#231;&#227;o da matura&#231;&#227;o pulmonar&#46; Verificou-se SDR em 21&#47;40 &#40;53&#37;&#41; casos do grupo nCPAP e em 17&#47;56 &#40;30&#37;&#41; casos do grupo INSURE &#40;OR ajustado &#91;IC 95&#37;&#93; &#8211; 0&#44;2 &#91;0&#44;1-0&#44;6&#93;&#41;&#46; No grupo nCPAP todos estes casos realizaram surfactante com intuito terap&#234;utico&#44; n&#227;o tendo sido efectuada nenhuma dose adicional de surfactante no grupo INSURE&#46; Verificou-se maior n&#250;mero de casos com necessidade de VI no grupo nCPAP do que no grupo INSURE &#40;11&#47;40&#44; 28&#37; <span class="elsevierStyleItalic">vs</span> 9&#47;56&#44; 12&#37;&#41;&#46; N&#227;o foram encontradas diferen&#231;as estatisticamente significativas relativamente aos <span class="elsevierStyleItalic">outcomes</span> tardios&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#227;o</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Em RNMBP com IG &#8804;30sem&#44; o uso isolado de nCPAP poder&#225; traduzir-se numa ligeira desvantagem em <span class="elsevierStyleItalic">outcomes</span> precoces&#44; sem evidentes repercuss&#245;es em termos de DPC ou mortalidade&#46;</p>"
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Early nasal continuous positive airway pressure versus INSURE in VLBW neonates
Uso do método INSURE versus CPAP nasal isolado em recém-nascidos de muito baixo peso com 30 ou menos semanas de gestação
Ana Saianda1,
Corresponding author
asaianda@gmail.pt

Correspondence to/Correspondência: Departamento de Pediatria. Hospital de Santa Maria, Av. Professor. Egas Moniz, 1649-035 Lisboa.
, Ricardo M. Fernandes1, Joana Saldanha2
1 Interno do Complementar. Departamento da Criança e da Família. Hospital de Santa Maria – Lisboa/Resident. Child and Family Health Service. Hospital de Santa Maria – Lisboa, Neonatal Unit. Hospital de Santa Maria – Lisboa
2 Assistente graduada. Departamento da Criança e da Família. Unidade de Neonatologia. Hospital de Santa Maria – Lisboa/Consultant. Child and Family Health Service., Neonatal Unit. Hospital de Santa Maria – Lisboa
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      "pt" => array:1 [
        "titulo" => "Uso do m&#233;todo INSURE <span class="elsevierStyleItalic">versus</span> CPAP nasal isolado em rec&#233;m-nascidos de muito baixo peso com 30 ou menos semanas de gesta&#231;&#227;o"
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            0 => "Very low birth weight"
            1 => "nCPAP ventilation"
            2 => "INSURE"
            3 => "respiratory distress syndrome &#40;newborn&#41;"
            4 => "chronic lung disease of prematurity"
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            0 => "Rec&#233;m-nascido muito baixo peso"
            1 => "nCPAP"
            2 => "INSURE"
            3 => "sindroma de dificuldade respirat&#243;ria neonatal"
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      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Evidence suggests the INSURE strategy &#40;INtubate-SURfactant administration and Extubate to nasal continuous positive airway pressure &#91;nCPAP&#93;&#41; is superior to mechanical ventilation &#40;MV&#41; with rescue surfactant for the management of respiratory distress syndrome &#40;RDS&#41; in very low birth weight &#40;VLBW&#41; neonates&#46; There is limited data&#44; however&#44; to assess whether INSURE is superior to nCPAP alone&#46; We aimed to compare these two strategies regarding early and late outcomes&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Retrospective cohort study from Jan&#47;2002 to Aug&#47;2008&#46; We included VLBW neonateswith gestational age &#40;GA&#41; &#8804; 30 weeks registered in the Vermont Oxford Network that used either nCPAP alone &#40;nCPAP group&#44; N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#41;&#44; or with INSURE &#40;INSURE group&#44; N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>56&#41;&#46; We assessed early &#40;RDS&#44; need for rescue surfactant&#44; and CPAP failure with MV&#41; and late outcomes &#40;chronic lung disease of prematurity &#40;CLD&#41;&#44; mortality&#44; and composite outcome of mortality and&#47;or CLD&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Neonates in the INSURE group had lower mean GA&#44; while other baseline variables were comparable&#46; The proportion of RDS was significantly superior in the nCPAP group &#40;53&#37; vs&#46; 30&#37;&#59; adjusted OR &#91;95&#37; CI&#93; &#8211; 0&#46;2 &#91;0&#46;1-0&#46;6&#93;&#41;&#46; Therapeutic surfactant was administered to all cases with RDS in the nCPAP group&#44; but to none from the INSURE group&#46; MV was more frequently required in the nCPAP group &#40;11&#47; 40&#44; 28&#37; <span class="elsevierStyleItalic">vs</span>&#46; 9&#47; 56&#44; 12&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46; No statistically significant differences were found in either of the late outcomes&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The use of nCPAP alone in VLBW neonates with GA &#8804; 30 weeks may be associated with slightly poorer early outcomes than the INSURE strategy&#44; but there were no significant differences in CLD or mortality&#46;</p>"
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        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pretende-se determinar se a utiliza&#231;&#227;o do m&#233;todo INSURE em rec&#233;m-nascidos de muito baixo peso&#44; com idade gestacional &#40;IG&#41; &#8804; 30 semanas se associa a menor morbilidade e mortalidade quando comparado com uso de nCPAP isolado&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudo de coorte retrospectiva dos RNMBP nascidos num hospital de apoio perinatal diferenciado entre Janeiro&#47;2002-Agosto&#47;2008&#46; Inclu&#237;ram-se as crian&#231;as registadas na Vermont-Oxford Network com IG &#8804;30semanas e com uso de nCPAP logo ap&#243;s o nascimento &#40;N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>96&#41;&#46; Estabeleceu-se Grupo nCPAP &#8211; uso de nCPAP isolado &#40;N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>40&#41; e Grupo INSURE &#40;N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>56&#41;&#46; Consideraram-se <span class="elsevierStyleItalic">outcomes</span> precoces&#58; s&#237;ndroma de dificuldade respirat&#243;ria &#40;SDR&#41;&#44; necessidade de administrar surfactante com intuito terap&#234;utico ou recurso a ventila&#231;&#227;o invasiva&#46; Compararam-se igualmente <span class="elsevierStyleItalic">outcomes</span> tardios&#58; doen&#231;a pulmonar cr&#243;nica da prematuridade &#40;DPC&#41;&#44; mortalidade e o <span class="elsevierStyleItalic">outcome</span> composto DPC-mortalidade&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">No grupo INSURE verificou-se menor IG&#44; n&#227;o se registando diferen&#231;as relativamente ao peso ao nascer e indu&#231;&#227;o da matura&#231;&#227;o pulmonar&#46; Verificou-se SDR em 21&#47;40 &#40;53&#37;&#41; casos do grupo nCPAP e em 17&#47;56 &#40;30&#37;&#41; casos do grupo INSURE &#40;OR ajustado &#91;IC 95&#37;&#93; &#8211; 0&#44;2 &#91;0&#44;1-0&#44;6&#93;&#41;&#46; No grupo nCPAP todos estes casos realizaram surfactante com intuito terap&#234;utico&#44; n&#227;o tendo sido efectuada nenhuma dose adicional de surfactante no grupo INSURE&#46; Verificou-se maior n&#250;mero de casos com necessidade de VI no grupo nCPAP do que no grupo INSURE &#40;11&#47;40&#44; 28&#37; <span class="elsevierStyleItalic">vs</span> 9&#47;56&#44; 12&#37;&#41;&#46; N&#227;o foram encontradas diferen&#231;as estatisticamente significativas relativamente aos <span class="elsevierStyleItalic">outcomes</span> tardios&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#227;o</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Em RNMBP com IG &#8804;30sem&#44; o uso isolado de nCPAP poder&#225; traduzir-se numa ligeira desvantagem em <span class="elsevierStyleItalic">outcomes</span> precoces&#44; sem evidentes repercuss&#245;es em termos de DPC ou mortalidade&#46;</p>"
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ISSN: 21735115
Original language: English
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