Complicações pulmonares não infecciosas após transplante de células-tronco hematopoiéticas
Non-infectious pulmonary complications after the hematoppoietic stem cell trasplantation
Eliane Viana Mancuzo1, Marina Augusto Neves2, Henrique Bittencourt3, Nilton Alves de Rezende1,
Corresponding author
narezende@terra.com.br
Correspondência: Departamento de Clinica Medica, Faculdade de Medicina da UFMG, Avenida Alfredo Balena 190, CEP-30130-100, Belo Horizonte, Brasil.
Correspondência: Departamento de Clinica Medica, Faculdade de Medicina da UFMG, Avenida Alfredo Balena 190, CEP-30130-100, Belo Horizonte, Brasil.
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O avanço na profilaxia e tratamento de complicações infecciosas tem aumentado de forma significativa a parcela de complicações pulmonares não infecciosas. O diagnóstico e o tratamento precoce destas complicações podem mudar o prognóstico dos receptores de transplante de células-tronco hematopoéticas. O objectivo deste estudo é rever as principais complicações não infecciosas associadas ao TCTH desde a realização do primeiro transplante de medula óssea em 1957.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Foi realizada uma revisão sistemática da literatura utilizando-se a estratégia PICO para a construção das perguntas. Os descritores transplante de células-tronco hematopoiéticas, complicações pulmonares não infecciosas, revisão sistemática, em português e seus correspondentes em inglês, foram utilizados para acesso às seguintes bases de dados: MEDLINE, EBM, EMBASE, COCRANE LIBRARY, LILACS e SciELO. Nesta revisão foram identificados 263 trabalhos. Destes, 30 foram seleccionados para serem analisados na íntegra. As complicações pulmonares não infecciosas mais frequentemente descritas foram: bronquiolite obliterante, bronquiolite obliterante com pneumonia em organização, edema pulmonar, síndroma da pneumonia idiopática, síndroma da toxicidade pulmonar por droga, hemorragia alveolar difusa, síndroma do enxerto e trombo citolítico pulmonar.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Pulmonary complications are important cause of mortality and morbidity after hematopoietic stem cell transplantation, in 30% to 60% of the patients. Improvements in prophylaxis and treatment of infectious complications have been increasing the rate of non-infectious complications. Early diagnosis and treatment of those complications can significantly change the evolution of hematopoietic stem cell transplantation receptors.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The objective of this study is to review the most frequent non-infection complications associated to hematopoietic stem cell transplantation since the first bone marrow transplantation performed in 1957.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A systematic literature review was performed, using the PICO strategy to ask the questions. The descriptors hematopoietic stem cell transplantation, non-infectious pulmonary complications, systematic review, in portuguese and their english correspondents, were used to access the following databases: MEDLINE, EBM, Embase, Cocrane Library, LILACS and SciELO. In this review, 263 studies were identified, from which 31 were selected for full analyzis.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The non-infection pulmonary complications most frequently found were: bronchiolitis obliterans, bronchiolitis obliterans organizing pneumonia, pulmonary edema, idiopathic pneumonia syndrome, delayed pulmonary toxicity syndrome, diffuse alveolar hemorrhage, engrafment syndrome and pulmonary cytolitic thrombi.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografia" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:52 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic lung disease after hematopoietic stem cell transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Afessa" 1 => "S.G. 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ISSN: 21735115Original language: Portuguese
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