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Significance of specific IgG against sensitizing antigens in extrinsic allergic alveolitis: Serological methods in EAA
A importância da IgG específica contra antigénios sensibilizantes na alveolite alérgica extrínseca: Métodos serológicos na AAE
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Sterclova, M. Vasakova, M. Metlicka" "autores" => array:3 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Sterclova" "email" => array:1 [ 0 => "martina.sterclova@ftn.cz" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Vasakova" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Metlicka" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Respiratory Diseases, Thomayer's University Hospital, Videnska, Prague, Czech Republic" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Immunology, Thomayer's University Hospital, Videnska, Prague, Czech Republic" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "A importância da IgG específica contra antigénios sensibilizantes na alveolite alérgica extrínseca: Métodos serológicos na AAE" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec161695" "palabras" => array:4 [ 0 => "Aeroallergen" 1 => "Hypersensitivity pneumonitis" 2 => "Immunoglobulins" 3 => "Indoor environment" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras chave" "identificador" => "xpalclavsec161696" "palabras" => array:4 [ 0 => "Aeroalergénio" 1 => "Pneumonite de hipersensibilidade" 2 => "Imunoglobulinas" 3 => "Ambiente interior" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The aim of our study is to find differences in IgG in sera of potentially exposed and nonexposed individuals and to detect differences in concentrations of specific serum IgG among subjects with and without EAA. Seventy-two patients being followed for suspected interstitial lung disease were included. Specific IgG in sera were established by ImmunoCAP. Serum concentrations of Aspergillus fumigatus, Candida albicans IgG and mixture of moulds IgG were higher in subjects with exposure to relevant inhalation antigens (p < 0.05). Patients exposed to parrot and mammal hair mixture had higher serum concentration of specific IgG (p < 0.05). Subjects without exposure to mites had lower serum IgG to Dermatophagoides pteronyssinus, Dermatophagoides farinae, Dermatophagoides microceras and Glycophagus domesticus (p < 0.05). Higher concentration of serum specific IgG may show previous exposure to this antigen. Even though mite specific IgG are not commonly tested in EAA patients, we suggest their immunomodulatory activity may influence susceptibility to other inhalation antigens.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">O objetivo do nosso estudo é descobrir diferenças da IgG no soro de possíveis indi-víduos expostos e não-expostos, bem como detetar diferenças de concentrações da IgG sérica específico entre indivíduos com e sem AAE. Foram incluídos setenta e dois pacientes com suspeita de doença pulmonar intersticial. A IgG sérica específica foi definida pelo ImmunoCAP. As concentrações séricas de IgG para o Aspergillus fumigatus, Candida albicans e mistura de fungos foram superiores em sujeitos expostos a inalação de antigénios relevantes (p < 0,05). Os pacientes expostos a uma mistura de penas de papagaio e pelos de mamíferos apresentaram uma maior concentração sérica da IgG específica (p < 0,05). Os indivíduos sem exposição a ácaros apresentaram menor IgG sérica para Dermatophagoides pteronyssinus, D. farinae, D. microceras e Glycophagus domesticus (p < 0,05). Uma elevada concentração de IgG sérica específica pode indicar uma exposição prévia a este antigénio. Embora a IgG específica para os ácaros não seja normalmente testada em pacientes com AAE, referimos que a sua atividade imunomoduladora pode influenciar a suscetibilidade de outras inalações de antigénios.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "[1]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cladosporium species related hypersensitivity pneu-monitis in household environments" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Chiba" 1 => "S. 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| Year/Month | Html | Total | |
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