Editorial
From heart to bad sleep—Lessons for sleep apnoea in times of crisis
Do coração a dormir mal – lições para a apneia do sono em tempos de crise
J. Moutinho dos Santos
Centro de Medicina do Sono do Centro Hospitalar de Coimbra, Coimbra, Portugal
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"tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1" "paginaFinal" => "2" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Cartas ao editor: Like a rolling stone?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.C. Winck, A. Morais" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J.C." "apellidos" => "Winck" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Morais" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511511001023?idApp=UINPBA00004E" "url" => "/21735115/0000001800000001/v1_201305151555/S2173511511001023/v1_201305151555/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "From heart to bad sleep—Lessons for sleep apnoea in times of crisis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "3" "paginaFinal" => "4" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J. Moutinho dos Santos" "autores" => array:1 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Moutinho dos Santos" "email" => array:1 [ 0 => "josemoutinho@netcabo.pt" ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Centro de Medicina do Sono do Centro Hospitalar de Coimbra, Coimbra, Portugal" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Do coração a dormir mal – lições para a apneia do sono em tempos de crise" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Obstructive sleep apnoea syndrome (OSAS) is a largely prevalent disorder characterized by repeated episodes of pharyngeal obstruction that causes oxygen desaturation and sleep fragmentation. Besides the consequences of excessive daytime sleepiness including increased risk of traffic and labour accidents, OSAS has been implicated, with great or less evidence, as an independent risk factor for different cardiovascular diseases as hypertension, stroke, heart failure, arrhythmias, coronary heart disease and myocardial infarction.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The recognition of OSAS as a treatable putative cause of hypertension and the need for screening is present in international recommendations since 2003.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Several studies have found an association between OSAS and coronary artery disease (CAD). In a large prospective longitudinal study in men and women who were free of CAD at baseline and followed for 8.7 years, after adjustment for multiple risk factors, OSAS was positively associated to myocardial infarction, revascularization procedure or death only in men aged <70 years old (adjusted ratio 1.10 [95% CI 1.00, 1.21] per 10-unit increase in apnoea–hypopnea index), but not in older men or in women of any age.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Other studies showed that patients suffering from CAD with an AHI greater than 10 events/hour were more prone to die in 5-year follow-up than patients without OSAS (37.5% vs. 9.3%, respectively) after controlling for age, weight, and smoking.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a> On the other hand in patients with CAD that had percutaneous intervention the probability of restenosis, vessel remodelling and cardiac mortality was greater in the presence of OSAS.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a> Moreover patients with CAD treated with CPAP had better prognosis than those who were not treated.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8–11</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">So, it appears rational to establish strategies to search for OSAS in patients with a diagnosis of CAD. In this issue of RPP, Areias et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> contribute to this purpose: using a level IV equipment (ApneaLink™, a two-channel device that monitores respiratory flow and O<span class="elsevierStyleInf">2</span> saturation) they were able to detect the presence of OSAS, confirmed by polysomnography, in 43% of patients admitted to ICU for acute coronary syndrome. These results are not much different from other studies using different methodologies, that together point to a much greater prevalence in CAD than the admitted for general population.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13,14</span></a> Independently of some issues that need to be clarified, as the better methodology and time of screening, these date reinforce the importance of detecting OSAS in CAD patients.</p><p id="par0015" class="elsevierStylePara elsevierViewall">OSAS is a treatable condition and the first line treatment is ventilation with continuous positive airway pressure (CPAP); the main challenge of this form of treatment is patient adherence. It is known that multiple factors interfere in this matter that involves individual characteristics (including the symptomatic state, e.g. hypersomnolence but also personality profile), education and literacy, iatrogenicity, marital support, health care support or reimbursement policies. In this issue of RPP Mota et al.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> report an interesting finding of insomnia complaints <span class="elsevierStyleItalic">after</span> the initiation of CPAP treatment for OSAS. Despite some caveats of the study, mainly in psychological characterization of these patients or the timing of appearance and the duration of the symptoms, in our knowledge this is the first paper that gives data on a form of adjustment insomnia that, in this study, appeared to be related to tolerance to CPAP pressure. The association of insomnia to OSAS, in some instances, is already known and can be related to the presence of psychological disturbances<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16,17</span></a> or to be a manifestation of OSAS in and of itself. In the latter case we can expect that treating the respiratory problem solves insomnia and, in fact, in the present study by Mota et al., almost half the patients (11/24) with pre-existing insomnia showed resolution of this problem after initiation of CPAP. Nevertheless, is also known that insomnia complaints have a major impact on adherence to treatment<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18,19</span></a> and that a specific approach should be offered to deal with this problem which underline the importance of multidisciplinary to sleep medicine.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In summary, two articles in this issue of RPP<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,15</span></a> express two important factors in OSAS: one is the necessity to screen patients with cardiovascular disease for OSAS in order to treat them and reduce the risk of serious co-morbidities and, second, is the difficulty in resolving specific problems to assure proper treatment adherence.</p><p id="par0025" class="elsevierStylePara elsevierViewall">OSAS has become an important financial burden to the National Health Service costs: the annual expenses for domiciliary respiratory care amount to 55.5 millions euros/year and, according to data from ACSS, OSAS treatment accounts for more than 50% of that cost<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> As is estimated that only 10% of the patients with OSAS in Portugal are diagnosed and treated<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> an exponential increase in costs is foreseeable, particularly if the platform of patient recruitment is widened to include not only patients with “classic” symptoms but also refractory hypertension or CAD as is pointed by the study of Areias et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> In order to reduce the financial impact the Government has published, for public discussion, guidelines in domiciliary respiratory care that attempt to guarantee that OSAS treatment is provided based on specific diagnostic criteria (not difficult) but also assuming that the payment for treatment be assured only if patient is adherent and stipulating a 6-month “experimental period” (sic). Even if the principle is correct – payment conditioned by adherence – there are multiple causes for non-adherence (as, for instance, that showed in the study by Mota et al.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>) that deserve specific treatment approaches and the resolution of which may need longer time frames than the 6-month period admitted in the government proposal. Moreover, if it is true that short-term adherence can predict long-term adherence, difficulties in treatment compliance may arise at any time and for different reasons. In our experience, only 2–3% of patient refuse, definitively, treatment with CPAP; about 20% present other reasons for adherence below the stipulated as effective and these patients are at risk of having their CPAP payment withdrawn, increasing the burden of the disease due to co-morbidities that could be prevented with the treatment. So, the governmental desire to avoid waste in costs should be calibrated to assure that the patient is offered all solutions necessary to improve adherence and this is, frequently, a task for a multidisciplinary health team based in a reference sleep center. In other words, treatment suspension, even in a situation of refusal, should be a medical decision rather than a burocratic one.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the sleep heart health study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Shahar" 1 => "C.W. Whitney" 2 => "S. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 7 | 13 |
| 2024 October | 31 | 28 | 59 |
| 2024 September | 27 | 33 | 60 |
| 2024 August | 33 | 38 | 71 |
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| 2024 May | 31 | 36 | 67 |
| 2024 April | 22 | 24 | 46 |
| 2024 March | 25 | 20 | 45 |
| 2024 February | 30 | 25 | 55 |
| 2024 January | 25 | 24 | 49 |
| 2023 December | 19 | 20 | 39 |
| 2023 November | 16 | 25 | 41 |
| 2023 October | 18 | 29 | 47 |
| 2023 September | 15 | 32 | 47 |
| 2023 August | 17 | 22 | 39 |
| 2023 July | 18 | 26 | 44 |
| 2023 June | 15 | 8 | 23 |
| 2023 May | 23 | 21 | 44 |
| 2023 April | 9 | 8 | 17 |
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