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Duarte, C. Carvalho, C. Pereira, A. Bettencourt, A. Carvalho, M. Villar, A. Domingos, H. Barros, J.A. Marques, P. Pinho Costa, D. Mendonça, B. Martins" "autores" => array:12 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Duarte" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Carvalho" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Pereira" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Bettencourt" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Carvalho" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Villar" ] 6 => array:2 [ "nombre" => "A." "apellidos" => "Domingos" ] 7 => array:2 [ "nombre" => "H." "apellidos" => "Barros" ] 8 => array:2 [ "nombre" => "J.A." "apellidos" => "Marques" ] 9 => array:2 [ "nombre" => "P." "apellidos" => "Pinho Costa" ] 10 => array:2 [ "nombre" => "D." "apellidos" => "Mendonça" ] 11 => array:2 [ "nombre" => "B." "apellidos" => "Martins" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511511700057?idApp=UINPBA00004E" "url" => "/21735115/0000001700000001/v1_201305151540/S2173511511700057/v1_201305151540/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173511511700033" "issn" => "21735115" "doi" => "10.1016/S2173-5115(11)70003-3" "estado" => "S300" "fechaPublicacion" => "2011-01-01" "aid" => "70003" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "edi" "cita" => "Rev Port Pneumol. 2011;17:5-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3017 "formatos" => array:3 [ "EPUB" => 246 "HTML" => 1872 "PDF" => 899 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">EDITORIAL</span>" "titulo" => "Every year is the year of the lung!" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "5" "paginaFinal" => "6" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Todos os anos o ano do pulmão!" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 663 "Ancho" => 997 "Tamanyo" => 172710 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">For a good cause, a potent image and a consistent message.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Robalo Cordeiro" "autores" => array:1 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Robalo Cordeiro" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511511700033?idApp=UINPBA00004E" "url" => "/21735115/0000001700000001/v1_201305151540/S2173511511700033/v1_201305151540/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL ARTICLE</span>" "titulo" => "Hemoptysis – etiology, evaluation and treatment in a university hospital" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "7" "paginaFinal" => "14" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "F. Soares Pires, N. Teixeira, F. Coelho, C. Damas" "autores" => array:4 [ 0 => array:4 [ "nombre" => "F." "apellidos" => "Soares Pires" "email" => array:1 [ 0 => "filipasp@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Teixeira" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Coelho" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Damas" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Pulmonology Service, Hospital de São João, Porto, Portugal" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Hemoptises-etiologia, avaliação e tratamento num hospital universitário" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 924 "Ancho" => 965 "Tamanyo" => 65909 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Treatments performed for control of bleeding (n = 237).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0065">Introduction</span><p id="p0005" class="elsevierStylePara elsevierViewall">Hemoptysis is defined as the spitting or coughing up of blood, caused by bleeding of the lungs or from the tracheobronchial tree. It may be a symptom of several diseases, more or less severe, but its appearance induces concern to the patient and requires a full diagnostic investigation.</p><p id="p0010" class="elsevierStylePara elsevierViewall">Bronchiectasis, pulmonary tuberculosis and lung cancer are the main causes of hemoptysis. The frequency of each disease as a cause of hemoptysis varies in different series, according to the geographical area. Pulmonary tuberculosis is an important cause of hemoptysis in developing countries,<a class="elsevierStyleCrossRefs" href="#bb0005"><span class="elsevierStyleSup">1–4</span></a> whereas, in developed countries, bronchiectasis, lung cancer and bronchitis are the main causes.<a class="elsevierStyleCrossRefs" href="#bb0025"><span class="elsevierStyleSup">5–7</span></a> In Portugal, pulmonary tuberculosis is still a frequent disease, but it has significantly decreased in recent years.<a class="elsevierStyleCrossRefs" href="#bb0040"><span class="elsevierStyleSup">8,9</span></a></p><p id="p0015" class="elsevierStylePara elsevierViewall">In children, bronchiectasis (particularly in cystic fibrosis) and congenital cardiopathies are responsible for most cases of hemoptysis. <a class="elsevierStyleCrossRefs" href="#bb0050"><span class="elsevierStyleSup">10,11</span></a> Some studies have found pulmonary tuberculosis as an important cause in patients under 18 years old.<a class="elsevierStyleCrossRefs" href="#bb0060"><span class="elsevierStyleSup">12,13</span></a></p><p id="p0020" class="elsevierStylePara elsevierViewall">Besides a correct anamnesis and a detailed physical exam, diagnostic tests are an important part of the diagnostic evaluation, such as chest X-Ray, chest CT scan and bronchoscopy.<a class="elsevierStyleCrossRefs" href="#bb0030"><span class="elsevierStyleSup">6,14–17</span></a> Other tests may be important, namely bronchial arteriography and echocardiogram.<a class="elsevierStyleCrossRef" href="#bb0080"><span class="elsevierStyleSup">16</span></a> Studies also refer that the demand of the diagnostic investigation should be based on how high or low the probability for a lung cancer diagnostic is.<a class="elsevierStyleCrossRefs" href="#bb0030"><span class="elsevierStyleSup">6,15,18–20</span></a></p><p id="p0025" class="elsevierStylePara elsevierViewall">Even after an adequate investigation, no cause can be established in 20-30 % of patients.<a class="elsevierStyleCrossRefs" href="#bb0080"><span class="elsevierStyleSup">16,21,22</span></a></p><p id="p0030" class="elsevierStylePara elsevierViewall">In most patients, control of bleeding is achieved with conservative measures.<a class="elsevierStyleCrossRefs" href="#bb0020"><span class="elsevierStyleSup">4,7</span></a> However, other therapeutic measures may be necessary, such as bronchoscopic intervention,<a class="elsevierStyleCrossRef" href="#bb0115"><span class="elsevierStyleSup">23</span></a> surgery or bronchial artery embolization. Embolization‘s efficacy in the control of bleeding has already been validated, with success rates of 85-99 %, <a class="elsevierStyleCrossRefs" href="#bb0120"><span class="elsevierStyleSup">24–29</span></a> even higher than surgery.<a class="elsevierStyleCrossRef" href="#bb0150"><span class="elsevierStyleSup">30</span></a> Bronchial artery embolization has also an important role in recurrent chronic hemoptysis, for recurrence prevention. However, it has not yet been considered a definitive therapeutic measure, because of its recurrence rate which is higher than 25 %. <a class="elsevierStyleCrossRefs" href="#bb0140"><span class="elsevierStyleSup">28,31–33</span></a></p></span><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0070">Objective</span><p id="p0035" class="elsevierStylePara elsevierViewall">Evaluate patients admitted for hemoptysis, its etiology, use of diagnostic tests, treatment and evolution.</p></span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0075">Methods</span><p id="p0040" class="elsevierStylePara elsevierViewall">A retrospective study was performed, analyzing clinical files of patients admitted for hemoptysis, in the Hospital de Sao Joao, Porto, between 1<span class="elsevierStyleSup">st</span> January of 2004 and 31 December of 2008.</p><p id="p0045" class="elsevierStylePara elsevierViewall">Two hundred and eighty patients were included. Of these, 43 were excluded: 7 for hemorrhage of non-respiratory origin (digestive tract, mouth and otorhinolaryngological); 3 for lack of adequate information; and 33 for repeated admissions (only the 1<span class="elsevierStyleSup">st</span> admission of each patient was analyzed).</p><p id="p0050" class="elsevierStylePara elsevierViewall">Two hundred and thirty seven clinical files were analyzed. Clinical information was reviewed: age, sex, smoke status, medical history, use of anti-agregant or anticoagulant medication, severity criteria, use of diagnostic tests, definitive diagnosis, treatment and evolution. Due to the lack of information about the volume of blood loss, severity assessment was based on clinical criteria: reduction of hemoglobin concentration > 1<span class="elsevierStyleHsp" style=""></span>g, hemodynamic instability (defined as systolic arterial blood pressure < 90<span class="elsevierStyleHsp" style=""></span>mmHg) and respiratory failure (defined as arterial oxygen partial pressure < 60<span class="elsevierStyleHsp" style=""></span>mmHg).</p><p id="p0055" class="elsevierStylePara elsevierViewall">Tracheobronchitis diagnosis was defined as lower respiratory infection, without associated radiologic image.</p><p id="p0060" class="elsevierStylePara elsevierViewall">Data were analyzed using statistical software Epi Info, version 3.5.1. Exact Fisher Test was used to evaluate statistical significance (a p value less than 0.01 was considered statistically significant).</p></span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0080">Results</span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0085">Patients’ characterization</span><p id="p0065" class="elsevierStylePara elsevierViewall">Two hundred and thirty seven patients were studied, 165 male (69.6 %) and 72 female (30.4 %), with an average age of 57.9 years old. Pediatric age (less than 18 years) was found in 6.8 % of patients. Predominant age groups were 50-59 years and 60-69 years, both accounting for 21.1 % of patients.</p><p id="p0070" class="elsevierStylePara elsevierViewall">Most adults (57.9 %) were current or former smokers. Thirty-three patients (13.9 %) were under anticoagulants (warfarin) and 31 (13.1 %) under anti-agregants. Coagulation blood tests were normal in most patients (69.2 %) and showed alterations in 53 (22.4 %). Of these, 14 (26 %) were under anti-agregants and 33 (62.3 %) under oral anticoagulants.</p></span><span id="s0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0090">Etiology</span><p id="p0075" class="elsevierStylePara elsevierViewall">In pediatric age, most frequent diagnoses were bronchiectasis and congenital cardiopathy (25 % and 18.8 %, respectively), as shown in <a class="elsevierStyleCrossRef" href="#f0005">Figure 1</a>.</p><elsevierMultimedia ident="f0005"></elsevierMultimedia><p id="p0080" class="elsevierStylePara elsevierViewall">In adults (Table <a class="elsevierStyleCrossRef" href="#t0005">1</a>), pulmonary tuberculosis (PT) sequelae and bronchiectasis were the main diagnoses found (22.2 % and 15.8 %, respectively). Lung cancer was diagnosed in 33 patients, being the 3<span class="elsevierStyleSup">rd</span> most frequent diagnosis. Most (87.9 %) were found to have primary lung cancer, and adenocarcinoma was the predominant histological type. Only 4 patients (12.1 %) had secondary lung cancer (<a class="elsevierStyleCrossRef" href="#f0010">Figure 2</a>) - pulmonary metastasis of neoplasm in other location (breast, esophagus and larynx). We would like to acknowledge the large number of patients without a full histological characterization (7 patients - 21.2 % of all patients with lung cancer). In 5 patients, histological characterization was absent of the clinical file and 2 patients were diagnosed with non-small cell lung cancer without further characterization. Infection was responsible for bleeding in 51 patients (23 %), 22 with pulmonary tuberculosis, followed by pneumonia, tracheobronchitis and, less commonly, mycetoma and atypical mycobacteriosis. In 4 patients, hemoptysis’ etiology was coagulopathy; of these, coagulopathy was iatrogenic in 3. They were patients medicated with anticoagulants. No diagnosis was reached in 6.3 % (14 patients).</p><elsevierMultimedia ident="t0005"></elsevierMultimedia><elsevierMultimedia ident="f0010"></elsevierMultimedia><p id="p0085" class="elsevierStylePara elsevierViewall">By age group, it appears that pulmonary tuberculosis sequelae (PT sequelae) was one of the main diagnoses in all of them. Malignancy had an increasing predominance with the increasing of age, being the main diagnosis in the group of patients of 70-79 years.</p><p id="p0090" class="elsevierStylePara elsevierViewall">The 3 main diagnoses according to smoking history of adult patients are presented in Table <a class="elsevierStyleCrossRef" href="#t0010">2</a>. It‘s obvious the greater importance of malignancy in smokers and former smokers. In the patients with a positive smoking history (smokers and former smokers), lung cancer was responsible for 17.2 % of hemoptysis, and for only 8.3 % in non-smokers. No significant differences were found in hemoptysis’ etiology in former smokers whose date of smoking cessation was superior or inferior to 10 years.</p><elsevierMultimedia ident="t0010"></elsevierMultimedia><p id="p0095" class="elsevierStylePara elsevierViewall">Sixty-eight percent of patients with pulmonary tuberculosis were current smokers.</p><p id="p0100" class="elsevierStylePara elsevierViewall">In patients medicated with anticoagulants (33), the main diagnosis was lung cancer (18.2 %), predominantly adenocarcinoma.</p><p id="p0105" class="elsevierStylePara elsevierViewall">In 55.7 % (132 patients), this was the first episode of hemoptysis, while 35 % already had previous episodes. In others (9.3 %), no information was obtained. The main diagnoses were not significantly different in patients with or without previous episodes of hemoptysis, with the exception of pulmonary tuberculosis. In fact, this was the first episode in approximately 82 % of patients with pulmonary tuberculosis.</p><p id="p0110" class="elsevierStylePara elsevierViewall">Hemoptysis’ classification based on the amount of bleeding, besides being a non-specific data, was missing in most clinical files. So, severity was based on the magnitude of clinical effect, evaluating some clinical criteria, such as reduction of hemoglobin concentration (superior to 1<span class="elsevierStyleHsp" style=""></span>g), respiratory failure and hemodynamic instability. Table <a class="elsevierStyleCrossRef" href="#t0015">3</a> presents the main diagnoses for each severity criteria. When all severity criteria were found (16 patients), malignancy was predominant (80 %).</p><elsevierMultimedia ident="t0015"></elsevierMultimedia></span><span id="s0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0095">Diagnostic evaluation</span><p id="p0115" class="elsevierStylePara elsevierViewall">All patients performed a chest X-Ray, which was described as normal in only 30 (12.7 %). Of these, the main diagnoses were tracheobronchitis (6), bronchiectasis (4), unknown etiology (4) and PT sequelae (3). Among patients with unknown etiology of hemoptysis whose chest X-Ray was normal, chest CT scan was also described as normal in 2 (the other 2 patients had ground glass pattern in chest CT scan) and bronchoscopy didn‘t show abnormalities in the 3 patients who were submitted to it. One patient with pulmonary tuberculosis had a normal chest X-Ray. No malignancy was diagnosed in patients with a normal chest-X-Ray.</p><p id="p0120" class="elsevierStylePara elsevierViewall">Chest CT scan was performed in 193 patients (81.4 %), and abnormalities were found in most of them (187). The predominant pattern was linear retractile opacities (24.1 %), in accordance with the frequency of diagnoses. Among patients with lung cancer, CT scan had a good diagnostic yield, showing abnormalities in all of them. Only 1 patient had CT scan abnormalities that were not suggestive of malignancy. Among patients with a normal chest CT scan (6), the main diagnosis was tracheobronchitis (3 patients) and no diagnosis was found in the rest of them. Four patients with a normal CT scan performed bronchoscopy, and no endobronchial abnormalities were found.</p><p id="p0125" class="elsevierStylePara elsevierViewall">Bronchoscopy was performed in 125 patients (52.7 %). Among patients with a higher probability of malignancy (age > 50 years and a positive smoking history — current or former), excluding those whose malignancy was already known, we found that 67.4 % were submitted to a bronchoscopy. The higher probability of lung cancer was associated with the performance of a bronchoscopy; this association was statistically significant (p < 0.01).</p><p id="p0130" class="elsevierStylePara elsevierViewall">Bronchoscopy was able to localize the source of bleeding in 38.4 % of patients and allowed the establishment of a definitive diagnosis in 17.6 %, mainly pulmonary tuberculosis and lung cancer. In 55 patients (44 %), no endobronchial abnormality was found. Bronchoscopic evaluation was performed by a flexible fiberoptic bronchoscope in almost every patient. Rigid bronchoscopy was performed in only 5 patients, for different reasons: diagnosis (when the amount of bleeding was not compatible with a fiberoptic bronchoscopy), restoration of an adequate airway (in a case of obstruction of the airway by a tumor) and replacement of a tracheal stent.</p><p id="p0135" class="elsevierStylePara elsevierViewall">The diagnostic yield of each diagnostic test is presented in Table <a class="elsevierStyleCrossRef" href="#t0020">4</a>. We did not include angiography as a diagnostic test, because in this group of patients, it was used almost exclusively as a therapeutic method. Three patients were diagnosed with bronchial circulation abnormalities (2 with arteriovenous fistula and 1 with an abnormal origin of bronchial artery).</p><elsevierMultimedia ident="t0020"></elsevierMultimedia><p id="p0140" class="elsevierStylePara elsevierViewall">In 6.3 % (14), no diagnosis was reached. Among these patients, 5 (35.7 %) were transferred, after stabilization, to another hospital (according to the area of residence), which is why they did not complete the diagnostic evaluation in this hospital; 1 patient (7.1 %) died before completing the study. Among the 8 patients that completed the diagnostic evaluation in this hospital, 5 (62.5 %) performed a chest CT scan and a bronchoscopy; chest CT scan was normal in 2 and showed ground-glass pattern in 3 patients; endobronchial abnormalities were not found in any patient. In the other 3 patients, diagnostic evaluation was performed only with a chest CT scan, showing abnormalities in 2 (1 with ground-glass pattern and 1 with a discrete linear opacity).</p></span><span id="s0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0100">Treatment</span><p id="p0145" class="elsevierStylePara elsevierViewall">Most patients went on medical treatment (90.7 %), as seen on <a class="elsevierStyleCrossRef" href="#f0015">Figure 3</a>. Medical treatment was based, routinely, on the administration of antitussives (codeine) and antifibrinolytics (aminocaproic acid), and also morphine, in cases in which control of bleeding was not possible with medications previously described.</p><elsevierMultimedia ident="f0015"></elsevierMultimedia><p id="p0150" class="elsevierStylePara elsevierViewall">The main diagnoses, according to each therapeutic option, are listed in Table <a class="elsevierStyleCrossRef" href="#t0025">5</a>.</p><elsevierMultimedia ident="t0025"></elsevierMultimedia><p id="p0155" class="elsevierStylePara elsevierViewall">Only 1 patient needed a bronchoscopic intervention - a 7-year-old child with a congenital cardiopathy. Control of bleeding was initially possible with medical treatment. However, a rigid bronchoscopy performed for replacement of a tracheal stent (the child also had a tracheal stenosis) was complicated by severe bleeding, which was controlled with tamponade.</p><p id="p0160" class="elsevierStylePara elsevierViewall">Three patients (1.3 %) were submitted to a surgical intervention: lobectomy in a case of a pulmonary abscess; marsupialization of an aspergiloma cavity and replacement of mitral valve in a case of mitral stenosis.</p><p id="p0165" class="elsevierStylePara elsevierViewall">In all 237 admissions, arteriography with bronchial artery embolization was performed in 7.2 %. During these 5 years, considering every admission of each patient, we found that 11.8 % of patients went on bronchial artery embolization. The main diagnoses of these patients were PT sequelae and bronchiectasis, followed by vascular abnormalities and mycetoma. The reasons for embolization were recurrence prevention in 60.7 % and control of bleeding in the others. When embolization was performed for recurrence prevention, the admission was programmed in 64.7 %.</p></span><span id="s0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0105">Outcome</span><p id="p0170" class="elsevierStylePara elsevierViewall">Patients’ outcome was favorable in 94.1 %, with hospital discharge after control of bleeding. Fourteen patients died (5.9 %). We found a higher mortality rate for all severity criteria (with statistical significance - p < 0.01), mainly hemodynamic instability with a mortality rate of 24 %. The main diagnoses in patients who died were lung cancer (5 patients - 35.7 %), bronchiectasis and pulmonary tuberculosis (2 patients each 14.3 %).</p><p id="p0175" class="elsevierStylePara elsevierViewall">In Table <a class="elsevierStyleCrossRef" href="#t0030">6</a> the outcomes for each therapeutic approach are listed.</p><elsevierMultimedia ident="t0030"></elsevierMultimedia></span></span><span id="s0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0110">Discussion</span><p id="p0180" class="elsevierStylePara elsevierViewall">Pulmonary tuberculosis sequelae, bronchiectasis, lung cancer and pulmonary tuberculosis were the main diagnoses in the adult population studied. The importance of tuberculosis, active or previous, as a cause of hemoptysis, was the main difference compared to other studies, in developed countries.<a class="elsevierStyleCrossRefs" href="#bb0025"><span class="elsevierStyleSup">5–7</span></a> In fact, tuberculosis is still endemic in Portugal, although a significant decrease has occurred in recent years.<a class="elsevierStyleCrossRefs" href="#bb0040"><span class="elsevierStyleSup">8,9</span></a> Among malignancies, in most series, squamous cell carcinoma is the main responsible for hemoptysis.<a class="elsevierStyleCrossRefs" href="#bb0025"><span class="elsevierStyleSup">5,34</span></a> This histological type, due to its central localization, is more frequently associated with the occurrence of hemoptysis, compared to adenocarcinoma, which has usually a peripheral localization. However, in this study, adenocarcinoma was the main histological type. Two main reasons can explain this finding: a high number of malignancies without a full histological characterization and the higher prevalence of adenocarcinoma compared to squamous cell carcinoma, nowadays.<a class="elsevierStyleCrossRefs" href="#bb0175"><span class="elsevierStyleSup">35,36</span></a> In fact, in 5 patients (15.2 % of all patients with lung cancer), histological type was not found in the clinical file and 2 patients (6 %) were diagnosed with non-small cell lung cancer without further characterization.</p><p id="p0185" class="elsevierStylePara elsevierViewall">By age group, it is notorious the increasing frequency of malignancies keeping pace with the increasing of age, in accordance with reviewed literature. <a class="elsevierStyleCrossRef" href="#bb0015"><span class="elsevierStyleSup">3</span></a> Smoking history, being the main established risk factor for lung cancer, is a fundamental clue in patients’ history. In this study, diagnoses of lung cancer in patients with a positive smoking history (current or former smokers) were more than twice as much as those without a smoking history.</p><p id="p0190" class="elsevierStylePara elsevierViewall">Most patients with pulmonary tuberculosis were current smokers. In fact, recent studies have described an association between tobacco smoke and the risk of developing tuberculosis.<a class="elsevierStyleCrossRefs" href="#bb0185"><span class="elsevierStyleSup">37,38</span></a></p><p id="p0195" class="elsevierStylePara elsevierViewall">In pediatric population, the main etiologies of hemoptysis (bronchiectasis and congenital cardiopathies) are in accordance with other studies.<a class="elsevierStyleCrossRefs" href="#bb0050"><span class="elsevierStyleSup">10,11</span></a> In Europe, cystic fibrosis is one of the main diseases that is responsible for the occurrence of hemoptysis.<a class="elsevierStyleCrossRef" href="#bb0060"><span class="elsevierStyleSup">12</span></a> In this study, 1 child with bronchiectasis was diagnosed with this genetic disease.</p><p id="p0200" class="elsevierStylePara elsevierViewall">Hemoptysis’ severity is classically classified based on the amount of bleeding. In this study, such a classification was not possible, because this type of information was absent in most clinical files. Nevertheless, severity criteria considered are inevitably associated with a higher amount of bleeding. Several authors sustain that hemoptysis’ severity should be based, not in the amount of bleeding, but in the magnitude of the clinical effect - clinical and analytic criteria that reflect a severe bleeding, necessity of transfusion, among others.<a class="elsevierStyleCrossRefs" href="#bb0195"><span class="elsevierStyleSup">39,40</span></a></p><p id="p0205" class="elsevierStylePara elsevierViewall">In most series, massive hemoptysis constitute 5-23 % of all hemoptyses <a class="elsevierStyleCrossRefs" href="#bb0020"><span class="elsevierStyleSup">4,19,41</span></a> and their mortality rate varies, from 23 to 75 %.<a class="elsevierStyleCrossRefs" href="#bb0020"><span class="elsevierStyleSup">4,41</span></a> In this study, hemodynamic instability occurred in 10.5 % of patients and was associated with a mortality rate of 24 %. Clinical criteria used in this study (reduction of hemoglobin concentration > 1<span class="elsevierStyleHsp" style=""></span>g; respiratory failure and hemodynamic instability) were good indicators of severity, showing a statistically significant association with mortality.</p><p id="p0210" class="elsevierStylePara elsevierViewall">The main diseases responsible for massive hemoptysis vary among series: bronchiectasis, pulmonary tuberculosis, lung cancer, bronchitis, pulmonary abscess, aspergiloma, among others.<a class="elsevierStyleCrossRef" href="#bb0210"><span class="elsevierStyleSup">42</span></a> Some studies found that lung cancer was associated with a small bleeding.<a class="elsevierStyleCrossRefs" href="#bb0095"><span class="elsevierStyleSup">19,43</span></a> However, in this study, this diagnosis was the most frequent for all considered severity criteria.</p><p id="p0215" class="elsevierStylePara elsevierViewall">Chest X-Ray, chest CT scan and bronchoscopy are the main diagnostic tests in etiologic investigation.<a class="elsevierStyleCrossRefs" href="#bb0030"><span class="elsevierStyleSup">6,14–16</span></a> Their use vary among series, with the exception of the almost universal use of chest X-Ray. It seems consensual that a higher probability of malignancy should be reflected in a more exhaustive diagnostic investigation.<a class="elsevierStyleCrossRefs" href="#bb0030"><span class="elsevierStyleSup">6,15,18,19</span></a> In this study, the finding of characteristics related to a higher risk of lung cancer was associated with the performance of bronchoscopy, in a statistically significant manner. This association was not found in chest CT scan. The performance of chest CT scan in this group of patients (81.4 %) was below to what was desirable. Several recent studies on the diagnostic impact of diagnostic tests suggest, as a protocol, the performance of chest X-Ray and chest CT scan in all patients with hemoptysis and bronchoscopic evaluation if there are risk factors for lung cancer, such as a smoking history.<a class="elsevierStyleCrossRefs" href="#bb0030"><span class="elsevierStyleSup">6,15</span></a></p><p id="p0220" class="elsevierStylePara elsevierViewall">Diagnostic evaluation performed in this study is still far from what‘s suggested in such protocol. In fact, there was a low performance of chest CT scan (only 81.4 % of all). Among patients with a higher risk of lung cancer, chest CT scan was performed in 84.7 %, and chest CT scan plus bronchoscopy in only 62.2 %, far below the desirable 100 %. However, some of the patients included in this study had already had previous admissions for hemoptysis, and their diagnosis was already known - so, in these cases, there was a lower use of diagnostic tests.</p><p id="p0225" class="elsevierStylePara elsevierViewall">Chest CT scan was the most sensitive diagnostic test when used alone. However, the combined use of chest CT scan together with a bronchoscopy had the best diagnostic yield. Both these results have already been described.<a class="elsevierStyleCrossRef" href="#bb0095"><span class="elsevierStyleSup">19</span></a></p><p id="p0230" class="elsevierStylePara elsevierViewall">In accordance with the experience of several authors,<a class="elsevierStyleCrossRefs" href="#bb0020"><span class="elsevierStyleSup">4,7</span></a> hemoptysis’ control was possible mainly through conservative measures. Literature validates the importance of bronchial artery embolization, either in the control of bleeding, or in recurrence prevention. The latter was the main reason for its performance in this study. Success rate in the control of bleeding was 72.7 %, below what‘s referred on other studies (85-99 %). <a class="elsevierStyleCrossRefs" href="#bb0120"><span class="elsevierStyleSup">24–28</span></a> Some factors may have contributed to this, such as the small amount of patients (11), and their higher severity (54.5 % of patients had already had hemodynamic instability). Another factor that seems to limit the success rate in the control of bleeding is some postponement of embolization‘s performance. In fact, conservative measures are the initial therapeutic options and the advance to other therapies occurs when the first fails. This management may be justified for limited resources, such as trained teams for the procedure.</p><p id="p0235" class="elsevierStylePara elsevierViewall">This study was not able to evaluate success rate of bronchial artery embolization about recurrence prevention.</p></span><span id="s0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0115">Conclusions</span><p id="p0240" class="elsevierStylePara elsevierViewall">Nowadays, the main diseases responsible for hemoptysis are chronic infections sequelae and malignancies.</p><p id="p0245" class="elsevierStylePara elsevierViewall">Hemodynamic instability and malignancy were associated with a bad prognosis.</p><p id="p0250" class="elsevierStylePara elsevierViewall">Bronchial artery embolization has been used with an increasing frequency, and its efficacy has already been established in the control of bleeding.</p><p id="p0255" class="elsevierStylePara elsevierViewall">This study and the review of literature on this subject highlighted the necessity of a greater uniformization in hemoptysis’ management. So, the elaboration of protocols in order to uniformize, either diagnostic approach, or therapeutic approach is important.</p></span><span id="s0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0120">Conflict of interest</span><p id="p0260" class="elsevierStylePara elsevierViewall">Authors state that they don‘t have any conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:2 [ "identificador" => "xres172986" "titulo" => array:5 [ 0 => "Abstract" 1 => "Objective" 2 => "Material and methods" 3 => "Results" 4 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec161251" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres172987" "titulo" => array:5 [ 0 => "Resumo" 1 => "Objectivo" 2 => "Material e métodos" 3 => "Resultados" 4 => "Conclusões" ] ] 3 => array:2 [ "identificador" => "xpalclavsec161250" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "s0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "s0010" "titulo" => "Objective" ] 6 => array:2 [ "identificador" => "s0015" "titulo" => "Methods" ] 7 => array:3 [ "identificador" => "s0020" "titulo" => "Results" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "s0025" "titulo" => "Patients’ characterization" ] 1 => array:2 [ "identificador" => "s0030" "titulo" => "Etiology" ] 2 => array:2 [ "identificador" => "s0035" "titulo" => "Diagnostic evaluation" ] 3 => array:2 [ "identificador" => "s0040" "titulo" => "Treatment" ] 4 => array:2 [ "identificador" => "s0045" "titulo" => "Outcome" ] ] ] 8 => array:2 [ "identificador" => "s0050" "titulo" => "Discussion" ] 9 => array:2 [ "identificador" => "s0055" "titulo" => "Conclusions" ] 10 => array:2 [ "identificador" => "s0060" "titulo" => "Conflict of interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-01-19" "fechaAceptado" => "2010-08-02" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec161251" "palabras" => array:4 [ 0 => "Hemoptysis" 1 => "Etiology" 2 => "Diagnosis" 3 => "Treatment" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec161250" "palabras" => array:3 [ 0 => "Hemoptises" 1 => "Etiologia" 2 => "Diagnóstico ;Tratamento" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="st0010">Objective</span><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">Evaluate patients admitted for hemoptysis, its etiology, use of diagnostic tests, treatment and outcome.</p> <span class="elsevierStyleSectionTitle" id="st0015">Material and methods</span><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall">A retrospective analysis was done, checking clinical files of patients admitted for hemoptysis, between 1<span class="elsevierStyleSup">st</span> January 2004 and 31<span class="elsevierStyleSup">st</span> December 2008.</p> <span class="elsevierStyleSectionTitle" id="st0020">Results</span><p id="sp0065" class="elsevierStyleSimplePara elsevierViewall">Two hundred and thirty seven patients were included in this study, with a mean age of 57.9 years. In patients under 18 years, the most frequent diagnoses were bronchiectasis and congenital cardiopathy. In adults, pulmonary tuberculosis sequelae and bronchiectasis were the dominant diagnoses (22.2 % and 15.8 %, respectively), followed by lung cancer. Active infection was responsible for bleeding in 51 patients, especially pulmonary tuberculosis, pneumonia and tracheobronchitis. The etiology of hemoptysis was not established in 6.3 %. All patients performed chest X-Ray. Chest CT was performed in 81.4 % of patients and fiberoptic bronchoscopy in 52.7 %, the latter locating the source of bleeding in 38.4 % and establishing a final diagnosis in 17.6 %. In most patients, effective control of bleeding was achieved by medical treatment (90.7 %). During these 5 years, arterial embolization was performed in 11.8 % of patients. The main reason for embolization was recurrence prevention. There were 14 deaths (5.9 %), being identified as poor prognostic factors, hemodynamic instability and malignancy.</p> <span class="elsevierStyleSectionTitle" id="st0025">Conclusions</span><p id="sp0070" class="elsevierStyleSimplePara elsevierViewall">Hemoptysis is still a frequent symptom, being chronic infection sequelae and lung cancer their main causes. In this study, factors associated with a worse prognosis were hemodynamic instability and malignancy.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span class="elsevierStyleSectionTitle" id="st0035">Objectivo</span><p id="sp0075" class="elsevierStyleSimplePara elsevierViewall">Avaliar doentes admitidos por hemoptises quanto à etiologia, meios diagnósticos, tratamento e evolução.</p> <span class="elsevierStyleSectionTitle" id="st0040">Material e métodos</span><p id="sp0080" class="elsevierStyleSimplePara elsevierViewall">Realizou-se um estudo retrospectivo dos doentes admitidos no Hospital de São João, por hemoptises, entre 1 de janeiro de 2004 e 31 de dezembro de 2008.</p> <span class="elsevierStyleSectionTitle" id="st0045">Resultados</span><p id="sp0085" class="elsevierStyleSimplePara elsevierViewall">Foram estudados 237 doentes, com idade média de 57,9 anos. Nos doentes com idade inferior a 18 anos, os diagnósticos mais frequentes foram bronquiectasias e cardiopatia congénita. Nos adultos, as sequelas de tuberculose pulmonar e as Bronquiectasias foram os diagnósticos predominantes (22,2 % e 15,8 %, respectivamente), seguidos pela neoplasia pulmonar. A infecção foi responsável pelas perdas hemáticas em 51 doentes, essencialmente tuberculose pulmonar, pneumonia e traqueobronquite. A etiologia ficou por esclarecer em 6,3 %. Todos os doentes realizaram radiografia de tórax. A TAC foi realizada em 81,4 % dos doentes e a broncofibroscopia em 52,7 %, esta última localizando a fonte da hemorragia em 38,4 % e estabelecendo diagnóstico definitivo em 17,6 %. Na maioria dos casos (90,7 %), a hemorragia foi controlada com tratamento médico. Ao longo destes 5 anos, 11,8 % dos doentes foram submetidos a embolização arterial, sendo a prevenção de recidiva o principal motivo da sua realização. Foram registados 14 óbitos (5,9 %), sendo identificados, como factores de mau prognóstico, a instabilidade hemodinâmica e a etiologia neoplásica.</p> <span class="elsevierStyleSectionTitle" id="st0050">Conclusões</span><p id="sp0090" class="elsevierStyleSimplePara elsevierViewall">As hemoptises continuam a ser um sintoma frequente, sendo actualmente as sequelas associadas a infecções crónicas e as neoplasias as principais etiologias. Neste estudo, os factores de pior prognóstico foram a instabilidade hemodinâmica e a etiologia neoplásica.</p>" ] ] "multimedia" => array:9 [ 0 => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 904 "Ancho" => 985 "Tamanyo" => 87501 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Hemoptysis’ etiology in patients under 18 years (n = 16).</p>" ] ] 1 => array:7 [ "identificador" => "f0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 473 "Ancho" => 1322 "Tamanyo" => 62400 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Lung cancer as a cause of hemoptysis (n = 33).</p>" ] ] 2 => array:7 [ "identificador" => "f0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 924 "Ancho" => 965 "Tamanyo" => 65909 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Treatments performed for control of bleeding (n = 237).</p>" ] ] 3 => array:7 [ "identificador" => "t0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diagnosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients, n (%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PT sequelae \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">49 (22.2 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bronchiectasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 (15.8 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lung cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33 (13.9 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pulmonary tuberculosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 (10 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Unknown \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (6.3 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tracheobronchitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 (4.5 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pneumonia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 (4.5 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Silicosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (2.7 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mycetoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (2.3 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Coagulopathy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (1.8 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cardiac failure \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (1.8 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Atypical mycobacteriosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (1.8 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pulmonary thromboembolism \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (1.4 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vasculitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (1.4 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Others<a class="elsevierStyleCrossRef" href="#tf0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 (8.6 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab266239.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tf0005" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="np0005">Arteriovenous fistulae (2), post-lobectomy complication (2), mitral stenosis (2), COPD (2), pulmonary abscess (1), congenital cardiopathy (1), tracheal foreign body (1), post-radiation pulmonary fibrosis (1), foreign body granuloma (1), tracheal invasion for medastinal mass (1), benign endobronchial lesion (1), vascular malformation (1), interstitial pneumonitis (1), radiation pneumonitis (1), aortic aneurysm rupture (1).</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Hemoptysis’ etiology in adults (n = 221)</p>" ] ] 4 => array:7 [ "identificador" => "t0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Note: A smoking history was not found in 33 patients (14.9 %).</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Smokers (n = 72)</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Former smokers (n = 56)</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Non smokers (n = 60)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diagnosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diagnosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diagnosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n (%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PT sequelae \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 (25 %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lung cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (23.2 %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bronchiectasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 (33.3 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 (20.8 %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PT sequelae \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (23.2 %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PT sequelae \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (21.7 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lung cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (12.5 %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bronchiectasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (8.9 %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lung cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (8.3 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab266241.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Main etiologies of hemoptysis, according to the smoking history of adults (n = 188)</p>" ] ] 5 => array:7 [ "identificador" => "t0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diagnosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n (%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No severity criteria (n = 85)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PT sequelae \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 (22.4 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bronchiectasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 (18.8 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tracheobronchitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (9.4 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Unknown \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (9.4 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reduction Hb ≥ 1<span class="elsevierStyleHsp" style=""></span>g (n = 140)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lung cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 (18.6 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PT sequelae \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 (17.1 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bronchiectasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 (13.6 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pulmonary tuberculosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 (10.7 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Respiratory failure (n = 66)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lung cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (19.7 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PT sequelae \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (13.6 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bronchiectasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (9.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pulmonary tuberculosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (7.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hemodinamic instability (n = 25)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lung cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (24 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Congenital cardiopathy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (8 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Vascular malformation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (8 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Arteriovenous fistulae \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (8 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab266238.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Hemoptysis’ etiology, according to severity criteria</p>" ] ] 6 => array:7 [ "identificador" => "t0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diagnostic test \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Performed (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Positive result<a class="elsevierStyleCrossRef" href="#tf0010">*</a> (%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chest X-Ray \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">237 (100 %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">121/237 (51.1 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chest CT scan \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">193 (81.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">148/193 (76.7 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bronchoscopy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">125 (52.7 %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56/125 (44.8 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chest CT + bronchoscopy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">118 (49.8 %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">103/118 (87.3 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab266236.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tf0010" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="np0010">Positive result: any abnormal finding that contributed to the final diagnosis.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Diagnostic yield of each diagnostic test performed in the group of patients of this study (n = 237)</p>" ] ] 7 => array:7 [ "identificador" => "t0025" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Treatment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Main diagnoses \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Medical \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">215 (90.7 %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PT sequelae \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45 (20.9 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bronchiectasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 (16.3 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lung cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28 (13 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Embolization \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (7.2 %) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PT sequelae \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (23.5 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" colspan="2"></td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bronchiectasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (23.5 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mycetoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (11.8 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgical \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (1.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Aspergiloma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (33.3 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" colspan="2"></td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pulmonary abscess \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (33.3 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mitral stenosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (33.3 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bronchoscopic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Congenital cardiopathy (post rigid bronchoscopy complication)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Radiation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lung cancer</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab266240.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Main diagnoses found for each therapeutic option (n = 237)</p>" ] ] 8 => array:7 [ "identificador" => "t0030" "etiqueta" => "Table 6" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Treatment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Outcome \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Medical (n = 215) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Control of bleeding \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">204 (94.9 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Death \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (5.1 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Embolization (n = 17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Control of bleeding \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 (88.2 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Death \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (11.8 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Surgery (n = 3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Control of bleeding \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (66.7 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Death \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (33.3 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bronchoscopic (n = 1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Control of bleeding \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (100 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Death \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Radiotherapy (n = 1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Control of bleeding \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (100 %) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Death \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab266237.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">Patients’ outcome according to each therapeutic option</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0005" "bibliografiaReferencia" => array:43 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hemoptysis: a 10-year retrospective study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.A. Coss-Bu" 1 => "R.C. Sachdeva" 2 => "J.T. Bricker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatrics" "fecha" => "1997" "volumen" => "100" "paginaInicial" => "e7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9382908" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary hemorrhage / hemoptysis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. 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