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array:24 [ "pii" => "S2173511511700306" "issn" => "21735115" "doi" => "10.1016/S2173-5115(11)70030-6" "estado" => "S300" "fechaPublicacion" => "2011-01-01" "aid" => "70030" "copyright" => "Sociedade Portuguesa de Pneumologia" "copyrightAnyo" => "2011" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "cor" "cita" => "Rev Port Pneumol. 2011;17:139-42" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1553 "formatos" => array:3 [ "EPUB" => 107 "HTML" => 1073 "PDF" => 373 ] ] "itemSiguiente" => array:19 [ "pii" => "S2173511511700318" "issn" => "21735115" "doi" => "10.1016/S2173-5115(11)70031-8" "estado" => "S300" "fechaPublicacion" => "2011-01-01" "aid" => "70031" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2011;17:143-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1524 "formatos" => array:3 [ "EPUB" => 110 "HTML" => 952 "PDF" => 462 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CASE DISCUSSION</span>" "titulo" => "Comment to the case: Successful pregnancy in a severely hypoxemic patient with alveolar proteinosis" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "143" "paginaFinal" => "145" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Discussão de caso clínico: Gravidez de termo em doente com proteinose alveolar e insuficiência respiratória grave" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.C. Mendes" "autores" => array:1 [ 0 => array:2 [ "nombre" => "A.C." "apellidos" => "Mendes" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511511700318?idApp=UINPBA00004E" "url" => "/21735115/0000001700000003/v1_201305151545/S2173511511700318/v1_201305151545/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S217351151170029X" "issn" => "21735115" "doi" => "10.1016/S2173-5115(11)70029-X" "estado" => "S300" "fechaPublicacion" => "2011-01-01" "aid" => "70029" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2011;17:131-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1619 "formatos" => array:3 [ "EPUB" => 115 "HTML" => 972 "PDF" => 532 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL ARTICLE</span>" "titulo" => "The importance of dyspnoea in the diagnosis of chronic obstructive pulmonary disease – a descriptive analysis of a stable cohort in Portugal (SAFE Trial)" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "131" "paginaFinal" => "138" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "A importância da dispneia no diagnóstico da doença pulmonar obstrutiva crónica – uma análise descritiva de uma coorte estável em Portugal (ensaio clínico SAFE)" ] ] "contieneResumen" => array:2 [ "es" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 766 "Ancho" => 1410 "Tamanyo" => 72250 ] ] "descripcion" => array:1 [ "es" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Distribution of patient-perceived symptoms leading to initial diagnosis of COPD by disease severity.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Bárbara, J. Moita, J. Cardoso, R. Costa, R. Redondeiro, M. Gaspar" "autores" => array:6 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Bárbara" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Moita" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Cardoso" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Costa" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Redondeiro" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Gaspar" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217351151170029X?idApp=UINPBA00004E" "url" => "/21735115/0000001700000003/v1_201305151545/S217351151170029X/v1_201305151545/es/main.assets" ] "es" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CASE REPORT</span>" "titulo" => "Successful pregnancy in a severely hypoxemic patient with pulmonary alveolar proteinosis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "139" "paginaFinal" => "142" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Belchior, A.S. Cerdeira, M. Santos, J. Sousa Braga, I. Aragão, A. Martins" "autores" => array:6 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "Belchior" "email" => array:1 [ 0 => "inesbelchior@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A.S." "apellidos" => "Cerdeira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Sousa Braga" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "I." "apellidos" => "Aragão" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 5 => array:3 [ "nombre" => "A." "apellidos" => "Martins" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Pneumologia, Centro Hospitalar do Porto, Hospital de Santo António Largo, Porto, Portugal" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Ginecologia e Obstetrícia, Hospital de Santo António Largo, Porto, Portugal" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Medicina Interna, Hospital de Santo António Largo, Porto, Portugal" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Anestesiologia, Hospital de Santo António Largo, Porto, Portugal" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Gravidez de termo em doente com proteinose alveolar e insuficiência respiratória grave" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1534 "Ancho" => 1601 "Tamanyo" => 322562 ] ] "descripcion" => array:1 [ "es" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Outflow lavage fluid from left whole-lung BPL. The first outflow fluid was turbid with a yellowish deposit (bag nr. 1), presenting almost clear on the last cycle of lavage (bag nr. 10).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0005">Introduction</span><p id="p0005" class="elsevierStylePara elsevierViewall">PAP is a rare disorder, characterized by abnormal accumulation of a lipoproteinaceous material in alveoli, with minimal interstitial inflammation or fibrosis. There is an increased risk of respiratory infections and clinical course may vary between stable disease with persistent symptoms, spontaneous improvement, and progressive disease evolving to respiratory failure. Whole-lung broncho-pulmonary lavage (BPL) has been the gold standard treatment since the 1960s.</p><p id="p0010" class="elsevierStylePara elsevierViewall">We report a successful full-term pregnancy in a patient with progressive PAP, whose pulmonary function deterioration evolved to such severe respiratory failure, that a whole-lung BPL was necessary. In the literature, a sole case of BPL has been described in a pregnant woman.</p></span><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0010">Case report</span><p id="p0015" class="elsevierStylePara elsevierViewall">The patient was a 44-year-old black woman, obese and hypertensive, controlled with nifedipine. She had seven previous pregnancies including one spontaneous abortion and one hydatiform mole. One of her children died from brain cell astrocytoma and the remaining four were healthy.</p><p id="p0020" class="elsevierStylePara elsevierViewall">Two years before admission, she had been diagnosed with primary PAP after investigation of complaints of exertional dyspnea, cough and mucous sputum for five months. The diagnosis was based on compatible imaging studies (chest tomography showing interstitial infiltrates and “crazy paving” aspect) and characteristic milky bronchoalveolar-lavage (BAL) fluid with granular material staining with periodic acid-Schiff. Respiratory function test showed a forced expiratory volume in the first second of 1,17<span class="elsevierStyleHsp" style=""></span>L (57 % of predicted), a Tiffeneau index of 65 % and total lung capacity of 3,31<span class="elsevierStyleHsp" style=""></span>L (63 % of predicted). Diffusing capacity (DLCO) was 35 % of predicted. A right whole-lung BPL was performed in May 2004, when symptoms and arterial blood gas (ABG) parameters worsened (<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>). After this procedure she remained asymptomatic until dyspnea recurred in October 2004, when she refused a new lavage.</p><elsevierMultimedia ident="t0005"></elsevierMultimedia><p id="p0025" class="elsevierStylePara elsevierViewall">In September 2005, she went to a local hospital with a progressive dyspnea, cough and copious yellow sputum for the previous 4 weeks, fever for 10 days and amenorrhea for 3 months. Antibiotic treatment was unsuccessful, and she was transferred to our hospital due to progressive respiratory failure.</p><p id="p0030" class="elsevierStylePara elsevierViewall">Initial examination revealed obesity (Body mass index of 35), tachypnea, and bibasilar crackles. She had neither ankle edema nor orthopnea. ABG revealed hypoxemic respiratory failure (<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>). A leucocytosis of 14400/μL and a normal hemoglobin level were present. Chest radiograph illustrated alveolar infiltrates in the inferior thirds bilaterally. Electrocardiogram and saline contrast echocardiogram were normal, excluding right-to-left circulatory shunt; Both BAL fluid (that displayed the characteristic pathologic features of PAP) and blood microbiologic cultures were negative. Although treatment with meropenem resolved leucocytosis, hypoxia persisted and a FiO<span class="elsevierStyleInf">2</span> of 40–50 % was necessary to maintain SatO<span class="elsevierStyleInf">2</span> above 90 %.</p><p id="p0035" class="elsevierStylePara elsevierViewall">An eight-week pregnancy was disclosed by ultrasound. It was the first pregnancy after the diagnosis of PAP. The risks of life threatening complications were discussed with the patient, who decided to keep the pregnancy and agreed to perform a right whole-lung BPL. The procedure was done in October 6th according to the protocol described by Ben-Abraham in an operating room under general anesthesia and hemodynamic and ventilatory monitoring; almost all of the 9,5<span class="elsevierStyleHsp" style=""></span>L of the instilled fluid was recovered and SatO<span class="elsevierStyleInf">2</span> remained always above 90 %. Improvement in respiratory failure was notorious as she decreased the need of oxygen supplements substantially until her release five days later (<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>).</p><p id="p0040" class="elsevierStylePara elsevierViewall">Poor compliance to prescribed oxygen (3<span class="elsevierStyleHsp" style=""></span>L/min) and aggravation of dyspnea were reported at follow-up appointment two weeks later. Gas exchange worsened (<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>), but there were no signs of infection. She was readmitted for left whole-lung BPL (<a class="elsevierStyleCrossRef" href="#f0005">Fig. 1</a>) with 14<span class="elsevierStyleHsp" style=""></span>L of saline on October 27th (13th week of gestation). After the procedure, although a gas exchange improvement was observed, she remained on oxygen (<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>). The patient was discharged on oxygen at 4<span class="elsevierStyleHsp" style=""></span>L/min and was closely monitored for the next 13 weeks by Internal medicine and obstetric teams.</p><elsevierMultimedia ident="f0005"></elsevierMultimedia><p id="p0045" class="elsevierStylePara elsevierViewall">On the 26<span class="elsevierStyleSup">th</span> week of pregnancy, due to progressive dyspnea, the patient was re-admitted and received oxygen through nonrebreathing mask to maintain SatO<span class="elsevierStyleInf">2</span> above 93 %. Due to superimposed preeclampsia and breech presentation, a cesarean was performed under epidural anesthesia on the 37<span class="elsevierStyleSup">th</span> week, and a healthy female baby was delivered. Throughout all the procedures SatO<span class="elsevierStyleInf">2</span> remained above 90 %. Postpartum SatO<span class="elsevierStyleInf">2</span> was 98 % with a FiO<span class="elsevierStyleInf">2</span> of 31 %, and improved in the next six months (SatO<span class="elsevierStyleInf">2</span> of 98 % on air).</p><p id="p0050" class="elsevierStylePara elsevierViewall">With time, gas exchange and chest radiography tended to deteriorate (<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>). On February 2007 a new BPL was performed sequentially in both lungs, resulting in significant improvement in gas exchange and two months later she dropped oxygen supplements (<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>). Three years later the patient is asymptomatic and with no need of oxygen supplements, while the child exhibits a normal development.</p></span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0015">Discussion</span><p id="p0055" class="elsevierStylePara elsevierViewall">This case of PAP turned out to be very challenging due to the need to manage a pregnant patient with severe hypoxemia in which both treatment and ongoing pregnancy could induce, at least temporarily, a decline in respiratory function. We found a single case of successful whole-lung BPL during pregnancy described in the literature in a young pregnant woman with PAP but healthy otherwise. In our patient, maternal age, hypertension and obesity increased pregnancy risk, making decisions even more difficult.</p><p id="p0060" class="elsevierStylePara elsevierViewall">She presented eight weeks pregnant with respiratory failure and although respiratory infection may have contributed to functional aggravation, it was probably not a preponderant factor, since an improvement was not observed after its resolution. Moreover, later in pregnancy, gas exchange worsening was also observed in the absence of infection. Other causes for the refractory respiratory failure in pregnancy like cardiac failure or right-to-left circulatory shunt were discarded.</p><p id="p0065" class="elsevierStylePara elsevierViewall">Although progression of PAP can not be excluded, the sudden deterioration of pulmonary function coinciding with the beginning of pregnancy and the persistence of respiratory impairment despite pulmonary lavage, suggest that pregnancy had an important role in worsening respiratory failure. Throughout normal pregnancy, anatomical, biochemical and hormonal changes cause adaptations in the respiratory system that compensate for the increased demands of fetal growth and development. These changes are usually well tolerated, however in the setting of underlying pulmonary disease they can lead to deterioration of an already impaired respiratory function. Elevated diaphragms in pregnancy can induce microatelectasis in lower lobes, which could aggravate the ventilation-perfusion mismatch and consequently exacerbate hypoxemia, especially in a patient with ventilatory restriction and severe decrease in DLCO.</p><p id="p0070" class="elsevierStylePara elsevierViewall">Interestingly, PAP has been associated with impaired function of alveolar macrophages (which are responsible for surfactant turnover), caused by auto-antibodies directed at GM-CSF, and is also associated with immunodeficiency states. On the other hand, during pregnancy, besides anatomical and biochemical adaptations, several changes occur in almost every aspect of the immune system. For instance, these changes are believed to modify the course of auto-immune diseases due to alterations in the activity of some immunity cells. Hence it is possible to reason that the known immunomodulation occurring in pregnancy could contribute to impaired macrophage function (with additional imbalance in surfactant homeostasis), thereby worsening clinical condition. This could explain ventilatory decline at an early stage of pregnancy, when the influence of the uterus growth is not yet noticed. Further studies are required to clarify this question.</p><p id="p0075" class="elsevierStylePara elsevierViewall">BPL, the gold-standard treatment for PAP, is described as safe and efficient, resulting in increased survival. It can be performed one lung at a time or in both lungs sequentially if patient is considered to tolerate one-lung ventilation of the lung that has just been treated.<a class="elsevierStyleCrossRefs" href="#bb0050"><span class="elsevierStyleSup">10,11</span></a> Improvement in arterial oxygen tension can be observed after one week. In this case, dyspnea, impact on daily activities and development of respiratory failure were indications to BPL<a class="elsevierStyleCrossRefs" href="#bb0050"><span class="elsevierStyleSup">10,12</span></a> and actual improvement was noted after the procedures, allowing significant decrease in oxygen needs.</p><p id="p0080" class="elsevierStylePara elsevierViewall">In conclusion, several aspects may have concurred to the severe hypoxemia observed, including PAP, obesity and anatomophysiologic changes of pregnancy. This case demonstrates that it is possible to carry out a full-term pregnancy in a patient with a serious pulmonary disease as PAP, as long as close monitoring of mother and fetus, as well as specific treatments (BPL included) and supplemental oxygenation are provided.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xres173177" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec161453" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres173178" "titulo" => "Resumo" ] 3 => array:2 [ "identificador" => "xpalclavsec161454" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "s0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "s0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "s0015" "titulo" => "Discussion" ] 7 => array:1 [ "titulo" => "<span class="elsevierStyleSectionTitle" id="st0020">References</span>" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-09-17" "fechaAceptado" => "2010-11-03" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec161453" "palabras" => array:4 [ 0 => "Pregnancy" 1 => "Pulmonary alveolar proteinosis" 2 => "Pulmonary lavage" 3 => "Respiratory failure" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec161454" "palabras" => array:4 [ 0 => "Gravidez" 1 => "Proteinose alveolar Pulmonar" 2 => "Lavagem pulmonar" 3 => "Insuficiência respiratória" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by abnormal accumulation of a lipoproteinaceous material in the alveoli, which may lead to respiratory failure and has an associated high risk for infections. The mainstay treatment for PAP is whole lung lavage.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">A pregnant woman, previously diagnosed with primary PAP, the most common form of PAP, was admitted with dyspnea and worsening respiratory function. In one month period, a wholelung bronchopulmonary lavage was performed twice, with clinical and functional improvement. Pregnancy was carried to term and a healthy baby was delivered.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">The mechanisms of respiratory impairment are discussed as well as treatment options and response.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">A proteinose alveolar pulmonar (PAP) é uma doença rara caracterizada pela acumulação anormal de material lipoproteináceo nos alvéolos, que pode levar a insuficiência respiratória, estando associada a um risco elevado de infecções. O tratamento <span class="elsevierStyleItalic">gold-standard</span> da PAP é a lavagem pulmonar total.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Uma mulher grávida, com diagnóstico prévio de PAP primária, a forma mais comum de PAP, foi internada com um quadro de dispneia e agravamento da função respiratória. No período de um mês, foi realizada lavagem pulmonar total duas vezes, com melhoria clínica e funcional. A gravidez foi levada a termo, com o nascimento de um bebé saudável.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Os mecanismos de comprometimento respiratório são discutidos, bem como as opções de tratamento e resposta.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1534 "Ancho" => 1601 "Tamanyo" => 322562 ] ] "descripcion" => array:1 [ "es" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Outflow lavage fluid from left whole-lung BPL. The first outflow fluid was turbid with a yellowish deposit (bag nr. 1), presenting almost clear on the last cycle of lavage (bag nr. 10).</p>" ] ] 1 => array:7 [ "identificador" => "t0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">BLL: bilateral lung lavage; FiO<span class="elsevierStyleInf">2</span>: fraction of inspired oxygen; LL: left lung; PaCO<span class="elsevierStyleInf">2</span>: arterial carbon dioxide tension (mmHg); PaO<span class="elsevierStyleInf">2</span>: arterial oxygen tension (mmHg); RL: right lung; SatO<span class="elsevierStyleInf">2</span>: oxygen saturation.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Date \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="5" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Measurement</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">FiO2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">pH \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">PaCO<span class="elsevierStyleInf">2</span> (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">PaO<span class="elsevierStyleInf">2</span> (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">SatO2 \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">May/2004 Before RL lavage</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">94 % \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Pregnancy</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>26/09/05 admission \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90 % \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>11/10/05 After RL lavage \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92 % \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>25/10/05 Before LL lavage \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">84 % \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>02/11/05 After LL lavage \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5<span class="elsevierStyleHsp" style=""></span>L/min \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">96 % \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">After pregnancy</span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>14/02/07 Before BLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">73 % \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>16/02/07 After BLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">94 % \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>09/04/07 2 month Follow-up \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">105 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">98 % \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab266394.png" ] ] ] ] "descripcion" => array:1 [ "es" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Arterial blood gases</p>" ] ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0020">References</span>" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.H. Rosen" 1 => "B. Castleman" 2 => "A.A. Liebow" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM195806052582301" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1958" "volumen" => "258" "paginaInicial" => "1123" "paginaFinal" => "1142" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13552931" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Progressive intrapartum respiratory insufficiency due to pulmonary alveolar proteinosis. Amelioration by therapeutic whole-lung bronchopulmonary lavage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.M. Matuschak" 1 => "G.R. Owens" 2 => "R.M. Rogers" 3 => "S.C. Tibbals" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "1984" "volumen" => "86" "paginaInicial" => "496" "paginaFinal" => "499" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6468015" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0213005X10001126" "estado" => "S300" "issn" => "0213005X" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary alveolar proteinosis: step-by-step perioperative care of whole lung lavage procedure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Ben-Abraham" 1 => "A. 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Year/Month | Html | Total | |
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2024 November | 4 | 4 | 8 |
2024 October | 28 | 38 | 66 |
2024 September | 28 | 40 | 68 |
2024 August | 35 | 41 | 76 |
2024 July | 35 | 29 | 64 |
2024 June | 20 | 24 | 44 |
2024 May | 33 | 42 | 75 |
2024 April | 28 | 37 | 65 |
2024 March | 24 | 30 | 54 |
2024 February | 21 | 28 | 49 |
2024 January | 19 | 33 | 52 |
2023 December | 15 | 35 | 50 |
2023 November | 17 | 31 | 48 |
2023 October | 16 | 52 | 68 |
2023 September | 16 | 33 | 49 |
2023 August | 18 | 17 | 35 |
2023 July | 18 | 26 | 44 |
2023 June | 18 | 18 | 36 |
2023 May | 27 | 30 | 57 |
2023 April | 9 | 5 | 14 |