array:24 [
  "pii" => "S2173511513000043"
  "issn" => "21735115"
  "doi" => "10.1016/j.rppnen.2013.01.003"
  "estado" => "S300"
  "fechaPublicacion" => "2013-01-01"
  "aid" => "113"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "sco"
  "cita" => "Rev Port Pneumol. 2013;19:42-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3927
    "formatos" => array:3 [
      "EPUB" => 294
      "HTML" => 2488
      "PDF" => 1145
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2173511512000504"
    "issn" => "21735115"
    "doi" => "10.1016/j.rppnen.2012.04.012"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "aid" => "96"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Pneumol. 2013;19:45-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 9562
      "formatos" => array:3 [
        "EPUB" => 271
        "HTML" => 7649
        "PDF" => 1642
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Granulomatosis with Polyangiitis initially misdiagnosed as lung cancer"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "45"
          "paginaFinal" => "48"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Granulomatose com poliange&#237;te inicialmente diagnosticada como cancro do pulm&#227;o"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1052
              "Ancho" => 3333
              "Tamanyo" => 278941
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; and &#40;B&#41; Chest radiograph &#40;A&#41; and CT &#40;B&#41; at the time of symptom relapse &#40;15 months after chemotherapy&#41;&#44; show multiple irregularly shaped nodules and masses&#44; some of which exhibiting cavitation&#46; &#40;C&#41; Bronchoscopic features evidencing multiple ulcerating lesions and superficial vascularization&#44; along the whole tracheobronchial tree&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#46; Campainha, M&#46; Gon&#231;alves, V&#46; Tavares, P&#46; Castel&#245;es, A&#46; Marinho, S&#46; Neves"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Campainha"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Gon&#231;alves"
            ]
            2 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Tavares"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Castel&#245;es"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Marinho"
            ]
            5 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Neves"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S0873215912000372"
        "doi" => "10.1016/j.rppneu.2012.04.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215912000372?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511512000504?idApp=UINPBA00004E"
    "url" => "/21735115/0000001900000001/v1_201305151601/S2173511512000504/v1_201305151601/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173511513000079"
    "issn" => "21735115"
    "doi" => "10.1016/j.rppnen.2012.09.002"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "aid" => "121"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Pneumol. 2013;19:38-41"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4509
      "formatos" => array:3 [
        "EPUB" => 237
        "HTML" => 2978
        "PDF" => 1294
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Brief Communication</span>"
      "titulo" => "Feasibility of routine respiratory function testing in preschool children"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "38"
          "paginaFinal" => "41"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Exequibilidade do estudo funcional respirat&#243;rio em idade pr&#233;-escolar na pr&#225;tica cl&#237;nica"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 955
              "Ancho" => 1583
              "Tamanyo" => 50399
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Cumulative percent of successful spirometry according to reported FEV<span class="elsevierStyleInf">t</span>&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "N&#46; Santos, I&#46; Almeida, M&#46; Couto, M&#46; Morais-Almeida, L&#46;M&#46; Borrego"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Santos"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Almeida"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Couto"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Morais-Almeida"
            ]
            4 => array:2 [
              "nombre" => "L&#46;M&#46;"
              "apellidos" => "Borrego"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511513000079?idApp=UINPBA00004E"
    "url" => "/21735115/0000001900000001/v1_201305151601/S2173511513000079/v1_201305151601/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "Flexible bronchoscopy during mechanical ventilation in the prone position to treat acute lung injury"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "42"
        "paginaFinal" => "44"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "F&#46; Guarracino, P&#46; Bertini, U&#46; Bortolotti, M&#46; Stefani, N&#46; Ambrosino"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "F&#46;"
            "apellidos" => "Guarracino"
            "email" => array:1 [
              0 => "f&#46;guarracino&#64;ao-pisa&#46;toscana&#46;it"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Bertini"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "U&#46;"
            "apellidos" => "Bortolotti"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Stefani"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "N&#46;"
            "apellidos" => "Ambrosino"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Cardiothoracic Intensive Care Unit&#44; Cardio-Thoracic Department&#44; University Hospital of Pisa&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Cardiac Surgery Unit&#44; Cardio-Thoracic Department&#44; University Hospital of Pisa&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Pulmonary and Respiratory Intensive Care Unit&#44; Cardio-Thoracic Department&#44; University Hospital of Pisa&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Weaning and Pulmonary Rehabilitation Unit&#44; Auxilium Vitae&#44; Volterra&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Broncoscopia flex&#237;vel durante a ventila&#231;&#227;o mec&#226;nica na posi&#231;&#227;o de dec&#250;bito ventral para tratar a les&#227;o pulmonar aguda"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1244
            "Ancho" => 1659
            "Tamanyo" => 209330
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Flexible bronchoscopy in a patient during prone mechanical ventilation&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In patients with severe acute lung injury &#40;ALI&#41; or acute respiratory distress syndrome &#40;ARDS&#41; the prone position during mechanical ventilation has been shown to be able to recruit lung parenchyma and to favour protective mechanical ventilation&#44; resulting in improved survival even in severely hypoxemic patients with an arterial oxygen tension to inspiratory oxygen fraction ratio &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#41;<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>100&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However prolonged sessions are required in order to obtain advantages&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> during which the prone position gives enhanced mobilization of airway secretions through postural drainage and lung recruitment&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Suctioning is therefore crucial for tracheobronchial toilet&#46; However when standard tracheal suctioning results are not satisfactory&#44; and arterial desaturation occurs&#44; this usually prompts the intensivist to switch the patient to the supine position in order to get improved tracheobronchial suctioning&#46; This means an earlier interruption of the prone ventilation with a loss of the positive respiratory effects which are gained when there is the full prone cycle&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Flexible fiberoptic bronchoscopy is widely recognized as an effective technique in removing retained airway secretions and improving atelectasis in a variety of clinical conditions&#44; including bronchial toilette and bronchoalveolar lavage in the intensive care unit &#40;ICU&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">No data are available on how and whether fiberoptic bronchoscopy could help prevent prolonged prone position ventilation sessions from being interrupted&#44; earlier than scheduled&#44; with potential detrimental therapeutic effects&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We describe bronchial toilette by flexible bronchoscopy performed during prone mechanical ventilation in two cardiosurgical patients who developed ALI after combined coronary artery surgery&#44; aortic valve replacement and carotid endoarterectomy&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case 1</span><p id="par0030" class="elsevierStylePara elsevierViewall">A 75-year-old lady&#44; although extubated uneventfully on the first postoperative day&#44; on the second postoperative day she showed dyspnoea&#44; a PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> ratio of 70 and SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>92&#37; which required tracheal reintubation and mechanical ventilation&#46; After 24<span class="elsevierStyleHsp" style=""></span>h of ineffective protective mechanical ventilation in Biphasic Intermittent Airway Pressure &#40;BiPAP&#44; Drager&#44; Lubeck&#44; Germany&#41; modality with FiO<span class="elsevierStyleInf">2</span> 0&#46;7&#44; respiratory rate &#40;RR&#41; 18<span class="elsevierStyleHsp" style=""></span>breath&#47;min&#44; I&#47;E ratio 1&#58;1&#44; peak airway inspiratory pressure 25<span class="elsevierStyleHsp" style=""></span>cmH<span class="elsevierStyleInf">2</span>O and PEEP 10<span class="elsevierStyleHsp" style=""></span>cmH<span class="elsevierStyleInf">2</span>O&#44; prone ventilation was applied with immediate rise in SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>98&#37;&#46; The patient was passive and completely controlled by ventilation&#46; Five hours after starting the prone session&#44; an acute deterioration of SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>88&#37; was observed&#46; Arterial blood gas analysis &#40;ABG&#41; showed hypoxaemia and metabolic acidaemia due to secondary cardiovascular impairment &#40;pH 7&#46;21&#44; PaO<span class="elsevierStyleInf">2</span> 65<span class="elsevierStyleHsp" style=""></span>mmHg&#44; PaCO<span class="elsevierStyleInf">2</span> 48<span class="elsevierStyleHsp" style=""></span>mmHg and HCO<span class="elsevierStyleInf">3</span> 20<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&#41;&#46; Clinical examination through auscultation showed airways obstruction due to secretions&#46; Tracheal suctioning through a closed circuit aspiration system and also a larger tube through a standard catheter mount was only partially effective and the SaO<span class="elsevierStyleInf">2</span> remained &#60;92&#37;&#46; Therefore we performed flexible fiberoptic bronchoscopy while the patient maintained the prone position by inserting the bronchoscope through the elbow port of the catheter mount &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; into the endotracheal tube&#46; During the procedure FiO<span class="elsevierStyleInf">2</span> was raised to 1&#46;0 while PEEP and respiratory frequency were reduced to avoid a possible increase in intrinsic PEEP &#40;PEEPi&#41;&#46; Simultaneously&#44; peak airway inspiratory pressure was increased to maintain an expiratory minute ventilation equal to what it had been before the bronchoscope insertion&#46; PEEPi was measured by achieving an end expiratory hold pause&#44; after this the bronchoscopy ventilatory settings were reset to the previous BiPAP modality&#46; The bronchoscopy revealed the presence of a clot obstructing the lower left bronchus lumen which was removed&#44; resulting in rapid recovery of oxygenation &#40;SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>98&#37; pH 7&#46;27&#44; <span class="elsevierStyleItalic">p</span>O<span class="elsevierStyleInf">2</span> 122<span class="elsevierStyleHsp" style=""></span>mmHg&#44; <span class="elsevierStyleItalic">p</span>CO<span class="elsevierStyleInf">2</span> 43<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case 2</span><p id="par0035" class="elsevierStylePara elsevierViewall">A 75-year-old lady was treated with prone mechanical ventilation in Biphasic Intermittent Airway Pressure &#40;BIPAP&#44; Drager&#44; Lubeck&#44; Germany&#41; modality for early postoperative ARDS&#46; Ventilator setting was RR 18<span class="elsevierStyleHsp" style=""></span>breath&#47;min&#44; I&#47;E ratio 1&#58;1&#44; peak airway inspiratory pressure<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>cmH<span class="elsevierStyleInf">2</span>O&#44; PEEP 10&#8211;15<span class="elsevierStyleHsp" style=""></span>cmH<span class="elsevierStyleInf">2</span>O and FiO<span class="elsevierStyleInf">2</span> 0&#46;8&#46; On the third postoperative day&#44; during a prone session with the patient passive and completely controlled by ventilation&#44; a sudden drop in SaO<span class="elsevierStyleInf">2</span> occurred&#46; ABG showed pH 7&#46;19 <span class="elsevierStyleItalic">p</span>O<span class="elsevierStyleInf">2</span> 61<span class="elsevierStyleHsp" style=""></span>mmHg&#44; <span class="elsevierStyleItalic">p</span>CO<span class="elsevierStyleInf">2</span> 56<span class="elsevierStyleHsp" style=""></span>mmHg and HCO<span class="elsevierStyleInf">3</span> 18<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&#46; Clinical examination through auscultation showed that airways were obstructed by a large amount of secretions&#46; Tracheal suctioning resulted in unsatisfactory SaO<span class="elsevierStyleInf">2</span> improvement and auscultation still confirmed that the airways were obstructed by secretions&#44; therefore a selective bronchial toilet was deemed necessary&#46; A flexible bronchoscopy was then carried out in the prone position as described in the first case&#46; Ventilator parameters were set as mentioned above&#46; A large amount of secretions were suctioned in the lower lung regions with quick normalization of SaO2 and ABG values &#40;pH 7&#46;30 <span class="elsevierStyleItalic">p</span>O<span class="elsevierStyleInf">2</span> 116<span class="elsevierStyleHsp" style=""></span>mmHg pCO2 45<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#46; Previous ventilatory settings were restored after the procedure&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Both patients were discharged home alive from the hospital&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">This preliminary experience suggests that flexible bronchoscopy in the patient undergoing mechanical ventilation in the prone position is feasible and safe&#46; Most importantly such endoscopic technique helps to avoid undesirable premature interruption of the prone mechanical ventilation and the consequent loss of the favourable physiological gains&#44; which had the potential to achieve&#44; atelectasis of the lung regions recruited while prone&#44; increased intrapulmonary shunt&#44; decreased SaO<span class="elsevierStyleInf">2</span> and increased pulmonary artery resistances&#46; To date there are no guidelines for the ventilator setting during fiberoptic bronchoscopy&#46; Great care must be taken when bronchoscopy is performed on a patient receiving mechanical ventilation&#46; Extremely low VT and significant PEEPi may develop unless flow&#44; respiratory rate&#44; mode&#44; and tube size are carefully selected&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> We increased FiO<span class="elsevierStyleInf">2</span> to 1&#44; reduce PEEP level and respiratory frequency to avoid an increase in PEEPi&#46; At the same time inspiratory pressure was increased to maintain minute volume and avoid an increase in carbon dioxide</p><p id="par0050" class="elsevierStylePara elsevierViewall">Although performing flexible bronchoscopy in the prone position patient does not seem to make the procedure more difficult when compared to the supine position&#44; decision making about bronchoscopy in severe hypoxia should be even more cautious than in the supine patient&#44; as a dangerous delay in resuscitation manoeuvres due to postponed switching the patient to the supine position should always be avoided&#46; In addition ventilator parameters must be appropriately set to prevent oxygen desaturation and pulmonary hyperinflation due to the severe reduction in the internal diameter of the endotracheal tube&#46; It could be worth carrying out a randomized controlled trial to investigate the impact of such an approach on the outcome of critically ill patients undergoing prone mechanical ventilation&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:8 [
        0 => array:2 [
          "identificador" => "xres175774"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec164108"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres175775"
          "titulo" => "Resumo"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec164109"
          "titulo" => "Palavras-chave"
        ]
        4 => array:3 [
          "identificador" => "sec0005"
          "titulo" => "Case report"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0010"
              "titulo" => "Case 1"
            ]
            1 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Case 2"
            ]
          ]
        ]
        5 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        6 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflicts of interest"
        ]
        7 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2011-12-19"
    "fechaAceptado" => "2012-06-12"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec164108"
          "palabras" => array:7 [
            0 => "Intensive care"
            1 => "Respiratory failure"
            2 => "Mechanical ventilation"
            3 => "Physiotherapy"
            4 => "Acute lung injury"
            5 => "Bronchoscopy"
            6 => "Prone position"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec164109"
          "palabras" => array:7 [
            0 => "Cuidados intensivos"
            1 => "Insufici&#234;ncia respirat&#243;ria"
            2 => "Ventila&#231;&#227;o Mec&#226;nica"
            3 => "Fisioterapia"
            4 => "Les&#227;o pulmonar aguda"
            5 => "Broncoscopia"
            6 => "Posi&#231;&#227;o prona"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">In patients with severe acute lung injury &#40;ALI&#41; or acute respiratory distress syndrome &#40;ARDS&#41; the prone position has been shown to improve survival of patients who are severely hypoxemic with an arterial oxygen tension to inspiratory oxygen fraction ratio &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#41;<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>100&#46; In those patients tracheobronchial toilette is crucial in preventing or treating airways obstructed by secretions and deterioration of oxygenation&#46; Flexible fiberoptic bronchoscopy is widely recognized as an effective technique to perform bronchial toilette in the intensive care unit &#40;ICU&#41;&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Flexible bronchoscopy performed during prone mechanical ventilation in two cardiosurgical patients who developed ALI after complex surgery&#44; proved feasible and safe and helped to avoid undesirable earlier cessation of prone mechanical ventilation&#46; However decision making about bronchoscopy in severe hypoxia should be even more cautious than in the supine patient&#44; as dangerous delay in resuscitation manoeuvres due to postponed switching the patient to the supine position should always be prevented&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Em pacientes com les&#227;o pulmonar aguda grave &#40;LPA&#41; ou s&#237;ndrome de dificuldade respirat&#243;ria aguda &#40;ARDS&#41;&#44; foi demonstrado que a posi&#231;&#227;o de dec&#250;bito ventral melhora a sobreviv&#234;ncia de pacientes que sejam gravemente hipox&#233;micos com uma rela&#231;&#227;o entre a press&#227;o de oxig&#233;nio no sangue arterial e a fra&#231;&#227;o inspirada de oxig&#233;nio &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#41; &#60;100&#46; Nesses pacientes&#44; a toilette traqueobr&#244;nquica &#233; fundamental para a preven&#231;&#227;o ou tratamento das vias respirat&#243;rias obstru&#237;das por secre&#231;&#245;es e a deteriora&#231;&#227;o da oxigena&#231;&#227;o&#46; A fibrobroncoscopia flex&#237;vel &#233; amplamente reconhecida como uma t&#233;cnica eficaz para realizar a toilette br&#244;nquica na unidade de cuidados intensivos &#40;UCI&#41;&#46; A broncoscopia flex&#237;vel realizada durante a ventila&#231;&#227;o mec&#226;nica em posi&#231;&#227;o de dec&#250;bito ventral em 2 pacientes de cirurgia card&#237;aca que desenvolveram LPA ap&#243;s cirurgias complicadas&#44; provaram ser vi&#225;veis e seguras&#44; e ajudaram a evitar uma interrup&#231;&#227;o precoce indesej&#225;vel da ventila&#231;&#227;o mec&#226;nica em posi&#231;&#227;o de dec&#250;bito ventral&#46; No entanto&#44; a tomada de decis&#227;o sobre a broncoscopia em caso de hip&#243;xia grave deve ser ainda mais cautelosa do que no paciente em posi&#231;&#227;o supina&#44; dado que um atraso perigoso nas manobras de reanima&#231;&#227;o devido &#224; mudan&#231;a adiada do paciente para a posi&#231;&#227;o supina deve ser sempre evitado&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1244
            "Ancho" => 1659
            "Tamanyo" => 209330
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Flexible bronchoscopy in a patient during prone mechanical ventilation&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:4 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia&#58; systematic review and metaanalysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Sud"
                            1 => "J&#46;O&#46; Friedrich"
                            2 => "P&#46; Taccone"
                            3 => "F&#46; Polli"
                            4 => "N&#46;K&#46; Adhikari"
                            5 => "R&#46; Latini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-009-1748-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2010"
                        "volumen" => "36"
                        "paginaInicial" => "585"
                        "paginaFinal" => "599"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20130832"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extended prone position ventilation in severe acute respiratory distress syndrome&#58; a pilot feasibility study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;M&#46; Romero"
                            1 => "R&#46;A&#46; Cornejo"
                            2 => "L&#46;R&#46; G&#225;lvez"
                            3 => "O&#46;P&#46; Llanos"
                            4 => "E&#46;A&#46; Tobar"
                            5 => "M&#46;A&#46; Berasa&#237;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jcrc.2008.02.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Crit Care"
                        "fecha" => "2009"
                        "volumen" => "24"
                        "paginaInicial" => "81"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19272543"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ICU procedures of the critically ill"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;C&#46; Phua"
                            1 => "M&#46;M&#46; Wahidi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1440-1843.2009.01643.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respirology"
                        "fecha" => "2009"
                        "volumen" => "14"
                        "paginaInicial" => "1092"
                        "paginaFinal" => "1097"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19909459"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of fiberoptic bronchoscopy during mechanical ventilation in a lung model"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;W&#46; Lawson"
                            1 => "J&#46;I&#46; Peters"
                            2 => "D&#46;C&#46; Shelledy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2000"
                        "volumen" => "118"
                        "paginaInicial" => "312"
                        "paginaFinal" => "824"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735115/0000001900000001/v1_201305151601/S2173511513000043/v1_201305151601/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9711"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001900000001/v1_201305151601/S2173511513000043/v1_201305151601/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511513000043?idApp=UINPBA00004E"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case report
Flexible bronchoscopy during mechanical ventilation in the prone position to treat acute lung injury
Broncoscopia flexível durante a ventilação mecânica na posição de decúbito ventral para tratar a lesão pulmonar aguda
F. Guarracinoa,
Corresponding author
f.guarracino@ao-pisa.toscana.it

Corresponding author.
, P. Bertinia, U. Bortolottib, M. Stefania, N. Ambrosinoc,d
a Cardiothoracic Intensive Care Unit, Cardio-Thoracic Department, University Hospital of Pisa, Italy
b Cardiac Surgery Unit, Cardio-Thoracic Department, University Hospital of Pisa, Italy
c Pulmonary and Respiratory Intensive Care Unit, Cardio-Thoracic Department, University Hospital of Pisa, Italy
d Weaning and Pulmonary Rehabilitation Unit, Auxilium Vitae, Volterra, Italy
Read
1042
Times
was read the article
525
Total PDF
517
Total HTML
Share statistics
 array:24 [
  "pii" => "S2173511513000043"
  "issn" => "21735115"
  "doi" => "10.1016/j.rppnen.2013.01.003"
  "estado" => "S300"
  "fechaPublicacion" => "2013-01-01"
  "aid" => "113"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "sco"
  "cita" => "Rev Port Pneumol. 2013;19:42-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3927
    "formatos" => array:3 [
      "EPUB" => 294
      "HTML" => 2488
      "PDF" => 1145
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2173511512000504"
    "issn" => "21735115"
    "doi" => "10.1016/j.rppnen.2012.04.012"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "aid" => "96"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Pneumol. 2013;19:45-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 9562
      "formatos" => array:3 [
        "EPUB" => 271
        "HTML" => 7649
        "PDF" => 1642
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Granulomatosis with Polyangiitis initially misdiagnosed as lung cancer"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "45"
          "paginaFinal" => "48"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Granulomatose com poliange&#237;te inicialmente diagnosticada como cancro do pulm&#227;o"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1052
              "Ancho" => 3333
              "Tamanyo" => 278941
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; and &#40;B&#41; Chest radiograph &#40;A&#41; and CT &#40;B&#41; at the time of symptom relapse &#40;15 months after chemotherapy&#41;&#44; show multiple irregularly shaped nodules and masses&#44; some of which exhibiting cavitation&#46; &#40;C&#41; Bronchoscopic features evidencing multiple ulcerating lesions and superficial vascularization&#44; along the whole tracheobronchial tree&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#46; Campainha, M&#46; Gon&#231;alves, V&#46; Tavares, P&#46; Castel&#245;es, A&#46; Marinho, S&#46; Neves"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Campainha"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Gon&#231;alves"
            ]
            2 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Tavares"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Castel&#245;es"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Marinho"
            ]
            5 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Neves"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S0873215912000372"
        "doi" => "10.1016/j.rppneu.2012.04.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215912000372?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511512000504?idApp=UINPBA00004E"
    "url" => "/21735115/0000001900000001/v1_201305151601/S2173511512000504/v1_201305151601/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173511513000079"
    "issn" => "21735115"
    "doi" => "10.1016/j.rppnen.2012.09.002"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "aid" => "121"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Pneumol. 2013;19:38-41"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4509
      "formatos" => array:3 [
        "EPUB" => 237
        "HTML" => 2978
        "PDF" => 1294
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Brief Communication</span>"
      "titulo" => "Feasibility of routine respiratory function testing in preschool children"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "38"
          "paginaFinal" => "41"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Exequibilidade do estudo funcional respirat&#243;rio em idade pr&#233;-escolar na pr&#225;tica cl&#237;nica"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 955
              "Ancho" => 1583
              "Tamanyo" => 50399
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Cumulative percent of successful spirometry according to reported FEV<span class="elsevierStyleInf">t</span>&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "N&#46; Santos, I&#46; Almeida, M&#46; Couto, M&#46; Morais-Almeida, L&#46;M&#46; Borrego"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Santos"
            ]
            1 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Almeida"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Couto"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Morais-Almeida"
            ]
            4 => array:2 [
              "nombre" => "L&#46;M&#46;"
              "apellidos" => "Borrego"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511513000079?idApp=UINPBA00004E"
    "url" => "/21735115/0000001900000001/v1_201305151601/S2173511513000079/v1_201305151601/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
    "titulo" => "Flexible bronchoscopy during mechanical ventilation in the prone position to treat acute lung injury"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "42"
        "paginaFinal" => "44"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "F&#46; Guarracino, P&#46; Bertini, U&#46; Bortolotti, M&#46; Stefani, N&#46; Ambrosino"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "F&#46;"
            "apellidos" => "Guarracino"
            "email" => array:1 [
              0 => "f&#46;guarracino&#64;ao-pisa&#46;toscana&#46;it"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Bertini"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "U&#46;"
            "apellidos" => "Bortolotti"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Stefani"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "N&#46;"
            "apellidos" => "Ambrosino"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Cardiothoracic Intensive Care Unit&#44; Cardio-Thoracic Department&#44; University Hospital of Pisa&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Cardiac Surgery Unit&#44; Cardio-Thoracic Department&#44; University Hospital of Pisa&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Pulmonary and Respiratory Intensive Care Unit&#44; Cardio-Thoracic Department&#44; University Hospital of Pisa&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Weaning and Pulmonary Rehabilitation Unit&#44; Auxilium Vitae&#44; Volterra&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Broncoscopia flex&#237;vel durante a ventila&#231;&#227;o mec&#226;nica na posi&#231;&#227;o de dec&#250;bito ventral para tratar a les&#227;o pulmonar aguda"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1244
            "Ancho" => 1659
            "Tamanyo" => 209330
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Flexible bronchoscopy in a patient during prone mechanical ventilation&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In patients with severe acute lung injury &#40;ALI&#41; or acute respiratory distress syndrome &#40;ARDS&#41; the prone position during mechanical ventilation has been shown to be able to recruit lung parenchyma and to favour protective mechanical ventilation&#44; resulting in improved survival even in severely hypoxemic patients with an arterial oxygen tension to inspiratory oxygen fraction ratio &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#41;<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>100&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However prolonged sessions are required in order to obtain advantages&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> during which the prone position gives enhanced mobilization of airway secretions through postural drainage and lung recruitment&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Suctioning is therefore crucial for tracheobronchial toilet&#46; However when standard tracheal suctioning results are not satisfactory&#44; and arterial desaturation occurs&#44; this usually prompts the intensivist to switch the patient to the supine position in order to get improved tracheobronchial suctioning&#46; This means an earlier interruption of the prone ventilation with a loss of the positive respiratory effects which are gained when there is the full prone cycle&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Flexible fiberoptic bronchoscopy is widely recognized as an effective technique in removing retained airway secretions and improving atelectasis in a variety of clinical conditions&#44; including bronchial toilette and bronchoalveolar lavage in the intensive care unit &#40;ICU&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">No data are available on how and whether fiberoptic bronchoscopy could help prevent prolonged prone position ventilation sessions from being interrupted&#44; earlier than scheduled&#44; with potential detrimental therapeutic effects&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We describe bronchial toilette by flexible bronchoscopy performed during prone mechanical ventilation in two cardiosurgical patients who developed ALI after combined coronary artery surgery&#44; aortic valve replacement and carotid endoarterectomy&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case 1</span><p id="par0030" class="elsevierStylePara elsevierViewall">A 75-year-old lady&#44; although extubated uneventfully on the first postoperative day&#44; on the second postoperative day she showed dyspnoea&#44; a PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> ratio of 70 and SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>92&#37; which required tracheal reintubation and mechanical ventilation&#46; After 24<span class="elsevierStyleHsp" style=""></span>h of ineffective protective mechanical ventilation in Biphasic Intermittent Airway Pressure &#40;BiPAP&#44; Drager&#44; Lubeck&#44; Germany&#41; modality with FiO<span class="elsevierStyleInf">2</span> 0&#46;7&#44; respiratory rate &#40;RR&#41; 18<span class="elsevierStyleHsp" style=""></span>breath&#47;min&#44; I&#47;E ratio 1&#58;1&#44; peak airway inspiratory pressure 25<span class="elsevierStyleHsp" style=""></span>cmH<span class="elsevierStyleInf">2</span>O and PEEP 10<span class="elsevierStyleHsp" style=""></span>cmH<span class="elsevierStyleInf">2</span>O&#44; prone ventilation was applied with immediate rise in SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>98&#37;&#46; The patient was passive and completely controlled by ventilation&#46; Five hours after starting the prone session&#44; an acute deterioration of SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>88&#37; was observed&#46; Arterial blood gas analysis &#40;ABG&#41; showed hypoxaemia and metabolic acidaemia due to secondary cardiovascular impairment &#40;pH 7&#46;21&#44; PaO<span class="elsevierStyleInf">2</span> 65<span class="elsevierStyleHsp" style=""></span>mmHg&#44; PaCO<span class="elsevierStyleInf">2</span> 48<span class="elsevierStyleHsp" style=""></span>mmHg and HCO<span class="elsevierStyleInf">3</span> 20<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&#41;&#46; Clinical examination through auscultation showed airways obstruction due to secretions&#46; Tracheal suctioning through a closed circuit aspiration system and also a larger tube through a standard catheter mount was only partially effective and the SaO<span class="elsevierStyleInf">2</span> remained &#60;92&#37;&#46; Therefore we performed flexible fiberoptic bronchoscopy while the patient maintained the prone position by inserting the bronchoscope through the elbow port of the catheter mount &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; into the endotracheal tube&#46; During the procedure FiO<span class="elsevierStyleInf">2</span> was raised to 1&#46;0 while PEEP and respiratory frequency were reduced to avoid a possible increase in intrinsic PEEP &#40;PEEPi&#41;&#46; Simultaneously&#44; peak airway inspiratory pressure was increased to maintain an expiratory minute ventilation equal to what it had been before the bronchoscope insertion&#46; PEEPi was measured by achieving an end expiratory hold pause&#44; after this the bronchoscopy ventilatory settings were reset to the previous BiPAP modality&#46; The bronchoscopy revealed the presence of a clot obstructing the lower left bronchus lumen which was removed&#44; resulting in rapid recovery of oxygenation &#40;SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>98&#37; pH 7&#46;27&#44; <span class="elsevierStyleItalic">p</span>O<span class="elsevierStyleInf">2</span> 122<span class="elsevierStyleHsp" style=""></span>mmHg&#44; <span class="elsevierStyleItalic">p</span>CO<span class="elsevierStyleInf">2</span> 43<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case 2</span><p id="par0035" class="elsevierStylePara elsevierViewall">A 75-year-old lady was treated with prone mechanical ventilation in Biphasic Intermittent Airway Pressure &#40;BIPAP&#44; Drager&#44; Lubeck&#44; Germany&#41; modality for early postoperative ARDS&#46; Ventilator setting was RR 18<span class="elsevierStyleHsp" style=""></span>breath&#47;min&#44; I&#47;E ratio 1&#58;1&#44; peak airway inspiratory pressure<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>cmH<span class="elsevierStyleInf">2</span>O&#44; PEEP 10&#8211;15<span class="elsevierStyleHsp" style=""></span>cmH<span class="elsevierStyleInf">2</span>O and FiO<span class="elsevierStyleInf">2</span> 0&#46;8&#46; On the third postoperative day&#44; during a prone session with the patient passive and completely controlled by ventilation&#44; a sudden drop in SaO<span class="elsevierStyleInf">2</span> occurred&#46; ABG showed pH 7&#46;19 <span class="elsevierStyleItalic">p</span>O<span class="elsevierStyleInf">2</span> 61<span class="elsevierStyleHsp" style=""></span>mmHg&#44; <span class="elsevierStyleItalic">p</span>CO<span class="elsevierStyleInf">2</span> 56<span class="elsevierStyleHsp" style=""></span>mmHg and HCO<span class="elsevierStyleInf">3</span> 18<span class="elsevierStyleHsp" style=""></span>mEq&#47;l&#46; Clinical examination through auscultation showed that airways were obstructed by a large amount of secretions&#46; Tracheal suctioning resulted in unsatisfactory SaO<span class="elsevierStyleInf">2</span> improvement and auscultation still confirmed that the airways were obstructed by secretions&#44; therefore a selective bronchial toilet was deemed necessary&#46; A flexible bronchoscopy was then carried out in the prone position as described in the first case&#46; Ventilator parameters were set as mentioned above&#46; A large amount of secretions were suctioned in the lower lung regions with quick normalization of SaO2 and ABG values &#40;pH 7&#46;30 <span class="elsevierStyleItalic">p</span>O<span class="elsevierStyleInf">2</span> 116<span class="elsevierStyleHsp" style=""></span>mmHg pCO2 45<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#46; Previous ventilatory settings were restored after the procedure&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Both patients were discharged home alive from the hospital&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">This preliminary experience suggests that flexible bronchoscopy in the patient undergoing mechanical ventilation in the prone position is feasible and safe&#46; Most importantly such endoscopic technique helps to avoid undesirable premature interruption of the prone mechanical ventilation and the consequent loss of the favourable physiological gains&#44; which had the potential to achieve&#44; atelectasis of the lung regions recruited while prone&#44; increased intrapulmonary shunt&#44; decreased SaO<span class="elsevierStyleInf">2</span> and increased pulmonary artery resistances&#46; To date there are no guidelines for the ventilator setting during fiberoptic bronchoscopy&#46; Great care must be taken when bronchoscopy is performed on a patient receiving mechanical ventilation&#46; Extremely low VT and significant PEEPi may develop unless flow&#44; respiratory rate&#44; mode&#44; and tube size are carefully selected&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> We increased FiO<span class="elsevierStyleInf">2</span> to 1&#44; reduce PEEP level and respiratory frequency to avoid an increase in PEEPi&#46; At the same time inspiratory pressure was increased to maintain minute volume and avoid an increase in carbon dioxide</p><p id="par0050" class="elsevierStylePara elsevierViewall">Although performing flexible bronchoscopy in the prone position patient does not seem to make the procedure more difficult when compared to the supine position&#44; decision making about bronchoscopy in severe hypoxia should be even more cautious than in the supine patient&#44; as a dangerous delay in resuscitation manoeuvres due to postponed switching the patient to the supine position should always be avoided&#46; In addition ventilator parameters must be appropriately set to prevent oxygen desaturation and pulmonary hyperinflation due to the severe reduction in the internal diameter of the endotracheal tube&#46; It could be worth carrying out a randomized controlled trial to investigate the impact of such an approach on the outcome of critically ill patients undergoing prone mechanical ventilation&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:8 [
        0 => array:2 [
          "identificador" => "xres175774"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec164108"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres175775"
          "titulo" => "Resumo"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec164109"
          "titulo" => "Palavras-chave"
        ]
        4 => array:3 [
          "identificador" => "sec0005"
          "titulo" => "Case report"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0010"
              "titulo" => "Case 1"
            ]
            1 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Case 2"
            ]
          ]
        ]
        5 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        6 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflicts of interest"
        ]
        7 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2011-12-19"
    "fechaAceptado" => "2012-06-12"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec164108"
          "palabras" => array:7 [
            0 => "Intensive care"
            1 => "Respiratory failure"
            2 => "Mechanical ventilation"
            3 => "Physiotherapy"
            4 => "Acute lung injury"
            5 => "Bronchoscopy"
            6 => "Prone position"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec164109"
          "palabras" => array:7 [
            0 => "Cuidados intensivos"
            1 => "Insufici&#234;ncia respirat&#243;ria"
            2 => "Ventila&#231;&#227;o Mec&#226;nica"
            3 => "Fisioterapia"
            4 => "Les&#227;o pulmonar aguda"
            5 => "Broncoscopia"
            6 => "Posi&#231;&#227;o prona"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">In patients with severe acute lung injury &#40;ALI&#41; or acute respiratory distress syndrome &#40;ARDS&#41; the prone position has been shown to improve survival of patients who are severely hypoxemic with an arterial oxygen tension to inspiratory oxygen fraction ratio &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#41;<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>100&#46; In those patients tracheobronchial toilette is crucial in preventing or treating airways obstructed by secretions and deterioration of oxygenation&#46; Flexible fiberoptic bronchoscopy is widely recognized as an effective technique to perform bronchial toilette in the intensive care unit &#40;ICU&#41;&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Flexible bronchoscopy performed during prone mechanical ventilation in two cardiosurgical patients who developed ALI after complex surgery&#44; proved feasible and safe and helped to avoid undesirable earlier cessation of prone mechanical ventilation&#46; However decision making about bronchoscopy in severe hypoxia should be even more cautious than in the supine patient&#44; as dangerous delay in resuscitation manoeuvres due to postponed switching the patient to the supine position should always be prevented&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Em pacientes com les&#227;o pulmonar aguda grave &#40;LPA&#41; ou s&#237;ndrome de dificuldade respirat&#243;ria aguda &#40;ARDS&#41;&#44; foi demonstrado que a posi&#231;&#227;o de dec&#250;bito ventral melhora a sobreviv&#234;ncia de pacientes que sejam gravemente hipox&#233;micos com uma rela&#231;&#227;o entre a press&#227;o de oxig&#233;nio no sangue arterial e a fra&#231;&#227;o inspirada de oxig&#233;nio &#40;PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&#41; &#60;100&#46; Nesses pacientes&#44; a toilette traqueobr&#244;nquica &#233; fundamental para a preven&#231;&#227;o ou tratamento das vias respirat&#243;rias obstru&#237;das por secre&#231;&#245;es e a deteriora&#231;&#227;o da oxigena&#231;&#227;o&#46; A fibrobroncoscopia flex&#237;vel &#233; amplamente reconhecida como uma t&#233;cnica eficaz para realizar a toilette br&#244;nquica na unidade de cuidados intensivos &#40;UCI&#41;&#46; A broncoscopia flex&#237;vel realizada durante a ventila&#231;&#227;o mec&#226;nica em posi&#231;&#227;o de dec&#250;bito ventral em 2 pacientes de cirurgia card&#237;aca que desenvolveram LPA ap&#243;s cirurgias complicadas&#44; provaram ser vi&#225;veis e seguras&#44; e ajudaram a evitar uma interrup&#231;&#227;o precoce indesej&#225;vel da ventila&#231;&#227;o mec&#226;nica em posi&#231;&#227;o de dec&#250;bito ventral&#46; No entanto&#44; a tomada de decis&#227;o sobre a broncoscopia em caso de hip&#243;xia grave deve ser ainda mais cautelosa do que no paciente em posi&#231;&#227;o supina&#44; dado que um atraso perigoso nas manobras de reanima&#231;&#227;o devido &#224; mudan&#231;a adiada do paciente para a posi&#231;&#227;o supina deve ser sempre evitado&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1244
            "Ancho" => 1659
            "Tamanyo" => 209330
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Flexible bronchoscopy in a patient during prone mechanical ventilation&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:4 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia&#58; systematic review and metaanalysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Sud"
                            1 => "J&#46;O&#46; Friedrich"
                            2 => "P&#46; Taccone"
                            3 => "F&#46; Polli"
                            4 => "N&#46;K&#46; Adhikari"
                            5 => "R&#46; Latini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00134-009-1748-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Intensive Care Med"
                        "fecha" => "2010"
                        "volumen" => "36"
                        "paginaInicial" => "585"
                        "paginaFinal" => "599"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20130832"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extended prone position ventilation in severe acute respiratory distress syndrome&#58; a pilot feasibility study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;M&#46; Romero"
                            1 => "R&#46;A&#46; Cornejo"
                            2 => "L&#46;R&#46; G&#225;lvez"
                            3 => "O&#46;P&#46; Llanos"
                            4 => "E&#46;A&#46; Tobar"
                            5 => "M&#46;A&#46; Berasa&#237;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jcrc.2008.02.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Crit Care"
                        "fecha" => "2009"
                        "volumen" => "24"
                        "paginaInicial" => "81"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19272543"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ICU procedures of the critically ill"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;C&#46; Phua"
                            1 => "M&#46;M&#46; Wahidi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1440-1843.2009.01643.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respirology"
                        "fecha" => "2009"
                        "volumen" => "14"
                        "paginaInicial" => "1092"
                        "paginaFinal" => "1097"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19909459"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of fiberoptic bronchoscopy during mechanical ventilation in a lung model"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;W&#46; Lawson"
                            1 => "J&#46;I&#46; Peters"
                            2 => "D&#46;C&#46; Shelledy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2000"
                        "volumen" => "118"
                        "paginaInicial" => "312"
                        "paginaFinal" => "824"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735115/0000001900000001/v1_201305151601/S2173511513000043/v1_201305151601/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9711"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001900000001/v1_201305151601/S2173511513000043/v1_201305151601/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511513000043?idApp=UINPBA00004E"
]
Article information
ISSN: 21735115
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 7 4 11
2024 October 36 26 62
2024 September 34 50 84
2024 August 43 39 82
2024 July 35 30 65
2024 June 29 23 52
2024 May 34 33 67
2024 April 30 32 62
2024 March 24 26 50
2024 February 27 18 45
2024 January 18 29 47
2023 December 16 24 40
2023 November 22 27 49
2023 October 21 30 51
2023 September 31 33 64
2023 August 23 29 52
2023 July 23 21 44
2023 June 20 16 36
2023 May 27 24 51
2023 April 17 11 28
Show all

Follow this link to access the full text of the article

Pulmonology

Are you a health professional able to prescribe or dispense drugs?