was read the article
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Computed tomographies (CT) of the thorax demonstrating: (A) (4th week after admission) bilateral pleural effusion and condensation, with an aspergilloma on left hemithorax; (B) (9th week after admission) hydropneumothorax; (C and D) (6th month after admission) improvement of pleural effusion and hydropneumothorax. Aspergilloma was removed during the surgery.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Ponces Bento, F. Esteves, O. Matos, A.C. Miranda, F. Ventura, C. Araújo, K. Mansinho" "autores" => array:7 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Ponces Bento" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Esteves" ] 2 => array:2 [ "nombre" => "O." "apellidos" => "Matos" ] 3 => array:2 [ "nombre" => "A.C." "apellidos" => "Miranda" ] 4 => array:2 [ "nombre" => "F." "apellidos" => "Ventura" ] 5 => array:2 [ "nombre" => "C." "apellidos" => "Araújo" ] 6 => array:2 [ "nombre" => "K." "apellidos" => "Mansinho" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S0873215913000275" "doi" => "10.1016/j.rppneu.2013.01.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215913000275?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511513000328?idApp=UINPBA00004E" "url" => "/21735115/0000001900000003/v1_201308021408/S2173511513000328/v1_201308021408/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2173511513000304" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2013.01.006" "estado" => "S300" "fechaPublicacion" => "2013-05-01" "aid" => "136" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2013;19:114-24" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4339 "formatos" => array:3 [ "EPUB" => 279 "HTML" => 2915 "PDF" => 1145 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Environmental tobacco smoke exposure at home and smoking prevalence in the general Portuguese population—The INAsma study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "114" "paginaFinal" => "124" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Prevalência da exposição ao fumo ambiental do tabaco em casa e do tabagismo na população Portuguesa – o estudo INAsma" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2030 "Ancho" => 3113 "Tamanyo" => 363848 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Prevalence of tobacco smoking in the population aged 15 years or more in Portugal (data since 1994) and evolution of tobacco price (pack of premium brand); stratification by gender is also presented.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,15,18,24</span></a></p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.M. Pereira, M. Morais-Almeida, A. Sá e Sousa, T. Jacinto, L.F. Azevedo, C. Robalo Cordeiro, A. Bugalho de Almeida, J.A. Fonseca" "autores" => array:8 [ 0 => array:2 [ "nombre" => "A.M." "apellidos" => "Pereira" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Morais-Almeida" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Sá e Sousa" ] 3 => array:2 [ "nombre" => "T." "apellidos" => "Jacinto" ] 4 => array:2 [ "nombre" => "L.F." "apellidos" => "Azevedo" ] 5 => array:2 [ "nombre" => "C." "apellidos" => "Robalo Cordeiro" ] 6 => array:2 [ "nombre" => "A." "apellidos" => "Bugalho de Almeida" ] 7 => array:2 [ "nombre" => "J.A." "apellidos" => "Fonseca" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S0873215913000214" "doi" => "10.1016/j.rppneu.2013.01.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215913000214?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511513000304?idApp=UINPBA00004E" "url" => "/21735115/0000001900000003/v1_201308021408/S2173511513000304/v1_201308021408/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Aquagenic keratoderma associated with a mutation of the cystic fibrosis gene" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "125" "paginaFinal" => "128" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "V. Coelho-Macias, S. Fernandes, P. Lamarão, F. Assis-Pacheco, J. Cardoso" "autores" => array:5 [ 0 => array:4 [ "nombre" => "V." "apellidos" => "Coelho-Macias" "email" => array:1 [ 0 => "vmcmacias@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Fernandes" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Lamarão" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Assis-Pacheco" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Cardoso" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Serviço de Dermatologia e Venereologia, Hospital de Curry Cabral, Lisboa, Portugal" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Acroqueratodermia aquagénica associada a uma mutação do gene da fibrose quística" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1025 "Ancho" => 1583 "Tamanyo" => 220677 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Palmar skin on initial physical examination.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Aquagenic wrinkling of the palms was first reported in 1996 by English and McCollough.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Since then, different designations have been used in the literature: Transient Reactive Papulotranslucent Acrokeratoderma,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Aquagenic Syringeal Acrokeratoderma,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and Aquagenic Palmoplantar Keratoderma.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> It is characterized by thickening of the palms, and on rare occasions also the soles, after brief immersion in water. To date fewer than 50 cases have been reported in the literature.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Although multiple associations have been reported, recent papers highlight the connection with Cystic Fibrosis and Cystic Fibrosis gene (CFTR) mutations.</p><p id="par0015" class="elsevierStylePara elsevierViewall">In this article the authors describe a patient with aquagenic keratoderma associated with a CFTR mutation.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0020" class="elsevierStylePara elsevierViewall">An 18-year-old Caucasian female patient presented with a one-month history of pruritus and thickening of palmar skin, shortly after water immersion. Warm water triggered the symptoms more briefly and the dermatosis remitted 20<span class="elsevierStyleHsp" style=""></span>min after water exposure ceased. Her soles were unaffected and she had no other medical complaints. Her personal and family medical histories were irrelevant. On physical examination, palmar skin was unremarkable (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) but, 5<span class="elsevierStyleHsp" style=""></span>min after water immersion, multiple small, edematous, whitish flat-topped papules were evident. Dermoscopy revealed edematous skin with dilated puncta (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Skin biopsy of palmar papule after water immersion showed orthohyperkeratosis, dermal swelling and dilation of acrosyringia and eccrine ostia (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Genetic study of the CFTR gene identified a single F508 mutation. No sweat chloride test was performed.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The patient was treated with topical 20% aluminum chloride with improvement of the lesions and complaints. Due to the Cystic Fibrosis carrier state of the patient, she and her family were referred for genetic counseling.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">Aquagenic keratoderma is a rare condition characterized by symmetric, flesh-colored to white, edematous, flat-topped papules with dilated ostia located on the palms and finger margins. The soles are rarely involved. The skin lesions typically appear after brief exposure to hot<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> or cold water,<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2,5,6</span></a> and usually disappear soon after being dried. When not exposed to water, the skin of affected patients either looks normal or there is hyperlinearity or multiple unremarkable translucent white papules on the palms or soles.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,7</span></a> The condition is usually asymptomatic but it can cause pain, pruritus, burning or tightness. Patients are predominantly female,<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,8–10</span></a> especially among the younger ones (age of onset from 9 to 42 years).<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a> An autosomal recessive inheritance pattern was initially proposed,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> however more recent cases suggest an autosomal dominant pattern.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Typically, histological examination (after water exposure) shows hyperkeratosis, orthokeratosis and dilation of acrosyringia and eccrine ostia.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Multiple anecdotal associations have been described in the past, namely, atopy,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> COX-2 inhibitors therapy,<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14,15</span></a> marasmus,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> palmar hyperhidrosis,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Raynaud's phenomenon,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> malignant melanoma,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Behçet disease<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> and nail psoriasis.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> However recent studies tend to emphasize a possible relation between aquagenic keratoderma and cystic fibrosis. It is estimated that more than half the patients with aquagenic keratoderma (56.7%) have documented cystic fibrosis<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>. Although aquagenic keratoderma seems to be more prevalent in cystic fibrosis patients, Gild et al.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> reported the first case associated with a single mutation in the CFTR gene, suggesting that aquagenic keratoderma may be a sign of the cystic fibrosis carrier state.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The pathogenesis of aquagenic keratoderma remains unknown. Due to the increased sweat chloride concentration in Cystic Fibrosis patients, an increased water-binding capacity of epidermal keratinocytes has been suggested.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18,19</span></a> Berk et al.,<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> however, showed that there was no relationship between sweat chloride concentration and aquagenic wrinkling of the palms score. Several other hypotheses remain in debate, such as eccrine gland<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,21</span></a> or nerve<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> dysfunction, hyperhidrosis,<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> defective barrier function of the stratum corneum,<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> occlusion of eccrine duct ostia<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and weakness of the eccrine duct wall.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Like the patient described, the ΔF508 is the most commonly reported mutation associated with aquagenic keratoderma in cystic fibrosis patients.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Although this is the most common CFTR mutation (70% of cystic fibrosis mutations in north European Caucasian patients)<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17,23</span></a> some authors speculate that this particular mutation could represent a predisposing factor for aquagenic keratoderma.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17,20</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Multiple effective therapies have been reported, including aluminum chloride,<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,17</span></a> antihistamines,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> botulinum toxin injections,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> iontophoresis<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> with variable results. Spontaneous remission has also been described.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3,5,17</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In the present case, aquagenic keratoderma might represent the sole manifestation of the cystic fibrosis carrier state of the patient. This highlights the importance of considering and testing for this type of genetic abnormality in these patients. Similarly, this type of dermatologic condition should be looked for in both cystic fibrosis patients and known carriers, not only because there are available therapies but also due to the fact that new reports and studies could help clarify the pathogenesis of both conditions. The authors believe that aquagenic keratoderma is an under-diagnosed condition, which can be misdiagnosed as a physiologic whitish discoloration and wrinkling of the palms, a consequence of digit pulp vasoconstriction,<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> normally associated with prolonged water exposure.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Protection of human and animal subjects</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Confidentiality of data</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study received sufficient information and gave their written informed consent to participate in the study.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Right to privacy and informed consent</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "xres251816" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec239415" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres251817" "titulo" => "Resumo" ] 3 => array:2 [ "identificador" => "xpalclavsec239414" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:3 [ "identificador" => "sec0020" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0035" "titulo" => "Right to privacy and informed consent" ] ] ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-06-05" "fechaAceptado" => "2012-10-31" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec239415" "palabras" => array:3 [ 0 => "Aquagenic keratoderma" 1 => "Cystic fibrosis" 2 => "Genetic counseling" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec239414" "palabras" => array:3 [ 0 => "Acroqueratodermia aquagénica" 1 => "Fibrose quística" 2 => "Aconselhamento genético" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Reported for the first time in 1996, aquagenic keratoderma is a rare condition which is characterized by edematous flat-topped papules appearing on palmar skin after water immersion. Multiple anecdotal associations have been described but, recently, the association with cystic fibrosis gene mutations (CFTR) has been highlighted.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The authors describe an 18-year-old female, with one-month complaints of pruritus and swelling of palmar skin after water immersion. On examination, palmar skin was unremarkable but, 5<span class="elsevierStyleHsp" style=""></span>min after water immersion, multiple whitish papules became apparent. CFTR genotype study showed a F508del mutation in one allele (nonhomozygous). She had no other symptoms and no relevant family history.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Aquagenic keratoderma is probably an under-diagnosed entity that might represent a manifestation of CFTR mutations, making carrier state identification and genetic counseling possible.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Descrita em 1996, a acroqueratodermia aquagénica é uma entidade rara, caracterizada pelo aparecimento de pápulas edematosas palmares após contacto com água. Múltiplas associações foram enumeradas mas, recentemente, a associação a mutações do gene da fibrose quística foi demonstrada.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Descreve-se o caso de uma mulher de 18 anos, saudável, com prurido e edema palmar após imersão em água. O exame objetivo inicial não mostrava alterações mas, 5 min após imersão em água, observavam-se múltiplas pápulas esbranquiçadas palmares. O estudo do gene da fibrose quística (CFTR) revelou uma mutação F508del num dos alelos. A doente negava outras queixas ou história familiar relevante.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A acroqueratodermia aquagénica é uma entidade provavelmente subdiagnosticada que poderá constituir uma manifestação de mutações do gene CFTR, o que possibilitaria a identificação de portadores e aconselhamento genético.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Coelho-Macias, V. Acroqueratodermia aquagénica associada a uma mutação do gene da fibrose quística. Rev Port Pneumol 2013. <span class="elsevierStyleInterRef" href="doi:10.1016/j.rppneu.2012.10.005">http://dx.doi.org/10.1016/j.rppneu.2012.10.005</span>.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1025 "Ancho" => 1583 "Tamanyo" => 220677 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Palmar skin on initial physical examination.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 713 "Ancho" => 950 "Tamanyo" => 91881 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">(A) Palmar skin after 5<span class="elsevierStyleHsp" style=""></span>min water immersion: subtle whitish, edematous and flat-topped papules became apparent. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 18 | 9 | 27 |
2024 October | 95 | 52 | 147 |
2024 September | 120 | 84 | 204 |
2024 August | 149 | 62 | 211 |
2024 July | 109 | 63 | 172 |
2024 June | 61 | 32 | 93 |
2024 May | 64 | 48 | 112 |
2024 April | 61 | 38 | 99 |
2024 March | 50 | 31 | 81 |
2024 February | 42 | 24 | 66 |
2024 January | 44 | 46 | 90 |
2023 December | 61 | 26 | 87 |
2023 November | 51 | 36 | 87 |
2023 October | 56 | 41 | 97 |
2023 September | 55 | 33 | 88 |
2023 August | 75 | 27 | 102 |
2023 July | 62 | 33 | 95 |
2023 June | 46 | 22 | 68 |
2023 May | 90 | 25 | 115 |
2023 April | 85 | 21 | 106 |