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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic obstructive pulmonary disease &#40;COPD&#41; is a rising cause of morbidity and mortality worldwide&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> and Portugal is no exception&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In 1990 COPD was the sixth most common cause of death worldwide and was ranked 12th for DALYs &#40;disability-adjusted life years&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> It has been projected that by 2020 it will have risen to 5th rank&#44; and be the third most common cause of death&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">This situation has led to the development of the Global Initiative for COPD &#40;GOLD&#41;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> of which the primary goal is to control and invert the burden of COPD&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Historical background</span><p id="par0020" class="elsevierStylePara elsevierViewall">In 1995&#44; both the American Thoracic Society &#40;ATS&#41; and the European Respiratory Society &#40;ERS&#41; published data about the prevalence of airways obstruction in a general population as a plan to standardize the diagnosis of COPD&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">At that time&#44; in Portugal&#44; the information on the prevalence of respiratory diseases was scarce and pulmonary function evaluation and screening was not a regular practice in the diagnosis workup&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">For many years&#44; early manifestations of COPD were unnoticed and undetectable&#44; both by patients and physicians&#44; because the respiratory function characterization of the inflammatory airway pathology was rarely requested&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The implementation of a pulmonary function survey seemed to be an appropriate way of drawing attention to unknown symptoms and to measure disturbances&#44; and at the same time to alert both population and practitioners to this health problem&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The first Pneumobil Study took place in Portugal from 1995 to 1997 with the goal of estimating the prevalence of COPD&#44; asthma and respiratory symptoms and characterizing the associated risk factors in the Portuguese population&#44; including population above 18 years old&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In 1998 the Global Initiative for Chronic Obstructive Lung Disease &#40;GOLD&#41; was launched<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and in 2001 the guidelines<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> for the classification of COPD were published&#46; The main goals of GOLD are to increase awareness of COPD&#44; decrease morbidity and mortality&#44; and to improve prevention and management of COPD through a concerted worldwide effort by people involved in health care and health care policy-making&#44; as well as to encourage a renewed research interest in this highly prevalent disease&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">One major problem that GOLD came up with was the incomplete information in many countries about the prevalence and causes of COPD&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">By that time there were new consensual guidelines and the awareness that prevalence of COPD in a general population depended very much on the criteria used for airway obstruction definition&#44; and data showed wide prevalence rates across countries&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Considering these new aspects highlighted by GOLD&#44; a new Prevalence Study was implemented&#44; 2002 Prevalence Study&#44; which aimed to estimate the prevalence rates of COPD and evaluate the severity of obstruction&#44; smoking habits&#44; and other risk factors in Portugal&#46; GOLD</p><p id="par0065" class="elsevierStylePara elsevierViewall">Despite the implementation of GOLD&#44; COPD is nowadays ranked fourth in developed countries&#44; with approximately 2&#46;75 million deaths per year&#44; representing 4&#46;8&#37; of deaths&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> It still is an under-recognized&#44; under-diagnosed and under-treated disease&#44; and is frequently diagnosed too late&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#8211;15</span></a> GOLD&#39;s approach appears to overestimate</p><p id="par0070" class="elsevierStylePara elsevierViewall">COPD in older individuals and to underestimate it in younger adults&#46; This raises questions about which criteria should be used for the definition of obstruction and which reference equations are appropriate for the populations&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In 2004&#44; the international Burden of Obstructive Lung Disease &#40;BOLD&#41; initiative developed standardized methods for estimating prevalence and economic burden of population-based COPD&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> These methods can be used in countries at all levels of development&#46; The aim of BOLD is to measure the worldwide prevalence of COPD and its risk factors in adults aged 40 years and older and to investigate variation in prevalence across countries by age&#44; gender&#44; and smoking status&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">The BOLD Study has also been implemented in Portugal&#44; during 2008 and published results are awaited&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The purpose of this study is to revisit those two studies done in Portugal some years ago&#44; in order to make public some of the data and respective methodologies&#44; since data from both studies are dispersed in communications&#44; posters&#44; partial data published in books&#44; oral communications with no abstracts and publications in non-available journals&#44; which make searching of data very difficult&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;12&#44;17&#44;18</span></a> Moreover&#44; we present here&#44; for the first time&#44; the analysis of the fraction of the population older than 40 years of the Pneumobil Study&#46;</p></span></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material and methods</span><p id="par0090" class="elsevierStylePara elsevierViewall">The two studies had different methodology&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Pneumobil Study methodology</span><p id="par0095" class="elsevierStylePara elsevierViewall">This survey was carried out between September 1995 and December 1997 in 17 of the 18 districts of continental Portugal&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">This was a survey of volunteer individuals who attended the study collection sites&#44; mostly located on public places and who agreed to answer a questionnaire and perform a spirometry&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The population included was 14&#44;002 individuals but only 12&#44;684 adults over 18 years of age were considered eligible &#40;completed questionnaire and acceptable spirometry&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">For this analysis we have selected from the database only the individuals older than 40 years &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9061&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The questionnaire&#44; based on ATS Respiratory Questionnaire&#44; included demographic parameters&#44; smoking habits&#44; professional activity&#44; physical activity&#44; exposure to dust and chemical smoke&#44; history of pathology with effect on respiratory function and medication use&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Pre and post-bronchodilator spirometry was performed according to ATS guidelines<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#44; using electronic spirometers Masterscreen IOS &#40;Jaeger&#41;&#44; version 4&#46;3&#44; with a Silverman pneumotachograph&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">2002 Epidemiological Study methodology</span><p id="par0125" class="elsevierStylePara elsevierViewall">This Epidemiological Study was carried out between October 2001 and March 2002 in all districts of continental Portugal&#44; stratified by region&#44; age and gender according to demographic data from INE &#40;National Statistics Institute &#8211; census 2001&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">The sample was selected randomly from the telephone directory and for those who agreed to participate in the study a date and time was scheduled for questionnaire answering and spirometry measurements&#46; Because telephonic answers were very scarce 11&#44;500 individuals had to be contacted to obtain the planned sample size&#46; It included 1475 individuals aged between 35 and 69 years old&#44; with a participation rate of 12&#46;8&#37;&#46; From these only 1384 individuals were considered eligible &#40;having completed the questionnaire and acceptable spirometry&#41;&#59; however this sample was representative of the Portuguese population&#46; People over 70 years old were excluded as participation by the older individuals which could have resulted in bias&#44; as happened in the case of the Iberpoc Study&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">The questionnaire was the same as in the previous study&#46; Spirometry was performed according to ATS recommendations<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#44; using a Vitalograph alpha III<span class="elsevierStyleSup">&#174;</span> spirometer&#44; equipped with SafeTway<span class="elsevierStyleSup">&#174;</span> mouthpiece adaptors &#40;Fleisch pneumotachograph&#41;&#46; In this study&#44; the reversibility test was not performed for ethical and operational reasons &#40;for example&#44; no physician was available during spirometry tests&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Definitions</span><p id="par0140" class="elsevierStylePara elsevierViewall">In both studies COPD was defined as the presence of FEV1&#47;FVC<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>70&#37; &#40;post-BD in Pneumobil Study and pre-BD in 2002 Study&#41;&#44; with or without symptoms&#44; and without asthma or other respiratory diseases&#44; which were excluded by the questionnaire&#44; according to the Global Initiative for COPD &#40;GOLD&#41; definition&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Individuals with symptoms but FEV1&#47;FVC<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>70&#37; were excluded as non COPD cases&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The severity of COPD was based on GOLD criteria and the ECCS reference values for Pneumobil and adapted in the 2002 Study&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The Pneumobil data was re-analysed according to GOLD criteria&#44; which did not exist at the time&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical analysis</span><p id="par0155" class="elsevierStylePara elsevierViewall">Within the ambit of this publication only the most relevant results for the analysis are presented&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Qualitative variables were summarized through counts &#40;<span class="elsevierStyleItalic">n</span>&#41; and percentages &#40;&#37;&#41;&#46; Prevalence of COPD was calculated based on the total of individuals and by gender and smoking habits&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Statistical analyses were carried out using SPSS<span class="elsevierStyleSup">&#174;</span> version 16&#46;0&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0170" class="elsevierStylePara elsevierViewall">In <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; sociodemographic characteristics of study samples for both studies are described&#46; In the Pneumobil&#44; out of 9061 individuals included&#44; 62&#46;8&#37; were male&#44; 13&#46;3&#37; were smokers and 63&#46;6&#37; were never smokers&#46; In the 2002 Study&#44; from the 1384 individuals included&#44; 49&#46;5&#37; were male&#44; 25&#46;4&#37; were smokers and 52&#46;7&#37; were never smokers&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0175" class="elsevierStylePara elsevierViewall">As shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> and in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#44; there was an overall COPD prevalence of 8&#46;96&#37; in the Pneumobil studied population &#40;age range 40 years old&#41;&#44; 11&#46;9&#37; in males and 5&#46;9&#37; in females&#46; In the 2002 Study&#44; 5&#46;34&#37; of COPD cases were identified &#40;age range 35&#8211;69 years old&#41;&#44; 6&#46;3&#37; in males and 4&#46;5&#37; in females&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0180" class="elsevierStylePara elsevierViewall">In these two figures&#44; the distribution of COPD cases by age and gender was also shown&#46; More than 61&#37; of cases were identified above 60 years old in Pneumobil Study vs&#46; more than 32&#37; in 2002 Study&#46; Moreover&#44; 26&#46;5&#37; of cases were identified above 70 years old in Pneumobil Study&#44; an age range not studied in 2002&#46; It should also be noted&#44; that below 60 years old&#44; a higher proportion of cases were females in the 2002 Study vs&#46; Pneumobil &#40;29&#46;8&#37; vs&#46; 10&#46;8&#37;&#41;&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Regarding smoking habits for COPD cases found in both studies&#44; in Pneumobil the prevalence in smokers was 15&#46;4&#37; and in never smokers it was 6&#46;7&#37;&#46; In the 2002 Study the prevalence in smokers was 8&#46;8&#37; and in never smokers was 4&#46;4&#37;&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRefs" href="#fig0015">Figs&#46; 3 and 4</a> show the distribution of COPD severity &#40;GOLD in Pneumobil Study and adapted from GOLD in 2002 Study&#41;&#46; In both studies&#44; it can be seen that the proportion of the combination of stage I and II are similar&#44; 83&#46;9&#37; in Pneumobil Study and 87&#46;8&#37; in 2002 Study&#46; However&#44; more cases were found in stage I in 2002 Study &#40;47&#46;3&#37; vs&#46; 30&#46;8&#37;&#41;&#46; In addition&#44; even with a cut-off of 69 years old in the 2002 Study&#44; the proportion of combined stage III and IV is very similar in both studies&#44; but higher in Pneumobil &#40;16&#44;1&#37; vs&#46; 12&#44;2&#37;&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0195" class="elsevierStylePara elsevierViewall">In <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> we present the distribution of COPD cases by smoking status and severity&#46; In Pneumobil 21&#46;2&#37; of cases were found in smokers and in 2002 Study it doubled to 41&#46;9&#37;&#46; As referred to above&#44; there was a low prevalence of smokers in Pneumobil &#40;13&#46;3&#37;&#41; compared to 25&#46;4&#37; in the 2002 Study&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0200" class="elsevierStylePara elsevierViewall">In general&#44; the distribution of the cases by smoking status and severity &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41; overlaps the general distribution of severity in both studies &#40;<a class="elsevierStyleCrossRefs" href="#fig0015">Figs&#46; 3 and 4</a>&#41;&#44; with around 85&#8211;90&#37; of cases in stage I and II&#46; In more severe stages&#44; the trend is similar in both studies by smoking class&#44; but for instance&#44; in stage III the ex-smokers in 2002 are 9&#46;1&#37; of cases&#44; while in Pneumobil we found 18&#46;2&#37; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">The different age range and the higher fraction of ex-smokers in Pneumobil are possible reasons to account for these findings&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0210" class="elsevierStylePara elsevierViewall">Three major and important limitations are present in these studies&#58; &#40;1&#41; for Pneumobil&#44; it is not a truly randomized study&#59; &#40;2&#41; for 2002 Study&#44; the criterion for COPD was not based on a post-bronchodilator spirometry&#59; &#40;3&#41; criteria for obstruction is different in the two studies so the prevalence results cannot be compared&#46; Nevertheless&#44; some results are valid on their own&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Different figures for COPD prevalence were found in the two studies and diverse methodologies may explain these different values&#46; In Pneumobil the age range was larger with individuals over 70 years being included&#46; Even if the fixed ratio criteria for obstruction may overestimate the prevalence in this age range&#44; it is possibly more real than the prevalence of the 2002 Study that excluded individuals of 70 and over&#46; The COPD prevalence of the 2002 Study may be appropriate for the age range studied&#44; but it is surely an underestimate for the general population&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">The concern that older people could be missed because they might not come to centres &#40;possible reason for the low overall prevalence in participants of 70 years and over in Pneumobil Study&#41;&#44; was accounted for in the design of the 2002 Study that excluded this age range&#44; but did not translate into significant different degrees of severity&#46; Nevertheless&#44; more severe stages of disease were found in Pneumobil &#40;perhaps more severe cases volunteered to undergo testing&#41; and this may have under-estimated the prevalence of COPD in 2002&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">A different time frame is another reason for differences&#46; The known prevalence of smoking habits in Portugal was not different in 1995 vs&#46; 2002 &#40;total 17&#46;3&#37; vs&#46; 18&#46;0&#37;&#41;&#44; except for a slight increase in female smokers &#40;6&#46;5&#37; vs&#46; 7&#46;9&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><p id="par0230" class="elsevierStylePara elsevierViewall">The lack of randomization is a possible reason for the low prevalence of smokers and ex-smokers in Pneumobil Study&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">The occurrence of more female cases at younger ages in 2002 Study is in line with this time frame difference&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Although the participation rate of the 2002 Study was very low&#44; the representative and random selection procedure of the included sample was assured&#44; which is an added value for this study&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">The fact that Pneumobil was not a truly randomized study&#44; as individuals volunteered for the survey&#44; is a possible factor for discrepancies between the two studies &#40;people living far away from the collection sites might have been excluded&#41;&#46; But in a sample of 12&#44;684 individuals this bias would have been minimized and the bringing of the vehicle to people&#44; who were worried about having the disease&#44; may explain more severe COPD cases reached&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">As a protocol option&#44; in the 2002 Study no bronchodilator was administered to test reversibility&#44; mainly for ethical and operational reasons&#46; This was also a limitation of many other surveys at that time&#44; like NHANES III&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p><p id="par0255" class="elsevierStylePara elsevierViewall">Although it was not possible to apply a true GOLD criteria &#40;due to absence of reversibility test&#44; which might overestimate COPD cases&#41; data can be reasonably accepted&#44; since most of asthma and other chronic airflow limitations were excluded by the questionnaire&#46; This was also the opinion of Fukuchi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> in a Japanese prevalence study&#46;</p><p id="par0260" class="elsevierStylePara elsevierViewall">Another important aspect is that the two studies were done with two different spirometers&#46; If for the Pneumobil Study we think that there is no reason for suspecting errors&#44; for the 2002 Study it may not be the case&#46; A possible limitation of the FVC value &#40;software cutting values of low flows&#41; is suspected because the median of FEV1&#47;FVC ratio was higher than expected &#40;84&#46;4&#37;&#41;&#46; So&#44; the prevalence rate estimated using fixed ratio criteria can&#44; in fact&#44; be underestimated in 2002 Study&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Consistent with others&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;21&#44;26</span></a> these studies also showed higher prevalence rates in men&#46; Increasing age is a significant factor related to prevalence and the older population appears to have an increased risk for COPD&#44; independent of their smoking history&#46;</p><p id="par0270" class="elsevierStylePara elsevierViewall">Globally&#44; the most important risk factors associated with COPD in these studies were age over 60 years&#44; male gender and smoking exposure&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall">Nevertheless&#44; the presence of a significant proportion of COPD cases in never smokers may indicate that other risk factors may be present in the Portuguese population &#40;e&#46;g&#46; biomass exposure&#44; previous respiratory diseases&#44; childhood infections&#41;&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">Higher COPD prevalence values are expected in future prevalence studies as the major limitations of the two studies&#44; that accounted for underestimation &#40;age range&#44; randomization&#44; adequate spirometers&#44; use of post-BD spirometry&#41;&#44; should be corrected&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conclusions</span><p id="par0285" class="elsevierStylePara elsevierViewall">These two studies contributed to our knowledge of COPD prevalence in Portugal&#44; as they suggest a somewhat lower frequency of occurrence than in other European countries&#46; This can be accepted as the consequence of lower percentage of smoking people and of smoking history&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">Globally&#44; the most important risk factors associated with COPD were age over 60 years&#44; male gender and smoking exposure&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">In these surveys&#44; COPD severity stages I and II accounted for over 85&#37; of the cases&#44; and this fact indicates the need for special attention to spirometric approach&#44; its quality and its abnormalities&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">However more frequent in smokers and ex-smokers&#44; COPD occurred also frequently in non-smoker men and women&#44; and this fact justifies a closer attention to other causal factors in the future&#46;</p><p id="par0305" class="elsevierStylePara elsevierViewall">All aspects and limitations regarding methodology highlight the need for a standardized method to evaluate COPD prevalence and associated risks factors&#44; so that results can be compared across countries&#44; as is the case with BOLD project&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0310" class="elsevierStylePara elsevierViewall">It is believed that a concerted effort by everyone involved in health care&#44; governments&#44; public health officials&#44; health care workers&#44; and even the general public&#44; is needed to control this still major public health problem&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Funding</span><p id="par0315" class="elsevierStylePara elsevierViewall">Both studies were conducted by the Respiratory Portuguese Society and funded by <span class="elsevierStyleGrantSponsor" id="gs1">Boehringer Ingelheim</span> and <span class="elsevierStyleGrantSponsor" id="gs2">Pfizer</span>&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflicts of interest</span><p id="par0320" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        ]
        10 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Conflicts of interest"
        ]
        11 => array:2 [
          "identificador" => "xack54274"
          "titulo" => "Acknowledgments"
        ]
        12 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2012-01-18"
    "fechaAceptado" => "2012-11-07"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec239423"
          "palabras" => array:5 [
            0 => "Chronic obstructive pulmonary disease"
            1 => "Chronic obstructive pulmonary disease prevalence"
            2 => "Pneumobil"
            3 => "Airway obstruction"
            4 => "Portugal"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec239424"
          "palabras" => array:5 [
            0 => "Doen&#231;a pulmonar obstrutiva cr&#243;nica"
            1 => "Preval&#234;ncia da doen&#231;a pulmonar obstrutiva cr&#243;nica"
            2 => "Pneumobil"
            3 => "Obstru&#231;&#227;o das vias a&#233;reas"
            4 => "Portugal"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Summary"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Chronic obstructive pulmonary disease &#40;COPD&#41; has been a leading cause of morbidity and mortality worldwide&#44; over the years&#46; In 1995&#44; the implementation of a respiratory function survey seemed to be an adequate way to draw attention to neglected respiratory symptoms and increase the awareness of spirometry surveys&#46; By 2002 there were new consensual guidelines in place and the awareness that prevalence of COPD depended on the criteria used for airway obstruction definition&#46; The purpose of this study is to revisit the two studies and to turn public some of the data and respective methodologies&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">From Pneumobil Study database of 12&#44;684 subjects&#44; only the individuals with 40&#43; years old &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#46;061&#41; were selected&#46; The 2002 Study included a randomized representative sample of 1384 individuals with 35&#8211;69 years old&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The prevalence of COPD was 8&#46;96&#37; in Pneumobil and 5&#46;34&#37; in the 2002 Study&#46; In both studies&#44; presence of COPD was greater in males and there was a positive association between presence of COPD and older age groups&#46; Smokers and ex-smokers showed a higher proportion of cases of COPD&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Prevalence in Portugal is lower than in other European countries&#46; This may be related to lower smokers&#8217; prevalence&#46; Globally&#44; the most important risk factors associated with COPD were age over 60 years&#44; male gender and smoking exposure&#46; All aspects and limitations regarding different recruitment methodologies and different criteria for defining COPD cases highlight the need of a standardized method to evaluate COPD prevalence and associated risks factors&#44; whose results can be compared across countries&#44; as it is the case of BOLD project&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A doen&#231;a pulmonar obstrutiva cr&#243;nica &#40;DPOC&#41; tem sido&#44; ao longo dos anos&#44; uma importante causa de morbilidade e mortalidade no mundo&#46; Em 1995&#44; a implementa&#231;&#227;o de um rastreio da fun&#231;&#227;o respirat&#243;ria pareceu a forma mais adequada para alertar para os sintomas respirat&#243;rios negligenciados e sensibilizar para os rastreios espirom&#233;tricos&#46; Em 2002&#44; foram criadas novas normas consensuais de diagn&#243;stico e o reconhecimento de que a preval&#234;ncia da DPOC depende dos crit&#233;rios de defini&#231;&#227;o de obstru&#231;&#227;o das vias a&#233;reas&#46; O objetivo deste estudo foi revisitar estes 2 estudos e publicar alguns dos resultados e respetivas metodologias&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dos 12&#44;684 indiv&#237;duos que constavam da base de dados do Pneumobil&#44; apenas os indiv&#237;duos com 40 e mais anos &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9061&#41; foram considerados para esta an&#225;lise&#46; No estudo de 2002 foi inclu&#237;da uma amostra aleatorizada e representativa de 1384 indiv&#237;duos&#44; com idades entre os 35 e os 69 anos&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A preval&#234;ncia da DPOC foi de 8&#46;96&#37; no estudo Pneumobil e de 5&#46;34&#37; no estudo de 2002&#46; Em ambos os estudos&#44; a presen&#231;a da DPOC foi superior no sexo masculino&#44; tendo-se verificado uma associa&#231;&#227;o positiva entre a presen&#231;a da DPOC e os grupos et&#225;rios mais velhos&#46; Nos fumadores e ex-fumadores encontrou-se maior propor&#231;&#227;o de casos com DPOC&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#245;es</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A preval&#234;ncia em Portugal &#233; mais baixa do que noutros pa&#237;ses europeus&#44; o que pode estar relacionado com uma menor preval&#234;ncia de tabagismo&#46; De um modo geral&#44; os fatores de risco mais importantes que mostraram a associa&#231;&#227;o com a DPOC foram a idade maior do que 60 anos&#44; o sexo masculino e a exposi&#231;&#227;o tab&#225;gica&#46; Todos os aspetos e as limita&#231;&#245;es que se referem a diferentes crit&#233;rios de defini&#231;&#227;o e a metodologias de recrutamento real&#231;am a necessidade de m&#233;todos padronizados para determinar a preval&#234;ncia da DPOC e os fatores de risco associados&#44; cujos resultados possam ser comparados entre pa&#237;ses&#44; como acontece no projeto BOLD&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Cardoso&#44; J&#59; Doen&#231;a Pulmonar Obstrutiva Cr&#243;nica em Portugal&#58; estudo Pneumobil &#40;1995&#41; e estudo de preval&#234;ncia de 2002 revisitados&#46; Rev Port Pneumol 2013&#46; <span class="elsevierStyleInterRef" id="intr0005" href="doi:10.1016/j.rppneu.2012.11.005">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppneu&#46;2012&#46;11&#46;005</span></p>"
      ]
    ]
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution of Pneumobil COPD cases&#44; by age and gender &#40;post-BD criterion&#41;&#46;</p>"
        ]
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      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Distribution of 2002 Study COPD cases&#44; by age and gender &#40;pre-BD criterion&#41;&#46;</p>"
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      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Distribution of COPD cases by GOLD stages in Pneumobil &#40;post-BD&#41;&#46;</p>"
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      3 => array:7 [
        "identificador" => "fig0020"
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Distribution of COPD cases by adapted severity stages in the 2002 Study &#40;pre-BD&#41;&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Pneumobil Study &#40;&#8805;40<span class="elsevierStyleHsp" style=""></span>yr&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">2002 Study &#40;35&#8211;69<span class="elsevierStyleHsp" style=""></span>yr&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sample Size</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9061&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1384&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Mean Age</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">56&#46;4 &#40;&#177;15&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">48&#46;6 &#40;&#177;9&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gender</span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5690 &#40;62&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">685 &#40;49&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">3371 &#40;37&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">699 &#40;50&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Smokers&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1201 &#40;13&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">352 &#40;25&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">2097 &#40;23&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">303 &#40;21&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Never smokers&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5763 &#40;63&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">729 &#40;52&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Values are given as no&#46; &#40;&#37;&#41;&#46;</p>"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Socio-demographic characteristics of study sample in Pneumobil and 2002 Study&#46;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a></p>"
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">In both studies&#44; the proportion of the never smokers class was very similar&#44; i&#46;e&#46;&#44; around 44&#37;&#46; However&#44; the prevalence of COPD in this class was higher in Pneumobil than in 2002 Study &#40;6&#46;7&#37; vs&#46; 4&#46;4&#37;&#41;&#46;</p>"
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                  \t\t\t\t">GOLD stages&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">2002 Study &#40;35&#8211;69<span class="elsevierStyleHsp" style=""></span>yr&#41;</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Smokers&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Ex-smokers&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">COPD prevalence by smoking habits and GOLD stages&#46;</p>"
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        "texto" => "<p id="par0325" class="elsevierStylePara elsevierViewall">The authors would like to thank to&#58; &#40;a&#41; Working Committee of Pneumobil and 2002 studies&#44; under the scientific support of Respiratory Portuguese Society&#44; in particular to Prof&#46; J&#46;H&#46; Paiva de Carvalho&#44; Prof&#46; Ant&#243;nio Couto&#44; Prof&#46; Bensabat Rendas&#44; Dr&#46; J&#46; Pontes da Mata&#44; Dr&#46; Isabel Melo&#44; Dr&#46; Paes Cardoso&#46; Honour Committee&#58; Prof&#46; A&#46;J&#46; A&#46; Robalo Cordeiro&#44; Prof&#46; M&#46; Freitas e Costa&#44; Prof&#46; Ramiro &#193;vila e Prof&#46; J&#46; Agostinho Marques&#46; &#40;b&#41; Escola Superior de Tecnologia da Sa&#250;de de Coimbra &#8211; Prof&#46; Jorge Conde &#8211; and to Associa&#231;&#227;o Portuguesa de Cardiopneumologistas &#8211; Lu&#237;s Caldeira &#8211; and all the involved cardiopulmonology technicians&#44; in particular Alexandra Guardado and Helena Pedrosa&#46; &#40;c&#41; Prof&#46; Ant&#243;nio Gouveia for the statistical support&#46;</p> <p id="par0350" class="elsevierStylePara elsevierViewall">A special thank you to Prof&#46; G&#46; Viegi for all the sympathy and for the accurate and insightful revision of the 2002 Study data&#46;</p> <p id="par0355" class="elsevierStylePara elsevierViewall">The investigators would also like to thank to Carlos Capela&#44; as sponsor project leader&#44; Ana Dur&#227;o and Jos&#233; Antunes and everybody at Boehringer Ingelheim Portugal and Pfizer who were involved and collaborated in these two projects&#46;</p>"
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Original article
Chronic obstructive pulmonary disease in Portugal: Pneumobil (1995) and 2002 Prevalence Studies revisited
J. Cardosoa,
Corresponding author
, J.R. Ferreirab, J. Almeidac, J.M. Santosd, F. Rodriguese, M.J. Matosf, M. Gasparg
a Serviço de Pneumologia, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central, E.P.E., Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
b Serviço de Pneumologia, Laboratório de Função Pulmonar, Hospital das Forças Armadas, Lisboa, Portugal
c Serviço de Pneumologia, Hospital de São João, Porto, Portugal
d Serviço de Pneumologia, Centro Hospitalar de Coimbra, Coimbra, Portugal
e Serviço de Pneumologia II, Centro de Estudos Doenças Crónicas, Hospital Pulido Valente, Centro Hospitalar de Lisboa Norte, E.P.E., Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
f Serviço de Pneumologia, Hospitais Universitários de Coimbra, Coimbra, Portugal
g Departamento de Medicina, Boehringer Ingelheim Lda., Lisboa, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic obstructive pulmonary disease &#40;COPD&#41; is a rising cause of morbidity and mortality worldwide&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> and Portugal is no exception&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In 1990 COPD was the sixth most common cause of death worldwide and was ranked 12th for DALYs &#40;disability-adjusted life years&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> It has been projected that by 2020 it will have risen to 5th rank&#44; and be the third most common cause of death&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">This situation has led to the development of the Global Initiative for COPD &#40;GOLD&#41;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> of which the primary goal is to control and invert the burden of COPD&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Historical background</span><p id="par0020" class="elsevierStylePara elsevierViewall">In 1995&#44; both the American Thoracic Society &#40;ATS&#41; and the European Respiratory Society &#40;ERS&#41; published data about the prevalence of airways obstruction in a general population as a plan to standardize the diagnosis of COPD&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">At that time&#44; in Portugal&#44; the information on the prevalence of respiratory diseases was scarce and pulmonary function evaluation and screening was not a regular practice in the diagnosis workup&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">For many years&#44; early manifestations of COPD were unnoticed and undetectable&#44; both by patients and physicians&#44; because the respiratory function characterization of the inflammatory airway pathology was rarely requested&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The implementation of a pulmonary function survey seemed to be an appropriate way of drawing attention to unknown symptoms and to measure disturbances&#44; and at the same time to alert both population and practitioners to this health problem&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The first Pneumobil Study took place in Portugal from 1995 to 1997 with the goal of estimating the prevalence of COPD&#44; asthma and respiratory symptoms and characterizing the associated risk factors in the Portuguese population&#44; including population above 18 years old&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In 1998 the Global Initiative for Chronic Obstructive Lung Disease &#40;GOLD&#41; was launched<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and in 2001 the guidelines<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> for the classification of COPD were published&#46; The main goals of GOLD are to increase awareness of COPD&#44; decrease morbidity and mortality&#44; and to improve prevention and management of COPD through a concerted worldwide effort by people involved in health care and health care policy-making&#44; as well as to encourage a renewed research interest in this highly prevalent disease&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">One major problem that GOLD came up with was the incomplete information in many countries about the prevalence and causes of COPD&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">By that time there were new consensual guidelines and the awareness that prevalence of COPD in a general population depended very much on the criteria used for airway obstruction definition&#44; and data showed wide prevalence rates across countries&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Considering these new aspects highlighted by GOLD&#44; a new Prevalence Study was implemented&#44; 2002 Prevalence Study&#44; which aimed to estimate the prevalence rates of COPD and evaluate the severity of obstruction&#44; smoking habits&#44; and other risk factors in Portugal&#46; GOLD</p><p id="par0065" class="elsevierStylePara elsevierViewall">Despite the implementation of GOLD&#44; COPD is nowadays ranked fourth in developed countries&#44; with approximately 2&#46;75 million deaths per year&#44; representing 4&#46;8&#37; of deaths&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> It still is an under-recognized&#44; under-diagnosed and under-treated disease&#44; and is frequently diagnosed too late&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#8211;15</span></a> GOLD&#39;s approach appears to overestimate</p><p id="par0070" class="elsevierStylePara elsevierViewall">COPD in older individuals and to underestimate it in younger adults&#46; This raises questions about which criteria should be used for the definition of obstruction and which reference equations are appropriate for the populations&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In 2004&#44; 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since data from both studies are dispersed in communications&#44; posters&#44; partial data published in books&#44; oral communications with no abstracts and publications in non-available journals&#44; which make searching of data very difficult&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;12&#44;17&#44;18</span></a> Moreover&#44; we present here&#44; for the first time&#44; the analysis of the fraction of the population older than 40 years of the Pneumobil Study&#46;</p></span></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material and methods</span><p id="par0090" class="elsevierStylePara elsevierViewall">The two studies had different methodology&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Pneumobil Study methodology</span><p id="par0095" class="elsevierStylePara elsevierViewall">This survey was carried out between September 1995 and December 1997 in 17 of the 18 districts of continental Portugal&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">This was a survey of volunteer individuals who attended the study collection sites&#44; mostly located on public places and who agreed to answer a questionnaire and perform a spirometry&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The population included was 14&#44;002 individuals but only 12&#44;684 adults over 18 years of age were considered eligible &#40;completed questionnaire and acceptable spirometry&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">For this analysis we have selected from the database only the individuals older than 40 years &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9061&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The questionnaire&#44; based on ATS Respiratory Questionnaire&#44; included demographic parameters&#44; smoking habits&#44; professional activity&#44; physical activity&#44; exposure to dust and chemical smoke&#44; history of pathology with effect on respiratory function and medication use&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Pre and post-bronchodilator spirometry was performed according to ATS guidelines<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#44; using electronic spirometers Masterscreen IOS &#40;Jaeger&#41;&#44; version 4&#46;3&#44; with a Silverman pneumotachograph&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">2002 Epidemiological Study methodology</span><p id="par0125" class="elsevierStylePara elsevierViewall">This Epidemiological Study was carried out between October 2001 and March 2002 in all districts of continental Portugal&#44; stratified by region&#44; age and gender according to demographic data from INE &#40;National Statistics Institute &#8211; census 2001&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">The sample was selected randomly from the telephone directory and for those who agreed to participate in the study a date and time was scheduled for questionnaire answering and spirometry measurements&#46; Because telephonic answers were very scarce 11&#44;500 individuals had to be contacted to obtain the planned sample size&#46; It included 1475 individuals aged between 35 and 69 years old&#44; with a participation rate of 12&#46;8&#37;&#46; From these only 1384 individuals were considered eligible &#40;having completed the questionnaire and acceptable spirometry&#41;&#59; however this sample was representative of the Portuguese population&#46; People over 70 years old were excluded as participation by the older individuals which could have resulted in bias&#44; as happened in the case of the Iberpoc Study&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">The questionnaire was the same as in the previous study&#46; Spirometry was performed according to ATS recommendations<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&#44; using a Vitalograph alpha III<span class="elsevierStyleSup">&#174;</span> spirometer&#44; equipped with SafeTway<span class="elsevierStyleSup">&#174;</span> mouthpiece adaptors &#40;Fleisch pneumotachograph&#41;&#46; In this study&#44; the reversibility test was not performed for ethical and operational reasons &#40;for example&#44; no physician was available during spirometry tests&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Definitions</span><p id="par0140" class="elsevierStylePara elsevierViewall">In both studies COPD was defined as the presence of FEV1&#47;FVC<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>70&#37; &#40;post-BD in Pneumobil Study and pre-BD in 2002 Study&#41;&#44; with or without symptoms&#44; and without asthma or other respiratory diseases&#44; which were excluded by the questionnaire&#44; according to the Global Initiative for COPD &#40;GOLD&#41; definition&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Individuals with symptoms but FEV1&#47;FVC<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>70&#37; were excluded as non COPD cases&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The severity of COPD was based on GOLD criteria and the ECCS reference values for Pneumobil and adapted in the 2002 Study&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The Pneumobil data was re-analysed according to GOLD criteria&#44; which did not exist at the time&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical analysis</span><p id="par0155" class="elsevierStylePara elsevierViewall">Within the ambit of this publication only the most relevant results for the analysis are presented&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Qualitative variables were summarized through counts &#40;<span class="elsevierStyleItalic">n</span>&#41; and percentages &#40;&#37;&#41;&#46; Prevalence of COPD was calculated based on the total of individuals and by gender and smoking habits&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Statistical analyses were carried out using SPSS<span class="elsevierStyleSup">&#174;</span> version 16&#46;0&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0170" class="elsevierStylePara elsevierViewall">In <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; sociodemographic characteristics of study samples for both studies are described&#46; In the Pneumobil&#44; out of 9061 individuals included&#44; 62&#46;8&#37; were male&#44; 13&#46;3&#37; were smokers and 63&#46;6&#37; were never smokers&#46; In the 2002 Study&#44; from the 1384 individuals included&#44; 49&#46;5&#37; were male&#44; 25&#46;4&#37; were smokers and 52&#46;7&#37; were never smokers&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0175" class="elsevierStylePara elsevierViewall">As shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> and in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#44; there was an overall COPD prevalence of 8&#46;96&#37; in the Pneumobil studied population &#40;age range 40 years old&#41;&#44; 11&#46;9&#37; in males and 5&#46;9&#37; in females&#46; In the 2002 Study&#44; 5&#46;34&#37; of COPD cases were identified &#40;age range 35&#8211;69 years old&#41;&#44; 6&#46;3&#37; in males and 4&#46;5&#37; in females&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0180" class="elsevierStylePara elsevierViewall">In these two figures&#44; the distribution of COPD cases by age and gender was also shown&#46; More than 61&#37; of cases were identified above 60 years old in Pneumobil Study vs&#46; more than 32&#37; in 2002 Study&#46; Moreover&#44; 26&#46;5&#37; of cases were identified above 70 years old in Pneumobil Study&#44; an age range not studied in 2002&#46; It should also be noted&#44; that below 60 years old&#44; a higher proportion of cases were females in the 2002 Study vs&#46; Pneumobil &#40;29&#46;8&#37; vs&#46; 10&#46;8&#37;&#41;&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Regarding smoking habits for COPD cases found in both studies&#44; in Pneumobil the prevalence in smokers was 15&#46;4&#37; and in never smokers it was 6&#46;7&#37;&#46; In the 2002 Study the prevalence in smokers was 8&#46;8&#37; and in never smokers was 4&#46;4&#37;&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRefs" href="#fig0015">Figs&#46; 3 and 4</a> show the distribution of COPD severity &#40;GOLD in Pneumobil Study and adapted from GOLD in 2002 Study&#41;&#46; In both studies&#44; it can be seen that the proportion of the combination of stage I and II are similar&#44; 83&#46;9&#37; in Pneumobil Study and 87&#46;8&#37; in 2002 Study&#46; However&#44; more cases were found in stage I in 2002 Study &#40;47&#46;3&#37; vs&#46; 30&#46;8&#37;&#41;&#46; In addition&#44; even with a cut-off of 69 years old in the 2002 Study&#44; the proportion of combined stage III and IV is very similar in both studies&#44; but higher in Pneumobil &#40;16&#44;1&#37; vs&#46; 12&#44;2&#37;&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0195" class="elsevierStylePara elsevierViewall">In <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> we present the distribution of COPD cases by smoking status and severity&#46; In Pneumobil 21&#46;2&#37; of cases were found in smokers and in 2002 Study it doubled to 41&#46;9&#37;&#46; As referred to above&#44; there was a low prevalence of smokers in Pneumobil &#40;13&#46;3&#37;&#41; compared to 25&#46;4&#37; in the 2002 Study&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0200" class="elsevierStylePara elsevierViewall">In general&#44; the distribution of the cases by smoking status and severity &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41; overlaps the general distribution of severity in both studies &#40;<a class="elsevierStyleCrossRefs" href="#fig0015">Figs&#46; 3 and 4</a>&#41;&#44; with around 85&#8211;90&#37; of cases in stage I and II&#46; In more severe stages&#44; the trend is similar in both studies by smoking class&#44; but for instance&#44; in stage III the ex-smokers in 2002 are 9&#46;1&#37; of cases&#44; while in Pneumobil we found 18&#46;2&#37; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">The different age range and the higher fraction of ex-smokers in Pneumobil are possible reasons to account for these findings&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0210" class="elsevierStylePara elsevierViewall">Three major and important limitations are present in these studies&#58; &#40;1&#41; for Pneumobil&#44; it is not a truly randomized study&#59; &#40;2&#41; for 2002 Study&#44; the criterion for COPD was not based on a post-bronchodilator spirometry&#59; &#40;3&#41; criteria for obstruction is different in the two studies so the prevalence results cannot be compared&#46; Nevertheless&#44; some results are valid on their own&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Different figures for COPD prevalence were found in the two studies and diverse methodologies may explain these different values&#46; In Pneumobil the age range was larger with individuals over 70 years being included&#46; Even if the fixed ratio criteria for obstruction may overestimate the prevalence in this age range&#44; it is possibly more real than the prevalence of the 2002 Study that excluded individuals of 70 and over&#46; The COPD prevalence of the 2002 Study may be appropriate for the age range studied&#44; but it is surely an underestimate for the general population&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">The concern that older people could be missed because they might not come to centres &#40;possible reason for the low overall prevalence in participants of 70 years and over in Pneumobil Study&#41;&#44; was accounted for in the design of the 2002 Study that excluded this age range&#44; but did not translate into significant different degrees of severity&#46; Nevertheless&#44; more severe stages of disease were found in Pneumobil &#40;perhaps more severe cases volunteered to undergo testing&#41; and this may have under-estimated the prevalence of COPD in 2002&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">A different time frame is another reason for differences&#46; The known prevalence of smoking habits in Portugal was not different in 1995 vs&#46; 2002 &#40;total 17&#46;3&#37; vs&#46; 18&#46;0&#37;&#41;&#44; except for a slight increase in female smokers &#40;6&#46;5&#37; vs&#46; 7&#46;9&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><p id="par0230" class="elsevierStylePara elsevierViewall">The lack of randomization is a possible reason for the low prevalence of smokers and ex-smokers in Pneumobil Study&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">The occurrence of more female cases at younger ages in 2002 Study is in line with this time frame difference&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Although the participation rate of the 2002 Study was very low&#44; the representative and random selection procedure of the included sample was assured&#44; which is an added value for this study&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">The fact that Pneumobil was not a truly randomized study&#44; as individuals volunteered for the survey&#44; is a possible factor for discrepancies between the two studies &#40;people living far away from the collection sites might have been excluded&#41;&#46; But in a sample of 12&#44;684 individuals this bias would have been minimized and the bringing of the vehicle to people&#44; who were worried about having the disease&#44; may explain more severe COPD cases reached&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">As a protocol option&#44; in the 2002 Study no bronchodilator was administered to test reversibility&#44; mainly for ethical and operational reasons&#46; This was also a limitation of many other surveys at that time&#44; like NHANES III&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p><p id="par0255" class="elsevierStylePara elsevierViewall">Although it was not possible to apply a true GOLD criteria &#40;due to absence of reversibility test&#44; which might overestimate COPD cases&#41; data can be reasonably accepted&#44; since most of asthma and other chronic airflow limitations were excluded by the questionnaire&#46; This was also the opinion of Fukuchi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> in a Japanese prevalence study&#46;</p><p id="par0260" class="elsevierStylePara elsevierViewall">Another important aspect is that the two studies were done with two different spirometers&#46; If for the Pneumobil Study we think that there is no reason for suspecting errors&#44; for the 2002 Study it may not be the case&#46; A possible limitation of the FVC value &#40;software cutting values of low flows&#41; is suspected because the median of FEV1&#47;FVC ratio was higher than expected &#40;84&#46;4&#37;&#41;&#46; So&#44; the prevalence rate estimated using fixed ratio criteria can&#44; in fact&#44; be underestimated in 2002 Study&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Consistent with others&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;21&#44;26</span></a> these studies also showed higher prevalence rates in men&#46; Increasing age is a significant factor related to prevalence and the older population appears to have an increased risk for COPD&#44; independent of their smoking history&#46;</p><p id="par0270" class="elsevierStylePara elsevierViewall">Globally&#44; the most important risk factors associated with COPD in these studies were age over 60 years&#44; male gender and smoking exposure&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall">Nevertheless&#44; the presence of a significant proportion of COPD cases in never smokers may indicate that other risk factors may be present in the Portuguese population &#40;e&#46;g&#46; biomass exposure&#44; previous respiratory diseases&#44; childhood infections&#41;&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">Higher COPD prevalence values are expected in future prevalence studies as the major limitations of the two studies&#44; that accounted for underestimation &#40;age range&#44; randomization&#44; adequate spirometers&#44; use of post-BD spirometry&#41;&#44; should be corrected&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conclusions</span><p id="par0285" class="elsevierStylePara elsevierViewall">These two studies contributed to our knowledge of COPD prevalence in Portugal&#44; as they suggest a somewhat lower frequency of occurrence than in other European countries&#46; This can be accepted as the consequence of lower percentage of smoking people and of smoking history&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">Globally&#44; the most important risk factors associated with COPD were age over 60 years&#44; male gender and smoking exposure&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">In these surveys&#44; COPD severity stages I and II accounted for over 85&#37; of the cases&#44; and this fact indicates the need for special attention to spirometric approach&#44; its quality and its abnormalities&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">However more frequent in smokers and ex-smokers&#44; COPD occurred also frequently in non-smoker men and women&#44; and this fact justifies a closer attention to other causal factors in the future&#46;</p><p id="par0305" class="elsevierStylePara elsevierViewall">All aspects and limitations regarding methodology highlight the need for a standardized method to evaluate COPD prevalence and associated risks factors&#44; so that results can be compared across countries&#44; as is the case with BOLD project&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0310" class="elsevierStylePara elsevierViewall">It is believed that a concerted effort by everyone involved in health care&#44; governments&#44; public health officials&#44; health care workers&#44; and even the general public&#44; is needed to control this still major public health problem&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Funding</span><p id="par0315" class="elsevierStylePara elsevierViewall">Both studies were conducted by the Respiratory Portuguese Society and funded by <span class="elsevierStyleGrantSponsor" id="gs1">Boehringer Ingelheim</span> and <span class="elsevierStyleGrantSponsor" id="gs2">Pfizer</span>&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflicts of interest</span><p id="par0320" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Chronic obstructive pulmonary disease &#40;COPD&#41; has been a leading cause of morbidity and mortality worldwide&#44; over the years&#46; In 1995&#44; the implementation of a respiratory function survey seemed to be an adequate way to draw attention to neglected respiratory symptoms and increase the awareness of spirometry surveys&#46; By 2002 there were new consensual guidelines in place and the awareness that prevalence of COPD depended on the criteria used for airway obstruction definition&#46; The purpose of this study is to revisit the two studies and to turn public some of the data and respective methodologies&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">From Pneumobil Study database of 12&#44;684 subjects&#44; only the individuals with 40&#43; years old &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#46;061&#41; were selected&#46; The 2002 Study included a randomized representative sample of 1384 individuals with 35&#8211;69 years old&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The prevalence of COPD was 8&#46;96&#37; in Pneumobil and 5&#46;34&#37; in the 2002 Study&#46; In both studies&#44; presence of COPD was greater in males and there was a positive association between presence of COPD and older age groups&#46; Smokers and ex-smokers showed a higher proportion of cases of COPD&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Prevalence in Portugal is lower than in other European countries&#46; This may be related to lower smokers&#8217; prevalence&#46; Globally&#44; the most important risk factors associated with COPD were age over 60 years&#44; male gender and smoking exposure&#46; All aspects and limitations regarding different recruitment methodologies and different criteria for defining COPD cases highlight the need of a standardized method to evaluate COPD prevalence and associated risks factors&#44; whose results can be compared across countries&#44; as it is the case of BOLD project&#46;</p>"
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      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A doen&#231;a pulmonar obstrutiva cr&#243;nica &#40;DPOC&#41; tem sido&#44; ao longo dos anos&#44; uma importante causa de morbilidade e mortalidade no mundo&#46; Em 1995&#44; a implementa&#231;&#227;o de um rastreio da fun&#231;&#227;o respirat&#243;ria pareceu a forma mais adequada para alertar para os sintomas respirat&#243;rios negligenciados e sensibilizar para os rastreios espirom&#233;tricos&#46; Em 2002&#44; foram criadas novas normas consensuais de diagn&#243;stico e o reconhecimento de que a preval&#234;ncia da DPOC depende dos crit&#233;rios de defini&#231;&#227;o de obstru&#231;&#227;o das vias a&#233;reas&#46; O objetivo deste estudo foi revisitar estes 2 estudos e publicar alguns dos resultados e respetivas metodologias&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dos 12&#44;684 indiv&#237;duos que constavam da base de dados do Pneumobil&#44; apenas os indiv&#237;duos com 40 e mais anos &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9061&#41; foram considerados para esta an&#225;lise&#46; No estudo de 2002 foi inclu&#237;da uma amostra aleatorizada e representativa de 1384 indiv&#237;duos&#44; com idades entre os 35 e os 69 anos&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A preval&#234;ncia da DPOC foi de 8&#46;96&#37; no estudo Pneumobil e de 5&#46;34&#37; no estudo de 2002&#46; Em ambos os estudos&#44; a presen&#231;a da DPOC foi superior no sexo masculino&#44; tendo-se verificado uma associa&#231;&#227;o positiva entre a presen&#231;a da DPOC e os grupos et&#225;rios mais velhos&#46; Nos fumadores e ex-fumadores encontrou-se maior propor&#231;&#227;o de casos com DPOC&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#245;es</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A preval&#234;ncia em Portugal &#233; mais baixa do que noutros pa&#237;ses europeus&#44; o que pode estar relacionado com uma menor preval&#234;ncia de tabagismo&#46; De um modo geral&#44; os fatores de risco mais importantes que mostraram a associa&#231;&#227;o com a DPOC foram a idade maior do que 60 anos&#44; o sexo masculino e a exposi&#231;&#227;o tab&#225;gica&#46; Todos os aspetos e as limita&#231;&#245;es que se referem a diferentes crit&#233;rios de defini&#231;&#227;o e a metodologias de recrutamento real&#231;am a necessidade de m&#233;todos padronizados para determinar a preval&#234;ncia da DPOC e os fatores de risco associados&#44; cujos resultados possam ser comparados entre pa&#237;ses&#44; como acontece no projeto BOLD&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Cardoso&#44; J&#59; Doen&#231;a Pulmonar Obstrutiva Cr&#243;nica em Portugal&#58; estudo Pneumobil &#40;1995&#41; e estudo de preval&#234;ncia de 2002 revisitados&#46; Rev Port Pneumol 2013&#46; <span class="elsevierStyleInterRef" id="intr0005" href="doi:10.1016/j.rppneu.2012.11.005">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppneu&#46;2012&#46;11&#46;005</span></p>"
      ]
    ]
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        "figura" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution of Pneumobil COPD cases&#44; by age and gender &#40;post-BD criterion&#41;&#46;</p>"
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      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Distribution of 2002 Study COPD cases&#44; by age and gender &#40;pre-BD criterion&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Distribution of COPD cases by GOLD stages in Pneumobil &#40;post-BD&#41;&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Distribution of COPD cases by adapted severity stages in the 2002 Study &#40;pre-BD&#41;&#46;</p>"
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Pneumobil Study &#40;&#8805;40<span class="elsevierStyleHsp" style=""></span>yr&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">2002 Study &#40;35&#8211;69<span class="elsevierStyleHsp" style=""></span>yr&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sample Size</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9061&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1384&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Mean Age</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#46;4 &#40;&#177;15&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;6 &#40;&#177;9&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gender</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5690 &#40;62&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">685 &#40;49&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3371 &#40;37&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">699 &#40;50&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Smoking habits</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Smokers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1201 &#40;13&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">352 &#40;25&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ex-smokers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2097 &#40;23&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">303 &#40;21&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Never smokers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5763 &#40;63&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">729 &#40;52&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Values are given as no&#46; &#40;&#37;&#41;&#46;</p>"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Socio-demographic characteristics of study sample in Pneumobil and 2002 Study&#46;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a></p>"
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      5 => array:7 [
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">In both studies&#44; the proportion of the never smokers class was very similar&#44; i&#46;e&#46;&#44; around 44&#37;&#46; However&#44; the prevalence of COPD in this class was higher in Pneumobil than in 2002 Study &#40;6&#46;7&#37; vs&#46; 4&#46;4&#37;&#41;&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t">GOLD stages&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Pneumobil Study &#40;&#8805;40<span class="elsevierStyleHsp" style=""></span>yr&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">2002 Study &#40;35&#8211;69<span class="elsevierStyleHsp" style=""></span>yr&#41;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Smokers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Ex-smokers&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Never smokers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Smokers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Ex-smokers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Never smokers&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0325" class="elsevierStylePara elsevierViewall">The authors would like to thank to&#58; &#40;a&#41; Working Committee of Pneumobil and 2002 studies&#44; under the scientific support of Respiratory Portuguese Society&#44; in particular to Prof&#46; J&#46;H&#46; Paiva de Carvalho&#44; Prof&#46; Ant&#243;nio Couto&#44; Prof&#46; Bensabat Rendas&#44; Dr&#46; J&#46; Pontes da Mata&#44; Dr&#46; Isabel Melo&#44; Dr&#46; Paes Cardoso&#46; Honour Committee&#58; Prof&#46; A&#46;J&#46; A&#46; Robalo Cordeiro&#44; Prof&#46; M&#46; Freitas e Costa&#44; Prof&#46; Ramiro &#193;vila e Prof&#46; J&#46; Agostinho Marques&#46; &#40;b&#41; Escola Superior de Tecnologia da Sa&#250;de de Coimbra &#8211; Prof&#46; Jorge Conde &#8211; and to Associa&#231;&#227;o Portuguesa de Cardiopneumologistas &#8211; Lu&#237;s Caldeira &#8211; and all the involved cardiopulmonology technicians&#44; in particular Alexandra Guardado and Helena Pedrosa&#46; &#40;c&#41; Prof&#46; Ant&#243;nio Gouveia for the statistical support&#46;</p> <p id="par0350" class="elsevierStylePara elsevierViewall">A special thank you to Prof&#46; G&#46; Viegi for all the sympathy and for the accurate and insightful revision of the 2002 Study data&#46;</p> <p id="par0355" class="elsevierStylePara elsevierViewall">The investigators would also like to thank to Carlos Capela&#44; as sponsor project leader&#44; Ana Dur&#227;o and Jos&#233; Antunes and everybody at Boehringer Ingelheim Portugal and Pfizer who were involved and collaborated in these two projects&#46;</p>"
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