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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Adenosine deaminase &#40;ADA&#41; has been promoted as a quick&#44; efficient and cost-effective method in the diagnosis of tuberculous effusions&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However&#44; the predictive parameters of ADA&#44; in the diagnostic workup of tuberculous effusions&#44; depend on the prevalence of the disease in the population<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and no such analysis has been published in Portugal&#44; a country of intermediate tuberculosis &#40;TB&#41; incidence &#40;25&#46;9 per 100&#44;000 in 2010&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In response to this situation&#44; we carried out a cross-sectional analysis over a 4-year period&#44; beginning in January 2006&#44; in which we evaluated pleural fluid results from all patients admitted to our department with a pleural effusion of unknown etiology&#46; Only the results obtained from the first thoracocentesis were included and samples from empyema were excluded from our analysis&#46; Pleural ADA was measured using Giusti&#39;s colorimetric method&#46; Mann&#8211;Whitney test was performed to compare medians and a Receiver Operating Curve &#40;ROC&#41; was used to determine the predictive parameters of different cutoffs&#46; Prism 6 from Graphpad Software was used for the statistical analysis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A total of 107 pleural samples were analyzed&#44; including TB &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&#44; malignant &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>54&#41;&#44; parapneumonic &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41; and idiopathic &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#41; effusions&#46; Of the 107 patients&#44; 57&#46;9&#37; were males&#44; median age was 72&#46;5 &#40;interquartile range&#58; 59&#46;7&#59; 80&#46;2&#41; and all the patients were of European ethnicity&#46; TB pleural effusions were found to have the highest median ADA value &#40;98&#46;55<span class="elsevierStyleHsp" style=""></span>U&#47;L&#41;&#44; which were significantly higher than malignant effusions &#40;17&#46;99<span class="elsevierStyleHsp" style=""></span>U&#47;L&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; &#8211; the group with second highest median ADA value&#46; Using the ROC curve we found that an ADA cutoff of 40&#46;5<span class="elsevierStyleHsp" style=""></span>U&#47;L had the best performance in the diagnosis of pleural TB &#40;see <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; with a sensitivity of 95&#37;&#44; specificity of 91&#46;55&#37;&#44; positive predictive value &#40;PPV&#41; of 73&#46;08&#37; and negative predictive value &#40;NPV&#41; of 98&#46;77&#37;&#46; Seven nontuberculous exudates &#40;8&#46;0&#37;&#41; reached the diagnostic cutoff&#46; Using a &#62;50&#37; lymphocyte count criteria in the diagnostic workup&#44; only 4&#46;5&#37; nontuberculous exudates were misclassified &#8211; 2 malignant &#40;plasmocytoma and lymphoma&#41; and 2 parapneumonic&#46; The association of these two criteria increased specificity &#40;95&#46;40&#37;&#41; and PPV &#40;82&#46;61&#37;&#41;&#46; Using an ADA cutoff level of 74&#46;6<span class="elsevierStyleHsp" style=""></span>U&#47;L and the &#62;50&#37; lymphocyte criteria further increased specificity &#40;98&#46;85&#37;&#41; and PPV &#40;93&#46;75&#37;&#41;&#44; and only one &#40;1&#46;1&#37;&#41; nontuberculous exudate was misclassified&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The diagnosis of tuberculous pleural effusion is a common diagnostic challenge due to low mycobacterial detection rates and to the frequent need for invasive&#44; sometimes technically difficult&#44; operator dependent techniques like the pleural biopsy or thoracoscopy&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In this context&#44; a rational interpretation of pleural fluid characteristics&#44; particularly ADA level and differential leukocyte count&#44; is essential to the diagnostic workup&#46; In our research&#44; an ADA level<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>U&#47;L can virtually exclude pleural TB with a NPV of 98&#46;7&#37;&#44; while an ADA level<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>74&#46;6<span class="elsevierStyleHsp" style=""></span>U&#47;L with &#62;50&#37;lymphocyte has a very high PPV of 93&#46;75 and can thus be used to safely confirm pleural TB with a very small error rate of 1&#46;1&#37;&#46; The performance of the cutoff value of 40<span class="elsevierStyleHsp" style=""></span>U&#47;L and the error rate of 4&#46;5&#37; &#40;for ADA<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>U&#47;L and &#62;50&#37; lymphocytes&#41; and 1&#46;1&#37; &#40;for ADA<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>74&#46;6<span class="elsevierStyleHsp" style=""></span>U&#47;L and &#62;50&#37; lymphocytes&#41; is in line with other publications&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5&#44;6</span></a> In our analysis&#44; one patient with pleural TB had an ADA level<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>U&#47;L&#59; however&#44; in a sample collected just 3 days later&#44; ADA level was now 90<span class="elsevierStyleHsp" style=""></span>U&#47;L which reaffirms the diagnostic utility of ADA&#46; Also&#44; as we have shown&#44; hematological malignancies are frequent causes of error&#44; and they should be excluded by this analysis of the pleural lymphocyte populations&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;6</span></a> However&#44; the usefulness of ADA in the diagnosis of tuberculous effusions depends on the prevalence of the disease in the population&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> If tuberculosis is highly prevalent&#44; as in the African continent and Southeast Asia&#44; then a high value of pleural ADA is more likely to be due to tuberculosis&#44; thus increasing the PPV of pleural ADA in the diagnosis of pleural TB&#46; If&#44; however&#44; the disease is less prevalent&#44; the probability of a high ADA being due to other causes&#44; such as cancer&#44; increases&#44; and PPV of pleural ADA is lower&#46; This is most evident in countries with a low prevalence of tuberculosis and an aging population&#44; as it is in old age that malignant effusions are more prevalent&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In conclusion&#44; pleural ADA is a valuable tool in the diagnostic workup of pleural TB in Portugal and should routinely be used in the exclusion or confirmation of TB in the differential diagnosis of patients with a pleural effusion of unknown cause&#46; Furthermore&#44; in order to make a correct interpretation of its values&#44; we have highlighted&#58; potential false-positives&#59; the usefulness of different ADA cutoffs for the exclusion or confirmation of TB&#59; and the impact of TB prevalence on the predictive parameters of this tool&#46;</p></span>"
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Letter to the Editor
Pleural adenosine deaminase in the diagnostic workup of tuberculous pleural effusion
Adenosina deaminase do liquido pleural na abordagem diagnóstica do derrame pleural tuberculoso
R. Reisa,
Corresponding author
ricardomcreis@gmail.com

Corresponding author.
, A.S. Costab, B. Condea
a Respiratory Department, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal
b Respiratory Department, Centro Hospitalar do Alto Ave, Portugal
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          0 => array:3 [
            "entidad" => "Respiratory Department&#44; Centro Hospitalar de Tr&#225;s-os-Montes e Alto Douro&#44; Vila Real&#44; Portugal"
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          1 => array:3 [
            "entidad" => "Respiratory Department&#44; Centro Hospitalar do Alto Ave&#44; Portugal"
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            "identificador" => "cor0005"
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    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Adenosina deaminase do liquido pleural na abordagem diagn&#243;stica do derrame pleural tuberculoso"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Adenosine deaminase &#40;ADA&#41; has been promoted as a quick&#44; efficient and cost-effective method in the diagnosis of tuberculous effusions&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However&#44; the predictive parameters of ADA&#44; in the diagnostic workup of tuberculous effusions&#44; depend on the prevalence of the disease in the population<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and no such analysis has been published in Portugal&#44; a country of intermediate tuberculosis &#40;TB&#41; incidence &#40;25&#46;9 per 100&#44;000 in 2010&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In response to this situation&#44; we carried out a cross-sectional analysis over a 4-year period&#44; beginning in January 2006&#44; in which we evaluated pleural fluid results from all patients admitted to our department with a pleural effusion of unknown etiology&#46; Only the results obtained from the first thoracocentesis were included and samples from empyema were excluded from our analysis&#46; Pleural ADA was measured using Giusti&#39;s colorimetric method&#46; Mann&#8211;Whitney test was performed to compare medians and a Receiver Operating Curve &#40;ROC&#41; was used to determine the predictive parameters of different cutoffs&#46; Prism 6 from Graphpad Software was used for the statistical analysis&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A total of 107 pleural samples were analyzed&#44; including TB &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&#44; malignant &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>54&#41;&#44; parapneumonic &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41; and idiopathic &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#41; effusions&#46; Of the 107 patients&#44; 57&#46;9&#37; were males&#44; median age was 72&#46;5 &#40;interquartile range&#58; 59&#46;7&#59; 80&#46;2&#41; and all the patients were of European ethnicity&#46; TB pleural effusions were found to have the highest median ADA value &#40;98&#46;55<span class="elsevierStyleHsp" style=""></span>U&#47;L&#41;&#44; which were significantly higher than malignant effusions &#40;17&#46;99<span class="elsevierStyleHsp" style=""></span>U&#47;L&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; &#8211; the group with second highest median ADA value&#46; Using the ROC curve we found that an ADA cutoff of 40&#46;5<span class="elsevierStyleHsp" style=""></span>U&#47;L had the best performance in the diagnosis of pleural TB &#40;see <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; with a sensitivity of 95&#37;&#44; specificity of 91&#46;55&#37;&#44; positive predictive value &#40;PPV&#41; of 73&#46;08&#37; and negative predictive value &#40;NPV&#41; of 98&#46;77&#37;&#46; Seven nontuberculous exudates &#40;8&#46;0&#37;&#41; reached the diagnostic cutoff&#46; Using a &#62;50&#37; lymphocyte count criteria in the diagnostic workup&#44; only 4&#46;5&#37; nontuberculous exudates were misclassified &#8211; 2 malignant &#40;plasmocytoma and lymphoma&#41; and 2 parapneumonic&#46; The association of these two criteria increased specificity &#40;95&#46;40&#37;&#41; and PPV &#40;82&#46;61&#37;&#41;&#46; Using an ADA cutoff level of 74&#46;6<span class="elsevierStyleHsp" style=""></span>U&#47;L and the &#62;50&#37; lymphocyte criteria further increased specificity &#40;98&#46;85&#37;&#41; and PPV &#40;93&#46;75&#37;&#41;&#44; and only one &#40;1&#46;1&#37;&#41; nontuberculous exudate was misclassified&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The diagnosis of tuberculous pleural effusion is a common diagnostic challenge due to low mycobacterial detection rates and to the frequent need for invasive&#44; sometimes technically difficult&#44; operator dependent techniques like the pleural biopsy or thoracoscopy&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In this context&#44; a rational interpretation of pleural fluid characteristics&#44; particularly ADA level and differential leukocyte count&#44; is essential to the diagnostic workup&#46; In our research&#44; an ADA level<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>U&#47;L can virtually exclude pleural TB with a NPV of 98&#46;7&#37;&#44; while an ADA level<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>74&#46;6<span class="elsevierStyleHsp" style=""></span>U&#47;L with &#62;50&#37;lymphocyte has a very high PPV of 93&#46;75 and can thus be used to safely confirm pleural TB with a very small error rate of 1&#46;1&#37;&#46; The performance of the cutoff value of 40<span class="elsevierStyleHsp" style=""></span>U&#47;L and the error rate of 4&#46;5&#37; &#40;for ADA<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>U&#47;L and &#62;50&#37; lymphocytes&#41; and 1&#46;1&#37; &#40;for ADA<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>74&#46;6<span class="elsevierStyleHsp" style=""></span>U&#47;L and &#62;50&#37; lymphocytes&#41; is in line with other publications&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5&#44;6</span></a> In our analysis&#44; one patient with pleural TB had an ADA level<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>U&#47;L&#59; however&#44; in a sample collected just 3 days later&#44; ADA level was now 90<span class="elsevierStyleHsp" style=""></span>U&#47;L which reaffirms the diagnostic utility of ADA&#46; Also&#44; as we have shown&#44; hematological malignancies are frequent causes of error&#44; and they should be excluded by this analysis of the pleural lymphocyte populations&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;6</span></a> However&#44; the usefulness of ADA in the diagnosis of tuberculous effusions depends on the prevalence of the disease in the population&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> If tuberculosis is highly prevalent&#44; as in the African continent and Southeast Asia&#44; then a high value of pleural ADA is more likely to be due to tuberculosis&#44; thus increasing the PPV of pleural ADA in the diagnosis of pleural TB&#46; If&#44; however&#44; the disease is less prevalent&#44; the probability of a high ADA being due to other causes&#44; such as cancer&#44; increases&#44; and PPV of pleural ADA is lower&#46; This is most evident in countries with a low prevalence of tuberculosis and an aging population&#44; as it is in old age that malignant effusions are more prevalent&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In conclusion&#44; pleural ADA is a valuable tool in the diagnostic workup of pleural TB in Portugal and should routinely be used in the exclusion or confirmation of TB in the differential diagnosis of patients with a pleural effusion of unknown cause&#46; Furthermore&#44; in order to make a correct interpretation of its values&#44; we have highlighted&#58; potential false-positives&#59; the usefulness of different ADA cutoffs for the exclusion or confirmation of TB&#59; and the impact of TB prevalence on the predictive parameters of this tool&#46;</p></span>"
    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2014-02-09"
    "fechaAceptado" => "2014-03-10"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">PPV&#58; positive predictive value&#59; NPV&#58; negative predictive value&#59; lymph&#46;&#58; lymphocytes&#46;</p>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">40<span class="elsevierStyleHsp" style=""></span>U&#47;L&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">95&#46;24 &#40;76&#46;11&#8211;99&#46;21&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">95&#46;00 &#40;75&#46;05&#8211;99&#46;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">91&#46;95 &#40;84&#46;12&#8211;96&#46;69&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">95&#46;40 &#40;88&#46;63&#8211;98&#46;71&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">98&#46;85 &#40;93&#46;74&#8211;99&#46;81&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">PPV &#40;&#37;&#44; 95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">74&#46;07 &#40;53&#46;71&#8211;88&#46;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">82&#46;61 &#40;61&#46;20&#8211;94&#46;94&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">93&#46;75 &#40;69&#46;69&#8211;98&#46;86&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">NPV &#40;&#37;&#44; 95&#37;CI&#41;&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Diagnostic parameters of different pleural fluid characteristics&#46;</p>"
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      "titulo" => "References"
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        0 => array:2 [
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              "etiqueta" => "1"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel tests for diagnosing tuberculous pleural effusion&#58; what works and what does not&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Trajman"
                            1 => "M&#46; Pai"
                            2 => "K&#46; Dheda"
                            3 => "R&#46; van Zyl Smit"
                            4 => "A&#46;A&#46; Zwerling"
                            5 => "R&#46; Joshi"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1183/09031936.00147507"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2008"
                        "volumen" => "31"
                        "paginaInicial" => "1098"
                        "paginaFinal" => "1106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18448504"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic performance of adenosine deaminase activity in pleural fluid&#58; a single-center experience with over 2100 consecutive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Porcel"
                            1 => "A&#46; Esquerda"
                            2 => "S&#46; Bielsa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejim.2010.03.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Intern Med"
                        "fecha" => "2010"
                        "volumen" => "21"
                        "paginaInicial" => "419"
                        "paginaFinal" => "423"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20816597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relato¿rio para o dia mundial da tuberculose 2009"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;F&#46; Antunes"
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                  ]
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                      "Libro" => array:2 [
                        "fecha" => "2010"
                        "editorial" => "Direc&#231;&#227;o Geral de Sa&#250;de&#44; Minist&#233;rio da Sa&#250;de"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic tools in tuberculous pleurisy&#58; a direct comparative study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;H&#46; Diacon"
                            1 => "B&#46;W&#46; Van de Wal"
                            2 => "C&#46; Wyser"
                            3 => "J&#46;P&#46; Smedema"
                            4 => "J&#46; Bezuidenhout"
                            5 => "C&#46;T&#46; Bolliger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2003"
                        "volumen" => "22"
                        "paginaInicial" => "589"
                        "paginaFinal" => "591"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14582908"
                            "web" => "Medline"
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                  ]
                ]
              ]
            ]
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              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Q&#46;L&#46; Liang"
                            1 => "H&#46;Z&#46; Shi"
                            2 => "K&#46; Wang"
                            3 => "S&#46;M&#46; Qin"
                            4 => "X&#46;J&#46; Qin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rmed.2007.12.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2008"
                        "volumen" => "102"
                        "paginaInicial" => "744"
                        "paginaFinal" => "754"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18222681"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
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Article information
ISSN: 21735115
Original language: English
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Pulmonology

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