Letter to the Editor
Thoracic paraganglioma diagnosed in a patient with pulmonary tuberculosis – Case report
Paraganglioma torácico diagnosticado num paciente com tuberculose pulmonar – descrição de caso clínico
Read
971
Timeswas read the article
531
Total PDF
440
Total HTML
Share statistics
array:25 [ "pii" => "S2173511514000876" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2014.04.004" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "237" "copyright" => "Sociedade Portuguesa de Pneumologia" "copyrightAnyo" => "2014" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "cor" "cita" => "Rev Port Pneumol. 2014;20:279-81" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1789 "formatos" => array:3 [ "EPUB" => 240 "HTML" => 1021 "PDF" => 528 ] ] "Traduccion" => array:1 [ "en" => array:20 [ "pii" => "S0873215914000750" "issn" => "08732159" "doi" => "10.1016/j.rppneu.2014.04.003" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "237" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Rev Port Pneumol. 2014;20:279-81" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6141 "formatos" => array:3 [ "EPUB" => 273 "HTML" => 4810 "PDF" => 1058 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Thoracic paraganglioma diagnosed in a patient with pulmonary tuberculosis – Case report" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "279" "paginaFinal" => "281" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Paraganglioma torácico diagnosticado num paciente com tuberculose pulmonar – descrição de caso clínico" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1221 "Ancho" => 1400 "Tamanyo" => 195388 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Chest radiography: heterogeneous infiltration in the right upper lobe and homogeneous opacity in the left hilar region. (B)–(D) Chest Computed Tomography of the thorax: hypodense mass of 9<span class="elsevierStyleHsp" style=""></span>cm with well defined margins located in the mediastinum with extension to the left upper lobe, areas of consolidation in the right upper lobe associated with micro-nodular infiltration and ground-glass opacities.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.F. Cruz, L. Iglésias, M. Monteiro, M.J. Santos, T. Pimentel, R.P. Silva" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.F." "apellidos" => "Cruz" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Iglésias" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Monteiro" ] 3 => array:2 [ "nombre" => "M.J." "apellidos" => "Santos" ] 4 => array:2 [ "nombre" => "T." "apellidos" => "Pimentel" ] 5 => array:2 [ "nombre" => "R.P." "apellidos" => "Silva" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173511514000876" "doi" => "10.1016/j.rppnen.2014.04.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511514000876?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215914000750?idApp=UINPBA00004E" "url" => "/08732159/0000002000000005/v2_201509041759/S0873215914000750/v2_201509041759/en/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2173511514000864" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2014.03.013" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "229" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "cor" "cita" => "Rev Port Pneumol. 2014;20:281-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1472 "formatos" => array:3 [ "EPUB" => 243 "HTML" => 762 "PDF" => 467 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Ethical limits for noninvasive ventilation prescription" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "281" "paginaFinal" => "282" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Limites éticos para a prescrição de ventilação não invasiva" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Simões Saldanha Mendes, C. Ferreira, C. Dias, J. Moita" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Simões Saldanha Mendes" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Ferreira" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Dias" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Moita" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0873215914000518" "doi" => "10.1016/j.rppneu.2014.03.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215914000518?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511514000864?idApp=UINPBA00004E" "url" => "/21735115/0000002000000005/v1_201408310143/S2173511514000864/v1_201408310143/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2173511514000840" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2013.08.004" "estado" => "S300" "fechaPublicacion" => "2014-09-01" "aid" => "215" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "sco" "cita" => "Rev Port Pneumol. 2014;20:273-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1947 "formatos" => array:3 [ "EPUB" => 246 "HTML" => 1179 "PDF" => 522 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "A novel immunodeficiency syndrome as a rare cause of secondary pulmonary alveolar proteinosis: A diagnosis after 5 decades" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "273" "paginaFinal" => "278" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Uma nova síndrome da imunodeficiência como causa rara de proteinose alveolar pulmonar: um diagnóstico após 5 décadas" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1840 "Ancho" => 3118 "Tamanyo" => 427297 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Flow cytometry analysis of peripheral blood. Normal T cells; (B) severe monocytopenia; (C) B cell deficiency; (D) NK cell deficiency; (E) absent myeloid dendritic cells; (F) absent plasmacytoid dendritic cells.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pedro G. Ferreira, Lina Carvalho, Fernanda Gamboa" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Pedro G." "apellidos" => "Ferreira" ] 1 => array:2 [ "nombre" => "Lina" "apellidos" => "Carvalho" ] 2 => array:2 [ "nombre" => "Fernanda" "apellidos" => "Gamboa" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0873215914000142" "doi" => "10.1016/j.rppneu.2013.08.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215914000142?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511514000840?idApp=UINPBA00004E" "url" => "/21735115/0000002000000005/v1_201408310143/S2173511514000840/v1_201408310143/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Thoracic paraganglioma diagnosed in a patient with pulmonary tuberculosis – Case report" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor</span>," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "279" "paginaFinal" => "281" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.F. Cruz, L. Iglésias, M. Monteiro, M.J. Santos, T. Pimentel, R.P. Silva" "autores" => array:6 [ 0 => array:4 [ "nombre" => "J.F." "apellidos" => "Cruz" "email" => array:1 [ 0 => "joaoffcruz@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "Iglésias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Monteiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "M.J." "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "T." "apellidos" => "Pimentel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "R.P." "apellidos" => "Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Serviço de Pneumologia, Hospital de Braga, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Serviço de Medicina Interna, Hospital de Braga, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Serviço de Endocrinologia, Hospital de Braga, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Serviço de Anatomia Patológica, Hospital de São João, Porto, Portugal" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Paraganglioma torácico diagnosticado num paciente com tuberculose pulmonar – descrição de caso clínico" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1056 "Ancho" => 1400 "Tamanyo" => 338889 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Surgical lung biopsy. A solid and poorly differentiated malignant neoplasm with extensive areas of necrosis (A – HE 200×). The tumor cells had abundant eosinophilic cytoplasm and round nuclei with evident nucleoli (B – HE 600×). Immunohistochemically, the neoplastic cells focally expressed vimentin (C – 600×) and synaptophysin (D – 600×) in the absence of epithelial and other markers (AE1/AE3, CK8/18, CK7, CK20, CK5, 34β12, EMA,TTF1, napsin-A, p63, calretinin, pS100, CD31, CD34, PLAP, beta-HCG, CD45, CD20, CD10, inhibin, C-kit, CD99, actin, desmin, GFAP, CD30, CD21, HMB45, CD56, CD23, alpha-fetoprotein, myeloperoxidase, lysozyme, WT1, ALK, HepPar-1). With those morphological and immunohistochemical characteristics in the appropriate clinical context, the diagnostic hypothesis of paraganglioma/pheochromocytoma was suggested.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Paragangliomas are rare tumors with an incidence of 0.3–0.95% of neuroendocrine tumors, which arise from specialized neural crest cells associated with autonomic ganglia (paraganglia) 1. Nearly 90% of these tumors arise from the medulla of the adrenal gland and are called “pheochromocytomas”. When they have an extra-adrenal origin, they are termed “paragangliomas”. Intrathoracic location is infrequent, corresponding only to 10% of paraganglioma cases.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Herein the authors described the case of a 50-year-old male patient, Caucasian, smoker. As a background he had arterial hypertension and discoid lupus erythematosus. His usual medication was candesartan 16<span class="elsevierStyleHsp" style=""></span>mg, deflazacort 3<span class="elsevierStyleHsp" style=""></span>mg/day and chloroquine 250<span class="elsevierStyleHsp" style=""></span>mg/day. He presented in our hospital complaining of dyspnea, cough, asthenia and weight loss with three weeks evolution. His physical exam was unremarkable, except for malar and cervical cutaneous rash related to his discoid lupus. Chest X-ray and computed tomography showed pulmonary infiltrations in the right upper lobe and a mediastinic mass of 9<span class="elsevierStyleHsp" style=""></span>cm (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Abdominal CT did not show any abnormalities. Sputum analysis confirmed a diagnosis of pulmonary tuberculosis and the patient started anti-tuberculosis treatment. His HIV and hepatitis virus status were negative. Bronchoalveolar samples were negative for malignancy and CT-guided transthoracic core biopsy of the mediastinal mass only showed necrotic tissue, so the patient underwent a surgical lung biopsy.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Despite treatment, clinical evolution was not favorable, with persistent fever, one episode of auricular flutter and hemodynamic instability. Antibacillary susceptibility testing revealed resistance to all first class drugs. At the 45th day of admission, patient developed an acute pulmonary edema with no response to medical treatment and he eventually died. Description of the surgical biopsy was only available post-mortem and suggested the diagnosis of a pheochromocytoma/paraganglioma – <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">This clinical case illustrates a patient with concomitant diagnosis of pulmonary tuberculosis and a thoracic paraganglioma. Because the results of surgical biopsy were only known post-mortem, additional research on the evaluation of the diagnosis of paraganglioma, including determination of catecholamine and metanephrine levels, presence of distant metastasis and genetic testing were not possible.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Because this is a rare tumor, most of the literature describes only single case reports.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> In 2008, Mayo Clinic reported their experience with fourteen cases of treated mediastinal paragangliomas.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Concomitant occurrence of tuberculosis and thoracic paraganglioma is even rarer, with very few previous reports<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>, making the diagnosis and treatment of these cases difficult and challenging.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, paragangliomas are not usually suspected in the initial evaluation of a mediastinal mass because of its rarity, but it should be part of the differential diagnosis. The concomitant occurrence of tuberculosis may pose a diagnostic challenge in this case, leading to a delay in the diagnosis of this type of tumors.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical considerations</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Protection of people and animals</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Confidentiality of data</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Right to privacy and informed consent</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this publication.</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflict of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest to the contents of the manuscript.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:3 [ "identificador" => "sec0005" "titulo" => "Ethical considerations" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Protection of people and animals" ] 1 => array:2 [ "identificador" => "sec0015" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0020" "titulo" => "Right to privacy and informed consent" ] ] ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflict of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1221 "Ancho" => 1400 "Tamanyo" => 195388 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Chest radiography: heterogeneous infiltration in the right upper lobe and homogeneous opacity in the left hilar region. (B)–(D) Chest Computed Tomography of the thorax: hypodense mass of 9<span class="elsevierStyleHsp" style=""></span>cm with well defined margins located in the mediastinum with extension to the left upper lobe, areas of consolidation in the right upper lobe associated with micro-nodular infiltration and ground-glass opacities.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1056 "Ancho" => 1400 "Tamanyo" => 338889 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Surgical lung biopsy. A solid and poorly differentiated malignant neoplasm with extensive areas of necrosis (A – HE 200×). The tumor cells had abundant eosinophilic cytoplasm and round nuclei with evident nucleoli (B – HE 600×). Immunohistochemically, the neoplastic cells focally expressed vimentin (C – 600×) and synaptophysin (D – 600×) in the absence of epithelial and other markers (AE1/AE3, CK8/18, CK7, CK20, CK5, 34β12, EMA,TTF1, napsin-A, p63, calretinin, pS100, CD31, CD34, PLAP, beta-HCG, CD45, CD20, CD10, inhibin, C-kit, CD99, actin, desmin, GFAP, CD30, CD21, HMB45, CD56, CD23, alpha-fetoprotein, myeloperoxidase, lysozyme, WT1, ALK, HepPar-1). With those morphological and immunohistochemical characteristics in the appropriate clinical context, the diagnostic hypothesis of paraganglioma/pheochromocytoma was suggested.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thoracic involvement with pheochromocytoma. A review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Sandur" 1 => "A. Dasgupta" 2 => "L.J. Shapiro" 3 => "A.C. Arroliga" 4 => "A.C. Mehta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1999" "volumen" => "115" "paginaInicial" => "511" "paginaFinal" => "521" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10027454" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional mediastinal pheochromocytoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.H. Lee" 1 => "S.S. Lee" 2 => "J.C. Lee" 3 => "M.S. Kim" 4 => "J.H. Choi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5090/kjtcs.2013.46.1.88" "Revista" => array:6 [ "tituloSerie" => "Korean J Thorac Cardiovasc Surg" "fecha" => "2013" "volumen" => "46" "paginaInicial" => "88" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23423879" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asymptomatic paraganglioma of the posterior mediastinum misdiagnosed until operation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Liu" 1 => "J. Mei" 2 => "G. Che" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-0029-1185874" "Revista" => array:6 [ "tituloSerie" => "Thorac Cardiovasc Surg" "fecha" => "2010" "volumen" => "58" "paginaInicial" => "302" "paginaFinal" => "304" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20680909" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mediastinal paragangliomas: the mayo clinic experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.L. Brown" 1 => "G.E. Zayas" 2 => "M.D. Abel" 3 => "W.F. Young Jr." 4 => "H.V. Schaff" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2008.04.105" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2008" "volumen" => "86" "paginaInicial" => "946" "paginaFinal" => "951" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18721588" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of pharmacologic tests as an aid in diagnosis of pheochromocytoma: with report of a case of pheochromocytoma and tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.M. Roth" 1 => "W.F. Kvale" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dis Chest" "fecha" => "1957" "volumen" => "32" "paginaInicial" => "295" "paginaFinal" => "304" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13461773" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735115/0000002000000005/v1_201408310143/S2173511514000876/v1_201408310143/en/main.assets" "Apartado" => array:4 [ "identificador" => "20584" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735115/0000002000000005/v1_201408310143/S2173511514000876/v1_201408310143/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511514000876?idApp=UINPBA00004E" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 4 | 10 |
| 2024 October | 35 | 28 | 63 |
| 2024 September | 27 | 24 | 51 |
| 2024 August | 26 | 42 | 68 |
| 2024 July | 35 | 49 | 84 |
| 2024 June | 23 | 36 | 59 |
| 2024 May | 24 | 35 | 59 |
| 2024 April | 23 | 40 | 63 |
| 2024 March | 25 | 16 | 41 |
| 2024 February | 20 | 26 | 46 |
| 2024 January | 17 | 28 | 45 |
| 2023 December | 18 | 26 | 44 |
| 2023 November | 22 | 27 | 49 |
| 2023 October | 15 | 28 | 43 |
| 2023 September | 27 | 33 | 60 |
| 2023 August | 29 | 14 | 43 |
| 2023 July | 17 | 31 | 48 |
| 2023 June | 16 | 11 | 27 |
| 2023 May | 19 | 22 | 41 |
| 2023 April | 16 | 11 | 27 |
Show all
