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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">According to the NAMDRC consensus conference&#44; prolonged mechanical ventilation &#40;PMV&#41; defines patients who require at least 6<span class="elsevierStyleHsp" style=""></span>h of mechanical ventilation for &#62;21 consecutive days&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">1</span></a> Recent estimates indicate that in the US the numbers of PMV are expected to double by the year 2020&#44; reaching more than 600&#44;000 patients&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The reasons for this are heterogeneous&#58; a greater capacity of ICUs to assist severe respiratory failure&#59; modulate systemic inflammatory response syndrome and severe sepsis in patients with a high prevalence of secondary neuromuscular dysfunction and severe physical deconditioning&#44; all these at increasingly advanced ages&#46; Another large group of patients is represented by those suffering from severe injuries to the central nervous system or incurable and progressive neuromuscular diseases&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Currently we only have partial information about the functional outcomes and quality of life of these patients&#44; who are now described as chronic critically ill patients&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">3</span></a> Their life trajectories&#44; during their stay at long-term acute care hospitals&#44; or LTACs or after a successful ventilatory weaning&#44; are yet to be described&#46; Many will have severe&#44; permanent cognitive and physical impairments and serious limitations due to their disability&#44; which will obviously involve high psychosocial costs&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Treating these patients in specific venues with strong rehabilitative focus is normally recommended&#44; with the cost savings and higher ventilator weaning rates&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">PMV patients &#40;also referred to as Chronically Critically Ill patients&#41; are very demanding due to multiple systems and organs dysfunctions&#46; Beyond prolonged dependence on mechanical ventilation&#44; muscle&#44; neuro-endocrine&#44; skin and brain dysfunctions give way to a distinct and complex syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Although liberation from the ventilator will be one of the most important interventions in this setting&#44; there is more than one type of weaning&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Psychological factors</span><p id="par0035" class="elsevierStylePara elsevierViewall">Psychological factors &#40;like depression or delirium&#41; may hinder ventilator weaning&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">6</span></a> Sleep deprivation or unrecognized sleep disorders may also interfere with weaning&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">7</span></a> So measures to improve sleep and psychological disorders can impact other outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">8</span></a> In fact educational interventions&#44; counseling and stress management can decrease the risk of developing psychological disorders&#46; Moreover&#44; effective pharmacological treatment of anxiety and depression is also mandatory&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Swallowing dysfunction</span><p id="par0040" class="elsevierStylePara elsevierViewall">Oropharyngeal dysphagia &#40;OPD&#41; has been described in patients with PVM for three decades&#44; and yet&#44; has not received much attention in research addressing different subgroups of this diverse population&#46;<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">9&#44;10</span></a> Swallowing dysfunction is a common complication in chronic critically ill patients&#44; which affects nearly half of the non-neurologic patients requiring percutaneous dilatational tracheostomy and almost all of those with neurologic involvement&#59; it is well known to deteriorate outcomes&#44; and delay the weaning and tracheostomy decannulation process&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">11</span></a> A number of possible specific swallowing dysfunctional conditions arise in PMV patients&#59; to mention a few&#44; sarcopenic dysphagia&#44; presbyphagia&#44; neuromuscular dysfunction related dysphagia and even with some structural swallowing disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">12</span></a> Overall evaluation measures and treatment are based on experiments with different methodologies<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">13&#44;14</span></a> but not on controlled studies which consider the unique pathophysiology of chronic critically ill patients&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">15</span></a> It is worth mentioning the potential role of fiberoptic endoscopic evaluation of swallowing &#40;FEES&#41; as an objective tool to precisely classify and guide therapeutic interventions after prolonged intubation and in tracheostomy patients&#46; In fact&#44; FEES with sensory testing is improving the rehabilitation designs and protocols&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">16</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The main components of a dysphagia rehabilitation program include oral health care&#44; swallowing rehabilitative techniques&#44; and food consistency modification&#46; To the best of our knowledge there are no detailed studies or any evidence about the most effective strategies to improve the swallowing process in different non-invasive and invasive PMV scenarios&#46; This role which has been suggested for FEES as an objective tool to precisely classify and guide therapeutic interventions after prolonged intubation and in tracheostomy patients should be considered&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">17</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Skin integrity</span><p id="par0050" class="elsevierStylePara elsevierViewall">Skin integrity is an independent determinant of survival in patients requiring prolonged mechanical ventilation and is a potentially modifiable factor&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">18</span></a> The most important risk factors for development of pressure ulcers while in ICU are total score on Braden Scale&#44; 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show positive results&#44; from increase in limb strength<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24&#44;25</span></a> to improvement in functional measures like FIM&#44;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24&#8211;28</span></a> respiratory muscle strength<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a> and mechanics&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">27</span></a> A RCT study has also shown a significant survival benefit in the rehabilitation group&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">26</span></a> In these studies mortality ranges from 12&#37;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a> to 30&#37;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a> and weaning rate from 47&#37;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">29</span></a> to 98&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a> The studies include also very different sub-groups of patients from chronic respiratory diseases<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">25&#8211;30</span></a> to post-operative and acute lung injuries&#46;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24&#8211;26</span></a> Only one study includes neuromuscular patients&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">28</span></a> Even in RCT&#44; rehabilitation programs are not uniform&#44; with some studies proposing 6-week long programs<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">25&#44;26</span></a> while others proposing shorter times<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">27&#44;30</span></a>&#59; some include specific inspiratory muscle training&#44;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a> a few others formal cardiopulmonary endurance exercise<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">27</span></a> and the others use electrical stimulation&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">29</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Type of intervention&#44; frequency&#44; duration and intensity based on Denehy et al&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">31</span></a> and Hanekom et al&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">32</span></a> is proposed in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Aims of multidisciplinary &#40;interdisciplinary or trans-disciplinary&#41; rehabilitation</span><p id="par0075" class="elsevierStylePara elsevierViewall">To improve survival&#44; diminish co-morbidities&#44; decrease ventilator dependence&#44; improve functional status and health related quality of life&#44; decrease hospital re-admissions&#44; decrease length of stay in long-term care&#44; favor return to work and social re-integration and reduce the amount of ineffective care&#46; Caution must be taken about potential contraindications &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Evidence-based multidisciplinary rehabilitative interventions</span><p id="par0080" class="elsevierStylePara elsevierViewall">There has been a growing interest in different rehabilitative strategies to treat PMV patients&#46; However most of the published studies covered non-randomized clinical trials&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">In <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a> we review some of the most interesting topics involved in these interventions&#46; Cognitive training has been tested among post-ICU survivors and preliminary data are encouraging<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">33</span></a> and a new RCT is being designed&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">34</span></a> A prospective non-randomized study has also shown that early intra-ICU clinical psychologist intervention may help critically ill trauma patients recover from post-traumatic stress disorder&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">8</span></a></p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">As mentioned before no RCT so far has analyzed swallowing dysfunction management&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Disruption of sleep is very common in mechanically ventilated patients&#46; In an observational study Koldobskyi et al&#46; have shown that specific facilities &#40;like LTAC&#39;s&#41; maintain the patients&#8217; circadian rhythm compared to the ICU environment&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">35</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">In a recent meta-analysis&#44; examining three trials involving a heterogeneous group of patients&#44; inspiratory muscle training was found to significantly increase inspiratory muscle strength in adults undergoing mechanical ventilation&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">36</span></a> Further research is needed including more homogeneous PMV populations and analyzing more relevant outcomes&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Concerning airway secretion management&#44; Gon&#231;alves et al&#46; showed in a RCT that adding mechanical in-exsufflation improved extubation outcomes&#44; increasing the efficacy of NIV post-extubation&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">37</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">There are few RCT in the context of weaning tracheostomized patients&#46; Hernandez showed that deflating the tracheal cuff in tracheostomized patients shortens weaning&#44; reduces respiratory infections&#44; and probably improves swallowing&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">38</span></a> Jubran et al&#46; in patients requiring PMV&#44; showed that unassisted breathing through a tracheostomy &#40;compared with pressure support&#41; resulted in shorter median weaning time&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">39</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Verceles et al&#46; have shown that in patients under PMV&#44; higher comorbidity burden is associated with increased risk of transfer to acute care&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">40</span></a> In fact&#44; in a retrospective study&#44; Schulman et al&#46; suggest that tighter glycemic control was associated with better outcomes in CCI patients&#46; Prospective studies addressing the importance of co-morbidities treatment optimization are warranted in this setting&#46;<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">41</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Members of the team and roles &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#41;</span><p id="par0120" class="elsevierStylePara elsevierViewall">Teamwork has been shown to improve outcomes&#46; In fact medical ICU nurses&#8217; reports of collaboration were associated positively with patient outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">42</span></a></p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">The core team is normally the <span class="elsevierStyleItalic">medical doctor</span>&#44; the <span class="elsevierStyleItalic">nurse</span> and the <span class="elsevierStyleItalic">respiratory therapist</span> &#40;or <span class="elsevierStyleItalic">specialized physiotherapist</span>&#41;&#59; the sense of interdependence exists between each other to ensure workflow is efficient&#44; effective and coordinated&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">43</span></a> Daily multidisciplinary rounds integrate the different knowledge to promote the clinical goals and formulate a plan of interventions&#46; Coordination between professionals is essential to make a personalized and integrated therapeutic plan&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">speech pathologist</span> has a very important role not only to facilitate speech in patients with tracheostomy but also to evaluate swallowing&#46;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">44</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Due to the high resource use and costs involved in supporting ventilator-dependent patients&#44; <span class="elsevierStyleItalic">social workers</span> are indispensable to assure effective integration of health&#44; social&#44; education and employment services and voluntary and independent sectors when pertinent&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">45</span></a> It also plays a fundamental role avoiding any possible discrimination that may rise from the disability surrounding PMV&#46; Frequent communication with the family with discussion about realistic versus futile goals is also an important goal&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Evaluation of efficacy</span><p id="par0140" class="elsevierStylePara elsevierViewall">The traditional severity-of-illness scoring systems like the SOFA &#40;Sepsis-related organ failure Assessment&#41; score or the APACHE III were developed in the acute Intensive care Unit &#40;ICU&#41; population&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">46</span></a> These systems were not established or validated using populations of patients under PMV &#40;or also referred to as Chronically Critically Ill patients&#41;&#44; as a result caution should be used when interpreting such data&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">47</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Therefore the development of adequately performing severity-of-illness measures appropriate to this patient population is highly needed&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In the absence of newer multidimensional tools&#44; the majority of authors use the Functional Independence Measure &#40;FIM&#41; to evaluate the efficacy of a rehabilitation program&#46;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24&#44;25&#44;27&#44;28</span></a> They evaluate the functional status of the patient at admission&#44; after half the length of the program&#44; at the end of the program and at discharge&#46; If the results are not improving significantly the program&#47;interventions should be adjusted on a regular basis&#44; decreasing&#47;increasing or maintaining intensity based on the eventual resolution of contraindications&#47;significant improvement&#47;deterioration&#47;plateauing&#46; To make this choice the Minimal Detectable Change &#40;MDC&#41; or Minimal Clinically Important Difference &#40;MCID&#41; of the disability scoring system being used should be considered&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">48</span></a> For stroke patients the MCID for total FIM score was 22 points&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">48</span></a> In studies including PMV patients the improvement in total FIM score ranged from 11<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a> at 6 weeks to 44 points at 1 year&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">26</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">Eventually after &#62;1 month of structured multidisciplinary approach&#44; consider transferring the patient to another setting &#40;home or nursing home&#41; if no improvement is gained&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Challenges</span><p id="par0160" class="elsevierStylePara elsevierViewall">In one facility with more than 30 patients with heterogeneous diagnosis&#44; the logistics of tailored therapeutic interventions can be very complex&#44; from timing and chronobiology to coordination&#46; To maintain a constant flow of interventions a highly flexible team is needed&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The role of the family&#47;non-professional caregivers to support and assist in the rehabilitation program can have a role in improving functional outcomes and potentiate team interventions&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">It is possible that some subgroups of PMV&#47;CCI benefit more from whole body rehabilitation than others&#46; A challenge for the future will be identifying which subgroups of PMV&#47;CCI benefit most from these programs&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusions</span><p id="par0175" class="elsevierStylePara elsevierViewall">Until now&#44; post-ICU patients have not had a recognized rehabilitation program and the care process is still fragmented&#46; There is a clear need to establish guidelines to define the optimal rehabilitation program in this setting&#46; Integrated&#44; multidisciplinary rehabilitation programs for ventilator-dependent chronic critically ill patients should be urgently defined&#46; Randomized studies for this situation are welcomed&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Ethical disclosures</span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Protection of human and animal subjects</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Confidentiality of data</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Right to privacy and informed consent</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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              "identificador" => "abst0005"
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          "identificador" => "xpalclavsec647188"
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          "titulo" => "Introduction"
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          "identificador" => "sec0010"
          "titulo" => "Psychological factors"
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          "identificador" => "sec0015"
          "titulo" => "Swallowing dysfunction"
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          "identificador" => "sec0020"
          "titulo" => "Skin integrity"
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        6 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Whole body rehabilitation &#40;Fig&#46; 1&#41;"
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        7 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Aims of multidisciplinary &#40;interdisciplinary or trans-disciplinary&#41; rehabilitation"
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          "identificador" => "sec0035"
          "titulo" => "Evidence-based multidisciplinary rehabilitative interventions"
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          "titulo" => "Members of the team and roles &#40;Table 5&#41;"
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          "titulo" => "Evaluation of efficacy"
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          "titulo" => "Ethical disclosures"
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              "identificador" => "sec0065"
              "titulo" => "Protection of human and animal subjects"
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              "identificador" => "sec0070"
              "titulo" => "Confidentiality of data"
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            2 => array:2 [
              "identificador" => "sec0075"
              "titulo" => "Right to privacy and informed consent"
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          "identificador" => "sec0080"
          "titulo" => "Conflicts of interest"
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          "titulo" => "References"
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    "fechaRecibido" => "2015-03-18"
    "fechaAceptado" => "2015-03-24"
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          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec647188"
          "palabras" => array:3 [
            0 => "Rehabilitation"
            1 => "Ventilator-dependent patients"
            2 => "Weaning facilities"
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    "resumen" => array:1 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The numbers of patients needing prolonged mechanical ventilation are growing&#46; The rehabilitation programs to be implemented in specialized inpatient facilities are ill defined&#46; There is a clear need to establish guidelines to define the optimal rehabilitation program in this setting&#46; In this article we review the current evidence and propose some guidance&#46;</p></span>"
      ]
    ]
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A ventilator-dependent tracheostomized patient walking with assistance from the staff&#46;</p>"
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      ]
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        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
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        "tabla" => array:3 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">CHF&#44; chronic heart failure&#59; FIM&#44; functional independence measure&#59; IMT&#44; inspiratory muscle training&#59; BI&#44; barthel index&#59; Post-op&#44; post-operative&#59; ALI&#44; acute lung injury&#59; SCI&#44; spinal cord injury&#59; NMD&#44; neuromuscular disorders&#59; ARF&#44; acute respiratory Failure&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Article&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Number of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Design&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Frequency of exercise sessions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Martin<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pneumonia&#44; CHF&#44; ARDS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab&#44; IMT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Weaning success&#44; FIM&#44; MRC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5days&#47;wk 30&#8211;60<span class="elsevierStyleHsp" style=""></span>min &#40;1&#8211;2 sessions&#47;day&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; limbs strength&#59; ability to sit to stand and supine to sit&#59; FIM<br>Mortality 12&#37;<br>Weaning rate 98&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chiang<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic lung disease&#44; Post-op&#44; ALI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab&#44; Diaphragmatic breathing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Barthel Index&#44; FIM&#44; ventilator free time&#44; Pi<span class="elsevierStyleInf">max</span>&#44; Pe<span class="elsevierStyleInf">max</span>&#44; Dynamometer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 days&#47;wk for 6 wks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; limbs strength&#59; Pimax&#44; Pemax FIM&#44; BI<br>Ventilator free time<br>Mortality 17&#46;6&#37;<br>Weaning rate 47&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chen<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">26</span></a><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic lung disease&#44; Post-op&#44; ALI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab&#44; Diaphragmatic breathing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1-year Survival<br>FIM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5days&#47;wk for 6 wks<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>1day&#47;wk for 6 wks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; FIM&#44; survival<br>Mortality 30&#37;<br>Weaning rate &#40;at 1 year&#41; 36&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Clini<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">30</span></a><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">COPD&#44; Post-Op&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab &#40;including pedaling and weights holding&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ADL&#44; survival weaning success&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6days&#47;wk for 15 sessions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; ADL<br>Mortality 13&#37;<br>Weaning rate 74&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chen<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">27</span></a><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">COPD&#47;Chronic Lung Disease&#44; CHF&#44; SCI&#44; Pneumonia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab&#44; Cardiopulmonary endurance exercise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary mechanics&#44; Barthel Index&#44; FIM&#44; weaning success&#44; mortality&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 exercise training sessions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; VT&#44; RSBI&#44; FIM<br>Mortality 0&#37;<br>Weaning rate 75&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Montagnini<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">28</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">COPD&#44; NMD&#44; Trauma&#44; CHF&#44; Post-op&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab &#40;including bed-side cycle ergometer&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FIM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 days&#47;wk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; FIM Dyspnea &#40;MRC&#41;<br>PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span><br>&#8595; PaCO<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Vitacca <a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">29</span></a><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">240&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">COPD&#44; ARF&#44; Neurological diseases&#44; Post-op&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab &#40;including electrical stimulation&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Barthel Index&#44; Gussago Nursing Scale&#44; survival&#44; weaning success&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 days&#47;wk 1<span class="elsevierStyleHsp" style=""></span>h&#47;day &#40;in 1 or 2 30<span class="elsevierStyleHsp" style=""></span>min sessions&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; BI&#44; GNS&#44; DPAP<br>PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span><br>&#8595; PaCO<span class="elsevierStyleInf">2</span><br>&#8595; Borg<br>Mortality 13&#46;8&#37;<br>Weaning rate 47&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1041296.png"
              ]
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            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Excluded NMD&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Excluded neurological disorders&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Summary of retrospective&#47;prospective&#47;RCT in weaning facilities&#46;</p>"
        ]
      ]
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        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Frequency of exercise sessions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">15<span class="elsevierStyleHsp" style=""></span>min&#47;day &#40;if &#60;4<span class="elsevierStyleHsp" style=""></span>h spontaneous breathing&#41;<br>2&#215; 15<span class="elsevierStyleHsp" style=""></span>min&#47;day &#40;if &#62;4<span class="elsevierStyleHsp" style=""></span>h spontaneous breathing&#41;</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Type of exercise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Marching in place<br>Moving from sitting to standing<br>Arm and leg active and active resistance movements&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Based on<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">34</span></a> Active range of motion exercises for all major joints&#44; bed mobility exercises &#40;e&#46;g&#46; lateral rolling&#44; supine to sit&#41;&#44; dangling at the edge of the bed&#44; postural retraining&#44; balance exercises &#40;e&#46;g&#46; reaching in and out of the base support&#44; challenges to elicit &#8220;righting&#8221; reflexes&#41;&#44; training in ADL &#40;eating or simulated eating&#44; grooming&#44; bathing&#44; dressing&#44; and toileting&#41;&#44; transfer from seated to a standing position and from bed to chair or commode&#44; standing exercises such as reaching in and out of the base of support&#44; mini-squats&#44; marching&#44; and ambulation &#40;with or without assistive devices&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Intensity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Target modified Borg Scale score 3&#8211;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab1041295.png"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Type of intervention&#44; frequency&#44; duration and intensity&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; ICU&#44; intensive care unit&#59; Hgb&#44; hemoglobin&#59; HR&#44; heart rate&#59; ABP&#44; arterial blood pressure&#46;</p>"
          "tablatextoimagen" => array:1 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemodynamic instability &#40;in this case the patient should be discharged to an ICU&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Non-controlled behavioral disorders &#40;in this case also the patient should be discharged&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Severe anemia &#40;less than Hgb 7<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41; or thrombocytopenia &#40;Platelets &#60;40&#8211;50&#46;000&#47;dl&#41;&#46; In Hemato-oncologic patients levels between 20 and 30&#46;000 can be accepted&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">HR &#60;60 or &#62;110&#47;min &#40;or &#62;30<span class="elsevierStyleHsp" style=""></span>bpm above resting predicted HR&#41;&#59; also consider underlying cardiac disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Mean ABP &#60;65<span class="elsevierStyleHsp" style=""></span>mmHg or &#62;200<span class="elsevierStyleHsp" style=""></span>mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sepsis or persistent fever &#40;&#62;38<span class="elsevierStyleHsp" style=""></span>&#176;C&#41; &#40;in fever of central cause or while fever cause is being investigated&#44; between fever peaks&#44; consider lower intensity&#47;passive interventions&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">End-stage patients included in palliative care&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab1041294.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Contraindications of physical therapy in PMV&#46;</p>"
        ]
      ]
      4 => array:7 [
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        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; CHF&#44; chronic heart failure&#59; DM&#44; diabetes mellitus&#59; COPD&#44; chronic obstructive pulmonary disease&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Cognitive rehabilitation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">8&#44;33&#44;34</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Feeding&#47;nutrition and swallowing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sleep&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">35</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Respiratory &#8211; respiratory muscle training<br>Secretion management&#59; Weaning&#47;decannulation protocols&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">36</span></a><br><a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">37</span></a><br><a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">38&#44;39</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Physical therapy &#8211; limb exercises&#44; exercise training&#44; neuromuscular electrical stimulation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">See <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Co-morbidities management &#40;e&#46;g&#46; CHF&#44; DM&#44; COPD&#41;&#44;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Skin care&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab1041293.png"
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            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Evidence-based multidisciplinary rehabilitative interventions&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl0025"
        "etiqueta" => "Table 5"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Core team&#58; MD&#44; Nurse&#44; RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">MD&#58; Serve as a coordinator&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Nurse&#58; Liaise with RT&#47;PT as required&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Speech pathologist&#58; Liaise with RT&#47;PT as required to evaluate swallowing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Occupational therapist&#44; psychologist&#44; nutritionist&#47;dietitian&#44; social worker involved as required&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1041292.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Members of the team and roles&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:48 [
            0 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of patients requiring prolonged mechanical ventilation&#58; report of a NAMDRC consensus conference"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46;R&#46; MacIntyre"
                            1 => "S&#46;K&#46; Epstein"
                            2 => "S&#46; Carson"
                            3 => "D&#46; Scheinhorn"
                            4 => "K&#46; Christopher"
                            5 => "S&#46; Muldoon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.128.6.3937"
                      "Revista" => array:7 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "paginaInicial" => "3937"
                        "paginaFinal" => "3954"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16354866"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0266613812002501"
                          "estado" => "S300"
                          "issn" => "02666138"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth in adult prolonged acute mechanical ventilation&#58; implications for healthcare delivery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;D&#46; Zilberberg"
                            1 => "M&#46; de Wit"
                            2 => "J&#46;R&#46; Pirone"
                            3 => "A&#46;F&#46; Shorr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0b013e3181691a49"
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Special Article
Multidisciplinary rehabilitation in ventilator-dependent patients: Call for action in specialized inpatient facilities
J. Wincka,
Corresponding author
jcwinck@mail.telepac.pt

Corresponding author.
, R. Camachob, N. Ambrosinoc
a Department of Pulmonology, Faculdade de Medicina, Universidade do Porto, Portugal & Linde Healthcare, Pullach, Germany
b REMEO Program, Colombia
c Weaning and Rehabilitation Unit, Auxilium Vitae Rehabilitation Center, Volterra, Italy
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    "cabecera" => "<span class="elsevierStyleTextfn">Special Article</span>"
    "titulo" => "Multidisciplinary rehabilitation in ventilator-dependent patients&#58; Call for action in specialized inpatient facilities"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A ventilator-dependent tracheostomized patient walking with assistance from the staff&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">According to the NAMDRC consensus conference&#44; prolonged mechanical ventilation &#40;PMV&#41; defines patients who require at least 6<span class="elsevierStyleHsp" style=""></span>h of mechanical ventilation for &#62;21 consecutive days&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">1</span></a> Recent estimates indicate that in the US the numbers of PMV are expected to double by the year 2020&#44; reaching more than 600&#44;000 patients&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The reasons for this are heterogeneous&#58; a greater capacity of ICUs to assist severe respiratory failure&#59; modulate systemic inflammatory response syndrome and severe sepsis in patients with a high prevalence of secondary neuromuscular dysfunction and severe physical deconditioning&#44; all these at increasingly advanced ages&#46; Another large group of patients is represented by those suffering from severe injuries to the central nervous system or incurable and progressive neuromuscular diseases&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Currently we only have partial information about the functional outcomes and quality of life of these patients&#44; who are now described as chronic critically ill patients&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">3</span></a> Their life trajectories&#44; during their stay at long-term acute care hospitals&#44; or LTACs or after a successful ventilatory weaning&#44; are yet to be described&#46; Many will have severe&#44; permanent cognitive and physical impairments and serious limitations due to their disability&#44; which will obviously involve high psychosocial costs&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Treating these patients in specific venues with strong rehabilitative focus is normally recommended&#44; with the cost savings and higher ventilator weaning rates&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">PMV patients &#40;also referred to as Chronically Critically Ill patients&#41; are very demanding due to multiple systems and organs dysfunctions&#46; Beyond prolonged dependence on mechanical ventilation&#44; muscle&#44; neuro-endocrine&#44; skin and brain dysfunctions give way to a distinct and complex syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Although liberation from the ventilator will be one of the most important interventions in this setting&#44; there is more than one type of weaning&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Psychological factors</span><p id="par0035" class="elsevierStylePara elsevierViewall">Psychological factors &#40;like depression or delirium&#41; may hinder ventilator weaning&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">6</span></a> Sleep deprivation or unrecognized sleep disorders may also interfere with weaning&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">7</span></a> So measures to improve sleep and psychological disorders can impact other outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">8</span></a> In fact educational interventions&#44; counseling and stress management can decrease the risk of developing psychological disorders&#46; Moreover&#44; effective pharmacological treatment of anxiety and depression is also mandatory&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Swallowing dysfunction</span><p id="par0040" class="elsevierStylePara elsevierViewall">Oropharyngeal dysphagia &#40;OPD&#41; has been described in patients with PVM for three decades&#44; and yet&#44; has not received much attention in research addressing different subgroups of this diverse population&#46;<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">9&#44;10</span></a> Swallowing dysfunction is a common complication in chronic critically ill patients&#44; which affects nearly half of the non-neurologic patients requiring percutaneous dilatational tracheostomy and almost all of those with neurologic involvement&#59; it is well known to deteriorate outcomes&#44; and delay the weaning and tracheostomy decannulation process&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">11</span></a> A number of possible specific swallowing dysfunctional conditions arise in PMV patients&#59; to mention a few&#44; sarcopenic dysphagia&#44; presbyphagia&#44; neuromuscular dysfunction related dysphagia and even with some structural swallowing disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">12</span></a> Overall evaluation measures and treatment are based on experiments with different methodologies<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">13&#44;14</span></a> but not on controlled studies which consider the unique pathophysiology of chronic critically ill patients&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">15</span></a> It is worth mentioning the potential role of fiberoptic endoscopic evaluation of swallowing &#40;FEES&#41; as an objective tool to precisely classify and guide therapeutic interventions after prolonged intubation and in tracheostomy patients&#46; In fact&#44; FEES with sensory testing is improving the rehabilitation designs and protocols&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">16</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The main components of a dysphagia rehabilitation program include oral health care&#44; swallowing rehabilitative techniques&#44; and food consistency modification&#46; To the best of our knowledge there are no detailed studies or any evidence about the most effective strategies to improve the swallowing process in different non-invasive and invasive PMV scenarios&#46; This role which has been suggested for FEES as an objective tool to precisely classify and guide therapeutic interventions after prolonged intubation and in tracheostomy patients should be considered&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">17</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Skin integrity</span><p id="par0050" class="elsevierStylePara elsevierViewall">Skin integrity is an independent determinant of survival in patients requiring prolonged mechanical ventilation and is a potentially modifiable factor&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">18</span></a> The most important risk factors for development of pressure ulcers while in ICU are total score on Braden Scale&#44; mobility&#44; activity&#44; sensory perception&#44; moisture&#44; friction&#47;shear&#44; nutrition&#44; age&#44; blood pressure&#44; length of stay&#44; APACHE II&#44; vasopressor administration&#44; and co-morbid conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">19</span></a> Where it is chronic&#44; central neurological involvement and small fiber pathology &#40;which explains chronic sensory impairment and pain in neuro-critical care survivors&#41; are the main features&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">20</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Whole body rehabilitation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;</span><p id="par0055" class="elsevierStylePara elsevierViewall">Increasing evidence supports early physiotherapy for the critically ill patient<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">21&#44;22</span></a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">RCT in ICU settings have already shown that early physical and occupational rehabilitation of mechanically ventilated patients translates into better weaning outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">23</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In weaning facilities the studies evaluating the impact of rehabilitation in prolonged mechanical ventilated patients &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; show positive results&#44; from increase in limb strength<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24&#44;25</span></a> to improvement in functional measures like FIM&#44;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24&#8211;28</span></a> respiratory muscle strength<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a> and mechanics&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">27</span></a> A RCT study has also shown a significant survival benefit in the rehabilitation group&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">26</span></a> In these studies mortality ranges from 12&#37;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a> to 30&#37;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a> and weaning rate from 47&#37;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">29</span></a> to 98&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a> The studies include also very different sub-groups of patients from chronic respiratory diseases<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">25&#8211;30</span></a> to post-operative and acute lung injuries&#46;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24&#8211;26</span></a> Only one study includes neuromuscular patients&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">28</span></a> Even in RCT&#44; rehabilitation programs are not uniform&#44; with some studies proposing 6-week long programs<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">25&#44;26</span></a> while others proposing shorter times<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">27&#44;30</span></a>&#59; some include specific inspiratory muscle training&#44;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a> a few others formal cardiopulmonary endurance exercise<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">27</span></a> and the others use electrical stimulation&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">29</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Type of intervention&#44; frequency&#44; duration and intensity based on Denehy et al&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">31</span></a> and Hanekom et al&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">32</span></a> is proposed in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Aims of multidisciplinary &#40;interdisciplinary or trans-disciplinary&#41; rehabilitation</span><p id="par0075" class="elsevierStylePara elsevierViewall">To improve survival&#44; diminish co-morbidities&#44; decrease ventilator dependence&#44; improve functional status and health related quality of life&#44; decrease hospital re-admissions&#44; decrease length of stay in long-term care&#44; favor return to work and social re-integration and reduce the amount of ineffective care&#46; Caution must be taken about potential contraindications &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Evidence-based multidisciplinary rehabilitative interventions</span><p id="par0080" class="elsevierStylePara elsevierViewall">There has been a growing interest in different rehabilitative strategies to treat PMV patients&#46; However most of the published studies covered non-randomized clinical trials&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">In <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a> we review some of the most interesting topics involved in these interventions&#46; Cognitive training has been tested among post-ICU survivors and preliminary data are encouraging<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">33</span></a> and a new RCT is being designed&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">34</span></a> A prospective non-randomized study has also shown that early intra-ICU clinical psychologist intervention may help critically ill trauma patients recover from post-traumatic stress disorder&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">8</span></a></p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">As mentioned before no RCT so far has analyzed swallowing dysfunction management&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Disruption of sleep is very common in mechanically ventilated patients&#46; In an observational study Koldobskyi et al&#46; have shown that specific facilities &#40;like LTAC&#39;s&#41; maintain the patients&#8217; circadian rhythm compared to the ICU environment&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">35</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">In a recent meta-analysis&#44; examining three trials involving a heterogeneous group of patients&#44; inspiratory muscle training was found to significantly increase inspiratory muscle strength in adults undergoing mechanical ventilation&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">36</span></a> Further research is needed including more homogeneous PMV populations and analyzing more relevant outcomes&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Concerning airway secretion management&#44; Gon&#231;alves et al&#46; showed in a RCT that adding mechanical in-exsufflation improved extubation outcomes&#44; increasing the efficacy of NIV post-extubation&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">37</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">There are few RCT in the context of weaning tracheostomized patients&#46; Hernandez showed that deflating the tracheal cuff in tracheostomized patients shortens weaning&#44; reduces respiratory infections&#44; and probably improves swallowing&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">38</span></a> Jubran et al&#46; in patients requiring PMV&#44; showed that unassisted breathing through a tracheostomy &#40;compared with pressure support&#41; resulted in shorter median weaning time&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">39</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Verceles et al&#46; have shown that in patients under PMV&#44; higher comorbidity burden is associated with increased risk of transfer to acute care&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">40</span></a> In fact&#44; in a retrospective study&#44; Schulman et al&#46; suggest that tighter glycemic control was associated with better outcomes in CCI patients&#46; Prospective studies addressing the importance of co-morbidities treatment optimization are warranted in this setting&#46;<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">41</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Members of the team and roles &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#41;</span><p id="par0120" class="elsevierStylePara elsevierViewall">Teamwork has been shown to improve outcomes&#46; In fact medical ICU nurses&#8217; reports of collaboration were associated positively with patient outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">42</span></a></p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">The core team is normally the <span class="elsevierStyleItalic">medical doctor</span>&#44; the <span class="elsevierStyleItalic">nurse</span> and the <span class="elsevierStyleItalic">respiratory therapist</span> &#40;or <span class="elsevierStyleItalic">specialized physiotherapist</span>&#41;&#59; the sense of interdependence exists between each other to ensure workflow is efficient&#44; effective and coordinated&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">43</span></a> Daily multidisciplinary rounds integrate the different knowledge to promote the clinical goals and formulate a plan of interventions&#46; Coordination between professionals is essential to make a personalized and integrated therapeutic plan&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">speech pathologist</span> has a very important role not only to facilitate speech in patients with tracheostomy but also to evaluate swallowing&#46;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">44</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Due to the high resource use and costs involved in supporting ventilator-dependent patients&#44; <span class="elsevierStyleItalic">social workers</span> are indispensable to assure effective integration of health&#44; social&#44; education and employment services and voluntary and independent sectors when pertinent&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">45</span></a> It also plays a fundamental role avoiding any possible discrimination that may rise from the disability surrounding PMV&#46; Frequent communication with the family with discussion about realistic versus futile goals is also an important goal&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Evaluation of efficacy</span><p id="par0140" class="elsevierStylePara elsevierViewall">The traditional severity-of-illness scoring systems like the SOFA &#40;Sepsis-related organ failure Assessment&#41; score or the APACHE III were developed in the acute Intensive care Unit &#40;ICU&#41; population&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">46</span></a> These systems were not established or validated using populations of patients under PMV &#40;or also referred to as Chronically Critically Ill patients&#41;&#44; as a result caution should be used when interpreting such data&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">47</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Therefore the development of adequately performing severity-of-illness measures appropriate to this patient population is highly needed&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In the absence of newer multidimensional tools&#44; the majority of authors use the Functional Independence Measure &#40;FIM&#41; to evaluate the efficacy of a rehabilitation program&#46;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24&#44;25&#44;27&#44;28</span></a> They evaluate the functional status of the patient at admission&#44; after half the length of the program&#44; at the end of the program and at discharge&#46; If the results are not improving significantly the program&#47;interventions should be adjusted on a regular basis&#44; decreasing&#47;increasing or maintaining intensity based on the eventual resolution of contraindications&#47;significant improvement&#47;deterioration&#47;plateauing&#46; To make this choice the Minimal Detectable Change &#40;MDC&#41; or Minimal Clinically Important Difference &#40;MCID&#41; of the disability scoring system being used should be considered&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">48</span></a> For stroke patients the MCID for total FIM score was 22 points&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">48</span></a> In studies including PMV patients the improvement in total FIM score ranged from 11<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a> at 6 weeks to 44 points at 1 year&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">26</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">Eventually after &#62;1 month of structured multidisciplinary approach&#44; consider transferring the patient to another setting &#40;home or nursing home&#41; if no improvement is gained&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Challenges</span><p id="par0160" class="elsevierStylePara elsevierViewall">In one facility with more than 30 patients with heterogeneous diagnosis&#44; the logistics of tailored therapeutic interventions can be very complex&#44; from timing and chronobiology to coordination&#46; To maintain a constant flow of interventions a highly flexible team is needed&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The role of the family&#47;non-professional caregivers to support and assist in the rehabilitation program can have a role in improving functional outcomes and potentiate team interventions&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">It is possible that some subgroups of PMV&#47;CCI benefit more from whole body rehabilitation than others&#46; A challenge for the future will be identifying which subgroups of PMV&#47;CCI benefit most from these programs&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusions</span><p id="par0175" class="elsevierStylePara elsevierViewall">Until now&#44; post-ICU patients have not had a recognized rehabilitation program and the care process is still fragmented&#46; There is a clear need to establish guidelines to define the optimal rehabilitation program in this setting&#46; Integrated&#44; multidisciplinary rehabilitation programs for ventilator-dependent chronic critically ill patients should be urgently defined&#46; Randomized studies for this situation are welcomed&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Ethical disclosures</span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Protection of human and animal subjects</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Confidentiality of data</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Right to privacy and informed consent</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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          "identificador" => "sec0010"
          "titulo" => "Psychological factors"
        ]
        4 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Swallowing dysfunction"
        ]
        5 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Skin integrity"
        ]
        6 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Whole body rehabilitation &#40;Fig&#46; 1&#41;"
        ]
        7 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Aims of multidisciplinary &#40;interdisciplinary or trans-disciplinary&#41; rehabilitation"
        ]
        8 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Evidence-based multidisciplinary rehabilitative interventions"
        ]
        9 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Members of the team and roles &#40;Table 5&#41;"
        ]
        10 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Evaluation of efficacy"
        ]
        11 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Challenges"
        ]
        12 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Conclusions"
        ]
        13 => array:3 [
          "identificador" => "sec0060"
          "titulo" => "Ethical disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0065"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0070"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0075"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        14 => array:2 [
          "identificador" => "sec0080"
          "titulo" => "Conflicts of interest"
        ]
        15 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-03-18"
    "fechaAceptado" => "2015-03-24"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec647188"
          "palabras" => array:3 [
            0 => "Rehabilitation"
            1 => "Ventilator-dependent patients"
            2 => "Weaning facilities"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The numbers of patients needing prolonged mechanical ventilation are growing&#46; The rehabilitation programs to be implemented in specialized inpatient facilities are ill defined&#46; There is a clear need to establish guidelines to define the optimal rehabilitation program in this setting&#46; In this article we review the current evidence and propose some guidance&#46;</p></span>"
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1735
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A ventilator-dependent tracheostomized patient walking with assistance from the staff&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">CHF&#44; chronic heart failure&#59; FIM&#44; functional independence measure&#59; IMT&#44; inspiratory muscle training&#59; BI&#44; barthel index&#59; Post-op&#44; post-operative&#59; ALI&#44; acute lung injury&#59; SCI&#44; spinal cord injury&#59; NMD&#44; neuromuscular disorders&#59; ARF&#44; acute respiratory Failure&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Article&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Number of patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Design&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Frequency of exercise sessions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Martin<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pneumonia&#44; CHF&#44; ARDS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab&#44; IMT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Weaning success&#44; FIM&#44; MRC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5days&#47;wk 30&#8211;60<span class="elsevierStyleHsp" style=""></span>min &#40;1&#8211;2 sessions&#47;day&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; limbs strength&#59; ability to sit to stand and supine to sit&#59; FIM<br>Mortality 12&#37;<br>Weaning rate 98&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chiang<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic lung disease&#44; Post-op&#44; ALI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab&#44; Diaphragmatic breathing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Barthel Index&#44; FIM&#44; ventilator free time&#44; Pi<span class="elsevierStyleInf">max</span>&#44; Pe<span class="elsevierStyleInf">max</span>&#44; Dynamometer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 days&#47;wk for 6 wks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; limbs strength&#59; Pimax&#44; Pemax FIM&#44; BI<br>Ventilator free time<br>Mortality 17&#46;6&#37;<br>Weaning rate 47&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chen<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">26</span></a><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chronic lung disease&#44; Post-op&#44; ALI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab&#44; Diaphragmatic breathing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1-year Survival<br>FIM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5days&#47;wk for 6 wks<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>1day&#47;wk for 6 wks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; FIM&#44; survival<br>Mortality 30&#37;<br>Weaning rate &#40;at 1 year&#41; 36&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Clini<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">30</span></a><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">COPD&#44; Post-Op&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab &#40;including pedaling and weights holding&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ADL&#44; survival weaning success&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6days&#47;wk for 15 sessions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; ADL<br>Mortality 13&#37;<br>Weaning rate 74&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chen<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">27</span></a><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">COPD&#47;Chronic Lung Disease&#44; CHF&#44; SCI&#44; Pneumonia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab&#44; Cardiopulmonary endurance exercise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Pulmonary mechanics&#44; Barthel Index&#44; FIM&#44; weaning success&#44; mortality&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 exercise training sessions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; VT&#44; RSBI&#44; FIM<br>Mortality 0&#37;<br>Weaning rate 75&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Montagnini<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">28</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">COPD&#44; NMD&#44; Trauma&#44; CHF&#44; Post-op&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab &#40;including bed-side cycle ergometer&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FIM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 days&#47;wk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; FIM Dyspnea &#40;MRC&#41;<br>PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span><br>&#8595; PaCO<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Vitacca <a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">29</span></a><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">240&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">COPD&#44; ARF&#44; Neurological diseases&#44; Post-op&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Whole body Rehab &#40;including electrical stimulation&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Barthel Index&#44; Gussago Nursing Scale&#44; survival&#44; weaning success&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 days&#47;wk 1<span class="elsevierStyleHsp" style=""></span>h&#47;day &#40;in 1 or 2 30<span class="elsevierStyleHsp" style=""></span>min sessions&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8593; BI&#44; GNS&#44; DPAP<br>PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span><br>&#8595; PaCO<span class="elsevierStyleInf">2</span><br>&#8595; Borg<br>Mortality 13&#46;8&#37;<br>Weaning rate 47&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Excluded NMD&#46;</p>"
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            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Excluded neurological disorders&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Summary of retrospective&#47;prospective&#47;RCT in weaning facilities&#46;</p>"
        ]
      ]
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        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
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        "tabla" => array:1 [
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Frequency of exercise sessions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">15<span class="elsevierStyleHsp" style=""></span>min&#47;day &#40;if &#60;4<span class="elsevierStyleHsp" style=""></span>h spontaneous breathing&#41;<br>2&#215; 15<span class="elsevierStyleHsp" style=""></span>min&#47;day &#40;if &#62;4<span class="elsevierStyleHsp" style=""></span>h spontaneous breathing&#41;</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Type of exercise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Marching in place<br>Moving from sitting to standing<br>Arm and leg active and active resistance movements&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Based on<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">34</span></a> Active range of motion exercises for all major joints&#44; bed mobility exercises &#40;e&#46;g&#46; lateral rolling&#44; supine to sit&#41;&#44; dangling at the edge of the bed&#44; postural retraining&#44; balance exercises &#40;e&#46;g&#46; reaching in and out of the base support&#44; challenges to elicit &#8220;righting&#8221; reflexes&#41;&#44; training in ADL &#40;eating or simulated eating&#44; grooming&#44; bathing&#44; dressing&#44; and toileting&#41;&#44; transfer from seated to a standing position and from bed to chair or commode&#44; standing exercises such as reaching in and out of the base of support&#44; mini-squats&#44; marching&#44; and ambulation &#40;with or without assistive devices&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Intensity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Target modified Borg Scale score 3&#8211;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Type of intervention&#44; frequency&#44; duration and intensity&#46;</p>"
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        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; ICU&#44; intensive care unit&#59; Hgb&#44; hemoglobin&#59; HR&#44; heart rate&#59; ABP&#44; arterial blood pressure&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemodynamic instability &#40;in this case the patient should be discharged to an ICU&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Non-controlled behavioral disorders &#40;in this case also the patient should be discharged&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Severe anemia &#40;less than Hgb 7<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41; or thrombocytopenia &#40;Platelets &#60;40&#8211;50&#46;000&#47;dl&#41;&#46; In Hemato-oncologic patients levels between 20 and 30&#46;000 can be accepted&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">HR &#60;60 or &#62;110&#47;min &#40;or &#62;30<span class="elsevierStyleHsp" style=""></span>bpm above resting predicted HR&#41;&#59; also consider underlying cardiac disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Mean ABP &#60;65<span class="elsevierStyleHsp" style=""></span>mmHg or &#62;200<span class="elsevierStyleHsp" style=""></span>mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sepsis or persistent fever &#40;&#62;38<span class="elsevierStyleHsp" style=""></span>&#176;C&#41; &#40;in fever of central cause or while fever cause is being investigated&#44; between fever peaks&#44; consider lower intensity&#47;passive interventions&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">End-stage patients included in palliative care&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Contraindications of physical therapy in PMV&#46;</p>"
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          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; CHF&#44; chronic heart failure&#59; DM&#44; diabetes mellitus&#59; COPD&#44; chronic obstructive pulmonary disease&#46;</p>"
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                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Cognitive rehabilitation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">8&#44;33&#44;34</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Feeding&#47;nutrition and swallowing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sleep&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">35</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Respiratory &#8211; respiratory muscle training<br>Secretion management&#59; Weaning&#47;decannulation protocols&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">36</span></a><br><a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">37</span></a><br><a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">38&#44;39</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Physical therapy &#8211; limb exercises&#44; exercise training&#44; neuromuscular electrical stimulation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">See <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Co-morbidities management &#40;e&#46;g&#46; CHF&#44; DM&#44; COPD&#41;&#44;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Skin care&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Evidence-based multidisciplinary rehabilitative interventions&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Core team&#58; MD&#44; Nurse&#44; RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">MD&#58; Serve as a coordinator&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Nurse&#58; Liaise with RT&#47;PT as required&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Speech pathologist&#58; Liaise with RT&#47;PT as required to evaluate swallowing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Occupational therapist&#44; psychologist&#44; nutritionist&#47;dietitian&#44; social worker involved as required&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Members of the team and roles&#46;</p>"
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      "titulo" => "References"
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        0 => array:2 [
          "identificador" => "bibs0005"
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Article information
ISSN: 21735115
Original language: English
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Pulmonology

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