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array:24 [ "pii" => "S2173511515000834" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2015.03.005" "estado" => "S300" "fechaPublicacion" => "2015-11-01" "aid" => "1056" "copyright" => "Sociedade Portuguesa de Pneumologia" "copyrightAnyo" => "2015" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2015;21:334-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1465 "formatos" => array:3 [ "EPUB" => 214 "HTML" => 730 "PDF" => 521 ] ] "itemSiguiente" => array:19 [ "pii" => "S2173511515001335" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2015.07.002" "estado" => "S300" "fechaPublicacion" => "2015-11-01" "aid" => "1078" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "sco" "cita" => "Rev Port Pneumol. 2015;21:341-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1373 "formatos" => array:3 [ "EPUB" => 199 "HTML" => 651 "PDF" => 523 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief Communication</span>" "titulo" => "Alpha-1 antitrypsin deficiency caused by a novel mutation (p.Leu263Pro): Pi*ZQ0gaia – Q0gaia allele" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "341" "paginaFinal" => "343" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1068 "Ancho" => 1555 "Tamanyo" => 83683 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Characterization of Q0Gaia allele. (A) Protein gel electrophoresis. Index case ZQ0 displays only a band corresponding to PI*Z allele. (B) Electropherogram of the index case. The arrow shows the region of the T to C mutation in codon 263.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.J. Oliveira, S. Seixas, I. Ladeira, R. Monteiro, T. Shiang, M. Guimarães, R. Lima" "autores" => array:7 [ 0 => array:2 [ "nombre" => "M.J." "apellidos" => "Oliveira" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Seixas" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Ladeira" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Monteiro" ] 4 => array:2 [ "nombre" => "T." "apellidos" => "Shiang" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Guimarães" ] 6 => array:2 [ "nombre" => "R." "apellidos" => "Lima" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511515001335?idApp=UINPBA00004E" "url" => "/21735115/0000002100000006/v4_201605090016/S2173511515001335/v4_201605090016/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173511515000809" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2015.03.002" "estado" => "S300" "fechaPublicacion" => "2015-11-01" "aid" => "1053" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2015;21:327-33" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1512 "formatos" => array:3 [ "EPUB" => 232 "HTML" => 721 "PDF" => 559 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Asthma control and exacerbations in patients with severe asthma treated with omalizumab in Portugal" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "327" "paginaFinal" => "333" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 4078 "Ancho" => 3034 "Tamanyo" => 354337 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">(A) Percentage of visits reporting controlled asthma and exacerbations according to the month of the year (all patients included). (B) Reports of controlled asthma and exacerbations during follow-up, per patient. In (B) numbers on the right indicate total months of follow-up; continuous grey lines represent the follow-up period and dashed grey lines interruptions in omalizumab treatment; red dots represent visits with report of exacerbation and blue dashes visits with CARAT global score >24–data from the 20 patients treated with omalizumab in Centro Hospitalar São João, EPE.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A.S. Sousa, A.M. Pereira, J.A. Fonseca, L.F. Azevedo, C. Abreu, A. Arrobas, T. Calvo, M.J. Silvestre, L. Cunha, H. Falcão, M. Drummond, L. Geraldes, C. Loureiro" "autores" => array:14 [ 0 => array:2 [ "nombre" => "A.S." "apellidos" => "Sousa" ] 1 => array:2 [ "nombre" => "A.M." "apellidos" => "Pereira" ] 2 => array:2 [ "nombre" => "J.A." "apellidos" => "Fonseca" ] 3 => array:2 [ "nombre" => "L.F." "apellidos" => "Azevedo" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Abreu" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Arrobas" ] 6 => array:2 [ "nombre" => "T." "apellidos" => "Calvo" ] 7 => array:2 [ "nombre" => "M.J." "apellidos" => "Silvestre" ] 8 => array:2 [ "nombre" => "L." "apellidos" => "Cunha" ] 9 => array:2 [ "nombre" => "H." "apellidos" => "Falcão" ] 10 => array:2 [ "nombre" => "M." "apellidos" => "Drummond" ] 11 => array:2 [ "nombre" => "L." "apellidos" => "Geraldes" ] 12 => array:2 [ "nombre" => "C." "apellidos" => "Loureiro" ] 13 => array:1 [ "colaborador" => "on behalf of Severe Asthma Specialist Network (Rede de Especialistas de Asma Grave REAG)" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511515000809?idApp=UINPBA00004E" "url" => "/21735115/0000002100000006/v4_201605090016/S2173511515000809/v4_201605090016/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Special Article</span>" "titulo" => "Multidisciplinary rehabilitation in ventilator-dependent patients: Call for action in specialized inpatient facilities" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "334" "paginaFinal" => "340" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Winck, R. Camacho, N. Ambrosino" "autores" => array:3 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Winck" "email" => array:1 [ 0 => "jcwinck@mail.telepac.pt" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Camacho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "N." "apellidos" => "Ambrosino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Pulmonology, Faculdade de Medicina, Universidade do Porto, Portugal & Linde Healthcare, Pullach, Germany" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "REMEO Program, Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Weaning and Rehabilitation Unit, Auxilium Vitae Rehabilitation Center, Volterra, Italy" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1735 "Ancho" => 975 "Tamanyo" => 240948 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A ventilator-dependent tracheostomized patient walking with assistance from the staff.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">According to the NAMDRC consensus conference, prolonged mechanical ventilation (PMV) defines patients who require at least 6<span class="elsevierStyleHsp" style=""></span>h of mechanical ventilation for >21 consecutive days.<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">1</span></a> Recent estimates indicate that in the US the numbers of PMV are expected to double by the year 2020, reaching more than 600,000 patients.<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The reasons for this are heterogeneous: a greater capacity of ICUs to assist severe respiratory failure; modulate systemic inflammatory response syndrome and severe sepsis in patients with a high prevalence of secondary neuromuscular dysfunction and severe physical deconditioning, all these at increasingly advanced ages. Another large group of patients is represented by those suffering from severe injuries to the central nervous system or incurable and progressive neuromuscular diseases.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Currently we only have partial information about the functional outcomes and quality of life of these patients, who are now described as chronic critically ill patients.<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">3</span></a> Their life trajectories, during their stay at long-term acute care hospitals, or LTACs or after a successful ventilatory weaning, are yet to be described. Many will have severe, permanent cognitive and physical impairments and serious limitations due to their disability, which will obviously involve high psychosocial costs.<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Treating these patients in specific venues with strong rehabilitative focus is normally recommended, with the cost savings and higher ventilator weaning rates.<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">PMV patients (also referred to as Chronically Critically Ill patients) are very demanding due to multiple systems and organs dysfunctions. Beyond prolonged dependence on mechanical ventilation, muscle, neuro-endocrine, skin and brain dysfunctions give way to a distinct and complex syndrome.<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Although liberation from the ventilator will be one of the most important interventions in this setting, there is more than one type of weaning.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Psychological factors</span><p id="par0035" class="elsevierStylePara elsevierViewall">Psychological factors (like depression or delirium) may hinder ventilator weaning.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">6</span></a> Sleep deprivation or unrecognized sleep disorders may also interfere with weaning.<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">7</span></a> So measures to improve sleep and psychological disorders can impact other outcomes.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">8</span></a> In fact educational interventions, counseling and stress management can decrease the risk of developing psychological disorders. Moreover, effective pharmacological treatment of anxiety and depression is also mandatory.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Swallowing dysfunction</span><p id="par0040" class="elsevierStylePara elsevierViewall">Oropharyngeal dysphagia (OPD) has been described in patients with PVM for three decades, and yet, has not received much attention in research addressing different subgroups of this diverse population.<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">9,10</span></a> Swallowing dysfunction is a common complication in chronic critically ill patients, which affects nearly half of the non-neurologic patients requiring percutaneous dilatational tracheostomy and almost all of those with neurologic involvement; it is well known to deteriorate outcomes, and delay the weaning and tracheostomy decannulation process.<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">11</span></a> A number of possible specific swallowing dysfunctional conditions arise in PMV patients; to mention a few, sarcopenic dysphagia, presbyphagia, neuromuscular dysfunction related dysphagia and even with some structural swallowing disorders.<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">12</span></a> Overall evaluation measures and treatment are based on experiments with different methodologies<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">13,14</span></a> but not on controlled studies which consider the unique pathophysiology of chronic critically ill patients.<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">15</span></a> It is worth mentioning the potential role of fiberoptic endoscopic evaluation of swallowing (FEES) as an objective tool to precisely classify and guide therapeutic interventions after prolonged intubation and in tracheostomy patients. In fact, FEES with sensory testing is improving the rehabilitation designs and protocols.<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">16</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The main components of a dysphagia rehabilitation program include oral health care, swallowing rehabilitative techniques, and food consistency modification. To the best of our knowledge there are no detailed studies or any evidence about the most effective strategies to improve the swallowing process in different non-invasive and invasive PMV scenarios. This role which has been suggested for FEES as an objective tool to precisely classify and guide therapeutic interventions after prolonged intubation and in tracheostomy patients should be considered.<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">17</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Skin integrity</span><p id="par0050" class="elsevierStylePara elsevierViewall">Skin integrity is an independent determinant of survival in patients requiring prolonged mechanical ventilation and is a potentially modifiable factor.<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">18</span></a> The most important risk factors for development of pressure ulcers while in ICU are total score on Braden Scale, mobility, activity, sensory perception, moisture, friction/shear, nutrition, age, blood pressure, length of stay, APACHE II, vasopressor administration, and co-morbid conditions.<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">19</span></a> Where it is chronic, central neurological involvement and small fiber pathology (which explains chronic sensory impairment and pain in neuro-critical care survivors) are the main features.<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">20</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Whole body rehabilitation (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>)</span><p id="par0055" class="elsevierStylePara elsevierViewall">Increasing evidence supports early physiotherapy for the critically ill patient<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">21,22</span></a>.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">RCT in ICU settings have already shown that early physical and occupational rehabilitation of mechanically ventilated patients translates into better weaning outcomes.<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">23</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In weaning facilities the studies evaluating the impact of rehabilitation in prolonged mechanical ventilated patients (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>) show positive results, from increase in limb strength<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24,25</span></a> to improvement in functional measures like FIM,<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24–28</span></a> respiratory muscle strength<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a> and mechanics.<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">27</span></a> A RCT study has also shown a significant survival benefit in the rehabilitation group.<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">26</span></a> In these studies mortality ranges from 12%<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a> to 30%<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a> and weaning rate from 47%<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">29</span></a> to 98%.<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a> The studies include also very different sub-groups of patients from chronic respiratory diseases<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">25–30</span></a> to post-operative and acute lung injuries.<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24–26</span></a> Only one study includes neuromuscular patients.<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">28</span></a> Even in RCT, rehabilitation programs are not uniform, with some studies proposing 6-week long programs<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">25,26</span></a> while others proposing shorter times<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">27,30</span></a>; some include specific inspiratory muscle training,<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a> a few others formal cardiopulmonary endurance exercise<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">27</span></a> and the others use electrical stimulation.<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">29</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Type of intervention, frequency, duration and intensity based on Denehy et al.<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">31</span></a> and Hanekom et al.<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">32</span></a> is proposed in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Aims of multidisciplinary (interdisciplinary or trans-disciplinary) rehabilitation</span><p id="par0075" class="elsevierStylePara elsevierViewall">To improve survival, diminish co-morbidities, decrease ventilator dependence, improve functional status and health related quality of life, decrease hospital re-admissions, decrease length of stay in long-term care, favor return to work and social re-integration and reduce the amount of ineffective care. Caution must be taken about potential contraindications (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Evidence-based multidisciplinary rehabilitative interventions</span><p id="par0080" class="elsevierStylePara elsevierViewall">There has been a growing interest in different rehabilitative strategies to treat PMV patients. However most of the published studies covered non-randomized clinical trials.</p><p id="par0085" class="elsevierStylePara elsevierViewall">In <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a> we review some of the most interesting topics involved in these interventions. Cognitive training has been tested among post-ICU survivors and preliminary data are encouraging<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">33</span></a> and a new RCT is being designed.<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">34</span></a> A prospective non-randomized study has also shown that early intra-ICU clinical psychologist intervention may help critically ill trauma patients recover from post-traumatic stress disorder.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">8</span></a></p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">As mentioned before no RCT so far has analyzed swallowing dysfunction management.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Disruption of sleep is very common in mechanically ventilated patients. In an observational study Koldobskyi et al. have shown that specific facilities (like LTAC's) maintain the patients’ circadian rhythm compared to the ICU environment.<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">35</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">In a recent meta-analysis, examining three trials involving a heterogeneous group of patients, inspiratory muscle training was found to significantly increase inspiratory muscle strength in adults undergoing mechanical ventilation.<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">36</span></a> Further research is needed including more homogeneous PMV populations and analyzing more relevant outcomes.</p><p id="par0105" class="elsevierStylePara elsevierViewall">Concerning airway secretion management, Gonçalves et al. showed in a RCT that adding mechanical in-exsufflation improved extubation outcomes, increasing the efficacy of NIV post-extubation.<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">37</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">There are few RCT in the context of weaning tracheostomized patients. Hernandez showed that deflating the tracheal cuff in tracheostomized patients shortens weaning, reduces respiratory infections, and probably improves swallowing.<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">38</span></a> Jubran et al. in patients requiring PMV, showed that unassisted breathing through a tracheostomy (compared with pressure support) resulted in shorter median weaning time.<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">39</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Verceles et al. have shown that in patients under PMV, higher comorbidity burden is associated with increased risk of transfer to acute care.<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">40</span></a> In fact, in a retrospective study, Schulman et al. suggest that tighter glycemic control was associated with better outcomes in CCI patients. Prospective studies addressing the importance of co-morbidities treatment optimization are warranted in this setting.<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">41</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Members of the team and roles (<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>)</span><p id="par0120" class="elsevierStylePara elsevierViewall">Teamwork has been shown to improve outcomes. In fact medical ICU nurses’ reports of collaboration were associated positively with patient outcomes.<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">42</span></a></p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">The core team is normally the <span class="elsevierStyleItalic">medical doctor</span>, the <span class="elsevierStyleItalic">nurse</span> and the <span class="elsevierStyleItalic">respiratory therapist</span> (or <span class="elsevierStyleItalic">specialized physiotherapist</span>); the sense of interdependence exists between each other to ensure workflow is efficient, effective and coordinated.<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">43</span></a> Daily multidisciplinary rounds integrate the different knowledge to promote the clinical goals and formulate a plan of interventions. Coordination between professionals is essential to make a personalized and integrated therapeutic plan.</p><p id="par0130" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">speech pathologist</span> has a very important role not only to facilitate speech in patients with tracheostomy but also to evaluate swallowing.<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">44</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Due to the high resource use and costs involved in supporting ventilator-dependent patients, <span class="elsevierStyleItalic">social workers</span> are indispensable to assure effective integration of health, social, education and employment services and voluntary and independent sectors when pertinent.<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">45</span></a> It also plays a fundamental role avoiding any possible discrimination that may rise from the disability surrounding PMV. Frequent communication with the family with discussion about realistic versus futile goals is also an important goal.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Evaluation of efficacy</span><p id="par0140" class="elsevierStylePara elsevierViewall">The traditional severity-of-illness scoring systems like the SOFA (Sepsis-related organ failure Assessment) score or the APACHE III were developed in the acute Intensive care Unit (ICU) population.<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">46</span></a> These systems were not established or validated using populations of patients under PMV (or also referred to as Chronically Critically Ill patients), as a result caution should be used when interpreting such data.<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">47</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Therefore the development of adequately performing severity-of-illness measures appropriate to this patient population is highly needed.</p><p id="par0150" class="elsevierStylePara elsevierViewall">In the absence of newer multidimensional tools, the majority of authors use the Functional Independence Measure (FIM) to evaluate the efficacy of a rehabilitation program.<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">24,25,27,28</span></a> They evaluate the functional status of the patient at admission, after half the length of the program, at the end of the program and at discharge. If the results are not improving significantly the program/interventions should be adjusted on a regular basis, decreasing/increasing or maintaining intensity based on the eventual resolution of contraindications/significant improvement/deterioration/plateauing. To make this choice the Minimal Detectable Change (MDC) or Minimal Clinically Important Difference (MCID) of the disability scoring system being used should be considered.<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">48</span></a> For stroke patients the MCID for total FIM score was 22 points.<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">48</span></a> In studies including PMV patients the improvement in total FIM score ranged from 11<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a> at 6 weeks to 44 points at 1 year.<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">26</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">Eventually after >1 month of structured multidisciplinary approach, consider transferring the patient to another setting (home or nursing home) if no improvement is gained.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Challenges</span><p id="par0160" class="elsevierStylePara elsevierViewall">In one facility with more than 30 patients with heterogeneous diagnosis, the logistics of tailored therapeutic interventions can be very complex, from timing and chronobiology to coordination. To maintain a constant flow of interventions a highly flexible team is needed.</p><p id="par0165" class="elsevierStylePara elsevierViewall">The role of the family/non-professional caregivers to support and assist in the rehabilitation program can have a role in improving functional outcomes and potentiate team interventions.</p><p id="par0170" class="elsevierStylePara elsevierViewall">It is possible that some subgroups of PMV/CCI benefit more from whole body rehabilitation than others. A challenge for the future will be identifying which subgroups of PMV/CCI benefit most from these programs.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusions</span><p id="par0175" class="elsevierStylePara elsevierViewall">Until now, post-ICU patients have not had a recognized rehabilitation program and the care process is still fragmented. There is a clear need to establish guidelines to define the optimal rehabilitation program in this setting. Integrated, multidisciplinary rehabilitation programs for ventilator-dependent chronic critically ill patients should be urgently defined. Randomized studies for this situation are welcomed.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Ethical disclosures</span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Protection of human and animal subjects</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Confidentiality of data</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Right to privacy and informed consent</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.</p></span></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:16 [ 0 => array:3 [ "identificador" => "xres634659" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec647188" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Psychological factors" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Swallowing dysfunction" ] 5 => array:2 [ "identificador" => "sec0020" "titulo" => "Skin integrity" ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Whole body rehabilitation (Fig. 1)" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Aims of multidisciplinary (interdisciplinary or trans-disciplinary) rehabilitation" ] 8 => array:2 [ "identificador" => "sec0035" "titulo" => "Evidence-based multidisciplinary rehabilitative interventions" ] 9 => array:2 [ "identificador" => "sec0040" "titulo" => "Members of the team and roles (Table 5)" ] 10 => array:2 [ "identificador" => "sec0045" "titulo" => "Evaluation of efficacy" ] 11 => array:2 [ "identificador" => "sec0050" "titulo" => "Challenges" ] 12 => array:2 [ "identificador" => "sec0055" "titulo" => "Conclusions" ] 13 => array:3 [ "identificador" => "sec0060" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0065" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0070" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0075" "titulo" => "Right to privacy and informed consent" ] ] ] 14 => array:2 [ "identificador" => "sec0080" "titulo" => "Conflicts of interest" ] 15 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-03-18" "fechaAceptado" => "2015-03-24" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec647188" "palabras" => array:3 [ 0 => "Rehabilitation" 1 => "Ventilator-dependent patients" 2 => "Weaning facilities" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The numbers of patients needing prolonged mechanical ventilation are growing. The rehabilitation programs to be implemented in specialized inpatient facilities are ill defined. There is a clear need to establish guidelines to define the optimal rehabilitation program in this setting. In this article we review the current evidence and propose some guidance.</p></span>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1735 "Ancho" => 975 "Tamanyo" => 240948 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A ventilator-dependent tracheostomized patient walking with assistance from the staff.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">CHF, chronic heart failure; FIM, functional independence measure; IMT, inspiratory muscle training; BI, barthel index; Post-op, post-operative; ALI, acute lung injury; SCI, spinal cord injury; NMD, neuromuscular disorders; ARF, acute respiratory Failure.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Article \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Number of patients \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Design \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Intervention \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Frequency of exercise sessions \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Results \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Martin<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">24</span></a><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pneumonia, CHF, ARDS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Retrospective \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Whole body Rehab, IMT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Weaning success, FIM, MRC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5days/wk 30–60<span class="elsevierStyleHsp" style=""></span>min (1–2 sessions/day) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">↑ limbs strength; ability to sit to stand and supine to sit; FIM<br>Mortality 12%<br>Weaning rate 98% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Chiang<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">25</span></a><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">**</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Chronic lung disease, Post-op, ALI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">RCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Whole body Rehab, Diaphragmatic breathing \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Barthel Index, FIM, ventilator free time, Pi<span class="elsevierStyleInf">max</span>, Pe<span class="elsevierStyleInf">max</span>, Dynamometer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5 days/wk for 6 wks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">↑ limbs strength; Pimax, Pemax FIM, BI<br>Ventilator free time<br>Mortality 17.6%<br>Weaning rate 47% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Chen<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">26</span></a><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">**</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Chronic lung disease, Post-op, ALI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">RCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Whole body Rehab, Diaphragmatic breathing \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1-year Survival<br>FIM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5days/wk for 6 wks<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>1day/wk for 6 wks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">↑ FIM, survival<br>Mortality 30%<br>Weaning rate (at 1 year) 36% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Clini<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">30</span></a><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">COPD, Post-Op \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Prospective \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Whole body Rehab (including pedaling and weights holding) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ADL, survival weaning success \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6days/wk for 15 sessions \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">↑ ADL<br>Mortality 13%<br>Weaning rate 74% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Chen<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">27</span></a><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">**</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">COPD/Chronic Lung Disease, CHF, SCI, Pneumonia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">RCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Whole body Rehab, Cardiopulmonary endurance exercise \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pulmonary mechanics, Barthel Index, FIM, weaning success, mortality \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10 exercise training sessions \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">↑ VT, RSBI, FIM<br>Mortality 0%<br>Weaning rate 75% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Montagnini<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">28</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">COPD, NMD, Trauma, CHF, Post-op \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Retrospective \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Whole body Rehab (including bed-side cycle ergometer) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FIM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6 days/wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">↑ FIM Dyspnea (MRC)<br>PaO<span class="elsevierStyleInf">2</span>/FiO<span class="elsevierStyleInf">2</span><br>↓ PaCO<span class="elsevierStyleInf">2</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Vitacca <a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">29</span></a><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">*</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">240 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">COPD, ARF, Neurological diseases, Post-op \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Prospective \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Whole body Rehab (including electrical stimulation) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Barthel Index, Gussago Nursing Scale, survival, weaning success \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6 days/wk 1<span class="elsevierStyleHsp" style=""></span>h/day (in 1 or 2 30<span class="elsevierStyleHsp" style=""></span>min sessions) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">↑ BI, GNS, DPAP<br>PaO<span class="elsevierStyleInf">2</span>/FiO<span class="elsevierStyleInf">2</span><br>↓ PaCO<span class="elsevierStyleInf">2</span><br>↓ Borg<br>Mortality 13.8%<br>Weaning rate 47% \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1041296.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Excluded NMD.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "**" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Excluded neurological disorders.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Summary of retrospective/prospective/RCT in weaning facilities.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Frequency of exercise sessions \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">15<span class="elsevierStyleHsp" style=""></span>min/day (if <4<span class="elsevierStyleHsp" style=""></span>h spontaneous breathing)<br>2× 15<span class="elsevierStyleHsp" style=""></span>min/day (if >4<span class="elsevierStyleHsp" style=""></span>h spontaneous breathing)</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Type of exercise \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Marching in place<br>Moving from sitting to standing<br>Arm and leg active and active resistance movements \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Based on<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">34</span></a> Active range of motion exercises for all major joints, bed mobility exercises (e.g. lateral rolling, supine to sit), dangling at the edge of the bed, postural retraining, balance exercises (e.g. reaching in and out of the base support, challenges to elicit “righting” reflexes), training in ADL (eating or simulated eating, grooming, bathing, dressing, and toileting), transfer from seated to a standing position and from bed to chair or commode, standing exercises such as reaching in and out of the base of support, mini-squats, marching, and ambulation (with or without assistive devices) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Intensity \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Target modified Borg Scale score 3–5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1041295.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Type of intervention, frequency, duration and intensity.</p>" ] ] 3 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>: ICU, intensive care unit; Hgb, hemoglobin; HR, heart rate; ABP, arterial blood pressure.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Hemodynamic instability (in this case the patient should be discharged to an ICU) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Non-controlled behavioral disorders (in this case also the patient should be discharged) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Severe anemia (less than Hgb 7<span class="elsevierStyleHsp" style=""></span>g/dl) or thrombocytopenia (Platelets <40–50.000/dl). In Hemato-oncologic patients levels between 20 and 30.000 can be accepted \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">HR <60 or >110/min (or >30<span class="elsevierStyleHsp" style=""></span>bpm above resting predicted HR); also consider underlying cardiac disease \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Mean ABP <65<span class="elsevierStyleHsp" style=""></span>mmHg or >200<span class="elsevierStyleHsp" style=""></span>mmHg \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Sepsis or persistent fever (>38<span class="elsevierStyleHsp" style=""></span>°C) (in fever of central cause or while fever cause is being investigated, between fever peaks, consider lower intensity/passive interventions) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">End-stage patients included in palliative care \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1041294.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Contraindications of physical therapy in PMV.</p>" ] ] 4 => array:7 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>: CHF, chronic heart failure; DM, diabetes mellitus; COPD, chronic obstructive pulmonary disease.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Cognitive rehabilitation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">8,33,34</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Feeding/nutrition and swallowing \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Sleep \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">35</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Respiratory – respiratory muscle training<br>Secretion management; Weaning/decannulation protocols \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">36</span></a><br><a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">37</span></a><br><a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">38,39</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Physical therapy – limb exercises, exercise training, neuromuscular electrical stimulation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">See <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Co-morbidities management (e.g. CHF, DM, COPD), \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Skin care \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NA \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1041293.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Evidence-based multidisciplinary rehabilitative interventions.</p>" ] ] 5 => array:7 [ "identificador" => "tbl0025" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Core team: MD, Nurse, RT \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">MD: Serve as a coordinator \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Nurse: Liaise with RT/PT as required \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Speech pathologist: Liaise with RT/PT as required to evaluate swallowing \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Occupational therapist, psychologist, nutritionist/dietitian, social worker involved as required \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1041292.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Members of the team and roles.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:48 [ 0 => array:3 [ "identificador" => "bib0245" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of patients requiring prolonged mechanical ventilation: report of a NAMDRC consensus conference" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N.R. MacIntyre" 1 => "S.K. Epstein" 2 => "S. Carson" 3 => "D. Scheinhorn" 4 => "K. Christopher" 5 => "S. Muldoon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.128.6.3937" "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "128" "paginaInicial" => "3937" "paginaFinal" => "3954" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16354866" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0266613812002501" "estado" => "S300" "issn" => "02666138" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0250" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Growth in adult prolonged acute mechanical ventilation: implications for healthcare delivery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.D. Zilberberg" 1 => "M. de Wit" 2 => "J.R. Pirone" 3 => "A.F. Shorr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/CCM.0b013e3181691a49" "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "2008" "volumen" => "36" "paginaInicial" => "1451" "paginaFinal" => "1455" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18434911" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0255" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic critical illness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.E. Nelson" 1 => "C.E. Cox" 2 => "A.A. Hope" 3 => "S.S. Carson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.201002-0210CI" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2010" "volumen" => "182" "paginaInicial" => "446" "paginaFinal" => "454" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20448093" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0260" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expectations and outcomes of prolonged mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.E. Cox" 1 => "T. Martinu" 2 => "S.J. Sathy" 3 => "A.S. Clay" 4 => "J. Chia" 5 => "A.L. Gray" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/CCM.0b013e3181ab86ed" "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "2009" "volumen" => "37" "paginaInicial" => "2888" "paginaFinal" => "2894" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19770733" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0265" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Streamlining weaning: protocols and weaning units" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.K. Simonds" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2004.028688" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2005" "volumen" => "60" "paginaInicial" => "175" "paginaFinal" => "182" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15741427" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0270" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Depressive disorders during weaning from prolonged mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Jubran" 1 => "G. Lawm" 2 => "J. Kelly" 3 => "L.A. Duffner" 4 => "G. Gungor" 5 => "E.G. Collins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Intens Care Med" "fecha" => "2010" "volumen" => "36" "paginaInicial" => "828" "paginaFinal" => "835" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0275" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep-disordered breathing may be under-recognized in patients who wean from prolonged mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Diaz-Abad" 1 => "A.C. Verceles" 2 => "J.E. Brown" 3 => "S.M. Scharf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4187/respcare.01260" "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2012" "volumen" => "57" "paginaInicial" => "229" "paginaFinal" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21762560" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0280" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early intra-intensive care unit psychological intervention promotes recovery from post traumatic stress disorders, anxiety and depression symptoms in critically ill patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Peris" 1 => "M. Bonizzoli" 2 => "D. Iozzelli" 3 => "M.L. Migliaccio" 4 => "G. Zagli" 5 => "A. Bacchereti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/cc10003" "Revista" => array:5 [ "tituloSerie" => "Crit Care" "fecha" => "2011" "volumen" => "15" "paginaInicial" => "R41" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21272307" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0285" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Swallowing dysfunction in patients receiving prolonged mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Tolep" 1 => "C.L. Getch" 2 => "G.J. Criner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1996" "volumen" => "109" "paginaInicial" => "167" "paginaFinal" => "172" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8549181" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0290" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Swallowing disorders in patients with prolonged orotracheal intubation or tracheostomy tubes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.A. DeVita" 1 => "L. Spierer-Rundback" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1990" "volumen" => "18" "paginaInicial" => "1328" "paginaFinal" => "1330" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2245604" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0295" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Swallowing dysfunction in nonneurologic critically ill patients who require percutaneous dilatational tracheostomy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.M. Romero" 1 => "A. Marambio" 2 => "J. Larrondo" 3 => "K. Walker" 4 => "M.T. Lira" 5 => "E. Tobar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.09-2792" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2010" "volumen" => "137" "paginaInicial" => "1278" "paginaFinal" => "1282" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20299629" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0300" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transdisciplinary approach for sarcopenia. Sarcopenic Dysphagia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H. Wakabayashi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "CliCa141015091517" "Revista" => array:6 [ "tituloSerie" => "Clin Calcium" "fecha" => "2014" "volumen" => "24" "paginaInicial" => "1509" "paginaFinal" => "1517" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25266097" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0305" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation and treatment of swallowing disorders following endotracheal intubation and tracheostomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Goldsmith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int Anesthesiol Clin" "fecha" => "2000" "volumen" => "38" "paginaInicial" => "219" "paginaFinal" => "242" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10984854" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0310" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exploration and approach to artificial airway dysphagia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Fernandez-Carmona" 1 => "L. Penas-Maldonado" 2 => "E. Yuste-Osorio" 3 => "A. Diaz-Redondo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.medin.2011.09.006" "Revista" => array:6 [ "tituloSerie" => "Med Intensiva" "fecha" => "2012" "volumen" => "36" "paginaInicial" => "423" "paginaFinal" => "433" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22055775" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0315" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Muscle weakness predicts pharyngeal dysfunction and symptomatic aspiration in long-term ventilated patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Mirzakhani" 1 => "J.N. Williams" 2 => "J. Mello" 3 => "S. Joseph" 4 => "M.J. Meyer" 5 => "K. Waak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ALN.0b013e31829373fe" "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "2013" "volumen" => "119" "paginaInicial" => "389" "paginaFinal" => "397" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23584384" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0320" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dysphagia management of acute and long-term critically ill intensive care patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Zielske" 1 => "S. Bohne" 2 => "H. Axer" 3 => "F.M. Brunkhorst" 4 => "O. Guntinas-Lichius" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00063-013-0217-3" "Revista" => array:6 [ "tituloSerie" => "Med Klin Intensivmed Notfmed" "fecha" => "2014" "volumen" => "109" "paginaInicial" => "516" "paginaFinal" => "525" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23430119" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0325" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Routine fiberoptic endoscopic evaluation of swallowing following prolonged intubation: implications for management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.S. Ajemian" 1 => "G.B. Nirmul" 2 => "M.T. Anderson" 3 => "D.M. Zirlen" 4 => "E.M. Kwasnik" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Surg" "fecha" => "2001" "volumen" => "136" "paginaInicial" => "434" "paginaFinal" => "437" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11296115" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0330" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Determinants of long-term mortality after prolonged mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.S. Aboussouan" 1 => "C.D. Lattin" 2 => "J.L. Kline" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00408-008-9110-x" "Revista" => array:6 [ "tituloSerie" => "Lung" "fecha" => "2008" "volumen" => "186" "paginaInicial" => "299" "paginaFinal" => "306" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18668291" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0335" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of pressure ulcers in adult critical care patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Cox" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4037/ajcc2011934" "Revista" => array:6 [ "tituloSerie" => "Am J Crit Care" "fecha" => "2011" "volumen" => "20" "paginaInicial" => "364" "paginaFinal" => "375" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21885457" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0340" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small nerve fiber pathology in critical illness" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Latronico" 1 => "M. Filosto" 2 => "N. Fagoni" 3 => "L. Gheza" 4 => "B. Guarneri" 5 => "A. Todeschini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0075696" "Revista" => array:5 [ "tituloSerie" => "PLoS ONE" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "e75696" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24098716" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0345" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early physiotherapy in the respiratory intensive care unit" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Clini" 1 => "N. Ambrosino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2005.02.024" "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2005" "volumen" => "99" "paginaInicial" => "1096" "paginaFinal" => "1104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16085211" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0350" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rehabilitation, weaning and physical therapy strategies in chronic critically ill patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Ambrosino" 1 => "E. Venturelli" 2 => "G. Vagheggini" 3 => "E. Clini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00094411" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2012" "volumen" => "39" "paginaInicial" => "487" "paginaFinal" => "492" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22135278" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0355" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.D. Schweickert" 1 => "M.C. Pohlman" 2 => "A.S. Pohlman" 3 => "C. Nigos" 4 => "A.J. Pawlik" 5 => "C.L. Esbrook" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(09)60658-9" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2009" "volumen" => "373" "paginaInicial" => "1874" "paginaFinal" => "1882" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19446324" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0360" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of whole-body rehabilitation in patients receiving chronic mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "U.J. Martin" 1 => "L. Hincapie" 2 => "M. Nimchuk" 3 => "J. Gaughan" 4 => "G.J. Criner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "2005" "volumen" => "33" "paginaInicial" => "2259" "paginaFinal" => "2265" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16215380" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0365" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of physical training on functional status in patients with prolonged mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L.L. Chiang" 1 => "L.Y. Wang" 2 => "C.P. Wu" 3 => "H.D. Wu" 4 => "Y.T. Wu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2522/ptj.20050036" "Revista" => array:6 [ "tituloSerie" => "Phys Ther" "fecha" => "2006" "volumen" => "86" "paginaInicial" => "1271" "paginaFinal" => "1281" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16959675" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0370" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical training is beneficial to functional status and survival in patients with prolonged mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Chen" 1 => "C.L. Su" 2 => "Y.T. Wu" 3 => "L.Y. Wang" 4 => "C.P. Wu" 5 => "H.D. Wu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jfma.2011.07.008" "Revista" => array:6 [ "tituloSerie" => "J Formos Med Assoc" "fecha" => "2011" "volumen" => "110" "paginaInicial" => "572" "paginaFinal" => "579" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21930067" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0375" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of exercise training on pulmonary mechanics and functional status in patients with prolonged mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y.H. Chen" 1 => "H.L. Lin" 2 => "H.F. Hsiao" 3 => "L.T. Chou" 4 => "K.C. Kao" 5 => "C.C. Huang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4187/respcare.01341" "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2012" "volumen" => "57" "paginaInicial" => "727" "paginaFinal" => "734" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22152978" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0380" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of the functional independence measure in people for whom weaning from mechanical ventilation is difficult" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Montagnani" 1 => "G. Vagheggini" 2 => "E. Panait Vlad" 3 => "D. Berrighi" 4 => "L. Pantani" 5 => "N. Ambrosino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2522/ptj.20100369" "Revista" => array:6 [ "tituloSerie" => "Phys Ther" "fecha" => "2011" "volumen" => "91" "paginaInicial" => "1109" "paginaFinal" => "1115" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21596958" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0385" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of a multidisciplinary care program on disability, autonomy, and nursing needs in subjects recovering from acute respiratory failure in a chronic ventilator facility" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Vitacca" 1 => "M. Paneroni" 2 => "R. Peroni" 3 => "L. Barbano" 4 => "V. Dodaj" 5 => "G. Piaggi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4187/respcare.03030" "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2014" "volumen" => "59" "paginaInicial" => "1863" "paginaFinal" => "1871" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25185151" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0390" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional recovery following physical training in tracheotomized and chronically ventilated patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.M. Clini" 1 => "E. Crisafulli" 2 => "F.D. Antoni" 3 => "C. Beneventi" 4 => "L. Trianni" 5 => "S. Costi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4187/respcare.00956" "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2011" "volumen" => "56" "paginaInicial" => "306" "paginaFinal" => "313" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21235844" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0395" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Denehy" 1 => "E.H. Skinner" 2 => "L. Edbrooke" 3 => "K. Haines" 4 => "S. Warrillow" 5 => "G. Hawthorne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/cc12835" "Revista" => array:5 [ "tituloSerie" => "Crit Care" "fecha" => "2013" "volumen" => "17" "paginaInicial" => "R156" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23883525" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0400" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The development of a clinical management algorithm for early physical activity and mobilization of critically ill patients: synthesis of evidence and expert opinion and its translation into practice" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Hanekom" 1 => "R. Gosselink" 2 => "E. Dean" 3 => "H. van Aswegen" 4 => "R. Roos" 5 => "N. Ambrosino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0269215510397677" "Revista" => array:6 [ "tituloSerie" => "Clin Rehabil" "fecha" => "2011" "volumen" => "25" "paginaInicial" => "771" "paginaFinal" => "787" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21504951" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0405" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cognitive and physical rehabilitation of intensive care unit survivors: results of the RETURN randomized controlled pilot investigation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.C. Jackson" 1 => "E.W. Ely" 2 => "M.C. Morey" 3 => "V.M. Anderson" 4 => "L.B. Denne" 5 => "J. Clune" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/CCM.0b013e3182373115" "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "2012" "volumen" => "40" "paginaInicial" => "1088" "paginaFinal" => "1097" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22080631" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0410" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A combined early cognitive and physical rehabilitation program for people who are critically ill: the activity and cognitive therapy in the intensive care unit (ACT-ICU) trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.E. Brummel" 1 => "J.C. Jackson" 2 => "T.D. Girard" 3 => "P.P. Pandharipande" 4 => "E. Schiro" 5 => "B. Work" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2522/ptj.20110414" "Revista" => array:6 [ "tituloSerie" => "Phys Ther" "fecha" => "2012" "volumen" => "92" "paginaInicial" => "1580" "paginaFinal" => "1592" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22577067" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0415" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term acute care patients weaning from prolonged mechanical ventilation maintain circadian rhythm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Koldobskiy" 1 => "M. Diaz-Abad" 2 => "S.M. Scharf" 3 => "J. Brown" 4 => "A.C. Verceles" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4187/respcare.02344" "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2014" "volumen" => "59" "paginaInicial" => "518" "paginaFinal" => "524" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24026184" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0420" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inspiratory muscle training increases inspiratory muscle strength in patients weaning from mechanical ventilation: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Moodie" 1 => "J. Reeve" 2 => "M. Elkins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1836-9553(11)70051-0" "Revista" => array:6 [ "tituloSerie" => "J Physiother" "fecha" => "2011" "volumen" => "57" "paginaInicial" => "213" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22093119" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0425" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of mechanical insufflation–exsufflation in preventing respiratory failure after extubation: a randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.R. Goncalves" 1 => "T. Honrado" 2 => "J.C. Winck" 3 => "J.A. Paiva" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/cc11249" "Revista" => array:6 [ "tituloSerie" => "Crit Care" "fecha" => "2012" "volumen" => "16" "paginaInicial" => "R48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22420538" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0266613811002130" "estado" => "S300" "issn" => "02666138" ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0430" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effects of increasing effective airway diameter on weaning from mechanical ventilation in tracheostomized patients: a randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Hernandez" 1 => "A. Pedrosa" 2 => "R. Ortiz" 3 => "M. Cruz Accuaroni Mdel" 4 => "R. Cuena" 5 => "C. Vaquero Collado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Intens Care Med" "fecha" => "2013" "volumen" => "39" "paginaInicial" => "1063" "paginaFinal" => "1070" ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0435" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of pressure support vs unassisted breathing through a tracheostomy collar on weaning duration in patients requiring prolonged mechanical ventilation: a randomized trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Jubran" 1 => "B.J. Grant" 2 => "L.A. Duffner" 3 => "E.G. Collins" 4 => "D.M. Lanuza" 5 => "L.A. Hoffman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Am Med Assoc" "fecha" => "2013" "volumen" => "309" "paginaInicial" => "671" "paginaFinal" => "677" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0440" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The association between comorbid illness, colonization status, and acute hospitalization in patients receiving prolonged mechanical ventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.C. Verceles" 1 => "E.J. Lechner" 2 => "D. Halpin" 3 => "S.M. Scharf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4187/respcare.01677" "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2013" "volumen" => "58" "paginaInicial" => "250" "paginaFinal" => "256" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22709565" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0445" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of glycemic control parameters with clinical outcomes in chronic critical illness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.C. Schulman" 1 => "E.L. Moshier" 2 => "L. Rho" 3 => "M.F. Casey" 4 => "J.H. Godbold" 5 => "J.I. Mechanick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4158/EP13324.OR" "Revista" => array:6 [ "tituloSerie" => "Endocr Pract" "fecha" => "2014" "volumen" => "20" "paginaInicial" => "884" "paginaFinal" => "893" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24641919" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0450" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between nurse-physician collaboration and patient outcomes in three intensive care units" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.G. Baggs" 1 => "M.H. Schmitt" 2 => "A.I. Mushlin" 3 => "P.H. Mitchell" 4 => "D.H. Eldredge" 5 => "D. Oakes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "1999" "volumen" => "27" "paginaInicial" => "1991" "paginaFinal" => "1998" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10507630" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0455" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Culture of early mobility in mechanically ventilated patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.P. Bailey" 1 => "R.R. Miller III" 2 => "T.P. Clemmer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/CCM.0b013e3181b6e227" "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "2009" "volumen" => "37" "paginaInicial" => "S429" "paginaFinal" => "S435" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20046131" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0460" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Facilitating speech in the patient with a tracheostomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.R. Hess" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2005" "volumen" => "50" "paginaInicial" => "519" "paginaFinal" => "525" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15807915" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0465" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resource use and service costs for ventilator-dependent children and young people in the UK" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Noyes" 1 => "C. Godfrey" 2 => "J. Beecham" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2524.2006.00639.x" "Revista" => array:6 [ "tituloSerie" => "Health Soc Care Community" "fecha" => "2006" "volumen" => "14" "paginaInicial" => "508" "paginaFinal" => "522" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17059493" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0470" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical review: scoring systems in the critically ill" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.L. Vincent" 1 => "R. Moreno" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/cc8204" "Revista" => array:5 [ "tituloSerie" => "Crit Care" "fecha" => "2010" "volumen" => "14" "paginaInicial" => "207" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20392287" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0475" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predicting mortality in patients suffering from prolonged critical illness: an assessment of four severity-of-illness measures" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.S. Carson" 1 => "P.B. Bach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2001" "volumen" => "120" "paginaInicial" => "928" "paginaFinal" => "933" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11555531" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0480" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Determination of the minimal clinically important difference in the FIM instrument in patients with stroke" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Beninato" 1 => "K.M. Gill-Body" 2 => "S. Salles" 3 => "P.C. Stark" 4 => "R.M. Black-Schaffer" 5 => "J. Stein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.apmr.2005.08.130" "Revista" => array:6 [ "tituloSerie" => "Arch Phys Med Rehabil" "fecha" => "2006" "volumen" => "87" "paginaInicial" => "32" "paginaFinal" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16401435" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735115/0000002100000006/v4_201605090016/S2173511515000834/v4_201605090016/en/main.assets" "Apartado" => array:4 [ "identificador" => "9694" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Special article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735115/0000002100000006/v4_201605090016/S2173511515000834/v4_201605090016/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511515000834?idApp=UINPBA00004E" ]
Year/Month | Html | Total | |
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2024 November | 8 | 8 | 16 |
2024 October | 49 | 32 | 81 |
2024 September | 30 | 21 | 51 |
2024 August | 49 | 30 | 79 |
2024 July | 34 | 30 | 64 |
2024 June | 41 | 23 | 64 |
2024 May | 45 | 34 | 79 |
2024 April | 37 | 27 | 64 |
2024 March | 36 | 16 | 52 |
2024 February | 34 | 29 | 63 |
2024 January | 26 | 28 | 54 |
2023 December | 18 | 15 | 33 |
2023 November | 28 | 47 | 75 |
2023 October | 33 | 32 | 65 |
2023 September | 24 | 33 | 57 |
2023 August | 31 | 13 | 44 |
2023 July | 29 | 28 | 57 |
2023 June | 34 | 15 | 49 |
2023 May | 70 | 26 | 96 |
2023 April | 27 | 7 | 34 |