Non-small cell lung cancer in octogenarian patients – The experience in a tertiary university hospital

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(B) The second chest CT showing posteromedial hepatization of the left lower field, compatible with superimposed infection. (C) CT angiography showing the anomalous artery arising from the thoracic aorta. (D) CT angiography images showing the venous drainage (arrow) to the pulmonary veins. (E–F) 3D CT reconstructions showing the anomalous artery." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Silva, J. Vale, A. Reis" "autores" => array:3 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Silva" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Vale" ] 2 => array:2 [ "nombre" => "A." 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Oliveira, L. Martins, M. Félix" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Oliveira" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Martins" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Félix" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511515000871?idApp=UINPBA00004E" "url" => "/21735115/0000002100000005/v3_201605090007/S2173511515000871/v3_201605090007/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "Letter to the Editor" "titulo" => "Non-small cell lung cancer in octogenarian patients – The experience in a tertiary university hospital" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "281" "paginaFinal" => "282" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "H. Dabó, R. Gomes, V. Hespanhol, H. Queiroga" "autores" => array:4 [ 0 => array:4 [ "nombre" => "H." "apellidos" => "Dabó" "email" => array:1 [ 0 => "hansdabo@yahoo.com.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Gomes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "V." "apellidos" => "Hespanhol" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "H." 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Therefore, the clinical practice in this population often poses challenges to clinicians.The authors report the incidence, clinical characteristics, treatment and prognosis of non-small cell lung cancer (NSCLC) in octogenarian patients (80 years and over), in a tertiary academic hospital in Oporto, Portugal. We retrospectively evaluated 1292 patients newly diagnosed with lung cancer, from January 2009 to December 2014. For the purpose of analysis, only patients with NSCLC that had a follow-up in our center were included.Ninety-two octogenarians were included (7.1% of total), 79.3% (n=73) were male with a median age of 82.0 years (80–90). Smoking history was present in 65% (n=58) of patients. The median time from symptom onset to diagnosis was 2.0 months (0–12.0). The diagnosis was obtained by bronchoscopy in 45.7% (n=42) of patients, transthoracic biopsy guided by CT in 46.7% (n=43) and blind pleural biopsy in 7.6% (n=7). Adenocarcinoma was the most common histopathological type, recorded in 51.1% (n=47) of patients, followed by squamous cell carcinoma in 41.3% (n=38). Clinical staging revealed 23.8% (n=22) of patients with stage I and II, 8.7% (n=8) with III-A and 67.4% (n=62) with III-B and IV. The initial Performance Status (PS) was 0 and 1 in 60.9% (n=56) of patients, 2 in 16.3% (n=15) and 3 and 4 in 22.8% (n=21). After careful consideration, the following treatments were performed: surgery in 5.4% (n=5), surgery followed by adjuvant chemotherapy in 1.1% (n=1), chemotherapy only in 17.4% (n=16), chemotherapy plus conventional radiotherapy in 8.7% (n=8), conventional radiotherapy in 5.4% (n=5) and stereotactic body radiation therapy (SBRT) in 2.2% (n=2). Most patients (58.7%, n=54) were submitted to best supportive care (BSC), two-thirds presenting PS≥2. Platinum-based doublet regimens were used in one-third of patients submitted to chemotherapy. Surgery was performed on 6 patients: lobectomy and mediastinal lymph node dissection in 3, lobectomy without mediastinal lymph node dissection in 1, segmentectomy in 1 and atypical lung resection in 1. Using Charlson Comorbidity Index, all patients scored high, even the potential surgical candidates, reducing the number of surgeries performed. One postoperative death was the major complication encountered. During the follow-up period, 38% (n=35) of octogenarians are still alive, 53.5% (n=49) died and 8.7% (n=8) were lost to follow-up. In Kaplan–Meier analyses, the median survival rate was about 2.5 months in the BSC group and 12.5 months for those submitted to other non-surgical treatments. More than 80.0% of patients who had surgery are still alive (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia>With social and medical evolutions, and consequently global aging, it is expected that more elderly will be affected by lung cancer. For clinicians, it will be increasingly a challenge to manage these patients because they usually have a high burden of comorbidities, a high risk of complications and shorter life expectancy.<a class="elsevierStyleCrossRefs" href="#bib0050">3,4</a> Thus, some clinicians are reluctant to propose anticancer treatments (including surgery) to octogenarians. Nevertheless, surgery is the best chance of a cure,<a class="elsevierStyleCrossRef" href="#bib0055">4</a> and should not be denied based on older age alone. Furthermore, the mortality rates associated to surgery have reached acceptable levels.<a class="elsevierStyleCrossRef" href="#bib0060">5</a> In our study, we found that more than 40% of patients were submitted to some form of anticancer treatment. Only a minority of octogenarians presented in surgical staging, and only just over a quarter of them were submitted to surgery, with acceptable outcomes. The presence of significant comorbidities was a major reason for excluding surgery. In patients with contraindications to surgery, SBRT has emerged as an attractive treatment option.<a class="elsevierStyleCrossRef" href="#bib0065">6</a> Two of our patients had SBRT, without significant morbidity. Chemotherapy was also performed in about a quarter of patients. In a recent study, octogenarians with NSCLC treated with chemotherapy showed prolonged survival compared with those submitted to BSC.<a class="elsevierStyleCrossRef" href="#bib0070">7</a>Our results suggest that selected octogenarians with NSCLC, regardless of age, may benefit from specific anticancer treatment. Thus, a multidisciplinary assessment is recommended. Further studies are warranted to provide an optimal treatment approach for octogenarians.Conflicts of interestThe authors have no conflicts of interest to declare." 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Xu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1995-7645(12)60079-0" "Revista" => array:6 [ "tituloSerie" => "Asian Pac J Trop Med" "fecha" => "2012" "volumen" => "5" "paginaInicial" => "465" "paginaFinal" => "468" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22575979" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0055" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of thoracic surgery in octogenarians with non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Rizzi" 1 => "M. De Simone" 2 => "F. Raveglia" 3 => "U. 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Miranda" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/icvts/ivt020" "Revista" => array:6 [ "tituloSerie" => "Interact Cardiovasc Thorac Surg" "fecha" => "2013" "volumen" => "16" "paginaInicial" => "673" "paginaFinal" => "680" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23396622" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0065" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stereotactic body radiation therapy in octogenarians with stage I lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.P. Sandhu" 1 => "S.K. Lau" 2 => "D. Rahn" 3 => "S.K. Nath" 4 => "D. Kim" 5 => "W.Y. Song" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cllc.2013.08.007" "Revista" => array:6 [ "tituloSerie" => "Clin Lung Cancer" "fecha" => "2014" "volumen" => "15" "paginaInicial" => "131" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24157245" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0070" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current status of chemotherapy use and clinical outcome in octogenarians with advanced non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.H. Sim" 1 => "Y.J. Kim" 2 => "S.H. Kim" 3 => "B. Keam" 4 => "T.M. Kim" 5 => "S.H. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Cancer Res Clin Oncol" "fecha" => "2015" "volumen" => "14" "paginaInicial" => "1073" "paginaFinal" => "1081" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735115/0000002100000005/v3_201605090007/S2173511515001220/v3_201605090007/en/main.assets" "Apartado" => array:4 [ "identificador" => "20584" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735115/0000002100000005/v3_201605090007/S2173511515001220/v3_201605090007/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511515001220?idApp=UINPBA00004E"]

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Letter to the Editor

Non-small cell lung cancer in octogenarian patients – The experience in a tertiary university hospital

H. Dabóa,

Corresponding author

hansdabo@yahoo.com.br

Corresponding author.

, R. Gomesb, V. Hespanhola,c, H. Queirogaa,c

a Pulmonology Department of Centro Hospitalar de São João, Oporto, Portugal

b Pulmonology Department of Hospital Sousa Martins, Unidade Local de Saúde – Guarda, Portugal

c School of Medicine, University of Oporto, Oporto, Portugal

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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lung cancer is the most common cancer worldwide&#44; and the leading cause of cancer-related death&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> It is considered a disease of the elderly&#44; and octogenarians represent a rapidly growing population of patients diagnosed with this disease&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> Despite this&#44; the evidence-based standard of care for these patients is limited&#46; Therefore&#44; the clinical practice in this population often poses challenges to clinicians&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The authors report the incidence&#44; clinical characteristics&#44; treatment and prognosis of non-small cell lung cancer &#40;NSCLC&#41; in octogenarian patients &#40;80 years and over&#41;&#44; in a tertiary academic hospital in Oporto&#44; Portugal&#46; We retrospectively evaluated 1292 patients newly diagnosed with lung cancer&#44; from January 2009 to December 2014&#46; For the purpose of analysis&#44; only patients with NSCLC that had a follow-up in our center were included&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Ninety-two octogenarians were included &#40;7&#46;1&#37; of total&#41;&#44; 79&#46;3&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#41; were male with a median age of 82&#46;0 years &#40;80&#8211;90&#41;&#46; Smoking history was present in 65&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>58&#41; of patients&#46; The median time from symptom onset to diagnosis was 2&#46;0 months &#40;0&#8211;12&#46;0&#41;&#46; The diagnosis was obtained by bronchoscopy in 45&#46;7&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>42&#41; of patients&#44; transthoracic biopsy guided by CT in 46&#46;7&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>43&#41; and blind pleural biopsy in 7&#46;6&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#41;&#46; Adenocarcinoma was the most common histopathological type&#44; recorded in 51&#46;1&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>47&#41; of patients&#44; followed by squamous cell carcinoma in 41&#46;3&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>38&#41;&#46; Clinical staging revealed 23&#46;8&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>22&#41; of patients with stage I and II&#44; 8&#46;7&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#41; with III-A and 67&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>62&#41; with III-B and IV&#46; The initial <span class="elsevierStyleItalic">Performance Status</span> &#40;PS&#41; was 0 and 1 in 60&#46;9&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>56&#41; of patients&#44; 2 in 16&#46;3&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#41; and 3 and 4 in 22&#46;8&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>21&#41;&#46; After careful consideration&#44; the following treatments were performed&#58; surgery in 5&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#41;&#44; surgery followed by adjuvant chemotherapy in 1&#46;1&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; chemotherapy only in 17&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41;&#44; chemotherapy plus conventional radiotherapy in 8&#46;7&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#41;&#44; conventional radiotherapy in 5&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#41; and stereotactic body radiation therapy &#40;SBRT&#41; in 2&#46;2&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41;&#46; Most patients &#40;58&#46;7&#37;&#44; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>54&#41; were submitted to best supportive care &#40;BSC&#41;&#44; two-thirds presenting PS<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2&#46; <span class="elsevierStyleItalic">Platinum</span>-<span class="elsevierStyleItalic">based doublet regimens</span> were used in one-third of patients submitted to chemotherapy&#46; Surgery was performed on 6 patients&#58; lobectomy and mediastinal lymph node dissection in 3&#44; lobectomy without mediastinal lymph node dissection in 1&#44; segmentectomy in 1 and atypical lung resection in 1&#46; Using Charlson Comorbidity Index&#44; all patients scored high&#44; even the potential surgical candidates&#44; reducing the number of surgeries performed&#46; One postoperative death was the major complication encountered&#46; During the follow-up period&#44; 38&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>35&#41; of octogenarians are still alive&#44; 53&#46;5&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>49&#41; died and 8&#46;7&#37; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#41; were lost to follow-up&#46; In Kaplan&#8211;Meier analyses&#44; the median survival rate was about 2&#46;5 months in the BSC group and 12&#46;5 months for those submitted to other non-surgical treatments&#46; More than 80&#46;0&#37; of patients who had surgery are still alive &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">With social and medical evolutions&#44; and consequently global aging&#44; it is expected that more elderly will be affected by lung cancer&#46; For clinicians&#44; it will be increasingly a challenge to manage these patients because they usually have a high burden of comorbidities&#44; a high risk of complications and shorter life expectancy&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3&#44;4</span></a> Thus&#44; some clinicians are reluctant to propose anticancer treatments &#40;including surgery&#41; to octogenarians&#46; Nevertheless&#44; surgery is the best chance of a cure&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> and should not be denied based on older age alone&#46; Furthermore&#44; the mortality rates associated to surgery have reached acceptable levels&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> In our study&#44; we found that more than 40&#37; of patients were submitted to some form of anticancer treatment&#46; Only a minority of octogenarians presented in surgical staging&#44; and only just over a quarter of them were submitted to surgery&#44; with acceptable outcomes&#46; The presence of significant comorbidities was a major reason for excluding surgery&#46; In patients with contraindications to surgery&#44; SBRT has emerged as an attractive treatment option&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> Two of our patients had SBRT&#44; without significant morbidity&#46; Chemotherapy was also performed in about a quarter of patients&#46; In a recent study&#44; octogenarians with NSCLC treated with chemotherapy showed prolonged survival compared with those submitted to BSC&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Our results suggest that selected octogenarians with NSCLC&#44; regardless of age&#44; may benefit from specific anticancer treatment&#46; Thus&#44; a multidisciplinary assessment is recommended&#46; Further studies are warranted to provide an optimal treatment approach for octogenarians&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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Article information

ISSN: 21735115
Original language: English

DOI:10.1016/j.rppnen.2015.06.006

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Year/Month	Html	Pdf	Total

2024 November	9	4	13
2024 October	32	24	56
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