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Research Letter
Critical appraisal of the Portuguese clinical guideline 28/2011
T. Sousa-Veloso
Neurosciences and Mental Health Department, Medical Psychology Unit, Faculty of Medicine of the University of Porto, Porto, Portugal
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      0 => array:3 [
        "autoresLista" => "T&#46; Sousa-Veloso"
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            "nombre" => "T&#46;"
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            "entidad" => "Neurosciences and Mental Health Department&#44; Medical Psychology Unit&#44; Faculty of Medicine of the University of Porto&#44; Porto&#44; Portugal"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleDisplayedQuote" id="dsq0005"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#8220;It is not recommended the regular prescription of mucolytics nor antitussive agents&#46;&#8221;</p><span class="elsevierStyleSource">&#40;DGS Guideline 28&#47;2011 - COPD&#44; p&#46; 5&#41;&#46;</span></span></p><p id="par0010" class="elsevierStylePara elsevierViewall">This sentence addresses two very different therapeutic categories&#46; We agree only with the antitussive agents part&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">According to the 2015 update of GOLD guidelines&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> which address chronic obstructive pulmonary disease &#40;COPD&#41;&#44; the use of mucolytics&#44; such as N-acetylcysteine or carbocysteine&#44; can have a positive effect on the reduction of the number of exacerbations&#46; The most recent Cochrane<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> review on the issue included many non-identical studies &#40;a very high heterogeneity index&#44; <span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>87&#37;&#41;&#44; which makes it particularly difficult to identify statistically significant difference between groups&#46; Despite this fact&#44; the benefit reported from the use of mucolytics was significant as far as exacerbation reduction was concerned &#40;OR 1&#46;84&#59; CI<span class="elsevierStyleInf">95&#37;</span> 1&#46;63&#8211;2&#46;07&#41;&#44; which can also be translated into a number needing to be treated of 7 &#40;one should treat 7 patients for at least 10 months in order to achieve a reduction of 1 exacerbation episode&#41;&#44; as well as on the statistically significant lowering of the number of sick days &#40;on average&#44; a decrease of 0&#46;48 days&#44; CI<span class="elsevierStyleInf">95&#37;</span> &#8722;0&#46;65 to &#8722;0&#46;30&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Following what has been said&#44; we think that the sentence &#8220;<span class="elsevierStyleItalic">It is not recommended the regular prescription of mucolytics nor antitussive agents&#46;&#8221;</span> does not reflect the real potential benefit underlying the mucolytic drugs in COPD patients&#44; which has the additional advantage of low risk of adverse events&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Therefore&#44; we propose that the phrase quoted be replaced by sentences such as the two that follows&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall">&#8220;The real impact of a regular prescription of mucolytic agents is still not thoroughly understood&#46; It should be emphasized that among COPD patients of moderate or high severity&#44; the regular use of mucolytics &#40;such as N-acetylcysteine of carbocystein&#41; can have a beneficial effect on the decrease of the number of exacerbation episodes&#44;<a class="elsevierStyleCrossRef" href="#fn0005"><span class="elsevierStyleSup">&#42;</span></a> as well as on the reduction of the number of sick leave days&#46;<a class="elsevierStyleCrossRef" href="#fn0010"><span class="elsevierStyleSup">&#8224;</span></a>&#8221;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">&#8220;We do not recommend the regular prescription of antitussive agents&#44; as they have the potential for inhibiting the protective airway cough reflex&#46;&#8221;</p></li></ul></p></span>"
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                  "referenciaCompleta" => "Global Strategy for the Diagnosis&#44; Management and Prevention of COPD&#44; Global Initiative for Chronic Obstructive Lung Disease &#40;GOLD&#41; 2015&#46; Available at&#58; <a id="intr0005" class="elsevierStyleInterRef" href="http://www.goldcopd.org/">http&#58;&#47;&#47;www&#46;goldcopd&#46;org&#47;</a>&#46;"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Poole"
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                            2 => "C&#46;J&#46; Cates"
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                        "tituloSerie" => "Cochrane Datab Syst Rev"
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Article information
ISSN: 21735115
Original language: English
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