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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Although administering supplemental oxygen &#40;O<span class="elsevierStyleInf">2</span>&#41; to hypercapnic patients with cardiopulmonary disease can decrease dyspnea&#44; pulmonary hypertension&#44; polycythemia&#44; exercise intolerance&#44; permit greater ventilator-free breathing particularly for chronic lung disease patients&#44; and prolong life&#44;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1&#8211;5</span></a> it can also depress hypoxic ventilatory drive and exacerbate hypercapnia&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2&#44;3</span></a> With the advancing respiratory muscle weakness of patients with neuromuscular disease &#40;NMD&#41;&#44; however&#44; it can render noninvasive ventilation ineffective&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a> which can cause carbon dioxide &#40;CO<span class="elsevierStyleInf">2</span>&#41; narcosis&#44; coma&#44; and acute on chronic respiratory failure&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In intensive care units &#40;ICUs&#41;&#44; since it is far more common to encounter patients with lung disease than NMDs&#44; it is generally assumed that O<span class="elsevierStyleInf">2</span> administration is harmless for anyone with respiratory symptoms and that NMD patients must accommodate elevated baseline CO<span class="elsevierStyleInf">2</span> levels anyway so emergency services tend to administer O<span class="elsevierStyleInf">2</span> immediately to all such symptomatic patients without first determining CO<span class="elsevierStyleInf">2</span> levels&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a> The only publication that has thus far quantitated O<span class="elsevierStyleInf">2</span>-induced hypercapnia in NMD is that of Gay and Edmonds in 1995&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a> and they could only identify the pre- and post-O<span class="elsevierStyleInf">2</span> delivery CO<span class="elsevierStyleInf">2</span> levels for eight patients including three with polymyositis&#44; three with motor neuron disease&#44; and one each with inflammatory motor neuropathy and chronic poliomyelitis&#46; The patients received low-flow O<span class="elsevierStyleInf">2</span> and within 0&#46;8&#8211;144<span class="elsevierStyleHsp" style=""></span>h&#44; three became obtunded and required intubation but subsequently recovered&#59; and two died when intubation was declined&#46; Neither noninvasive ventilatory support &#40;NVS&#41; nor mechanical insufflation&#8211;exsufflation &#40;MIE&#41; was used to either avoid intubation or facilitate successful extubation&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Bi-level positive airway pressure &#40;PAP&#41; is generally used in acute and chronic care at less than full ventilatory support settings&#46; However&#44; many patients with little or no vital capacity &#40;VC&#41; require continuous NVS &#40;CNVS&#41; at volume or pressure settings that fully support respiratory muscle function&#46; Two studies reported 166 patients with respiratory pump failure who required intubation after having been administered O<span class="elsevierStyleInf">2</span> supplementation&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9&#44;10</span></a> Another 61 patients underwent tracheotomy after being intubated following O<span class="elsevierStyleInf">2</span> administration for acute on chronic respiratory failure&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a> None of these 227 patients had been offered CNVS or MIE<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">10</span></a> to either prevent intubation or facilitate extubation prior to transfer to a specialized unit for extubation or decanulation to CNVS and MIE&#46; The purpose of this case series is to determine the likelihood that clinicians obtain CO<span class="elsevierStyleInf">2</span> levels before administering O<span class="elsevierStyleInf">2</span> to patients with NMD&#44; to quantitate subsequent CO<span class="elsevierStyleInf">2</span> levels as a contributing factor in the need to intubate&#44; and to describe the use of CNVS and MIE to reverse hypercapnia and avert invasive airway intubation&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">Consecutive outpatients to a NMD clinic from 1996 to 2015 were screened for having received O<span class="elsevierStyleInf">2</span> therapy&#44; undergoing intubation then possibly tracheotomy&#44; then being extubated or decanulated to CNVS and MIE&#46; In addition&#44; we screened for others whose hypercapnia had been documented either by arterial blood gas sampling or by end-tidal CO<span class="elsevierStyleInf">2</span> &#40;EtCO<span class="elsevierStyleInf">2</span>&#41; measurements before O<span class="elsevierStyleInf">2</span> therapy but who were spared intubation by using CNVS and MIE&#46; The MIE was administered by both hospital staff via invasive airway tubes and by the patients&#8217; relatives post-extubation&#47;decanulation in the acute care setting up to every 20&#8211;30<span class="elsevierStyleHsp" style=""></span>min during waking hours via oronasal interfaces at insufflation and exsufflation pressures of 50&#8211;60<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O until ambient air oxyhemoglobin saturation &#40;O<span class="elsevierStyleInf">2</span> sat&#41; baseline remained greater than 94&#37;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="par0025" class="elsevierStylePara elsevierViewall">Of 2804 patients with NMD&#44; 316 were identified who had undergone intubation&#44; then 61 of 316 tracheotomy&#46; All were subsequently extubated or decanulated to CNVS and MIE&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9&#8211;11</span></a> Of these&#44; only nine cases had had CO<span class="elsevierStyleInf">2</span> levels available both pre- and during O<span class="elsevierStyleInf">2</span> administration&#44; and for only cases 1 and 4 was the CO<span class="elsevierStyleInf">2</span> known by the clinicians who administered the O<span class="elsevierStyleInf">2</span> and intubated the patients&#46; For cases 2&#44; 3&#44; 7&#44; and 9 whose hypercapnia worsened during O<span class="elsevierStyleInf">2</span> therapy&#44; intubation was averted by using CNVS and MIE&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Case presentations</span><p id="par0030" class="elsevierStylePara elsevierViewall">Case 1&#58; A 27-year-old woman with nemaline rod myopathy had failed extubation following scoliosis surgery at age 10&#44; but she was successfully extubated to CNVS and MIE upon transfer to our intensive care unit &#40;ICU&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9&#44;10</span></a> From age 10 to 27&#44; she used bi-level PAP at an inspiratory &#40;I&#41;PAP of 18<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; expiratory &#40;E&#41;PAP of 4<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; and rate 13<span class="elsevierStyleHsp" style=""></span>breaths&#47;min only during intercurrent upper respiratory tract infections &#40;URI&#41; despite having a VC as low as 340<span class="elsevierStyleHsp" style=""></span>mL&#46; In December 2014&#44; she presented to emergency services with a URI and partial pressure of CO<span class="elsevierStyleInf">2</span> in arterial blood &#40;PaCO<span class="elsevierStyleInf">2</span>&#41; of 47<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg despite continuous use of bi-level PAP&#46; Then&#44; she was started on supplemental O<span class="elsevierStyleInf">2</span>&#46; Over a 2-h period&#44; her PaCO<span class="elsevierStyleInf">2</span> increased to 67<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; She became obtunded&#44; was intubated&#44; and failed one extubation attempt to IPAP 8<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; EPAP 4<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; and supplemental O<span class="elsevierStyleInf">2</span>&#46; After nine total days of intubation&#44; she was transferred to our ICU&#44; where she was successfully extubated to CNVS and MIE&#46; Her PaCO<span class="elsevierStyleInf">2</span> remained below 40<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#44; and she was discharged home 4 days later&#44; where she eventually weaned to nocturnal nasal NVS&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Case 2&#58; 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An arterial blood gas &#40;ABG&#41; revealed a PaCO<span class="elsevierStyleInf">2</span> of 177<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#44; bicarbonate of 41<span class="elsevierStyleHsp" style=""></span>meq&#47;L&#44; and pH of 6&#46;98&#46; The patient was manually resuscitated and immediate intubation was recommended&#46; However&#44; the father insisted that the author &#40;Bach&#41; be called first&#44; and when it was discovered that the patient&#39;s portable ventilator was in the trunk of his car&#44; the father retrieved it and administered nasal CNVS at a volume-preset of 1150<span class="elsevierStyleHsp" style=""></span>mL and rate 12<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46; A few minutes later&#44; the patient transitioned to mouthpiece CNVS and&#44; 20<span class="elsevierStyleHsp" style=""></span>min later&#44; was discharged home with normal O<span class="elsevierStyleInf">2</span> sat&#44; fully coherent&#44; and in no distress&#46; At his next outpatient visit in May 2014&#44; now using CNVS&#44; the patient&#39;s EtCO<span class="elsevierStyleInf">2</span> remained below 40<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg and ambient air O<span class="elsevierStyleInf">2</span> sat was normal&#46; When breathing unassisted for a few minutes&#44; his EtCO<span class="elsevierStyleInf">2</span> increased to 46<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Case 3&#58; A 15-year-old boy with spinal muscular atrophy type 1 &#40;SMA&#41;&#44; who was CNVS-dependent with a VC of 10<span class="elsevierStyleHsp" style=""></span>mL and received all nutrition via a nasogastric tube since 8 months of age&#44; was admitted to a pediatric ICU for respiratory distress despite pressure-controlled continuous mandatory ventilation &#40;CMV&#41; at 24<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; rate 12<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46; At 5<span class="elsevierStyleHsp" style=""></span>PM&#44; his PaCO<span class="elsevierStyleInf">2</span> was 21<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg and partial pressure of O<span class="elsevierStyleInf">2</span> in arterial blood &#40;PaO<span class="elsevierStyleInf">2</span>&#41; of 42<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; He was placed on FiO<span class="elsevierStyleInf">2</span> of 32&#37; along with CNVS&#46; Thirteen hours later&#44; his PaCO<span class="elsevierStyleInf">2</span> increased to 56<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg with a PaO<span class="elsevierStyleInf">2</span> of 59<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; As his aspiration pneumonitis resolved&#44; his FiO<span class="elsevierStyleInf">2</span> was reduced to 28&#37;&#46; Two hours later&#44; his PaCO<span class="elsevierStyleInf">2</span> decreased to 49<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; He was discharged home with normal O<span class="elsevierStyleInf">2</span> sat and EtCO<span class="elsevierStyleInf">2</span> of 35<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; At a 2-week follow-up outpatient visit&#44; his EtCO<span class="elsevierStyleInf">2</span> was 30<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#44; which had been his baseline&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Case 4&#58; A 4-year-old boy with SMA2&#44; baseline VC of 480<span class="elsevierStyleHsp" style=""></span>mL&#44; and EtCO<span class="elsevierStyleInf">2</span> of 46<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg was admitted to a pediatric ICU for distress due to a URI&#46; He was using volume-preset CMV at 750<span class="elsevierStyleHsp" style=""></span>mL&#44; rate 16<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46; His PaCO<span class="elsevierStyleInf">2</span> was 41<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; He was placed on FiO<span class="elsevierStyleInf">2</span> of 50&#37; and became disoriented over the next 2<span class="elsevierStyleHsp" style=""></span>h&#46; A repeat ABG drawn on FiO<span class="elsevierStyleInf">2</span> of 40&#37; showed a PaCO<span class="elsevierStyleInf">2</span> of 73<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg and PaO<span class="elsevierStyleInf">2</span> of 67<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; He was then intubated and his PaCO<span class="elsevierStyleInf">2</span> normalized&#46; Two days later&#44; on FiO<span class="elsevierStyleInf">2</span> of 21&#37;&#44; he was extubated back to CNVS on CMV at 20<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; rate 16<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Case 5&#58; A 60-year-old woman with facioscapulohumeral muscular dystrophy using nocturnal CMV &#40;Vt 1000<span class="elsevierStyleHsp" style=""></span>mL&#44; rate 12<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#44; FiO<span class="elsevierStyleInf">2</span> 21&#37;&#41; had a VC of 640<span class="elsevierStyleHsp" style=""></span>mL &#40;sitting&#41; and 480<span class="elsevierStyleHsp" style=""></span>mL &#40;supine&#41; and EtCO<span class="elsevierStyleInf">2</span> of 39<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; On a routine visit to her pulmonologist&#44; despite normal pulse oximetry&#44; she was placed on 2<span class="elsevierStyleHsp" style=""></span>L&#47;min O<span class="elsevierStyleInf">2</span> and bronchodilators&#46; Three weeks later&#44; she was admitted for CO<span class="elsevierStyleInf">2</span> narcosis&#44; intubated&#44; and underwent tracheotomy&#46; She used continuous tracheostomy mechanical ventilation &#40;CTMV&#41; for 4 months until she was decanulated to CNVS on her previous settings&#46; Her EtCO<span class="elsevierStyleInf">2</span> remained 32&#8211;40<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg using CNVS over the next six outpatient visits spanning 5 years despite her VC decreasing to 250<span class="elsevierStyleHsp" style=""></span>mL&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Case 6&#58; A 7-year-old boy with SMA1 and CNVS dependence since 4 months of age&#44; who had an EtCO<span class="elsevierStyleInf">2</span> of 19&#8211;34<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg over 11 outpatient visits and a VC of 15<span class="elsevierStyleHsp" style=""></span>mL&#44; was hospitalized for gastroenteritis&#46; Although he had no respiratory symptoms&#44; he was placed on FiO<span class="elsevierStyleInf">2</span> of 50&#37;&#46; Eleven hours later&#44; on repeat ABG&#44; his PaCO<span class="elsevierStyleInf">2</span> had increased from 43 on admission to 62<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg with a PaO<span class="elsevierStyleInf">2</span> of 48<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#44; and he was intubated for 3 days&#46; Once stabilized with normal O<span class="elsevierStyleInf">2</span> sat and CO<span class="elsevierStyleInf">2</span> on ambient air&#44; he was extubated back to CNVS and discharged home 5 days later&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Case 7&#58; A 32-year-old man with myotonic dystrophy using CNVS was admitted for aspiration pneumonia&#46; On admission&#44; with a PaCO<span class="elsevierStyleInf">2</span> of 40<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg and PaO<span class="elsevierStyleInf">2</span> of 79<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#44; he was placed on FiO<span class="elsevierStyleInf">2</span> of 32&#37;&#46; Three days later&#44; his PaCO<span class="elsevierStyleInf">2</span> was 58<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg with PaO<span class="elsevierStyleInf">2</span> 53<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; Then&#44; O<span class="elsevierStyleInf">2</span> was discontinued and the PaCO<span class="elsevierStyleInf">2</span> normalized to 39<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; Three days later&#44; he was discharged home using nocturnal-only nasal NVS&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Case 8&#58; A 71-year-old woman with post-poliomyelitis ventilatory insufficiency&#44; baseline VC of 500<span class="elsevierStyleHsp" style=""></span>mL&#44; and EtCO<span class="elsevierStyleInf">2</span> 45<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg was placed on 2<span class="elsevierStyleHsp" style=""></span>L&#47;min O<span class="elsevierStyleInf">2</span> to treat exertional dyspnea&#46; Six weeks later&#44; she was hospitalized for CO<span class="elsevierStyleInf">2</span> narcosis with a PaCO<span class="elsevierStyleInf">2</span> of 106<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; She was intubated&#44; failed conventional weaning&#47;extubation&#44; and transferred for extubation to CNVS and MIE&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9&#44;10</span></a> Three days later&#44; she was discharged home using sleep NVS on CMV at Vt 950<span class="elsevierStyleHsp" style=""></span>mL&#44; rate 12<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46; At a 3-day follow-up&#44; her EtCO<span class="elsevierStyleInf">2</span> was 40<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg with normal O<span class="elsevierStyleInf">2</span> sat&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Case 9&#58; A 12-month-old CNVS dependent infant with SMA type 1 used nasal CNVS at 20<span class="elsevierStyleHsp" style=""></span>cm pressure and her PaCO<span class="elsevierStyleInf">2</span> ranged from 37 to 43<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg over a 5-day period&#46; Ventilator weaning was attempted&#44; but her PaCO<span class="elsevierStyleInf">2</span> increased to 59<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg and O<span class="elsevierStyleInf">2</span> sat decreased at which point she was placed back on CNVS with low-flow O<span class="elsevierStyleInf">2</span>&#46; Three hours later&#44; her PaCO<span class="elsevierStyleInf">2</span> was 168<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; Intubation was averted by discontinuing the O<span class="elsevierStyleInf">2</span>&#44; and use of CNVS quickly normalized her CO<span class="elsevierStyleInf">2</span> level to 36<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">Consistent with the report of Gay and Edmonds&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a> who found a mean increase in CO<span class="elsevierStyleInf">2</span> of 28&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#46;3<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg with O<span class="elsevierStyleInf">2</span> therapy for eight patients with NMD&#44; the CO<span class="elsevierStyleInf">2</span> of our cases increased from 43&#46;8 to 95&#46;9<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg or 52&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>42&#46;0<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg &#40;range of 21&#8211;59 to 56&#8211;177&#41; over a mean 17&#46;4<span class="elsevierStyleHsp" style=""></span>h &#40;range of 20<span class="elsevierStyleHsp" style=""></span>min to 6 weeks&#41;&#46; Whereas Gay and Edmonds did not use NVS or MIE&#44; our cases 2&#44; 3&#44; 7&#44; and 9 avoided intubation because of it&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Case 1 became hypercapnic because bi-level PAP settings were inadequate to fully rest or support a patient with little VC&#46; Normally compliant lungs require full tidal volumes or pressure settings of 18&#8211;20<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#46; While O<span class="elsevierStyleInf">2</span> therapy exacerbates hypercapnia by suppressing hypoxic drive for patients breathing spontaneously&#44; for nasal bi-level PAP or NVS users like cases 1&#44; 3&#44; 6&#44; and 9&#44; it resulted in increased ventilation leakage out of the mouth&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a> Patients with little or no VC can maintain normal lung ventilation during sleep by using open systems of NVS provided that ventilatory drive is adequate to reflexively prevent excessive air leakage to avoid severe hypercapnia&#46; This reflex activity occurs at the nadir of O<span class="elsevierStyleInf">2</span> desaturations and is suppressed by O<span class="elsevierStyleInf">2</span> administration&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a> Other mechanisms for O<span class="elsevierStyleInf">2</span>-exacerbated hypercapnia include worsening ventilation-perfusion matching secondary to attenuation of hypoxic pulmonary vasoconstriction&#44; depression of diaphragm function&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a> and decreased affinity of hemoglobin for CO<span class="elsevierStyleInf">2</span> &#40;Haldane effect&#41;&#44; which results in increased bicarbonate and dissolved CO<span class="elsevierStyleInf">2</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a> Although acute increases in PaCO<span class="elsevierStyleInf">2</span> and H&#43; stimulate ventilation&#44; as baseline PaCO<span class="elsevierStyleInf">2</span> and bicarbonate levels increase&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">13</span></a> further increases result in respiratory depression&#44; obtundation&#44; and agonal breathing as nasally insufflated air leaks out of the mouth&#46; Likewise&#44; nasal bi-level PAP is also less effective in the acute setting for patients receiving supplemental O<span class="elsevierStyleInf">2</span> for lung disease<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">14&#8211;16</span></a> as it is for patients receiving heavy sedation or narcotics&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">A limitation of this study is that for cases 2 and 8&#44; baseline EtCO<span class="elsevierStyleInf">2</span> was compared with PaCO<span class="elsevierStyleInf">2</span> during O<span class="elsevierStyleInf">2</span> delivery&#46; Since people with NMD generally have normal lung tissue diffusion&#44; EtCO<span class="elsevierStyleInf">2</span> differs minimally from PaCO<span class="elsevierStyleInf">2</span>&#46; Reports suggest that EtCO<span class="elsevierStyleInf">2</span> is 1<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">17</span></a> to 2&#8211;6<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg less than PaCO<span class="elsevierStyleInf">2</span> &#40;<span class="elsevierStyleItalic">R</span>-value of 0&#46;94&#8211;0&#46;98&#41; unless cardiac output and lung perfusion pressures are decreased&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">18&#44;19</span></a> Thus&#44; EtCO<span class="elsevierStyleInf">2</span> can be conveniently used for home sleep monitoring&#44; whereas PaCO<span class="elsevierStyleInf">2</span> necessitates indwelling arterial lines&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Administering O<span class="elsevierStyleInf">2</span> and pressure-preset bi-level PAP rather than volume-preset NVS precludes the use of active lung volume recruitment &#40;air stacking&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">20</span></a> which along with failure to use MIE&#44; prevented sufficient cough flows for cases 1 and 4 to avoid pneumonia and intubation&#46; Cases 5 and 8 demonstrate that even chronic low-flow O<span class="elsevierStyleInf">2</span> therapy &#40;2<span class="elsevierStyleHsp" style=""></span>L&#47;min&#41; can result in CO<span class="elsevierStyleInf">2</span> narcosis&#46; Although CTMV dependent&#44; decanulation to CNVS permitted case 5 to wean back to nocturnal-only NVS&#46; This effect of weaning from CTMV to part-time NVS is especially pronounced when hyperventilated&#44; hypocapnic CTMV users are decanulated to NVS&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">21&#44;22</span></a> Cases 1&#44; 4&#44; 5&#44; 6&#44; and 8 were all successfully extubated or decanulated to CNVS and MIE in ambient air despite having no ventilator-free breathing ability&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusion</span><p id="par0095" class="elsevierStylePara elsevierViewall">For only 2 of 316 intubated patients were CO<span class="elsevierStyleInf">2</span> levels known to the clinician administering O<span class="elsevierStyleInf">2</span> and intubating the patient&#46; Physicians need to obtain CO<span class="elsevierStyleInf">2</span> analyses before administering O<span class="elsevierStyleInf">2</span> to NMD patients with respiratory distress and to attempt to resolve the problem by using CNVS and MIE&#46; The O<span class="elsevierStyleInf">2</span> should only be administered if CNVS and MIE have failed to normalize ambient air O<span class="elsevierStyleInf">2</span> sat&#44; in which case they should be prepared to intubate&#46; Whereas hypercapnic lung disease patients have poor prognoses with a 5-year survival of 30&#37; for patients whose forced expiratory volume-one second &#40;FEV1&#41; is less than 750<span class="elsevierStyleHsp" style=""></span>mL&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">23</span></a> patients with NMD have been reported to have survived 20 to over 60 years using CNVS&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">20</span></a> Thus&#44; O<span class="elsevierStyleInf">2</span> therapy should not be used as a substitute for NVS and MIE to maintain normal O<span class="elsevierStyleInf">2</span> sat &#40;&#62;94&#37;&#41;&#46; Avoiding O<span class="elsevierStyleInf">2</span> also permits oximetry to gauge hypercapnia&#44; airway secretion encumbrance&#44; and intrinsic lung disease as well as the effectiveness of NVS and MIE in treating them&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Ethical disclosures</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Protection of human and animal subjects</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Confidentiality of data</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Right to privacy and informed consent</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to report&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0125" class="elsevierStylePara elsevierViewall">There was no external funding available for this work&#46;</p></span></span>"
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              "titulo" => "Basic procedures"
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          "titulo" => "Keywords"
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          "titulo" => "Abbreviations"
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          "titulo" => "Introduction"
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        4 => array:2 [
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          "titulo" => "Methods"
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    "fechaRecibido" => "2016-01-26"
    "fechaAceptado" => "2016-03-05"
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          "clase" => "keyword"
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          "palabras" => array:4 [
            0 => "Neuromuscular disease"
            1 => "Noninvasive ventilation"
            2 => "Permissive hypercapnia"
            3 => "Supplemental oxygen therapy"
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        1 => array:4 [
          "clase" => "abr"
          "titulo" => "Abbreviations"
          "identificador" => "xpalclavsec731941"
          "palabras" => array:23 [
            0 => "ABG"
            1 => "CMV"
            2 => "CNVS"
            3 => "CO<span class="elsevierStyleInf">2</span>"
            4 => "CTMV"
            5 => "EPAP"
            6 => "EtCO<span class="elsevierStyleInf">2</span>"
            7 => "FEV1"
            8 => "FiO<span class="elsevierStyleInf">2</span>"
            9 => "ICU"
            10 => "IPAP"
            11 => "MIE"
            12 => "NMD"
            13 => "NVS"
            14 => "O<span class="elsevierStyleInf">2</span>"
            15 => "O<span class="elsevierStyleInf">2</span> sat"
            16 => "PaCO<span class="elsevierStyleInf">2</span>"
            17 => "PaO<span class="elsevierStyleInf">2</span>"
            18 => "PAP"
            19 => "SMA"
            20 => "URI"
            21 => "VC"
            22 => "Vt"
          ]
        ]
      ]
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Purpose</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine the likelihood that clinicians know carbon dioxide levels before administering supplemental oxygen to patients with neuromuscular disorders&#44; to quantitate the effect of oxygen therapy on carbon dioxide retention&#44; and to explore hypercapnia contributing to the need to intubate and use of continuous noninvasive ventilatory support to avert it&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Basic procedures</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective chart review for patients with neuromuscular disorders intubated or having intubation averted by using continuous noninvasive ventilatory support with carbon dioxide known pre- and during oxygen administration&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Main findings</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">For only 2 of 316 patients who were intubated did clinicians know carbon dioxide levels prior to administering oxygen&#46; For four cases&#44; intubation was averted by continuous noninvasive ventilatory support and mechanical insufflation&#8211;exsufflation despite severe hypercapnia and acidosis&#46; After initiating oxygen therapy&#44; patients&#8217; carbon dioxide partial pressures increased 52&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>42&#46;0<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg in over as little as 20<span class="elsevierStyleHsp" style=""></span>min&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Principal conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Clinicians should attempt to use continuous noninvasive ventilatory support and mechanical insufflation&#8211;exsufflation rather than supplemental oxygen to normalize blood gases for neuromuscular ventilatory failure and should be prepared to intubate hypercapnic patients for whom oxygen is administered&#46;</p></span>"
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Original article
Quantitation of oxygen-induced hypercapnia in respiratory pump failure
M. Chioua, J.R. Bacha,
Corresponding author
bachjr@njms.rutgers.edu

Corresponding author.
, L.R. Saporitoa, O. Albertb
a Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ, USA
b Respiratory Critical Care Department, King Fahad Medical City, Riyadh, Saudi Arabia
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Although administering supplemental oxygen &#40;O<span class="elsevierStyleInf">2</span>&#41; to hypercapnic patients with cardiopulmonary disease can decrease dyspnea&#44; pulmonary hypertension&#44; polycythemia&#44; exercise intolerance&#44; permit greater ventilator-free breathing particularly for chronic lung disease patients&#44; and prolong life&#44;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1&#8211;5</span></a> it can also depress hypoxic ventilatory drive and exacerbate hypercapnia&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2&#44;3</span></a> With the advancing respiratory muscle weakness of patients with neuromuscular disease &#40;NMD&#41;&#44; however&#44; it can render noninvasive ventilation ineffective&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a> which can cause carbon dioxide &#40;CO<span class="elsevierStyleInf">2</span>&#41; narcosis&#44; coma&#44; and acute on chronic respiratory failure&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In intensive care units &#40;ICUs&#41;&#44; since it is far more common to encounter patients with lung disease than NMDs&#44; it is generally assumed that O<span class="elsevierStyleInf">2</span> administration is harmless for anyone with respiratory symptoms and that NMD patients must accommodate elevated baseline CO<span class="elsevierStyleInf">2</span> levels anyway so emergency services tend to administer O<span class="elsevierStyleInf">2</span> immediately to all such symptomatic patients without first determining CO<span class="elsevierStyleInf">2</span> levels&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a> The only publication that has thus far quantitated O<span class="elsevierStyleInf">2</span>-induced hypercapnia in NMD is that of Gay and Edmonds in 1995&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a> and they could only identify the pre- and post-O<span class="elsevierStyleInf">2</span> delivery CO<span class="elsevierStyleInf">2</span> levels for eight patients including three with polymyositis&#44; three with motor neuron disease&#44; and one each with inflammatory motor neuropathy and chronic poliomyelitis&#46; The patients received low-flow O<span class="elsevierStyleInf">2</span> and within 0&#46;8&#8211;144<span class="elsevierStyleHsp" style=""></span>h&#44; three became obtunded and required intubation but subsequently recovered&#59; and two died when intubation was declined&#46; Neither noninvasive ventilatory support &#40;NVS&#41; nor mechanical insufflation&#8211;exsufflation &#40;MIE&#41; was used to either avoid intubation or facilitate successful extubation&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Bi-level positive airway pressure &#40;PAP&#41; is generally used in acute and chronic care at less than full ventilatory support settings&#46; However&#44; many patients with little or no vital capacity &#40;VC&#41; require continuous NVS &#40;CNVS&#41; at volume or pressure settings that fully support respiratory muscle function&#46; Two studies reported 166 patients with respiratory pump failure who required intubation after having been administered O<span class="elsevierStyleInf">2</span> supplementation&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9&#44;10</span></a> Another 61 patients underwent tracheotomy after being intubated following O<span class="elsevierStyleInf">2</span> administration for acute on chronic respiratory failure&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a> None of these 227 patients had been offered CNVS or MIE<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">10</span></a> to either prevent intubation or facilitate extubation prior to transfer to a specialized unit for extubation or decanulation to CNVS and MIE&#46; The purpose of this case series is to determine the likelihood that clinicians obtain CO<span class="elsevierStyleInf">2</span> levels before administering O<span class="elsevierStyleInf">2</span> to patients with NMD&#44; to quantitate subsequent CO<span class="elsevierStyleInf">2</span> levels as a contributing factor in the need to intubate&#44; and to describe the use of CNVS and MIE to reverse hypercapnia and avert invasive airway intubation&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">Consecutive outpatients to a NMD clinic from 1996 to 2015 were screened for having received O<span class="elsevierStyleInf">2</span> therapy&#44; undergoing intubation then possibly tracheotomy&#44; then being extubated or decanulated to CNVS and MIE&#46; In addition&#44; we screened for others whose hypercapnia had been documented either by arterial blood gas sampling or by end-tidal CO<span class="elsevierStyleInf">2</span> &#40;EtCO<span class="elsevierStyleInf">2</span>&#41; measurements before O<span class="elsevierStyleInf">2</span> therapy but who were spared intubation by using CNVS and MIE&#46; The MIE was administered by both hospital staff via invasive airway tubes and by the patients&#8217; relatives post-extubation&#47;decanulation in the acute care setting up to every 20&#8211;30<span class="elsevierStyleHsp" style=""></span>min during waking hours via oronasal interfaces at insufflation and exsufflation pressures of 50&#8211;60<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O until ambient air oxyhemoglobin saturation &#40;O<span class="elsevierStyleInf">2</span> sat&#41; baseline remained greater than 94&#37;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="par0025" class="elsevierStylePara elsevierViewall">Of 2804 patients with NMD&#44; 316 were identified who had undergone intubation&#44; then 61 of 316 tracheotomy&#46; All were subsequently extubated or decanulated to CNVS and MIE&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9&#8211;11</span></a> Of these&#44; only nine cases had had CO<span class="elsevierStyleInf">2</span> levels available both pre- and during O<span class="elsevierStyleInf">2</span> administration&#44; and for only cases 1 and 4 was the CO<span class="elsevierStyleInf">2</span> known by the clinicians who administered the O<span class="elsevierStyleInf">2</span> and intubated the patients&#46; For cases 2&#44; 3&#44; 7&#44; and 9 whose hypercapnia worsened during O<span class="elsevierStyleInf">2</span> therapy&#44; intubation was averted by using CNVS and MIE&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Case presentations</span><p id="par0030" class="elsevierStylePara elsevierViewall">Case 1&#58; A 27-year-old woman with nemaline rod myopathy had failed extubation following scoliosis surgery at age 10&#44; but she was successfully extubated to CNVS and MIE upon transfer to our intensive care unit &#40;ICU&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9&#44;10</span></a> From age 10 to 27&#44; she used bi-level PAP at an inspiratory &#40;I&#41;PAP of 18<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; expiratory &#40;E&#41;PAP of 4<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; and rate 13<span class="elsevierStyleHsp" style=""></span>breaths&#47;min only during intercurrent upper respiratory tract infections &#40;URI&#41; despite having a VC as low as 340<span class="elsevierStyleHsp" style=""></span>mL&#46; In December 2014&#44; she presented to emergency services with a URI and partial pressure of CO<span class="elsevierStyleInf">2</span> in arterial blood &#40;PaCO<span class="elsevierStyleInf">2</span>&#41; of 47<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg despite continuous use of bi-level PAP&#46; Then&#44; she was started on supplemental O<span class="elsevierStyleInf">2</span>&#46; Over a 2-h period&#44; her PaCO<span class="elsevierStyleInf">2</span> increased to 67<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; She became obtunded&#44; was intubated&#44; and failed one extubation attempt to IPAP 8<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; EPAP 4<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; and supplemental O<span class="elsevierStyleInf">2</span>&#46; After nine total days of intubation&#44; she was transferred to our ICU&#44; where she was successfully extubated to CNVS and MIE&#46; Her PaCO<span class="elsevierStyleInf">2</span> remained below 40<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#44; and she was discharged home 4 days later&#44; where she eventually weaned to nocturnal nasal NVS&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Case 2&#58; A 32-year-old wheelchair-dependent man with Becker muscular dystrophy began to use nocturnal nasal NVS in November 2013 to treat fatigue&#44; sleepiness&#44; difficulty concentrating&#44; and hypercapnia&#46; He had a VC of 550<span class="elsevierStyleHsp" style=""></span>mL and an EtCO<span class="elsevierStyleInf">2</span> of 77<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; His symptoms cleared and diurnal EtCO<span class="elsevierStyleInf">2</span> decreased to 54<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#44; but since he refused to use NVS during daytime hours&#44; he again developed mild confusion and presented to emergency services in February 2014&#46; He was placed on 100&#37; fraction of inspired O<span class="elsevierStyleInf">2</span> &#40;FiO<span class="elsevierStyleInf">2</span>&#41; and became obtunded over the next 20<span class="elsevierStyleHsp" style=""></span>min&#46; An arterial blood gas &#40;ABG&#41; revealed a PaCO<span class="elsevierStyleInf">2</span> of 177<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#44; bicarbonate of 41<span class="elsevierStyleHsp" style=""></span>meq&#47;L&#44; and pH of 6&#46;98&#46; The patient was manually resuscitated and immediate intubation was recommended&#46; However&#44; the father insisted that the author &#40;Bach&#41; be called first&#44; and when it was discovered that the patient&#39;s portable ventilator was in the trunk of his car&#44; the father retrieved it and administered nasal CNVS at a volume-preset of 1150<span class="elsevierStyleHsp" style=""></span>mL and rate 12<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46; A few minutes later&#44; the patient transitioned to mouthpiece CNVS and&#44; 20<span class="elsevierStyleHsp" style=""></span>min later&#44; was discharged home with normal O<span class="elsevierStyleInf">2</span> sat&#44; fully coherent&#44; and in no distress&#46; At his next outpatient visit in May 2014&#44; now using CNVS&#44; the patient&#39;s EtCO<span class="elsevierStyleInf">2</span> remained below 40<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg and ambient air O<span class="elsevierStyleInf">2</span> sat was normal&#46; When breathing unassisted for a few minutes&#44; his EtCO<span class="elsevierStyleInf">2</span> increased to 46<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Case 3&#58; A 15-year-old boy with spinal muscular atrophy type 1 &#40;SMA&#41;&#44; who was CNVS-dependent with a VC of 10<span class="elsevierStyleHsp" style=""></span>mL and received all nutrition via a nasogastric tube since 8 months of age&#44; was admitted to a pediatric ICU for respiratory distress despite pressure-controlled continuous mandatory ventilation &#40;CMV&#41; at 24<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; rate 12<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46; At 5<span class="elsevierStyleHsp" style=""></span>PM&#44; his PaCO<span class="elsevierStyleInf">2</span> was 21<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg and partial pressure of O<span class="elsevierStyleInf">2</span> in arterial blood &#40;PaO<span class="elsevierStyleInf">2</span>&#41; of 42<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; He was placed on FiO<span class="elsevierStyleInf">2</span> of 32&#37; along with CNVS&#46; Thirteen hours later&#44; his PaCO<span class="elsevierStyleInf">2</span> increased to 56<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg with a PaO<span class="elsevierStyleInf">2</span> of 59<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; As his aspiration pneumonitis resolved&#44; his FiO<span class="elsevierStyleInf">2</span> was reduced to 28&#37;&#46; Two hours later&#44; his PaCO<span class="elsevierStyleInf">2</span> decreased to 49<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; He was discharged home with normal O<span class="elsevierStyleInf">2</span> sat and EtCO<span class="elsevierStyleInf">2</span> of 35<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; At a 2-week follow-up outpatient visit&#44; his EtCO<span class="elsevierStyleInf">2</span> was 30<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#44; which had been his baseline&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Case 4&#58; A 4-year-old boy with SMA2&#44; baseline VC of 480<span class="elsevierStyleHsp" style=""></span>mL&#44; and EtCO<span class="elsevierStyleInf">2</span> of 46<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg was admitted to a pediatric ICU for distress due to a URI&#46; He was using volume-preset CMV at 750<span class="elsevierStyleHsp" style=""></span>mL&#44; rate 16<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46; His PaCO<span class="elsevierStyleInf">2</span> was 41<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; He was placed on FiO<span class="elsevierStyleInf">2</span> of 50&#37; and became disoriented over the next 2<span class="elsevierStyleHsp" style=""></span>h&#46; A repeat ABG drawn on FiO<span class="elsevierStyleInf">2</span> of 40&#37; showed a PaCO<span class="elsevierStyleInf">2</span> of 73<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg and PaO<span class="elsevierStyleInf">2</span> of 67<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; He was then intubated and his PaCO<span class="elsevierStyleInf">2</span> normalized&#46; Two days later&#44; on FiO<span class="elsevierStyleInf">2</span> of 21&#37;&#44; he was extubated back to CNVS on CMV at 20<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#44; rate 16<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Case 5&#58; A 60-year-old woman with facioscapulohumeral muscular dystrophy using nocturnal CMV &#40;Vt 1000<span class="elsevierStyleHsp" style=""></span>mL&#44; rate 12<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#44; FiO<span class="elsevierStyleInf">2</span> 21&#37;&#41; had a VC of 640<span class="elsevierStyleHsp" style=""></span>mL &#40;sitting&#41; and 480<span class="elsevierStyleHsp" style=""></span>mL &#40;supine&#41; and EtCO<span class="elsevierStyleInf">2</span> of 39<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; On a routine visit to her pulmonologist&#44; despite normal pulse oximetry&#44; she was placed on 2<span class="elsevierStyleHsp" style=""></span>L&#47;min O<span class="elsevierStyleInf">2</span> and bronchodilators&#46; Three weeks later&#44; she was admitted for CO<span class="elsevierStyleInf">2</span> narcosis&#44; intubated&#44; and underwent tracheotomy&#46; She used continuous tracheostomy mechanical ventilation &#40;CTMV&#41; for 4 months until she was decanulated to CNVS on her previous settings&#46; Her EtCO<span class="elsevierStyleInf">2</span> remained 32&#8211;40<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg using CNVS over the next six outpatient visits spanning 5 years despite her VC decreasing to 250<span class="elsevierStyleHsp" style=""></span>mL&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Case 6&#58; A 7-year-old boy with SMA1 and CNVS dependence since 4 months of age&#44; who had an EtCO<span class="elsevierStyleInf">2</span> of 19&#8211;34<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg over 11 outpatient visits and a VC of 15<span class="elsevierStyleHsp" style=""></span>mL&#44; was hospitalized for gastroenteritis&#46; Although he had no respiratory symptoms&#44; he was placed on FiO<span class="elsevierStyleInf">2</span> of 50&#37;&#46; Eleven hours later&#44; on repeat ABG&#44; his PaCO<span class="elsevierStyleInf">2</span> had increased from 43 on admission to 62<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg with a PaO<span class="elsevierStyleInf">2</span> of 48<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#44; and he was intubated for 3 days&#46; Once stabilized with normal O<span class="elsevierStyleInf">2</span> sat and CO<span class="elsevierStyleInf">2</span> on ambient air&#44; he was extubated back to CNVS and discharged home 5 days later&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Case 7&#58; A 32-year-old man with myotonic dystrophy using CNVS was admitted for aspiration pneumonia&#46; On admission&#44; with a PaCO<span class="elsevierStyleInf">2</span> of 40<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg and PaO<span class="elsevierStyleInf">2</span> of 79<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#44; he was placed on FiO<span class="elsevierStyleInf">2</span> of 32&#37;&#46; Three days later&#44; his PaCO<span class="elsevierStyleInf">2</span> was 58<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg with PaO<span class="elsevierStyleInf">2</span> 53<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; Then&#44; O<span class="elsevierStyleInf">2</span> was discontinued and the PaCO<span class="elsevierStyleInf">2</span> normalized to 39<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; Three days later&#44; he was discharged home using nocturnal-only nasal NVS&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Case 8&#58; A 71-year-old woman with post-poliomyelitis ventilatory insufficiency&#44; baseline VC of 500<span class="elsevierStyleHsp" style=""></span>mL&#44; and EtCO<span class="elsevierStyleInf">2</span> 45<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg was placed on 2<span class="elsevierStyleHsp" style=""></span>L&#47;min O<span class="elsevierStyleInf">2</span> to treat exertional dyspnea&#46; Six weeks later&#44; she was hospitalized for CO<span class="elsevierStyleInf">2</span> narcosis with a PaCO<span class="elsevierStyleInf">2</span> of 106<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; She was intubated&#44; failed conventional weaning&#47;extubation&#44; and transferred for extubation to CNVS and MIE&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9&#44;10</span></a> Three days later&#44; she was discharged home using sleep NVS on CMV at Vt 950<span class="elsevierStyleHsp" style=""></span>mL&#44; rate 12<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46; At a 3-day follow-up&#44; her EtCO<span class="elsevierStyleInf">2</span> was 40<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg with normal O<span class="elsevierStyleInf">2</span> sat&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Case 9&#58; A 12-month-old CNVS dependent infant with SMA type 1 used nasal CNVS at 20<span class="elsevierStyleHsp" style=""></span>cm pressure and her PaCO<span class="elsevierStyleInf">2</span> ranged from 37 to 43<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg over a 5-day period&#46; Ventilator weaning was attempted&#44; but her PaCO<span class="elsevierStyleInf">2</span> increased to 59<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg and O<span class="elsevierStyleInf">2</span> sat decreased at which point she was placed back on CNVS with low-flow O<span class="elsevierStyleInf">2</span>&#46; Three hours later&#44; her PaCO<span class="elsevierStyleInf">2</span> was 168<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46; Intubation was averted by discontinuing the O<span class="elsevierStyleInf">2</span>&#44; and use of CNVS quickly normalized her CO<span class="elsevierStyleInf">2</span> level to 36<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">Consistent with the report of Gay and Edmonds&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a> who found a mean increase in CO<span class="elsevierStyleInf">2</span> of 28&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#46;3<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg with O<span class="elsevierStyleInf">2</span> therapy for eight patients with NMD&#44; the CO<span class="elsevierStyleInf">2</span> of our cases increased from 43&#46;8 to 95&#46;9<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg or 52&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>42&#46;0<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg &#40;range of 21&#8211;59 to 56&#8211;177&#41; over a mean 17&#46;4<span class="elsevierStyleHsp" style=""></span>h &#40;range of 20<span class="elsevierStyleHsp" style=""></span>min to 6 weeks&#41;&#46; Whereas Gay and Edmonds did not use NVS or MIE&#44; our cases 2&#44; 3&#44; 7&#44; and 9 avoided intubation because of it&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Case 1 became hypercapnic because bi-level PAP settings were inadequate to fully rest or support a patient with little VC&#46; Normally compliant lungs require full tidal volumes or pressure settings of 18&#8211;20<span class="elsevierStyleHsp" style=""></span>cm H<span class="elsevierStyleInf">2</span>O&#46; While O<span class="elsevierStyleInf">2</span> therapy exacerbates hypercapnia by suppressing hypoxic drive for patients breathing spontaneously&#44; for nasal bi-level PAP or NVS users like cases 1&#44; 3&#44; 6&#44; and 9&#44; it resulted in increased ventilation leakage out of the mouth&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a> Patients with little or no VC can maintain normal lung ventilation during sleep by using open systems of NVS provided that ventilatory drive is adequate to reflexively prevent excessive air leakage to avoid severe hypercapnia&#46; This reflex activity occurs at the nadir of O<span class="elsevierStyleInf">2</span> desaturations and is suppressed by O<span class="elsevierStyleInf">2</span> administration&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a> Other mechanisms for O<span class="elsevierStyleInf">2</span>-exacerbated hypercapnia include worsening ventilation-perfusion matching secondary to attenuation of hypoxic pulmonary vasoconstriction&#44; depression of diaphragm function&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a> and decreased affinity of hemoglobin for CO<span class="elsevierStyleInf">2</span> &#40;Haldane effect&#41;&#44; which results in increased bicarbonate and dissolved CO<span class="elsevierStyleInf">2</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a> Although acute increases in PaCO<span class="elsevierStyleInf">2</span> and H&#43; stimulate ventilation&#44; as baseline PaCO<span class="elsevierStyleInf">2</span> and bicarbonate levels increase&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">13</span></a> further increases result in respiratory depression&#44; obtundation&#44; and agonal breathing as nasally insufflated air leaks out of the mouth&#46; Likewise&#44; nasal bi-level PAP is also less effective in the acute setting for patients receiving supplemental O<span class="elsevierStyleInf">2</span> for lung disease<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">14&#8211;16</span></a> as it is for patients receiving heavy sedation or narcotics&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">A limitation of this study is that for cases 2 and 8&#44; baseline EtCO<span class="elsevierStyleInf">2</span> was compared with PaCO<span class="elsevierStyleInf">2</span> during O<span class="elsevierStyleInf">2</span> delivery&#46; Since people with NMD generally have normal lung tissue diffusion&#44; EtCO<span class="elsevierStyleInf">2</span> differs minimally from PaCO<span class="elsevierStyleInf">2</span>&#46; Reports suggest that EtCO<span class="elsevierStyleInf">2</span> is 1<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">17</span></a> to 2&#8211;6<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg less than PaCO<span class="elsevierStyleInf">2</span> &#40;<span class="elsevierStyleItalic">R</span>-value of 0&#46;94&#8211;0&#46;98&#41; unless cardiac output and lung perfusion pressures are decreased&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">18&#44;19</span></a> Thus&#44; EtCO<span class="elsevierStyleInf">2</span> can be conveniently used for home sleep monitoring&#44; whereas PaCO<span class="elsevierStyleInf">2</span> necessitates indwelling arterial lines&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Administering O<span class="elsevierStyleInf">2</span> and pressure-preset bi-level PAP rather than volume-preset NVS precludes the use of active lung volume recruitment &#40;air stacking&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">20</span></a> which along with failure to use MIE&#44; prevented sufficient cough flows for cases 1 and 4 to avoid pneumonia and intubation&#46; Cases 5 and 8 demonstrate that even chronic low-flow O<span class="elsevierStyleInf">2</span> therapy &#40;2<span class="elsevierStyleHsp" style=""></span>L&#47;min&#41; can result in CO<span class="elsevierStyleInf">2</span> narcosis&#46; Although CTMV dependent&#44; decanulation to CNVS permitted case 5 to wean back to nocturnal-only NVS&#46; This effect of weaning from CTMV to part-time NVS is especially pronounced when hyperventilated&#44; hypocapnic CTMV users are decanulated to NVS&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">21&#44;22</span></a> Cases 1&#44; 4&#44; 5&#44; 6&#44; and 8 were all successfully extubated or decanulated to CNVS and MIE in ambient air despite having no ventilator-free breathing ability&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusion</span><p id="par0095" class="elsevierStylePara elsevierViewall">For only 2 of 316 intubated patients were CO<span class="elsevierStyleInf">2</span> levels known to the clinician administering O<span class="elsevierStyleInf">2</span> and intubating the patient&#46; Physicians need to obtain CO<span class="elsevierStyleInf">2</span> analyses before administering O<span class="elsevierStyleInf">2</span> to NMD patients with respiratory distress and to attempt to resolve the problem by using CNVS and MIE&#46; The O<span class="elsevierStyleInf">2</span> should only be administered if CNVS and MIE have failed to normalize ambient air O<span class="elsevierStyleInf">2</span> sat&#44; in which case they should be prepared to intubate&#46; Whereas hypercapnic lung disease patients have poor prognoses with a 5-year survival of 30&#37; for patients whose forced expiratory volume-one second &#40;FEV1&#41; is less than 750<span class="elsevierStyleHsp" style=""></span>mL&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">23</span></a> patients with NMD have been reported to have survived 20 to over 60 years using CNVS&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">20</span></a> Thus&#44; O<span class="elsevierStyleInf">2</span> therapy should not be used as a substitute for NVS and MIE to maintain normal O<span class="elsevierStyleInf">2</span> sat &#40;&#62;94&#37;&#41;&#46; Avoiding O<span class="elsevierStyleInf">2</span> also permits oximetry to gauge hypercapnia&#44; airway secretion encumbrance&#44; and intrinsic lung disease as well as the effectiveness of NVS and MIE in treating them&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Ethical disclosures</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Protection of human and animal subjects</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Confidentiality of data</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Right to privacy and informed consent</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to report&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0125" class="elsevierStylePara elsevierViewall">There was no external funding available for this work&#46;</p></span></span>"
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          "titulo" => "Keywords"
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          "titulo" => "Abbreviations"
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        3 => array:2 [
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          "titulo" => "Introduction"
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        4 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Methods"
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        5 => array:3 [
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          "titulo" => "Results"
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              "titulo" => "Right to privacy and informed consent"
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          "titulo" => "References"
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    "tienePdf" => true
    "fechaRecibido" => "2016-01-26"
    "fechaAceptado" => "2016-03-05"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec731942"
          "palabras" => array:4 [
            0 => "Neuromuscular disease"
            1 => "Noninvasive ventilation"
            2 => "Permissive hypercapnia"
            3 => "Supplemental oxygen therapy"
          ]
        ]
        1 => array:4 [
          "clase" => "abr"
          "titulo" => "Abbreviations"
          "identificador" => "xpalclavsec731941"
          "palabras" => array:23 [
            0 => "ABG"
            1 => "CMV"
            2 => "CNVS"
            3 => "CO<span class="elsevierStyleInf">2</span>"
            4 => "CTMV"
            5 => "EPAP"
            6 => "EtCO<span class="elsevierStyleInf">2</span>"
            7 => "FEV1"
            8 => "FiO<span class="elsevierStyleInf">2</span>"
            9 => "ICU"
            10 => "IPAP"
            11 => "MIE"
            12 => "NMD"
            13 => "NVS"
            14 => "O<span class="elsevierStyleInf">2</span>"
            15 => "O<span class="elsevierStyleInf">2</span> sat"
            16 => "PaCO<span class="elsevierStyleInf">2</span>"
            17 => "PaO<span class="elsevierStyleInf">2</span>"
            18 => "PAP"
            19 => "SMA"
            20 => "URI"
            21 => "VC"
            22 => "Vt"
          ]
        ]
      ]
    ]
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    "resumen" => array:1 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Purpose</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine the likelihood that clinicians know carbon dioxide levels before administering supplemental oxygen to patients with neuromuscular disorders&#44; to quantitate the effect of oxygen therapy on carbon dioxide retention&#44; and to explore hypercapnia contributing to the need to intubate and use of continuous noninvasive ventilatory support to avert it&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Basic procedures</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective chart review for patients with neuromuscular disorders intubated or having intubation averted by using continuous noninvasive ventilatory support with carbon dioxide known pre- and during oxygen administration&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Main findings</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">For only 2 of 316 patients who were intubated did clinicians know carbon dioxide levels prior to administering oxygen&#46; For four cases&#44; intubation was averted by continuous noninvasive ventilatory support and mechanical insufflation&#8211;exsufflation despite severe hypercapnia and acidosis&#46; After initiating oxygen therapy&#44; patients&#8217; carbon dioxide partial pressures increased 52&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>42&#46;0<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg in over as little as 20<span class="elsevierStyleHsp" style=""></span>min&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Principal conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Clinicians should attempt to use continuous noninvasive ventilatory support and mechanical insufflation&#8211;exsufflation rather than supplemental oxygen to normalize blood gases for neuromuscular ventilatory failure and should be prepared to intubate hypercapnic patients for whom oxygen is administered&#46;</p></span>"
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