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with a diagnostic yield of 52&#8211;91&#37;&#44; when compared to 20&#8211;50&#37; with FNAB&#44; for definitive diagnosis of benign lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Although CT-guided CNB has been shown to be an accurate means of diagnosing lung malignancies&#44; there is relatively little information about its utility in diagnosing benign conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Previous series of lung CNB have included benign diagnosis but have not provided details of the histological features&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> and there are no studies specifically addressing interstitial lung diseases &#40;ILD&#41;&#46; The aim of this work is to evaluate the use of CT-guided CNB in patients with suspected ILD&#58; diagnostic yield for the different types of ILD&#44; factors that influence it and complications&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">All patients followed in our ILD outpatient clinic with suspected ILD&#44; who underwent CT-guided CNB between 08&#47;2010 and 02&#47;2015&#44; were consecutively recruited into this prospective study&#46; All cases were discussed in a multidisciplinary meeting before being proposed to CT-guided CNB&#46; Before the procedure&#44; risks and possible complications were explained to each patient and informed consent was obtained&#46; The procedure was performed by an interventional radiologist&#46; All cases were performed using the Philips 16-slice spiral CT &#40;120<span class="elsevierStyleHsp" style=""></span>kV&#44; 250<span class="elsevierStyleHsp" style=""></span>mA and a 3-mm thickness&#59; Philips Healthcare&#44; Andover&#44; MA&#44; USA&#41; for imaging guidance&#46; The biopsy tool used was an automated biopsy gun &#40;Magnum&#8482;&#44; Bard Biopsy Systems&#44; AZ&#44; USA&#41; with an 18 or 20-gauge needle&#46; The patient lay on the CT table and the puncture point and access routine were determined by CT scan to a desired area of diseased lung&#46; Following local anesthesia&#44; the needle was inserted through the skin and advanced to the lesion&#46; CT scans were performed to confirm the position of the needle&#46; Once the needle was located in an appropriate position within or near the lesion&#44; the operator triggered the needle&#44; trapping the specimen in the sample notch&#46; Immediately after the procedure&#44; a chest CT scan was performed to evaluate post procedural complications and 1 and 4<span class="elsevierStyleHsp" style=""></span>h after the procedure the patient performed a chest X-ray&#46; Data were analyzed with SPSS 19&#46;0&#44; the <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> test was used for the statistical analysis&#46; Statistical significance was attributed to <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">During the study period 22 patients underwent CT-guided CNB &#40;22 CNB&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows their characteristics&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The main reasons for performing CNB were&#58; surgical contra-indications &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#59; 68&#46;2&#37;&#41; and patient refusal of surgical lung biopsy &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#59; 31&#46;8&#37;&#41;&#46; Diagnostic histological features were obtained in 17 cases &#40;77&#46;3&#37;&#41;&#46; The suspected diagnosis was confirmed&#44; after multidisciplinary meeting&#44; in 16 cases &#40;72&#46;7&#37;&#41;&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; Multivariate statistical analysis indicated no statistically significant predictors of histological diagnosis&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Organizing pneumonia was significantly more diagnosed with CNB in patients with consolidations on CT and ground glass opacities &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Minor complications were observed in 5 &#40;22&#46;7&#37;&#41; cases &#40;4 alveolar hemorrhage and 1 pneumothorax requiring invasive chest tube drainage&#41;&#46; No patient required hospitalization&#46; The occurrence of complications was significantly higher in current smokers &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#59; 5 vs&#46; 0&#41; and COPD patients &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#59; 5 vs&#46; 0&#41;&#46; The median follow-up of the patients with confirmed diagnosis after the CNB was 18&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;9 months&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">CT-guided lung biopsy is a diagnostic procedure with a high diagnostic accuracy for benign pulmonary lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> At this point&#44; to the best of the authors&#8217; knowledge&#44; this study was the only one where only suspected ILD patients submitted to CNB were analyzed&#46; This study had some limitations such as being a retrospective study and the small sample size&#46; There is also an important bias related to the selection of patients with lesions considered more suitable for transthoracic approach&#46; In our study we had a diagnostic yield of 73&#37;&#44; which is consistent with the literature reports for benign disease&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> After multidisciplinary discussion&#44; organizing pneumonia was diagnosed in almost half of the cases &#40;45&#37;&#41;&#44; and the same diagnosis was maintained throughout the follow-up in all patients&#46; As it is the first study of CT-guided CNB specifically in patients with suspected ILD&#44; it brings new information about the usefulness of CNB in this setting&#46; CT-guided CNB is a safe and valid procedure in the diagnostic approach of selected patients with suspected ILD&#44; particularly in patients with suspected OP&#46; Due to the size of our sample&#44; as well as the selection bias&#44; more studies are needed to confirm the role of this technique in the diagnosis of ILD&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Valvular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">CT features</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ground glass opacities&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#46;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>FNAB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>EBUS TBNA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;1&nbsp;\t\t\t\t\t\t\n
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                        0 => array:2 [
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                      "titulo" => "FNA&#44; core biopsy&#44; or both for the diagnosis of lung carcinoma&#58; obtaining sufficient tissue for a specific diagnosis and molecular testing"
                      "autores" => array:1 [
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                            0 => "S&#46;M&#46; Coley"
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                            0 => "J&#46; Takeshita"
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                          "etal" => false
                          "autores" => array:5 [
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                            4 => "L&#46; Xu"
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Research Letter
Study of CT-guided core needle biopsy in patients with interstitial lung diseases: Diagnostic yield and complications
M. Oliveiraa,
Corresponding author
, T. Pereirab, M. Diasa, A. Sanchesc, S. Campainhaa, S. Nevesa
a Pulmonology Department, Centro Hospitalar de Vila Nova de Gaia e Espinho, Portugal
b Radiology Department, Centro Hospitalar de Vila Nova de Gaia e Espinho, Portugal
c Pathology Department, Centro Hospitalar de Vila Nova de Gaia e Espinho, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In the study of lung lesions&#44; tissue samples necessary for a pathomorphological assessment may be obtained by different techniques&#58; surgical&#44; bronchoscopic and percutaneous methods &#40;like computed tomography &#40;CT&#41; guided transthoracic needle biopsy &#40;TTNB&#41; by fine-needle aspiration biopsy &#40;FNAB&#41; or by core-needle biopsy &#40;CNB&#41;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> The decision to perform FNAB or CNB is multifactorial and highly operator dependent&#46; The diagnostic accuracy of FNAB is almost as good as CNB in the diagnosis of malignant lesions&#44; especially if onsite cytopathological evaluation is available&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> However&#44; for diagnosis of benign lesions CNB is preferred&#44; with a diagnostic yield of 52&#8211;91&#37;&#44; when compared to 20&#8211;50&#37; with FNAB&#44; for definitive diagnosis of benign lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Although CT-guided CNB has been shown to be an accurate means of diagnosing lung malignancies&#44; there is relatively little information about its utility in diagnosing benign conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Previous series of lung CNB have included benign diagnosis but have not provided details of the histological features&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> and there are no studies specifically addressing interstitial lung diseases &#40;ILD&#41;&#46; The aim of this work is to evaluate the use of CT-guided CNB in patients with suspected ILD&#58; diagnostic yield for the different types of ILD&#44; factors that influence it and complications&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">All patients followed in our ILD outpatient clinic with suspected ILD&#44; who underwent CT-guided CNB between 08&#47;2010 and 02&#47;2015&#44; were consecutively recruited into this prospective study&#46; All cases were discussed in a multidisciplinary meeting before being proposed to CT-guided CNB&#46; Before the procedure&#44; risks and possible complications were explained to each patient and informed consent was obtained&#46; The procedure was performed by an interventional radiologist&#46; All cases were performed using the Philips 16-slice spiral CT &#40;120<span class="elsevierStyleHsp" style=""></span>kV&#44; 250<span class="elsevierStyleHsp" style=""></span>mA and a 3-mm thickness&#59; Philips Healthcare&#44; Andover&#44; MA&#44; USA&#41; for imaging guidance&#46; The biopsy tool used was an automated biopsy gun &#40;Magnum&#8482;&#44; Bard Biopsy Systems&#44; AZ&#44; USA&#41; with an 18 or 20-gauge needle&#46; The patient lay on the CT table and the puncture point and access routine were determined by CT scan to a desired area of diseased lung&#46; Following local anesthesia&#44; the needle was inserted through the skin and advanced to the lesion&#46; CT scans were performed to confirm the position of the needle&#46; Once the needle was located in an appropriate position within or near the lesion&#44; the operator triggered the needle&#44; trapping the specimen in the sample notch&#46; Immediately after the procedure&#44; a chest CT scan was performed to evaluate post procedural complications and 1 and 4<span class="elsevierStyleHsp" style=""></span>h after the procedure the patient performed a chest X-ray&#46; Data were analyzed with SPSS 19&#46;0&#44; the <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> test was used for the statistical analysis&#46; Statistical significance was attributed to <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">During the study period 22 patients underwent CT-guided CNB &#40;22 CNB&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows their characteristics&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The main reasons for performing CNB were&#58; surgical contra-indications &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#59; 68&#46;2&#37;&#41; and patient refusal of surgical lung biopsy &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#59; 31&#46;8&#37;&#41;&#46; Diagnostic histological features were obtained in 17 cases &#40;77&#46;3&#37;&#41;&#46; The suspected diagnosis was confirmed&#44; after multidisciplinary meeting&#44; in 16 cases &#40;72&#46;7&#37;&#41;&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; Multivariate statistical analysis indicated no statistically significant predictors of histological diagnosis&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Organizing pneumonia was significantly more diagnosed with CNB in patients with consolidations on CT and ground glass opacities &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Minor complications were observed in 5 &#40;22&#46;7&#37;&#41; cases &#40;4 alveolar hemorrhage and 1 pneumothorax requiring invasive chest tube drainage&#41;&#46; No patient required hospitalization&#46; The occurrence of complications was significantly higher in current smokers &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#59; 5 vs&#46; 0&#41; and COPD patients &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#59; 5 vs&#46; 0&#41;&#46; The median follow-up of the patients with confirmed diagnosis after the CNB was 18&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;9 months&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">CT-guided lung biopsy is a diagnostic procedure with a high diagnostic accuracy for benign pulmonary lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> At this point&#44; to the best of the authors&#8217; knowledge&#44; this study was the only one where only suspected ILD patients submitted to CNB were analyzed&#46; This study had some limitations such as being a retrospective study and the small sample size&#46; There is also an important bias related to the selection of patients with lesions considered more suitable for transthoracic approach&#46; In our study we had a diagnostic yield of 73&#37;&#44; which is consistent with the literature reports for benign disease&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> After multidisciplinary discussion&#44; organizing pneumonia was diagnosed in almost half of the cases &#40;45&#37;&#41;&#44; and the same diagnosis was maintained throughout the follow-up in all patients&#46; As it is the first study of CT-guided CNB specifically in patients with suspected ILD&#44; it brings new information about the usefulness of CNB in this setting&#46; CT-guided CNB is a safe and valid procedure in the diagnostic approach of selected patients with suspected ILD&#44; particularly in patients with suspected OP&#46; Due to the size of our sample&#44; as well as the selection bias&#44; more studies are needed to confirm the role of this technique in the diagnosis of ILD&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nodules&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Septal thickening&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Consolidation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Honeycombing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Traction bronchiectasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Emphysema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Previous diagnostic procedures</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fiberoptic bronchoscopy with bronchoalveolar lavage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fiberoptic bronchoscopy with transbronchial biopsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>FNAB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>EBUS TBNA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Organizing pneumonia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nonspecific interstitial pneumonia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vasculitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hypersensitivity pneumonitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Silicosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pleuroparenchymal fibroelastosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Desquamative interstitial pneumonia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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