was read the article
array:24 [ "pii" => "S2173511516300628" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2016.06.004" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "1181" "copyright" => "Sociedade Portuguesa de Pneumologia" "copyrightAnyo" => "2016" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Rev Port Pneumol. 2016;22:362-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1580 "formatos" => array:3 [ "EPUB" => 208 "HTML" => 808 "PDF" => 564 ] ] "itemSiguiente" => array:19 [ "pii" => "S2173511516300239" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2016.04.002" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "1168" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Rev Port Pneumol. 2016;22:365-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2017 "formatos" => array:3 [ "EPUB" => 207 "HTML" => 752 "PDF" => 1058 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "A case of Birt–Hogg–Dubé syndrome" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "365" "paginaFinal" => "366" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 571 "Ancho" => 1500 "Tamanyo" => 103242 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a) Thoracoscopy shows cluster of cysts in the left superior lobe and (b) chest-CT shows multiple lung cysts with various size and irregular shape.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Martins, M. Caixeiro, C. Costa, S. Feijó, C. Bárbara" "autores" => array:5 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Martins" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Caixeiro" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Costa" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Feijó" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Bárbara" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511516300239?idApp=UINPBA00004E" "url" => "/21735115/0000002200000006/v1_201612110145/S2173511516300239/v1_201612110145/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173511516000117" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2015.12.011" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "1134" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Rev Port Pneumol. 2016;22:360-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1380 "formatos" => array:3 [ "EPUB" => 218 "HTML" => 592 "PDF" => 570 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Research Letter</span>" "titulo" => "Portuguese Pulmonology footprint in Europe: From abstracts to papers and grants" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "360" "paginaFinal" => "362" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1826 "Ancho" => 1568 "Tamanyo" => 107859 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Portuguese participation in the European Respiratory Society Congress (2013–2015).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.C. Winck, A. Bugalho, M. Drummond, A.J. Ferreira, S. Moreira" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J.C." "apellidos" => "Winck" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Bugalho" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Drummond" ] 3 => array:2 [ "nombre" => "A.J." "apellidos" => "Ferreira" ] 4 => array:2 [ "nombre" => "S." "apellidos" => "Moreira" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511516000117?idApp=UINPBA00004E" "url" => "/21735115/0000002200000006/v1_201612110145/S2173511516000117/v1_201612110145/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Research Letter</span>" "titulo" => "Asthma prevalence in Portuguese preschool children: More scientific evidence…" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "362" "paginaFinal" => "364" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Morais-Almeida, H. Pité, A.M. Pereira, M. Ferreira-Magalhães, J.A. Fonseca" "autores" => array:5 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Morais-Almeida" "email" => array:1 [ 0 => "mmoraisalmeida@netcabo.pt" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "H." "apellidos" => "Pité" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "A.M." "apellidos" => "Pereira" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 3 => array:3 [ "nombre" => "M." "apellidos" => "Ferreira-Magalhães" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] 4 => array:3 [ "nombre" => "J.A." "apellidos" => "Fonseca" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Allergy Center, CUF Descobertas Hospital and CUF Infante Santo Hospital, Lisbon, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "CINTESIS, Center for Research in Health Technologies and Information Systems, Faculty of Medicine, Porto University, Porto, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "CEDOC, Chronic Diseases Research Center, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Allergy Unit, CUF Porto Institute & Hospital, Porto, Portugal" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Paediatric Department, Centro Hospitalar de S. João, Porto, Portugal" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Paediatric Department, Faculty of Medicine, Porto University, Porto, Portugal" "etiqueta" => "f" "identificador" => "aff0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We read with interest the research letter “Asthma prevalence in Portuguese preschool children: The latest scientific evidence”, published by Branco et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> The authors intended to review the major findings of published papers on childhood asthma prevalence in preschool-aged children in our country. We agree with the authors that it is important to have nationwide-based surveys, so we would like to briefly cite two large surveys that were published by our group, and that can contribute to the knowledge about asthma and recurrent wheezing in the same age group (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2,3</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The first survey was a cross-sectional, questionnaire-based (ISAAC-adapted) descriptive study of children aged between 3 and 5 years living in mainland Portugal (ARPAkids); a representative sample of 5003 children was included in the analysis.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The prevalence of “wheezing in the last 12 months” (current wheezing – CW) was 24.5% [95% confidence interval (CI) 23.3–25.7]; most of these children (61.4%) had had 1–3 wheezing episodes in the previous year, and 7.5% reported >12 episodes. The prevalence of CW was significantly higher in children with a family history of allergic disease; those living in rural regions had a significantly lower wheezing prevalence. No statistically significant differences were found for gender, age, birth weight, or exposure to tobacco smoke at home. The prevalence of “physician diagnosed asthma” (PDA) in children with CW was 16.7% [95% CI 14.6–18.8] – vs. 4.6% [95% CI 4.0–5.2] in the general population; it was highest (73.0%) in those with >12 wheezing episodes.</p><p id="par0020" class="elsevierStylePara elsevierViewall">CW was strongly associated with rhinitis in this age group, especially with moderate – severe persistent disease; children with both wheezing and rhinitis had more wheezing episodes and needed treatment more frequently. The number of wheezing episodes significantly increased with increasing rhinitis severity/persistency.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2,4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The second survey included the paediatric-specific data (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>716; 21.4% younger than 6 years of age) from a cross-sectional, population-based, all-age, nationwide telephone interview study (INAsma), the first population-based epidemiological study aiming to estimate asthma prevalence in Portugal covering all ages.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> The methodology of this study has been previously described<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a>; a GA2LEN-adapted questionnaire was used. “Current asthma” (CA) was defined as a positive answer to “has the child ever had asthma?”, plus at least one of 4: wheezing, waking with breathlessness or having had an asthma attack in the previous 12 months, or currently taking asthma medication.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In children aged <6 years, the prevalence of CW and CA was 31.0% (95% CI 24.4–38.5) and 6.5% (95% CI 3.5–11.6), respectively. No statistically significant differences were found in the prevalence of CA according to region or other socio-demographic variables, but a higher risk for CA was found in children with rhinitis and eczema.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion, asthma-like symptoms were present in one-third to one-fourth of Portuguese preschool children; the prevalence of PDA was 4.6% (ARPAkids) and of CA was 6.5% (INAsma). Asthma prevalence can vary significantly according to different study methodologies, namely disease definition, and objective markers of disease must be included in future surveys.</p><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">95% CI–95% confidence intervals.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " colspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black"></th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">ARPAKids \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">INAsma \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Study design \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Date \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">February to March 2007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">March to May 2010 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Location \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mainland Portugal (nationwide) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Portugal (nationwide) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Study population \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5003 children (aged 3–5 years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">716 children (aged 0–17 years, of which 153 aged<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>6 years) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Aim \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">To estimate the prevalence of current wheezing in preschoolers; also estimate the prevalence of physician diagnosed asthma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">To estimate the prevalence of asthma-like symptoms, current asthma, asthma diagnostic tests and inhaled medication use in children \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Methodology \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">To recruit study population \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Stratified random population-based representative sample including all municipalities in mainland Portugal. Kindergartens and parish centers were used for data collection. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Stratified random population-based representative sample including all municipalities in Portugal. Houses with a landline telephone were used for data collection. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">To collect health information \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Face-to-face interview with caregivers using an ISAAC-adapted questionnaire \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Computer-assisted telephone interview with caregivers using GA2LEN-adapted questionnaire \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Criteria to define asthma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Current wheezing: positive answer to the question “Has the child had wheezing episodes over the last 12 months?”<br>Physician-diagnosed asthma: positive answer to the question “Has a doctor ever said that the child has asthma?” \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Current asthma: positive answer to the question “Has the child ever had asthma?”, plus at least one of 4: wheezing, waking with breathlessness or having an asthma attack in the last 12 months, or currently taking asthma medication.<br> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Outcomes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Asthma prevalence \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Current wheezing: 24.5% (95% CI 23.3–25.7)<br>Physician-diagnosed asthma: 4.6% (95% CI 4.0–5.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Current asthma in children: 8.4% (95% CI 6.6–10.7)<br>Current asthma in children aged <6 years: 6.5% (95% CI: 3.5–11.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Risk factors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Current wheezing and physician-diagnosed asthma were associated with rhinitis (persistency/severity)/rhinoconjunctivitis and family history of allergic diseases.<br>Physician-diagnosed asthma was associated with the frequency of wheezing episodes.<br>Children living in rural regions had a significantly lower wheezing prevalence (no significant differences were found for physician-diagnosed asthma). \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Current asthma was associated with rhinitis and eczema.<br>No statistically significant differences were found in the prevalence of current asthma according to region or other socio-demographic variables. \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1276981.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Comparison of the main characteristics of the nationwide studies analysis asthma prevalence in pre-school children.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma prevalence in Portuguese preschool children: the latest scientific evidence" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.T.B.S. Branco" 1 => "R.A.O. Nunes" 2 => "M.C.M. Alvim-Ferraz" 3 => "F.G. Martins" 4 => "C. Ferraz" 5 => "L.G. Vaz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rppnen.2016.03.013" "Revista" => array:6 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2016" "volumen" => "22" "paginaInicial" => "293" "paginaFinal" => "295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27216568" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severity of rhinitis and wheezing is strongly associated in preschoolers: a population-based study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.M. Pereira" 1 => "M. Morais-Almeida" 2 => "N. Santos" 3 => "C. Nunes" 4 => "J. Bousquet" 5 => "J.A. 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