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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Type 0 CAM. (A) Irregular bronchial-like structures lined by pseudostratified ciliated columnar epithelium (PAS, &times;400). (B) Columnar epithelium surrounded by prominent loose mesenchymal tissue (Vim, &times;400).</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cystic adenomatoid malformation (CAM) of the lung is thought to be a hamartomatous lesion, characterized by bronchiolar maturation disturbance,<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1,2</span></a> it is very rare in adults<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> and pathogenesis is still unknown.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> CAM is classified according to Yousem et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> into 4 types which are related with the underdeveloped bronchial-pulmonary segment and histological features. According to the literature the prevalence is as follows: type 1 (50&#8211;70%), type 2 (20&#8211;40%), type 4 (10&#8211;15%), type 3 (10%) and type 0 (1&#8211;3%). Clinical presentation varies (perinatal death, repeat infections, hemoptysis to lung carcinomas<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a>) and severity relates to the size of the lesion; it is more frequent in the lower lobes and rarely affects more than one lobe. Chest radiograph reveals rounded thin-walled spaces, filled with air or secretions, although CT scan correlates with better morphological characterization. The mainstay treatment is pulmonary resection, usually due to the risk of complications such as infection, cystic expansion or malignant transformation.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> For asymptomatic patients some authors recommend a conservative approach.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In order to get a better characterization of CAM in adults in our center, all cases between 2008 and 2015 were reviewed. CAM was diagnosed in 17 patients admitted to Coimbra Hospital and University Centre (CHUC). Patient demographics, presenting symptoms, chest radiography, CT scan, type of surgery and histopathology result were analyzed.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Five males and twelve females, aged between 20 and 85 years, with a mean age of 53.4 years were reviewed: the symptoms included recurrent infections in six patients, persistent productive cough in eight patients and hemoptysis in three. Chest radiographs and CT scans showed a pattern of bronchiectasis in seven patients, cystic lesions in six patients and nodular lesions in four patients; eight patients had it in the right lower lobe, four in the left lower lobe, two in the left upper lobe, one in the middle right lobe and two in more than one lobe in the right lung. All patients underwent surgery: lobectomy (9 cases) and pulmonary resection (8 cases). Histopathology reported two patients had CAM type 0, eight patients had CAM type 1, four patients had CAM type 2, one patient had CAM type 3 and CAM type 4 was not observed.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Our retrospective study included 17 adult patients with CAM. Although descriptions regarding gender differentials are not available, the majority of our patients were female. The most frequent complaints were recurrent infections and persistent productive cough, easily explained by the presence of bronchiectasis and fluid-filled cystic lesions depicted imagiologically. In most of these cases the presenting lesion was located in lower lobes, known from the literature to be the most common sites. The definitive diagnosis was only made by histological examination. The differential diagnosis included bronchogenic cysts, pulmonary sequestration, congenital lobar emphysema and mediastinal masses. According to the classification of Yousem et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> the CAM type 0 presents a tracheal/bronchial origin and involve all lobes. CAM type 1 is usually confined to a lobe with single or multiple cavitary lesions, with symptoms presenting in the first week of life.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> CAM type 2 is diagnosed in the first year of life and is associated with other malformations.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> CAM type 3 may involve the entire lung, usually without large space lesions.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> CAM type 4 has a distal acinar source and larger lesions that may develop pneumonia or pneumothorax; usually the diagnosis is incidental.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> Youssem et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> classification is a morphological compromise with prognostic value.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> Our series presented CAM type 1 as the most frequent type, in accordance with case series in the literature. CAM type 2 cases were not associated with other malformations. There was only one case of CAM type 3 affecting just the upper left lobe. There were no cases of CAM type 4 and there were two rare cases of CAM type 0 (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). These two rare cases had neither symptoms nor history of infections in childhood and the location was atypical since it did not involve all the lobes and there were no associated lung malformations which could explain the absence of symptoms during childhood/adolescence.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">In conclusion, surgery is the gold standard treatment for CAM adult cases and for diagnosis by histopathology analysis. This study demonstrated how CAM with late clinical alterations onset is rare and difficult to diagnose, as most cases presented as incidental radiological findings.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">Absence of financial support and off-label or investigational use.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>"
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                    0 => array:2 [
                      "titulo" => "Spontaneous resolution of nonimmune hydrops in the fetus with a cystic adenomatoid malformation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K. Higbee"
                            1 => "B.A. Melendez"
                            2 => "H.S. Heiman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Perinatol"
                        "fecha" => "1998"
                        "volumen" => "184"
                        "paginaInicial" => "308"
                        "paginaFinal" => "310"
                        "itemHostRev" => array:3 [
                          "pii" => "S002253470567512X"
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                          "issn" => "00225347"
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              "identificador" => "bib0045"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prenatal diagnosis and management of congenital cystic adenomatoid malformation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y.C. Wu"
                            1 => "J.H. Hung"
                            2 => "M.L. Yang"
                            3 => "P.L. Sun"
                            4 => "C. Yuan Shu"
                            5 => "H.T. Ng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Chung Hua I TsaChih Hsueh"
                        "fecha" => "2000"
                        "volumen" => "63"
                        "paginaInicial" => "581"
                        "paginaFinal" => "585"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0050"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dyskinesia presentation of the malformation congenital cystic adenomatoid lung"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Romancito"
                            1 => "Dessanti"
                            2 => "M. Scanu"
                            3 => "C.F. Feo"
                            4 => "L. Cocco"
                            5 => "G. Dettori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Miner Chirur"
                        "fecha" => "1998"
                        "volumen" => "53"
                        "paginaInicial" => "553"
                        "paginaFinal" => "556"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "[discussion 1047]"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased cell proliferation and decreased apoptosis characterize congenital cystic adenomatoide malformation of the lung"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D.L. Cass"
                            1 => "T.M. Quinn"
                            2 => "E.Y. Yang"
                            3 => "T.M. Crombleholme"
                            4 => "A.W. Flake"
                            5 => "N.S. Adzick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Surg"
                        "fecha" => "1998"
                        "volumen" => "33"
                        "paginaInicial" => "1043"
                        "paginaFinal" => "1046"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9694091"
                            "web" => "Medline"
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                    ]
                  ]
                ]
              ]
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              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Congenital pulmonary airway malformation &#8211; a new name for an expanded classification of congenital cystic adenomatoid malformation of the lung"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M. Kitaichi"
                            1 => "S. Yousem"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Histopathology"
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