Unusual diagnoses made by convex-probe endobronchial ultrasound-guided transbronchial needle aspiration

array:24 ["pii" => "S2531043718300187" "issn" => "25310437" "doi" => "10.1016/j.pulmoe.2017.12.004" "estado" => "S300" "fechaPublicacion" => "2018-09-01" "aid" => "5" "copyright" => "Sociedade Portuguesa de Pneumologia" "copyrightAnyo" => "2018" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Pulmonol. 2018;24:300-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2061 "formatos" => array:3 [ "EPUB" => 200 "HTML" => 1418 "PDF" => 443 ] ] "itemSiguiente" => array:19 [ "pii" => "S2531043718301168" "issn" => "25310437" "doi" => "10.1016/j.pulmoe.2018.08.002" "estado" => "S300" "fechaPublicacion" => "2018-09-01" "aid" => "58" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Pulmonol. 2018;24:307-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2026 "formatos" => array:3 [ "EPUB" => 163 "HTML" => 1438 "PDF" => 425 ] ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "Research letter" "titulo" => "Relationship of the Rapid Shallow Breathing Index (RSBI) and capnography successfully at weaning" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "307" "paginaFinal" => "309" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ewerton Cousin, Elielton de Almeida Machado, Gustavo Dias Ferreira, Marilene Rabuske, Isadora Pisani, Márcio Osório Guerreiro, Rafael Bueno Orcy" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Ewerton" "apellidos" => "Cousin" ] 1 => array:2 [ "nombre" => "Elielton de Almeida" "apellidos" => "Machado" ] 2 => array:2 [ "nombre" => "Gustavo Dias" "apellidos" => "Ferreira" ] 3 => array:2 [ "nombre" => "Marilene" "apellidos" => "Rabuske" ] 4 => array:2 [ "nombre" => "Isadora" "apellidos" => "Pisani" ] 5 => array:2 [ "nombre" => "Márcio Osório" "apellidos" => "Guerreiro" ] 6 => array:2 [ "nombre" => "Rafael Bueno" "apellidos" => "Orcy" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043718301168?idApp=UINPBA00004E" "url" => "/25310437/0000002400000005/v1_201810040621/S2531043718301168/v1_201810040621/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173511517301550" "issn" => "25310437" "doi" => "10.1016/j.rppnen.2017.10.002" "estado" => "S300" "fechaPublicacion" => "2018-09-01" "aid" => "1288" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Pulmonol. 2018;24:294-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2646 "formatos" => array:3 [ "EPUB" => 198 "HTML" => 1903 "PDF" => 545 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Diagnosis delay of tuberculosis in the Huambo province, Angola" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "294" "paginaFinal" => "299" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Santos, Ó. Felgueiras, O. Oliveira, R. Duarte" "autores" => array:4 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Santos" ] 1 => array:2 [ "nombre" => "Ó." "apellidos" => "Felgueiras" ] 2 => array:2 [ "nombre" => "O." "apellidos" => "Oliveira" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Duarte" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511517301550?idApp=UINPBA00004E" "url" => "/25310437/0000002400000005/v1_201810040621/S2173511517301550/v1_201810040621/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "Case series" "titulo" => "Unusual diagnoses made by convex-probe endobronchial ultrasound-guided transbronchial needle aspiration" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "300" "paginaFinal" => "306" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "S. Fernandez-Bussy, H. Inaty, I. Caviedes, G. Labarca, M.R. Vial, A. Majid" "autores" => array:6 [ 0 => array:4 [ "nombre" => "S." "apellidos" => "Fernandez-Bussy" "email" => array:1 [ 0 => "sfernandezbussy@alemana.cl" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "H." "apellidos" => "Inaty" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "I." "apellidos" => "Caviedes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "G." "apellidos" => "Labarca" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "M.R." "apellidos" => "Vial" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "A." "apellidos" => "Majid" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "e" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Interventional Pulmonology, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana – Universidad del Desarrollo, Santiago, Chile" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Pulmonary and Critical Care Medicine, Cleveland Clinic, Cleveland, OH, United States" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Facultad de Medicina, Universidad San Sebastian, Concepcion, Chile" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Complejo Asistencial Dr. Victor Rios Ruiz, Los Angeles, Chile" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA, United States" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 780 "Ancho" => 2500 "Tamanyo" => 404304 ] ] "descripcion" => array:1 [ "en" => "Inflammatory pseudotumor: spindle shaped cells in fascicles on a background of abundant inflammatory cells." ] ] ] "textoCompleto" => "IntroductionEndobronchial ultrasound-guided transbronchial needle biopsy (EBUS-TBNA) is a well-established tool for the diagnosis and staging of non-small cell lung cancer with reported sensitivity and specificity of 93% and 100% respectively.<a class="elsevierStyleCrossRefs" href="#bib0205">1,2</a> Recently, it has been increasingly recognized as a safe and minimally invasive tool for establishing the diagnosis of mediastinal and parenchymal masses of different etiologies, including various malignancies and rare benign diseases.<a class="elsevierStyleCrossRefs" href="#bib0215">3–5</a> The ability to perform adequate ancillary studies, such as immunohistochemical stains or molecular studies, on specimen obtained via EBUS-TBNA significantly enhances the specificity of the procedure, allowing pathologist to differentiate between different malignancies that might otherwise look similar cytologically. Furthermore, reports of genetic sequencing on specimen obtained by EBUS-TBNA have been reported in literature,<a class="elsevierStyleCrossRef" href="#bib0230">6</a> and recently found to be comparable to histologic samples.<a class="elsevierStyleCrossRefs" href="#bib0235">7,8</a> Our manuscript describes the use of EBUS-TBNA for diagnosis of seven rare mediastinal and parenchymal pathologies with review of the current literature.Case presentationCase 152 year-old woman presented with chronic non-productive cough and dysphagia to solids. Chest CT-scan revealed a 30×26mm left paratracheal mass amenable to EBUS-guided TBNA. An anechoic lesion was identified on endobronchial ultrasound, and transbronchial aspiration of 200ml of thick mucus using 21 Gauge needle was performed. The specimen was sent for cytology and microbiologic culture. Analysis revealed normal ciliated bronchial epithelial cells with no isolated organisms, thus compatible with benign uncomplicated bronchogenic cyst (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Case 2A 65 year-old man presented with chronic cough unresponsive to conventional therapy. A Chest CT scan revealed a lobulated low attenuation mass situated 8mm distal to the bifurcation of the left pulmonary artery measuring 45×62×33mm. He was referred for EBUS-TBNA. Cell block was positive for neoplastic cells, consistent with a spindle cell neoplasm with necrosis compatible with pulmonary artery sarcoma (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).<elsevierMultimedia ident="fig0010"></elsevierMultimedia>Case 3A 73 year-old man with a history of asbestos exposure, presented with recurrent right sided exudative pleural effusion. Pleural fluid cytology was highly suspicious for malignant mesothelial cells. PET-CT scan showed a diffuse patchy FDG-avid right pleural mass with associated mediastinal lymphadenopathy. The patient was referred to us for flexible broncoscopy and mediastinal staging. EBUS/TBNA of subcarinal lymph node revealed large epitheloid cells with moderate eosinophilic cytoplasm, central atypical nuclei, positive calretinin, thrombomodulin, and EMA, with negative CEA and TTF-1, consistent with malignant mesothelioma (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).<elsevierMultimedia ident="fig0015"></elsevierMultimedia>Case 463 year-old woman referred for evaluation of a right peribronchial lesion seen on CT scan of the chest. Tissue obtained via EBUS-TBNA showed amorphous eosinophilic material with positive Red Congo stain. Polarized light microscopy showed yellow-green birefringence reflecting localized amyloidosis type AA (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).<elsevierMultimedia ident="fig0020"></elsevierMultimedia>Case 525 year-old man with history of Ewing Sarcoma of the right femur resected 2 years prior, presented with a right interlobar lymph node positive on integrated positron emission tomography (PET-CT). EBUS-TBNA showed medium size cells with round nuclei, high nucleus-cytoplasm ratio, eosinophilic cytoplasm, CD99 positive, cytokeratin negative. These findings were consistent with mediastinal metastasis from Ewing Sarcoma (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>).<elsevierMultimedia ident="fig0025"></elsevierMultimedia>Case 657 year-old man with extensive smoking history presented for evaluation of chronic cough. Chest CT demonstrated a left upper lobe nodule, centrally located (16×18mm). This nodule was located adjacent to the left upper lobe take-off. EBUS-TBNA demonstrated fibrous tissue, fusoid and ovoid cells, nuclear pleomorphism and lymphoplasmocytic infiltrates. Since this was a high risk patient for malignancy, surgical resection was performed confirming the same findings and conclusive for the diagnosis of Inflammatory Pseudotumor (<a class="elsevierStyleCrossRef" href="#fig0030">Fig. 6</a>).<elsevierMultimedia ident="fig0030"></elsevierMultimedia>Case 760 years old woman with history of myelodysplastic syndrome status post bone marrow transplant from unrelated donor on immunosuppressive therapy, presented to the hospital with fever of unknown origin associated with chronic dry cough. Extensive infectious workup including lumbar puncture, blood and urine cultures were negative. CT scan of the chest showed a 4.5cm heterogenous mass with internal vascularity arising from the lingula, with associated mass effect at the junction of left main stem and superior segmental bronchi. This mass showed significant increase in size when compared to a CT scan done a month earlier. Flexible bronchoscopy with bronchoalveolar lavage, and EBUS-TBNA of the mass was performed. Gram stain of the aspirate showed gram positive branching filamentous organisms with cultures growing Nocardia farcinica (<a class="elsevierStyleCrossRef" href="#fig0035">Fig. 7</a>). Patient responded to antimicrobial therapy with significant reduction in size of the left hilar mass and improvement in symptoms.<elsevierMultimedia ident="fig0035"></elsevierMultimedia>DiscussionEBUS-TBNA is currently the procedure of choice for diagnosis and staging of lung cancer.<a class="elsevierStyleCrossRef" href="#bib0205">1</a> Being cost effective, less invasive with high diagnostic yield, allowing sampling of lymph node stations not accessible by mediastinoscopy, EBUS-TBNA has been increasingly used for diagnosis of mediastinal and parenchymal masses of various etiologies.<a class="elsevierStyleCrossRefs" href="#bib0220">4,5,9–12</a> A fair number of reported cases of rare pulmonary pathologies have been adequately diagnosed via EBUS-TBNA, otherwise sparing the patients invasive surgical approach.The use of EBUS-TBNA has been described in the diagnosis and management of bronchogenic cysts.<a class="elsevierStyleCrossRef" href="#bib0265">13</a> Although they are often asymptomatic, complications may arise including infection, bleeding, airway compression and rarely malignant transformation.<a class="elsevierStyleCrossRef" href="#bib0270">14</a> Uncomplicated cysts are anechoic on ultrasound, and the presence of echogenic substances or septations may indicate complications such as infection or bleeding within the cysts.<a class="elsevierStyleCrossRef" href="#bib0275">15</a> In addition, EBUS-TBNA can provide a reasonable alternative to excision for poor surgical candidates whose cyst is infected or large enough to create mechanical complications such as airway or esophageal compression.<a class="elsevierStyleCrossRefs" href="#bib0275">15–20</a> The use of real-time convex-probe ultrasound allows the complete aspiration of the cyst content under direct visualization, and consequently decreases the rate of recurrence by causing collapse and adherence of the cyst walls.<a class="elsevierStyleCrossRefs" href="#bib0290">18,19</a> Infection of the bronchogenic cyst following transbronchial aspiration has been reported, thus antibiotic prophylaxis is recommended.<a class="elsevierStyleCrossRefs" href="#bib0295">19–22</a>Aumiller et al. recently conducted a study which shed light on the use of EBUS for the diagnosis of central pulmonary embolism. This is particularly important in patient suspected to have vascular lesions such as angiosarcoma as a differential diagnosis.<a class="elsevierStyleCrossRef" href="#bib0315">23</a> Certain features on CT scan such as extravascular spread of the mass, low attenuation filling defect, heterogeneous enhancement of mass occupying the entire lumen of central pulmonary artery may point toward a diagnosis of angiosarcoma.<a class="elsevierStyleCrossRef" href="#bib0315">23</a> However, pathologic confirmation is necessary as the treatments differ substantially. EBUS not only help characterize the lesion but also to obtain tissue to confirm the diagnosis. Our case is the second reported on the use of EBUS for sampling and diagnosis of angiosarcoma. Park et al. published the first case, where the EBUS needle safely went through the pulmonary artery to sample the mass without complications.<a class="elsevierStyleCrossRef" href="#bib0320">24</a>In the workup of mesothelioma, a detailed algorithm was published by Zielinski et al. in 2009, and the use of EBUS-TBNA to stage malignant pleural mesothelioma (MPM).<a class="elsevierStyleCrossRef" href="#bib0325">25</a> According to this algorithm, patients with biopsy proven MPM, who are fit for surgery, should undergo EBUS-TBNA for mediastinal LN staging prior to surgery. Those patients with negative mediastinal lymph nodes should subsequently undergo laparoscopy to rule out intraperitoneal involvement. Most patients (77.7%) initially thought to be candidates for extensive multimodality approach including extrapleural pneumonectomy, were found to have distant metastasis using this algorithm, thus sparing them extensive unnecessary surgery.<a class="elsevierStyleCrossRef" href="#bib0325">25</a>Leiro et al. who published the first case of the use of EBUS-TBNA needle for histopathologic diagnosis of mediastinal nodal amyloidosis.<a class="elsevierStyleCrossRef" href="#bib0330">26</a> Primary pulmonary amyloidosis confined to the lung is very rare. It can present as tracheobronchial, interstitial, and nodular types.<a class="elsevierStyleCrossRef" href="#bib0335">27</a> Pulmonary nodules can be single or multiple and may be hard to differentiate from primary or metastatic neoplasms.<a class="elsevierStyleCrossRefs" href="#bib0330">26,27</a> Needle aspiration show band-like hyalinized material which should test positive for Congo-red stain on pathology as shown in <a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>.<a class="elsevierStyleCrossRef" href="#bib0330">26</a> A search of literature on Pubmed and Medline revealed one similar case, and other report using conventional TBNA needle for nodal sampling.<a class="elsevierStyleCrossRef" href="#bib0340">28</a> Thus EBUS-TBNA is a helpful tool for initial diagnosis of pulmonary nodular amyloidosis however results should be interpreted with caution as amyloid could be associated with an underlying malignancy either admixed with the amyloid lesion or present at a distant site.<a class="elsevierStyleCrossRefs" href="#bib0340">28,29</a>Ewing sarcoma is high grade malignancy of major long bones which mainly affect children and young adults. Extraskeletal Ewing sarcoma (EES) arising in the mediastinum is extremely rare, and is an aggressive however potentially curable disease.<a class="elsevierStyleCrossRefs" href="#bib0350">30,31</a> Rare cases of pathologic diagnosis of EES using CT-guided fine needle aspiration of large mediastinal masses and other sites of metastasis or local recurrence, have been reported in literature.<a class="elsevierStyleCrossRefs" href="#bib0360">32,33</a> Our case is the first reported where EBUS-TBNA is successfully used for tissue sampling and cytopathologic diagnosis. Diagnosis of Ewing sarcoma is aided by with immunohistochemistry as cells will demonstrate positivity for MIC2 (CD99).<a class="elsevierStyleCrossRefs" href="#bib0350">30,34</a> We believe that EBUS-TBNA is not only safe and effective tool for tissue sampling but also allows concomitant staging of the mediastinum to rule out metastatic disease which will significantly affect prognosis. Ongoing studies are currently focusing on applying genetic studies on samples obtained by EBUS-TBNA which would further increase its specificity achieving diagnosis in rare histologic subtypes of tumors such as sarcomas.<a class="elsevierStyleCrossRef" href="#bib0365">33</a>In addition, to the best of our knowledge this is the first case report of pulmonary inflammatory pseudotumor (IPT) diagnosed by EBUS-TBNA. Pulmonary Inflammatory pseudotumor is a very rare entity representing an inflammatory reaction in the lung or mediastinum.<a class="elsevierStyleCrossRefs" href="#bib0375">35–37</a> Given that IPT rarely transforms into malignancy and sometimes spontaneously regresses, asymptomatic lesions could be spared unnecessary surgeries.<a class="elsevierStyleCrossRef" href="#bib0380">36</a> There are a few case reports published in the literature where CT guided transthoracic FNA and core biopsies are used to make the diagnosis.<a class="elsevierStyleCrossRef" href="#bib0385">37</a> On cytopathology, it is characterized by spindle shaped cells on a background of inflammation. Those features are nonspecific and differential diagnosis is wide and includes melanoma, metastatic breast adenocarcinoma, sclerosing hemangioma, IgG4 sclerosing disease, and lymphoma to name a few, depending on the dominant cellular subtype.<a class="elsevierStyleCrossRefs" href="#bib0385">37,38</a> This explains why it is thought that the diagnosis of IPT should be by exclusion i.e. by ruling out other potential malignancies.<a class="elsevierStyleCrossRef" href="#bib0390">38</a>Finally, EBUS-TBNA has also been shown to be a useful tool for diagnosis of infections such as mycobacterial tuberculosis,<a class="elsevierStyleCrossRef" href="#bib0390">38</a> histoplasmosis, and blastomycosis. Pulmonary nocardiosis can present as nodules, lymphadenopathy, pleural effusions, or cavitations. Although the yield of transbronchial needle aspiration for nocardia has been previously reported to be low, Fujikura et al. published the first case report of nocardia diagnosed with EBUS-TBNA in an untreated HIV patient presenting with fever and mediastinal lymphadenopathy.<a class="elsevierStyleCrossRef" href="#bib0395">39</a> To the best of our knowledge, we present the second case in English literature. Potential dissemination of the organism remains a concern given prior reports of mediastinitis in the setting of EBUS-TBNA,<a class="elsevierStyleCrossRef" href="#bib0400">40</a> however this has not been reported. Minimizing the number of passes, performing it under real-time ultrasonography should minimize the risk.ConclusionIn summary, EBUS-TBNA has been increasingly recognized as a safe and effective tool for establishing the diagnosis of mediastinal and pulmonary lesions.<a class="elsevierStyleCrossRef" href="#bib0205">1</a> Enough tissue can be obtained to perform the additional testing (immunohistochemistry and fluorescent in situ hybridization) needed to make the diagnosis of rare entities such as the ones listed in this manuscript. In this way, patients are spared additional invasive procedures and unnecessary therapies. Larger studies are needed to assess the yield of EBUS-TBNA in establishing diagnosis, however, this could be challenging given the rarity of these diseases.ContributionSF, AM: Provided the cases, wrote the manuscript, and approved the final proof.HI: Wrote, submitted the manuscript, and approved the final proof.IC, GL and MR: Reviewed, edited the manuscript, and approved the final proof.Source of supportNo source(s) of support in the form of grants, gifts, equipment, and/or drugs are available for this manuscript.Conflicts of interestThe authors have no conflicts of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1090345" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1033637" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "sec0010" "titulo" => "Case presentation" "secciones" => array:7 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Case 1" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Case 2" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Case 3" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Case 4" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Case 5" ] 5 => array:2 [ "identificador" => "sec0040" "titulo" => "Case 6" ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "Case 7" ] ] ] 4 => array:2 [ "identificador" => "sec0050" "titulo" => "Discussion" ] 5 => array:2 [ "identificador" => "sec0055" "titulo" => "Conclusion" ] 6 => array:2 [ "identificador" => "sec0060" "titulo" => "Contribution" ] 7 => array:2 [ "identificador" => "sec0065" "titulo" => "Source of support" ] 8 => array:2 [ "identificador" => "sec0070" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-04-28" "fechaAceptado" => "2017-12-14" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1033637" "palabras" => array:4 [ 0 => "Convex-probe endobronchial ultrasound" 1 => "Transbronchial needle aspiration" 2 => "Pathology" 3 => "Unusual diagnosis" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Endobronchial ultrasound-guided transbronchial needle biopsy (EBUS-TBNA) has proven to be an effective and minimally invasive tool to diagnose and stage lung cancer. However, its use for the diagnosis of rare mediastinal and lung pathologies has been rarely described. Hereby we describe a retrospective chart review of our EBUS-TBNA database for unusual diagnosis made between July 2012 and October 2016. Those conditions considered unusual for EBUS-TBNA diagnosis were identified and their medical records reviewed." ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1087 "Ancho" => 2500 "Tamanyo" => 176141 ] ] "descripcion" => array:1 [ "en" => "Bronchogenic cyst: (a) A CT scan of the chest showing a 30×26mm left paratracheal mass. (b) Anechoic appearance on EBUS as expected for a fluid containing cyst." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 810 "Ancho" => 2500 "Tamanyo" => 147911 ] ] "descripcion" => array:1 [ "en" => "Angiosarcoma: a CT scan of the chest showing lobulated low attenuation mass situated 8mm distal to the bifurcation of the left pulmonary artery measuring 45×62×33mm, with its corresponding EBUS image." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 3812 "Ancho" => 2493 "Tamanyo" => 1165352 ] ] "descripcion" => array:1 [ "en" => "Mesothelioma: (A) Axial image of CT scan of the chest showing diffuse thickening of the pleura and enlarged mediastinal lymphadenopathy. (B) Epithelioid cohesive cells with positive Calretinin and Thrombomodulin as well as p53 protein and EMA (epitelial membrane antigen) in a membranous distribution." ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 778 "Ancho" => 2500 "Tamanyo" => 350253 ] ] "descripcion" => array:1 [ "en" => "Amyloidosis: fragments of amorphous eosinophilic material, which when stained with Congo red demonstrates the characteristic apple-green birefringence when viewed under polarized light." ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 760 "Ancho" => 2500 "Tamanyo" => 403761 ] ] "descripcion" => array:1 [ "en" => "Ewing sarcoma: a cell block preparation showing a collection of small uniform round blue cells with fine chromatin, high nuclear to cytoplasmic ratio, and strong cytoplasmic staining for CD99 by immunohistochemistry." ] ] 5 => array:7 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 780 "Ancho" => 2500 "Tamanyo" => 404304 ] ] "descripcion" => array:1 [ "en" => "Inflammatory pseudotumor: spindle shaped cells in fascicles on a background of abundant inflammatory cells." ] ] 6 => array:7 [ "identificador" => "fig0035" "etiqueta" => "Figure 7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr7.jpeg" "Alto" => 788 "Ancho" => 2500 "Tamanyo" => 223412 ] ] "descripcion" => array:1 [ "en" => "Nocardia farcinica: (left) Papanicolaou stained ThinPrep slide demonstrating clusters of cellular inflammatory debris with associated filamentous microbacterial forms (1000× oil original magnification). (Right) A FITE stain (modified AFB stain) performed on the associated cell block material highlights the numerous variably branching filamentous bacteria, consistent with nocardia species (1000× oil original magnification)." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib0205" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Methods for staging non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.A. Silvestri" 1 => "A.V. Gonzalez" 2 => "M.A. Jantz" 3 => "M.L. Margolis" 4 => "M.K. Gould" 5 => "L.T. Tanoue" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.12-2355" "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "2013" "volumen" => "143" "numero" => "5 Suppl" "paginaInicial" => "e211S" "paginaFinal" => "e250S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23649440" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0210" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Test performance of endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with lung cancer: systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Adams" 1 => "P.L. Shah" 2 => "L. Edmonds" 3 => "E. Lim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2008.109868" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2009" "volumen" => "64" "paginaInicial" => "757" "paginaFinal" => "762" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19454408" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0215" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The utility of endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal or hilar lymph node evaluation in extrathoracic malignancy: benign or malignant?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.T. Parmaksiz" 1 => "B. Caglayan" 2 => "B. Salepci" 3 => "S.S. Comert" 4 => "N. Kiral" 5 => "A. Fidan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/1817-1737.102171" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Med" "fecha" => "2012" "volumen" => "7" "paginaInicial" => "210" "paginaFinal" => "214" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23189097" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0220" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of endobronchial ultrasound guided transbronchial needle aspiration cytology in the investigation of mediastinal lymphadenopathy and masses, the North Tees experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Natu" 1 => "J. Hoffman" 2 => "M. Siddiqui" 3 => "C. Hobday" 4 => "J. Shrimankar" 5 => "R. Harrison" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jcp.2009.074328" "Revista" => array:6 [ "tituloSerie" => "J Clin Pathol" "fecha" => "2010" "volumen" => "63" "paginaInicial" => "445" "paginaFinal" => "451" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20299387" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0225" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Utility of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of mediastinal masses of unknown etiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Yasufuku" 1 => "T. Nakajima" 2 => "T. Fujiwara" 3 => "I. Yoshino" 4 => "S. Keshavjee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2010.11.032" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2011" "volumen" => "91" "paginaInicial" => "831" "paginaFinal" => "836" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21353007" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0230" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histological diagnosis of spinal chondrosarcoma by endobronchial ultrasound-guided transbronchial needle aspiration" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Nakajima" 1 => "K. Yasufuku" 2 => "M. Suzuki" 3 => "Y. Sekine" 4 => "K. Shibuya" 5 => "K. Hiroshima" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1440-1843.2006.01028.x" "Revista" => array:6 [ "tituloSerie" => "Respirology" "fecha" => "2007" "volumen" => "12" "paginaInicial" => "308" "paginaFinal" => "310" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17298471" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0235" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Success and failure rates of tumor genotyping techniques in routine pathological samples with non-small-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.A. Vanderlaan" 1 => "N. Yamaguchi" 2 => "E. Folch" 3 => "D.H. Boucher" 4 => "M.S. Kent" 5 => "S.P. Gangadharan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.lungcan.2014.01.013" "Revista" => array:6 [ "tituloSerie" => "Lung Cancer" "fecha" => "2014" "volumen" => "84" "paginaInicial" => "39" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24513263" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0240" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adequacy of lymph node transbronchial needle aspirates using convex probe endobronchial ultrasound for multiple tumor genotyping techniques in non-small-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Folch" 1 => "N. Yamaguchi" 2 => "P.A. VanderLaan" 3 => "O.N. Kocher" 4 => "D.H. Boucher" 5 => "M.A. Goldstein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/JTO.0b013e3182a471a9" "Revista" => array:6 [ "tituloSerie" => "J Thorac Oncol" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "1438" "paginaFinal" => "1444" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24128714" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0245" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of CP-EBUS-TBNA in the diagnosis of chondrosarcoma in a patient With Maffucci syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Wang" 1 => "E. Folch" 2 => "M. Paul" 3 => "A. Maskey" 4 => "F. Allard" 5 => "A. Majid" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/LBR.0000000000000069" "Revista" => array:6 [ "tituloSerie" => "J Bronchology Interv Pulmonol" "fecha" => "2014" "volumen" => "21" "paginaInicial" => "177" "paginaFinal" => "180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24739697" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0250" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cost-benefit of minimally invasive staging of non-small cell lung cancer: a decision tree sensitivity analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.P. Steinfort" 1 => "D. Liew" 2 => "M. Conron" 3 => "A.F. Hutchinson" 4 => "L.B. Irving" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/JTO.0b013e3181e8b2e6" "Revista" => array:6 [ "tituloSerie" => "J Thorac Oncol" "fecha" => "2010" "volumen" => "5" "paginaInicial" => "1564" "paginaFinal" => "1570" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20871261" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0255" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "iii–iv" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical effectiveness and cost-effectiveness of endobronchial and endoscopic ultrasound relative to surgical staging in potentially resectable lung cancer: results from the ASTER randomised controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.D. Sharples" 1 => "C. Jackson" 2 => "E. Wheaton" 3 => "G. Griffith" 4 => "J.T. Annema" 5 => "C. Dooms" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3310/hta16470" "Revista" => array:6 [ "tituloSerie" => "Health Technol Assess" "fecha" => "2012" "volumen" => "16" "paginaInicial" => "1" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23199586" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0260" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): an overview and update for the cytopathologist" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.A. VanderLaan" 1 => "H.H. Wang" 2 => "A. Majid" 3 => "E. Folch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncy.21431" "Revista" => array:6 [ "tituloSerie" => "Cancer Cytopathol" "fecha" => "2014" "volumen" => "122" "paginaInicial" => "561" "paginaFinal" => "576" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24760496" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0265" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of endobronchial ultrasound in the diagnosis of bronchogenic cysts" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Anantham" 1 => "G.C. Phua" 2 => "S.Y. Low" 3 => "M.S. Koh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2011/468237" "Revista" => array:5 [ "tituloSerie" => "Diagn Ther Endosc" "fecha" => "2011" "volumen" => "2011" "paginaInicial" => "468237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21747652" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0270" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Should asymptomatic bronchogenic cysts in adults be treated conservatively or with surgery?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Kirmani" 1 => "B. Kirmani" 2 => "F. Sogliani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1510/icvts.2010.233114" "Revista" => array:6 [ "tituloSerie" => "Interact Cardiovasc Thorac Surg" "fecha" => "2010" "volumen" => "11" "paginaInicial" => "649" "paginaFinal" => "659" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20709698" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0275" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic lesions of the thorax: role of endobronchial ultrasound-guided transbronchial needle aspiration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Twehues" 1 => "S. Islam" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Bronchol Interv Pulmonol" "fecha" => "2011" "volumen" => "18" "paginaInicial" => "265" "paginaFinal" => "268" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0280" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endobronchial ultrasound-guided needle aspiration of a bronchogenic cyst to liberate from mechanical ventilation: case report and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.A. Aragaki-Nakahodo" 1 => "J. Guitron-Roig" 2 => "W. Eschenbacher" 3 => "S. Benzaquen" 4 => "C. Cudzilo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Bronchol Interv Pulmonol" "fecha" => "2013" "volumen" => "20" "paginaInicial" => "152" "paginaFinal" => "154" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0285" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endobronchial ultrasound-guided transbronchial needle aspiration for the treatment of central airway stenosis caused by a mediastinal cyst" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T. Nakajima" 1 => "K. Yasufuku" 2 => "K. Shibuya" 3 => "T. Fujisawa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejcts.2007.06.010" "Revista" => array:6 [ "tituloSerie" => "Eur J Cardiothorac Surg" "fecha" => "2007" "volumen" => "32" "paginaInicial" => "538" "paginaFinal" => "540" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17629489" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0290" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "bcr2007078071" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchogenic cyst treated by endobronchial ultrasound drainage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Dhand" 1 => "W. Krimsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "BMJ Case Rep" "fecha" => "2009" "volumen" => "2009" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0295" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infected mediastinal bronchogenic cyst successfully treated by endobronchial ultrasound-guided fine-needle aspiration" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.F. Casal" 1 => "C.A. Jimenez" 2 => "R.J. Mehran" 3 => "G.A. Eapen" 4 => "D. Ost" 5 => "M. Sarkiss" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2010.06.062" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2010" "volumen" => "90" "paginaInicial" => "e52" "paginaFinal" => "e53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20868780" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0300" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "[discussion 9]" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mediastinal bronchogenic cyst's recurrence treated with EBUS-FNA with a long-term follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Galluccio" 1 => "G. Lucantoni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejcts.2005.12.052" "Revista" => array:6 [ "tituloSerie" => "Eur J Cardiothorac Surg" "fecha" => "2006" "volumen" => "29" "paginaInicial" => "627" "paginaFinal" => "629" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476541" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0305" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infection of a bronchogenic cyst after ultrasonography-guided fine needle aspiration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Gamrekeli" 1 => "G. Kalweit" 2 => "H. Schafer" 3 => "H. Huwer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2012.10.071" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2013" "volumen" => "95" "paginaInicial" => "2154" "paginaFinal" => "2155" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23706435" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0310" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchogenic cyst rupture and pneumonia after endobronchial ultrasound-guided transbronchial needle aspiration: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Hong" 1 => "J. Song" 2 => "K.J. Lee" 3 => "K. Jeon" 4 => "W.J. Koh" 5 => "G.Y. Suh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Tuberc Respir Dis (Seoul)" "fecha" => "2013" "volumen" => "74" "paginaInicial" => "177" "paginaFinal" => "180" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0315" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endobronchial ultrasound for detecting central pulmonary emboli: a pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Aumiller" 1 => "F.J. Herth" 2 => "M. Krasnik" 3 => "R. Eberhardt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000183197" "Revista" => array:6 [ "tituloSerie" => "Respiration" "fecha" => "2009" "volumen" => "77" "paginaInicial" => "298" "paginaFinal" => "302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19065053" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0320" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EBUS-TBNA in the differential diagnosis of pulmonary artery sarcoma and thromboembolism" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.S. Park" 1 => "J.H. Chung" 2 => "S. Jheon" 3 => "D.J. Choi" 4 => "H.I. Yoon" 5 => "J.H. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00043211" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2011" "volumen" => "38" "paginaInicial" => "1480" "paginaFinal" => "1482" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22130766" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0325" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Staging algorithm for diffuse malignant pleural mesothelioma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Zielinski" 1 => "J. Hauer" 2 => "L. Hauer" 3 => "J. Pankowski" 4 => "T. Nabialek" 5 => "A. Szlubowski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1510/icvts.2009.213611" "Revista" => array:6 [ "tituloSerie" => "Interact Cardiovasc Thorac Surg" "fecha" => "2010" "volumen" => "10" "paginaInicial" => "185" "paginaFinal" => "189" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19843550" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0330" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary amyloidosis involving mediastinal lymph nodes: diagnosis by transbronchial needle aspiration" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Leiro" 1 => "A. Fernandez-Villar" 2 => "R. Bandres" 3 => "A. Gonzalez" 4 => "C. Represas" 5 => "J.C. Barros" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000098821" "Revista" => array:6 [ "tituloSerie" => "Respiration" "fecha" => "2008" "volumen" => "76" "paginaInicial" => "218" "paginaFinal" => "220" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17230012" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0335" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mimicking pulmonary multiple metastatic tumors: a case of primary nodular parenchymal pulmonary amyloidosis with review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.N. Zhang" 1 => "X.Y. Xue" 2 => "N. Wang" 3 => "J.X. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3892/ol.2012.923" "Revista" => array:6 [ "tituloSerie" => "Oncol Lett" "fecha" => "2012" "volumen" => "4" "paginaInicial" => "1366" "paginaFinal" => "1370" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23205137" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0340" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transbronchial needle aspiration in the diagnosis of mediastinal amyloidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Leiro-Fernandez" 1 => "M. Botana-Rial" 2 => "C. Represas" 3 => "A. Fernandez-Villar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2010.148510" "Revista" => array:5 [ "tituloSerie" => "Thorax" "fecha" => "2011" "volumen" => "66" "paginaInicial" => "543" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20947897" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0345" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fine-needle aspiration cytology of amyloid associated with nonneoplastic and malignant lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.E. Halliday" 1 => "J.F. Silverman" 2 => "J.L. Finley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diagn Cytopathol" "fecha" => "1998" "volumen" => "18" "paginaInicial" => "270" "paginaFinal" => "275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9557261" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0350" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extraskeletal Ewing's sarcoma presenting with multifocal intrathoracic mass lesions associated with mediastinal shift" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Kuzucu" 1 => "H.S. Erkal" 2 => "O. Soysal" 3 => "M. Serin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2005.03.116" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2006" "volumen" => "81" "paginaInicial" => "1487" "paginaFinal" => "1488" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16564299" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0355" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extraskeletal Ewing's sarcoma presenting as a mediastinal mass" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Halliday" 1 => "S.Y. Soon" 2 => "H. Monaghan" 3 => "W.S. Walker" 4 => "V. Zamvar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2010.01.083" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2010" "volumen" => "90" "paginaInicial" => "1016" "paginaFinal" => "1017" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20732541" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0360" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of primary mediastinal Ewing's sarcoma/primitive neuroectodermal tumor presenting with initial compression of superior vena cava" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Reali" 1 => "G. Mortellaro" 2 => "S. Allis" 3 => "E. Trevisiol" 4 => "S.M. Anglesio" 5 => "S. Bartoncini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/1817-1737.109834" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Med" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "121" "paginaFinal" => "123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23741276" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0365" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extraskeletal Ewing's sarcoma family of tumours in adults: analysis of 57 patients from a single institution" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. El Weshi" 1 => "A. Allam" 2 => "D. Ajarim" 3 => "F. Al Dayel" 4 => "R. Pant" 5 => "S. Bazarbashi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Oncol (R Coll Radiol)" "fecha" => "2010" "volumen" => "22" "paginaInicial" => "374" "paginaFinal" => "381" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0370" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgically treated pulmonary inflammatory pseudotumor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Omasa" 1 => "T. Kobayashi" 2 => "Y. Takahashi" 3 => "J. Tamada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Jpn J Thorac Cardiovasc Surg" "fecha" => "2002" "volumen" => "50" "paginaInicial" => "305" "paginaFinal" => "308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12166272" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0375" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory pseudotumors of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.J. Cerfolio" 1 => "M.S. Allen" 2 => "A.G. Nascimento" 3 => "C. Deschamps" 4 => "V.F. Trastek" 5 => "D.L. Miller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "1999" "volumen" => "67" "paginaInicial" => "933" "paginaFinal" => "936" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10320231" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0380" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory pseudotumor: a diagnostic dilemma in cytopathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.A. Hosler" 1 => "D.M. Steinberg" 2 => "S. Sheth" 3 => "U.M. Hamper" 4 => "Y.S. Erozan" 5 => "S.Z. Ali" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/dc.20113" "Revista" => array:6 [ "tituloSerie" => "Diagn Cytopathol" "fecha" => "2004" "volumen" => "31" "paginaInicial" => "267" "paginaFinal" => "270" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15452903" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0385" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transthoracic fine-needle aspiration cytology of inflammatory pseudotumor, fibrohistiocytic type: a case report with immunohistochemical studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Bakhos" 1 => "E.M. Wojcik" 2 => "M.C. Olson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diagn Cytopathol" "fecha" => "1998" "volumen" => "19" "paginaInicial" => "216" "paginaFinal" => "220" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9740999" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0390" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Navani" 1 => "P.L. Molyneaux" 2 => "R.A. Breen" 3 => "D.W. Connell" 4 => "A. Jepson" 5 => "M. Nankivell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thoraxjnl-2011-200063" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2011" "volumen" => "66" "paginaInicial" => "889" "paginaFinal" => "893" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21813622" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0395" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of Nocardia asteroides infection in a patient with HIV/AIDS diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Fujikura" 1 => "Y. Kouzaki" 2 => "S. Ohta" 3 => "Y. Hara" 4 => "K. Mikita" 5 => "T. Maeda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Intern Med" "fecha" => "2012" "volumen" => "51" "paginaInicial" => "1413" "paginaFinal" => "1417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22687853" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0400" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complications associated with endobronchial ultrasound-guided transbronchial needle aspiration: a nationwide survey by the Japan Society for Respiratory Endoscopy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Asano" 1 => "M. Aoe" 2 => "Y. Ohsaki" 3 => "Y. Okada" 4 => "S. Sasada" 5 => "S. Sato" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1465-9921-14-50" "Revista" => array:5 [ "tituloSerie" => "Respir Res" "fecha" => "2013" "volumen" => "14" "paginaInicial" => "50" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23663438" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/25310437/0000002400000005/v1_201810040621/S2531043718300187/v1_201810040621/en/main.assets" "Apartado" => array:4 [ "identificador" => "75942" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case series" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/25310437/0000002400000005/v1_201810040621/S2531043718300187/v1_201810040621/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043718300187?idApp=UINPBA00004E"]

Statistics

Case series

Unusual diagnoses made by convex-probe endobronchial ultrasound-guided transbronchial needle aspiration

S. Fernandez-Bussya,

Corresponding author

sfernandezbussy@alemana.cl

Corresponding author.

, H. Inatyb, I. Caviedesa, G. Labarcac,d, M.R. Viala, A. Majide

a Interventional Pulmonology, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana – Universidad del Desarrollo, Santiago, Chile

b Department of Pulmonary and Critical Care Medicine, Cleveland Clinic, Cleveland, OH, United States

c Facultad de Medicina, Universidad San Sebastian, Concepcion, Chile

d Complejo Asistencial Dr. Victor Rios Ruiz, Los Angeles, Chile

e Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA, United States

Read

7389

Times
was read the article

2512

Total PDF

4877

Total HTML

Share statistics

 array:24 [
  "pii" => "S2531043718300187"
  "issn" => "25310437"
  "doi" => "10.1016/j.pulmoe.2017.12.004"
  "estado" => "S300"
  "fechaPublicacion" => "2018-09-01"
  "aid" => "5"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2018"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "sco"
  "cita" => "Pulmonol. 2018;24:300-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2061
    "formatos" => array:3 [
      "EPUB" => 200
      "HTML" => 1418
      "PDF" => 443
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2531043718301168"
    "issn" => "25310437"
    "doi" => "10.1016/j.pulmoe.2018.08.002"
    "estado" => "S300"
    "fechaPublicacion" => "2018-09-01"
    "aid" => "58"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Pulmonol. 2018;24:307-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2026
      "formatos" => array:3 [
        "EPUB" => 163
        "HTML" => 1438
        "PDF" => 425
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Research letter</span>"
      "titulo" => "Relationship of the Rapid Shallow Breathing Index &#40;RSBI&#41; and capnography successfully at weaning"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "307"
          "paginaFinal" => "309"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ewerton Cousin, Elielton de Almeida Machado, Gustavo Dias Ferreira, Marilene Rabuske, Isadora Pisani, M&#225;rcio Os&#243;rio Guerreiro, Rafael Bueno Orcy"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Ewerton"
              "apellidos" => "Cousin"
            ]
            1 => array:2 [
              "nombre" => "Elielton de Almeida"
              "apellidos" => "Machado"
            ]
            2 => array:2 [
              "nombre" => "Gustavo Dias"
              "apellidos" => "Ferreira"
            ]
            3 => array:2 [
              "nombre" => "Marilene"
              "apellidos" => "Rabuske"
            ]
            4 => array:2 [
              "nombre" => "Isadora"
              "apellidos" => "Pisani"
            ]
            5 => array:2 [
              "nombre" => "M&#225;rcio Os&#243;rio"
              "apellidos" => "Guerreiro"
            ]
            6 => array:2 [
              "nombre" => "Rafael Bueno"
              "apellidos" => "Orcy"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043718301168?idApp=UINPBA00004E"
    "url" => "/25310437/0000002400000005/v1_201810040621/S2531043718301168/v1_201810040621/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173511517301550"
    "issn" => "25310437"
    "doi" => "10.1016/j.rppnen.2017.10.002"
    "estado" => "S300"
    "fechaPublicacion" => "2018-09-01"
    "aid" => "1288"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Pulmonol. 2018;24:294-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2646
      "formatos" => array:3 [
        "EPUB" => 198
        "HTML" => 1903
        "PDF" => 545
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Diagnosis delay of tuberculosis in the Huambo province&#44; Angola"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "294"
          "paginaFinal" => "299"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E&#46; Santos, &#211;&#46; Felgueiras, O&#46; Oliveira, R&#46; Duarte"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Santos"
            ]
            1 => array:2 [
              "nombre" => "&#211;&#46;"
              "apellidos" => "Felgueiras"
            ]
            2 => array:2 [
              "nombre" => "O&#46;"
              "apellidos" => "Oliveira"
            ]
            3 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Duarte"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511517301550?idApp=UINPBA00004E"
    "url" => "/25310437/0000002400000005/v1_201810040621/S2173511517301550/v1_201810040621/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case series</span>"
    "titulo" => "Unusual diagnoses made by convex-probe endobronchial ultrasound-guided transbronchial needle aspiration"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "300"
        "paginaFinal" => "306"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "S&#46; Fernandez-Bussy, H&#46; Inaty, I&#46; Caviedes, G&#46; Labarca, M&#46;R&#46; Vial, A&#46; Majid"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "S&#46;"
            "apellidos" => "Fernandez-Bussy"
            "email" => array:1 [
              0 => "sfernandezbussy&#64;alemana&#46;cl"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "H&#46;"
            "apellidos" => "Inaty"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "I&#46;"
            "apellidos" => "Caviedes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "G&#46;"
            "apellidos" => "Labarca"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "M&#46;R&#46;"
            "apellidos" => "Vial"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Majid"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:5 [
          0 => array:3 [
            "entidad" => "Interventional Pulmonology&#44; Cl&#237;nica Alemana de Santiago&#44; Facultad de Medicina Cl&#237;nica Alemana &#8211; Universidad del Desarrollo&#44; Santiago&#44; Chile"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Department of Pulmonary and Critical Care Medicine&#44; Cleveland Clinic&#44; Cleveland&#44; OH&#44; United States"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Facultad de Medicina&#44; Universidad San Sebastian&#44; Concepcion&#44; Chile"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Complejo Asistencial Dr&#46; Victor Rios Ruiz&#44; Los Angeles&#44; Chile"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Division of Thoracic Surgery and Interventional Pulmonology&#44; Beth Israel Deaconess Medical Center&#44; Boston&#44; MA&#44; United States"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0030"
        "etiqueta" => "Figure 6"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr6.jpeg"
            "Alto" => 780
            "Ancho" => 2500
            "Tamanyo" => 404304
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Inflammatory pseudotumor&#58; spindle shaped cells in fascicles on a background of abundant inflammatory cells&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Endobronchial ultrasound-guided transbronchial needle biopsy &#40;EBUS-TBNA&#41; is a well-established tool for the diagnosis and staging of non-small cell lung cancer with reported sensitivity and specificity of 93&#37; and 100&#37; respectively&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">1&#44;2</span></a> Recently&#44; it has been increasingly recognized as a safe and minimally invasive tool for establishing the diagnosis of mediastinal and parenchymal masses of different etiologies&#44; including various malignancies and rare benign diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">3&#8211;5</span></a> The ability to perform adequate ancillary studies&#44; such as immunohistochemical stains or molecular studies&#44; on specimen obtained via EBUS-TBNA significantly enhances the specificity of the procedure&#44; allowing pathologist to differentiate between different malignancies that might otherwise look similar cytologically&#46; Furthermore&#44; reports of genetic sequencing on specimen obtained by EBUS-TBNA have been reported in literature&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">6</span></a> and recently found to be comparable to histologic samples&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">7&#44;8</span></a> Our manuscript describes the use of EBUS-TBNA for diagnosis of seven rare mediastinal and parenchymal pathologies with review of the current literature&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Case presentation</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Case 1</span><p id="par0010" class="elsevierStylePara elsevierViewall">52 year-old woman presented with chronic non-productive cough and dysphagia to solids&#46; Chest CT-scan revealed a 30<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>mm left paratracheal mass amenable to EBUS-guided TBNA&#46; An anechoic lesion was identified on endobronchial ultrasound&#44; and transbronchial aspiration of 200<span class="elsevierStyleHsp" style=""></span>ml of thick mucus using 21 Gauge needle was performed&#46; The specimen was sent for cytology and microbiologic culture&#46; Analysis revealed normal ciliated bronchial epithelial cells with no isolated organisms&#44; thus compatible with benign uncomplicated bronchogenic cyst &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case 2</span><p id="par0015" class="elsevierStylePara elsevierViewall">A 65 year-old man presented with chronic cough unresponsive to conventional therapy&#46; A Chest CT scan revealed a lobulated low attenuation mass situated 8<span class="elsevierStyleHsp" style=""></span>mm distal to the bifurcation of the left pulmonary artery measuring 45<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>62<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>33<span class="elsevierStyleHsp" style=""></span>mm&#46; He was referred for EBUS-TBNA&#46; Cell block was positive for neoplastic cells&#44; consistent with a spindle cell neoplasm with necrosis compatible with pulmonary artery sarcoma &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Case 3</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 73 year-old man with a history of asbestos exposure&#44; presented with recurrent right sided exudative pleural effusion&#46; Pleural fluid cytology was highly suspicious for malignant mesothelial cells&#46; PET-CT scan showed a diffuse patchy FDG-avid right pleural mass with associated mediastinal lymphadenopathy&#46; The patient was referred to us for flexible broncoscopy and mediastinal staging&#46; EBUS&#47;TBNA of subcarinal lymph node revealed large epitheloid cells with moderate eosinophilic cytoplasm&#44; central atypical nuclei&#44; positive calretinin&#44; thrombomodulin&#44; and EMA&#44; with negative CEA and TTF-1&#44; consistent with malignant mesothelioma &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Case 4</span><p id="par0025" class="elsevierStylePara elsevierViewall">63 year-old woman referred for evaluation of a right peribronchial lesion seen on CT scan of the chest&#46; Tissue obtained via EBUS-TBNA showed amorphous eosinophilic material with positive Red Congo stain&#46; Polarized light microscopy showed yellow-green birefringence reflecting localized amyloidosis type AA &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Case 5</span><p id="par0030" class="elsevierStylePara elsevierViewall">25 year-old man with history of Ewing Sarcoma of the right femur resected 2 years prior&#44; presented with a right interlobar lymph node positive on integrated positron emission tomography &#40;PET-CT&#41;&#46; EBUS-TBNA showed medium size cells with round nuclei&#44; high nucleus-cytoplasm ratio&#44; eosinophilic cytoplasm&#44; CD99 positive&#44; cytokeratin negative&#46; These findings were consistent with mediastinal metastasis from Ewing Sarcoma &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Case 6</span><p id="par0035" class="elsevierStylePara elsevierViewall">57 year-old man with extensive smoking history presented for evaluation of chronic cough&#46; Chest CT demonstrated a left upper lobe nodule&#44; centrally located &#40;16<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>18<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46; This nodule was located adjacent to the left upper lobe take-off&#46; EBUS-TBNA demonstrated fibrous tissue&#44; fusoid and ovoid cells&#44; nuclear pleomorphism and lymphoplasmocytic infiltrates&#46; Since this was a high risk patient for malignancy&#44; surgical resection was performed confirming the same findings and conclusive for the diagnosis of Inflammatory Pseudotumor &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41;&#46;</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Case 7</span><p id="par0040" class="elsevierStylePara elsevierViewall">60 years old woman with history of myelodysplastic syndrome status post bone marrow transplant from unrelated donor on immunosuppressive therapy&#44; presented to the hospital with fever of unknown origin associated with chronic dry cough&#46; Extensive infectious workup including lumbar puncture&#44; blood and urine cultures were negative&#46; CT scan of the chest showed a 4&#46;5<span class="elsevierStyleHsp" style=""></span>cm heterogenous mass with internal vascularity arising from the lingula&#44; with associated mass effect at the junction of left main stem and superior segmental bronchi&#46; This mass showed significant increase in size when compared to a CT scan done a month earlier&#46; Flexible bronchoscopy with bronchoalveolar lavage&#44; and EBUS-TBNA of the mass was performed&#46; Gram stain of the aspirate showed gram positive branching filamentous organisms with cultures growing <span class="elsevierStyleItalic">Nocardia farcinica</span> &#40;<a class="elsevierStyleCrossRef" href="#fig0035">Fig&#46; 7</a>&#41;&#46; Patient responded to antimicrobial therapy with significant reduction in size of the left hilar mass and improvement in symptoms&#46;</p><elsevierMultimedia ident="fig0035"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">EBUS-TBNA is currently the procedure of choice for diagnosis and staging of lung cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">1</span></a> Being cost effective&#44; less invasive with high diagnostic yield&#44; allowing sampling of lymph node stations not accessible by mediastinoscopy&#44; EBUS-TBNA has been increasingly used for diagnosis of mediastinal and parenchymal masses of various etiologies&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">4&#44;5&#44;9&#8211;12</span></a> A fair number of reported cases of rare pulmonary pathologies have been adequately diagnosed via EBUS-TBNA&#44; otherwise sparing the patients invasive surgical approach&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The use of EBUS-TBNA has been described in the diagnosis and management of bronchogenic cysts&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">13</span></a> Although they are often asymptomatic&#44; complications may arise including infection&#44; bleeding&#44; airway compression and rarely malignant transformation&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">14</span></a> Uncomplicated cysts are anechoic on ultrasound&#44; and the presence of echogenic substances or septations may indicate complications such as infection or bleeding within the cysts&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">15</span></a> In addition&#44; EBUS-TBNA can provide a reasonable alternative to excision for poor surgical candidates whose cyst is infected or large enough to create mechanical complications such as airway or esophageal compression&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">15&#8211;20</span></a> The use of real-time convex-probe ultrasound allows the complete aspiration of the cyst content under direct visualization&#44; and consequently decreases the rate of recurrence by causing collapse and adherence of the cyst walls&#46;<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">18&#44;19</span></a> Infection of the bronchogenic cyst following transbronchial aspiration has been reported&#44; thus antibiotic prophylaxis is recommended&#46;<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">19&#8211;22</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Aumiller et al&#46; recently conducted a study which shed light on the use of EBUS for the diagnosis of central pulmonary embolism&#46; This is particularly important in patient suspected to have vascular lesions such as angiosarcoma as a differential diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">23</span></a> Certain features on CT scan such as extravascular spread of the mass&#44; low attenuation filling defect&#44; heterogeneous enhancement of mass occupying the entire lumen of central pulmonary artery may point toward a diagnosis of angiosarcoma&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">23</span></a> However&#44; pathologic confirmation is necessary as the treatments differ substantially&#46; EBUS not only help characterize the lesion but also to obtain tissue to confirm the diagnosis&#46; Our case is the second reported on the use of EBUS for sampling and diagnosis of angiosarcoma&#46; Park et al&#46; published the first case&#44; where the EBUS needle safely went through the pulmonary artery to sample the mass without complications&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">24</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In the workup of mesothelioma&#44; a detailed algorithm was published by Zielinski et al&#46; in 2009&#44; and the use of EBUS-TBNA to stage malignant pleural mesothelioma &#40;MPM&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">25</span></a> According to this algorithm&#44; patients with biopsy proven MPM&#44; who are fit for surgery&#44; should undergo EBUS-TBNA for mediastinal LN staging prior to surgery&#46; Those patients with negative mediastinal lymph nodes should subsequently undergo laparoscopy to rule out intraperitoneal involvement&#46; Most patients &#40;77&#46;7&#37;&#41; initially thought to be candidates for extensive multimodality approach including extrapleural pneumonectomy&#44; were found to have distant metastasis using this algorithm&#44; thus sparing them extensive unnecessary surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">25</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Leiro et al&#46; who published the first case of the use of EBUS-TBNA needle for histopathologic diagnosis of mediastinal nodal amyloidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">26</span></a> Primary pulmonary amyloidosis confined to the lung is very rare&#46; It can present as tracheobronchial&#44; interstitial&#44; and nodular types&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">27</span></a> Pulmonary nodules can be single or multiple and may be hard to differentiate from primary or metastatic neoplasms&#46;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">26&#44;27</span></a> Needle aspiration show band-like hyalinized material which should test positive for Congo-red stain on pathology as shown in <a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">26</span></a> A search of literature on Pubmed and Medline revealed one similar case&#44; and other report using conventional TBNA needle for nodal sampling&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">28</span></a> Thus EBUS-TBNA is a helpful tool for initial diagnosis of pulmonary nodular amyloidosis however results should be interpreted with caution as amyloid could be associated with an underlying malignancy either admixed with the amyloid lesion or present at a distant site&#46;<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">28&#44;29</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Ewing sarcoma is high grade malignancy of major long bones which mainly affect children and young adults&#46; Extraskeletal Ewing sarcoma &#40;EES&#41; arising in the mediastinum is extremely rare&#44; and is an aggressive however potentially curable disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0350"><span class="elsevierStyleSup">30&#44;31</span></a> Rare cases of pathologic diagnosis of EES using CT-guided fine needle aspiration of large mediastinal masses and other sites of metastasis or local recurrence&#44; have been reported in literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">32&#44;33</span></a> Our case is the first reported where EBUS-TBNA is successfully used for tissue sampling and cytopathologic diagnosis&#46; Diagnosis of Ewing sarcoma is aided by with immunohistochemistry as cells will demonstrate positivity for MIC2 &#40;CD99&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0350"><span class="elsevierStyleSup">30&#44;34</span></a> We believe that EBUS-TBNA is not only safe and effective tool for tissue sampling but also allows concomitant staging of the mediastinum to rule out metastatic disease which will significantly affect prognosis&#46; Ongoing studies are currently focusing on applying genetic studies on samples obtained by EBUS-TBNA which would further increase its specificity achieving diagnosis in rare histologic subtypes of tumors such as sarcomas&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">33</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In addition&#44; to the best of our knowledge this is the first case report of pulmonary inflammatory pseudotumor &#40;IPT&#41; diagnosed by EBUS-TBNA&#46; Pulmonary Inflammatory pseudotumor is a very rare entity representing an inflammatory reaction in the lung or mediastinum&#46;<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">35&#8211;37</span></a> Given that IPT rarely transforms into malignancy and sometimes spontaneously regresses&#44; asymptomatic lesions could be spared unnecessary surgeries&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">36</span></a> There are a few case reports published in the literature where CT guided transthoracic FNA and core biopsies are used to make the diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">37</span></a> On cytopathology&#44; it is characterized by spindle shaped cells on a background of inflammation&#46; Those features are nonspecific and differential diagnosis is wide and includes melanoma&#44; metastatic breast adenocarcinoma&#44; sclerosing hemangioma&#44; IgG4 sclerosing disease&#44; and lymphoma to name a few&#44; depending on the dominant cellular subtype&#46;<a class="elsevierStyleCrossRefs" href="#bib0385"><span class="elsevierStyleSup">37&#44;38</span></a> This explains why it is thought that the diagnosis of IPT should be by exclusion i&#46;e&#46; by ruling out other potential malignancies&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">38</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Finally&#44; EBUS-TBNA has also been shown to be a useful tool for diagnosis of infections such as mycobacterial tuberculosis&#44;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">38</span></a> histoplasmosis&#44; and blastomycosis&#46; Pulmonary nocardiosis can present as nodules&#44; lymphadenopathy&#44; pleural effusions&#44; or cavitations&#46; Although the yield of transbronchial needle aspiration for nocardia has been previously reported to be low&#44; Fujikura et al&#46; published the first case report of nocardia diagnosed with EBUS-TBNA in an untreated HIV patient presenting with fever and mediastinal lymphadenopathy&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">39</span></a> To the best of our knowledge&#44; we present the second case in English literature&#46; Potential dissemination of the organism remains a concern given prior reports of mediastinitis in the setting of EBUS-TBNA&#44;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">40</span></a> however this has not been reported&#46; Minimizing the number of passes&#44; performing it under real-time ultrasonography should minimize the risk&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusion</span><p id="par0085" class="elsevierStylePara elsevierViewall">In summary&#44; EBUS-TBNA has been increasingly recognized as a safe and effective tool for establishing the diagnosis of mediastinal and pulmonary lesions&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">1</span></a> Enough tissue can be obtained to perform the additional testing &#40;immunohistochemistry and fluorescent in situ hybridization&#41; needed to make the diagnosis of rare entities such as the ones listed in this manuscript&#46; In this way&#44; patients are spared additional invasive procedures and unnecessary therapies&#46; Larger studies are needed to assess the yield of EBUS-TBNA in establishing diagnosis&#44; however&#44; this could be challenging given the rarity of these diseases&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Contribution</span><p id="par0090" class="elsevierStylePara elsevierViewall">SF&#44; AM&#58; Provided the cases&#44; wrote the manuscript&#44; and approved the final proof&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">HI&#58; Wrote&#44; submitted the manuscript&#44; and approved the final proof&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">IC&#44; GL and MR&#58; Reviewed&#44; edited the manuscript&#44; and approved the final proof&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Source of support</span><p id="par0110" class="elsevierStylePara elsevierViewall">No source&#40;s&#41; of support in the form of grants&#44; gifts&#44; equipment&#44; and&#47;or drugs are available for this manuscript&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflicts of interest</span><p id="par0115" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres1090345"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1033637"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        3 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Case presentation"
          "secciones" => array:7 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Case 1"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Case 2"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Case 3"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Case 4"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Case 5"
            ]
            5 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Case 6"
            ]
            6 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Case 7"
            ]
          ]
        ]
        4 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Discussion"
        ]
        5 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Conclusion"
        ]
        6 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Contribution"
        ]
        7 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Source of support"
        ]
        8 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Conflicts of interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2017-04-28"
    "fechaAceptado" => "2017-12-14"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1033637"
          "palabras" => array:4 [
            0 => "Convex-probe endobronchial ultrasound"
            1 => "Transbronchial needle aspiration"
            2 => "Pathology"
            3 => "Unusual diagnosis"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Endobronchial ultrasound-guided transbronchial needle biopsy &#40;EBUS-TBNA&#41; has proven to be an effective and minimally invasive tool to diagnose and stage lung cancer&#46; However&#44; its use for the diagnosis of rare mediastinal and lung pathologies has been rarely described&#46; Hereby we describe a retrospective chart review of our EBUS-TBNA database for unusual diagnosis made between July 2012 and October 2016&#46; Those conditions considered unusual for EBUS-TBNA diagnosis were identified and their medical records reviewed&#46;</p></span>"
      ]
    ]
    "multimedia" => array:7 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1087
            "Ancho" => 2500
            "Tamanyo" => 176141
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bronchogenic cyst&#58; &#40;a&#41; A CT scan of the chest showing a 30<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>mm left paratracheal mass&#46; &#40;b&#41; Anechoic appearance on EBUS as expected for a fluid containing cyst&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 810
            "Ancho" => 2500
            "Tamanyo" => 147911
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Angiosarcoma&#58; a CT scan of the chest showing lobulated low attenuation mass situated 8<span class="elsevierStyleHsp" style=""></span>mm distal to the bifurcation of the left pulmonary artery measuring 45<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>62<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>33<span class="elsevierStyleHsp" style=""></span>mm&#44; with its corresponding EBUS image&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 3812
            "Ancho" => 2493
            "Tamanyo" => 1165352
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Mesothelioma&#58; &#40;A&#41; Axial image of CT scan of the chest showing diffuse thickening of the pleura and enlarged mediastinal lymphadenopathy&#46; &#40;B&#41; Epithelioid cohesive cells with positive Calretinin and Thrombomodulin as well as p53 protein and EMA &#40;epitelial membrane antigen&#41; in a membranous distribution&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 778
            "Ancho" => 2500
            "Tamanyo" => 350253
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Amyloidosis&#58; fragments of amorphous eosinophilic material&#44; which when stained with Congo red demonstrates the characteristic apple-green birefringence when viewed under polarized light&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 760
            "Ancho" => 2500
            "Tamanyo" => 403761
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Ewing sarcoma&#58; a cell block preparation showing a collection of small uniform round blue cells with fine chromatin&#44; high nuclear to cytoplasmic ratio&#44; and strong cytoplasmic staining for CD99 by immunohistochemistry&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "fig0030"
        "etiqueta" => "Figure 6"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr6.jpeg"
            "Alto" => 780
            "Ancho" => 2500
            "Tamanyo" => 404304
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Inflammatory pseudotumor&#58; spindle shaped cells in fascicles on a background of abundant inflammatory cells&#46;</p>"
        ]
      ]
      6 => array:7 [
        "identificador" => "fig0035"
        "etiqueta" => "Figure 7"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr7.jpeg"
            "Alto" => 788
            "Ancho" => 2500
            "Tamanyo" => 223412
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Nocardia farcinica&#58; &#40;left&#41; Papanicolaou stained ThinPrep slide demonstrating clusters of cellular inflammatory debris with associated filamentous microbacterial forms &#40;1000&#215; oil original magnification&#41;&#46; &#40;Right&#41; A FITE stain &#40;modified AFB stain&#41; performed on the associated cell block material highlights the numerous variably branching filamentous bacteria&#44; consistent with nocardia species &#40;1000&#215; oil original magnification&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:40 [
            0 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Methods for staging non-small cell lung cancer&#58; diagnosis and management of lung cancer&#44; 3rd ed&#58; American College of Chest Physicians evidence-based clinical practice guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;A&#46; Silvestri"
                            1 => "A&#46;V&#46; Gonzalez"
                            2 => "M&#46;A&#46; Jantz"
                            3 => "M&#46;L&#46; Margolis"
                            4 => "M&#46;K&#46; Gould"
                            5 => "L&#46;T&#46; Tanoue"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.12-2355"
                      "Revista" => array:7 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2013"
                        "volumen" => "143"
                        "numero" => "5 Suppl"
                        "paginaInicial" => "e211S"
                        "paginaFinal" => "e250S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23649440"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Test performance of endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with lung cancer&#58; systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Adams"
                            1 => "P&#46;L&#46; Shah"
                            2 => "L&#46; Edmonds"
                            3 => "E&#46; Lim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2008.109868"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2009"
                        "volumen" => "64"
                        "paginaInicial" => "757"
                        "paginaFinal" => "762"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19454408"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The utility of endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal or hilar lymph node evaluation in extrathoracic malignancy&#58; benign or malignant&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;T&#46; Parmaksiz"
                            1 => "B&#46; Caglayan"
                            2 => "B&#46; Salepci"
                            3 => "S&#46;S&#46; Comert"
                            4 => "N&#46; Kiral"
                            5 => "A&#46; Fidan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/1817-1737.102171"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Med"
                        "fecha" => "2012"
                        "volumen" => "7"
                        "paginaInicial" => "210"
                        "paginaFinal" => "214"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23189097"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of endobronchial ultrasound guided transbronchial needle aspiration cytology in the investigation of mediastinal lymphadenopathy and masses&#44; the North Tees experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Natu"
                            1 => "J&#46; Hoffman"
                            2 => "M&#46; Siddiqui"
                            3 => "C&#46; Hobday"
                            4 => "J&#46; Shrimankar"
                            5 => "R&#46; Harrison"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jcp.2009.074328"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pathol"
                        "fecha" => "2010"
                        "volumen" => "63"
                        "paginaInicial" => "445"
                        "paginaFinal" => "451"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20299387"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utility of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of mediastinal masses of unknown etiology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46; Yasufuku"
                            1 => "T&#46; Nakajima"
                            2 => "T&#46; Fujiwara"
                            3 => "I&#46; Yoshino"
                            4 => "S&#46; Keshavjee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2010.11.032"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2011"
                        "volumen" => "91"
                        "paginaInicial" => "831"
                        "paginaFinal" => "836"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21353007"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Histological diagnosis of spinal chondrosarcoma by endobronchial ultrasound-guided transbronchial needle aspiration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Nakajima"
                            1 => "K&#46; Yasufuku"
                            2 => "M&#46; Suzuki"
                            3 => "Y&#46; Sekine"
                            4 => "K&#46; Shibuya"
                            5 => "K&#46; Hiroshima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1440-1843.2006.01028.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respirology"
                        "fecha" => "2007"
                        "volumen" => "12"
                        "paginaInicial" => "308"
                        "paginaFinal" => "310"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17298471"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Success and failure rates of tumor genotyping techniques in routine pathological samples with non-small-cell lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;A&#46; Vanderlaan"
                            1 => "N&#46; Yamaguchi"
                            2 => "E&#46; Folch"
                            3 => "D&#46;H&#46; Boucher"
                            4 => "M&#46;S&#46; Kent"
                            5 => "S&#46;P&#46; Gangadharan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.lungcan.2014.01.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lung Cancer"
                        "fecha" => "2014"
                        "volumen" => "84"
                        "paginaInicial" => "39"
                        "paginaFinal" => "44"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24513263"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adequacy of lymph node transbronchial needle aspirates using convex probe endobronchial ultrasound for multiple tumor genotyping techniques in non-small-cell lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Folch"
                            1 => "N&#46; Yamaguchi"
                            2 => "P&#46;A&#46; VanderLaan"
                            3 => "O&#46;N&#46; Kocher"
                            4 => "D&#46;H&#46; Boucher"
                            5 => "M&#46;A&#46; Goldstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/JTO.0b013e3182a471a9"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Oncol"
                        "fecha" => "2013"
                        "volumen" => "8"
                        "paginaInicial" => "1438"
                        "paginaFinal" => "1444"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24128714"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of CP-EBUS-TBNA in the diagnosis of chondrosarcoma in a patient With Maffucci syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Wang"
                            1 => "E&#46; Folch"
                            2 => "M&#46; Paul"
                            3 => "A&#46; Maskey"
                            4 => "F&#46; Allard"
                            5 => "A&#46; Majid"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/LBR.0000000000000069"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bronchology Interv Pulmonol"
                        "fecha" => "2014"
                        "volumen" => "21"
                        "paginaInicial" => "177"
                        "paginaFinal" => "180"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24739697"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cost-benefit of minimally invasive staging of non-small cell lung cancer&#58; a decision tree sensitivity analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;P&#46; Steinfort"
                            1 => "D&#46; Liew"
                            2 => "M&#46; Conron"
                            3 => "A&#46;F&#46; Hutchinson"
                            4 => "L&#46;B&#46; Irving"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/JTO.0b013e3181e8b2e6"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Oncol"
                        "fecha" => "2010"
                        "volumen" => "5"
                        "paginaInicial" => "1564"
                        "paginaFinal" => "1570"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20871261"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "iii&#8211;iv"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical effectiveness and cost-effectiveness of endobronchial and endoscopic ultrasound relative to surgical staging in potentially resectable lung cancer&#58; results from the ASTER randomised controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;D&#46; Sharples"
                            1 => "C&#46; Jackson"
                            2 => "E&#46; Wheaton"
                            3 => "G&#46; Griffith"
                            4 => "J&#46;T&#46; Annema"
                            5 => "C&#46; Dooms"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3310/hta16470"
                      "Revista" => array:6 [
                        "tituloSerie" => "Health Technol Assess"
                        "fecha" => "2012"
                        "volumen" => "16"
                        "paginaInicial" => "1"
                        "paginaFinal" => "75"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23199586"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endobronchial ultrasound-guided transbronchial needle aspiration &#40;EBUS-TBNA&#41;&#58; an overview and update for the cytopathologist"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;A&#46; VanderLaan"
                            1 => "H&#46;H&#46; Wang"
                            2 => "A&#46; Majid"
                            3 => "E&#46; Folch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cncy.21431"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Cytopathol"
                        "fecha" => "2014"
                        "volumen" => "122"
                        "paginaInicial" => "561"
                        "paginaFinal" => "576"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24760496"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of endobronchial ultrasound in the diagnosis of bronchogenic cysts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Anantham"
                            1 => "G&#46;C&#46; Phua"
                            2 => "S&#46;Y&#46; Low"
                            3 => "M&#46;S&#46; Koh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2011/468237"
                      "Revista" => array:5 [
                        "tituloSerie" => "Diagn Ther Endosc"
                        "fecha" => "2011"
                        "volumen" => "2011"
                        "paginaInicial" => "468237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21747652"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Should asymptomatic bronchogenic cysts in adults be treated conservatively or with surgery&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46; Kirmani"
                            1 => "B&#46; Kirmani"
                            2 => "F&#46; Sogliani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1510/icvts.2010.233114"
                      "Revista" => array:6 [
                        "tituloSerie" => "Interact Cardiovasc Thorac Surg"
                        "fecha" => "2010"
                        "volumen" => "11"
                        "paginaInicial" => "649"
                        "paginaFinal" => "659"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20709698"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystic lesions of the thorax&#58; role of endobronchial ultrasound-guided transbronchial needle aspiration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Twehues"
                            1 => "S&#46; Islam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Bronchol Interv Pulmonol"
                        "fecha" => "2011"
                        "volumen" => "18"
                        "paginaInicial" => "265"
                        "paginaFinal" => "268"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endobronchial ultrasound-guided needle aspiration of a bronchogenic cyst to liberate from mechanical ventilation&#58; case report and literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;A&#46; Aragaki-Nakahodo"
                            1 => "J&#46; Guitron-Roig"
                            2 => "W&#46; Eschenbacher"
                            3 => "S&#46; Benzaquen"
                            4 => "C&#46; Cudzilo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Bronchol Interv Pulmonol"
                        "fecha" => "2013"
                        "volumen" => "20"
                        "paginaInicial" => "152"
                        "paginaFinal" => "154"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endobronchial ultrasound-guided transbronchial needle aspiration for the treatment of central airway stenosis caused by a mediastinal cyst"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Nakajima"
                            1 => "K&#46; Yasufuku"
                            2 => "K&#46; Shibuya"
                            3 => "T&#46; Fujisawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejcts.2007.06.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cardiothorac Surg"
                        "fecha" => "2007"
                        "volumen" => "32"
                        "paginaInicial" => "538"
                        "paginaFinal" => "540"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17629489"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "bcr2007078071"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchogenic cyst treated by endobronchial ultrasound drainage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Dhand"
                            1 => "W&#46; Krimsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "BMJ Case Rep"
                        "fecha" => "2009"
                        "volumen" => "2009"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infected mediastinal bronchogenic cyst successfully treated by endobronchial ultrasound-guided fine-needle aspiration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;F&#46; Casal"
                            1 => "C&#46;A&#46; Jimenez"
                            2 => "R&#46;J&#46; Mehran"
                            3 => "G&#46;A&#46; Eapen"
                            4 => "D&#46; Ost"
                            5 => "M&#46; Sarkiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2010.06.062"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2010"
                        "volumen" => "90"
                        "paginaInicial" => "e52"
                        "paginaFinal" => "e53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20868780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;discussion 9&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mediastinal bronchogenic cyst&#39;s recurrence treated with EBUS-FNA with a long-term follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Galluccio"
                            1 => "G&#46; Lucantoni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejcts.2005.12.052"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cardiothorac Surg"
                        "fecha" => "2006"
                        "volumen" => "29"
                        "paginaInicial" => "627"
                        "paginaFinal" => "629"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16476541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infection of a bronchogenic cyst after ultrasonography-guided fine needle aspiration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Gamrekeli"
                            1 => "G&#46; Kalweit"
                            2 => "H&#46; Schafer"
                            3 => "H&#46; Huwer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2012.10.071"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2013"
                        "volumen" => "95"
                        "paginaInicial" => "2154"
                        "paginaFinal" => "2155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23706435"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchogenic cyst rupture and pneumonia after endobronchial ultrasound-guided transbronchial needle aspiration&#58; a case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Hong"
                            1 => "J&#46; Song"
                            2 => "K&#46;J&#46; Lee"
                            3 => "K&#46; Jeon"
                            4 => "W&#46;J&#46; Koh"
                            5 => "G&#46;Y&#46; Suh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Tuberc Respir Dis &#40;Seoul&#41;"
                        "fecha" => "2013"
                        "volumen" => "74"
                        "paginaInicial" => "177"
                        "paginaFinal" => "180"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endobronchial ultrasound for detecting central pulmonary emboli&#58; a pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Aumiller"
                            1 => "F&#46;J&#46; Herth"
                            2 => "M&#46; Krasnik"
                            3 => "R&#46; Eberhardt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000183197"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "2009"
                        "volumen" => "77"
                        "paginaInicial" => "298"
                        "paginaFinal" => "302"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19065053"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "EBUS-TBNA in the differential diagnosis of pulmonary artery sarcoma and thromboembolism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;S&#46; Park"
                            1 => "J&#46;H&#46; Chung"
                            2 => "S&#46; Jheon"
                            3 => "D&#46;J&#46; Choi"
                            4 => "H&#46;I&#46; Yoon"
                            5 => "J&#46;H&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00043211"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2011"
                        "volumen" => "38"
                        "paginaInicial" => "1480"
                        "paginaFinal" => "1482"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22130766"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Staging algorithm for diffuse malignant pleural mesothelioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Zielinski"
                            1 => "J&#46; Hauer"
                            2 => "L&#46; Hauer"
                            3 => "J&#46; Pankowski"
                            4 => "T&#46; Nabialek"
                            5 => "A&#46; Szlubowski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1510/icvts.2009.213611"
                      "Revista" => array:6 [
                        "tituloSerie" => "Interact Cardiovasc Thorac Surg"
                        "fecha" => "2010"
                        "volumen" => "10"
                        "paginaInicial" => "185"
                        "paginaFinal" => "189"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19843550"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary amyloidosis involving mediastinal lymph nodes&#58; diagnosis by transbronchial needle aspiration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Leiro"
                            1 => "A&#46; Fernandez-Villar"
                            2 => "R&#46; Bandres"
                            3 => "A&#46; Gonzalez"
                            4 => "C&#46; Represas"
                            5 => "J&#46;C&#46; Barros"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000098821"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "2008"
                        "volumen" => "76"
                        "paginaInicial" => "218"
                        "paginaFinal" => "220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17230012"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mimicking pulmonary multiple metastatic tumors&#58; a case of primary nodular parenchymal pulmonary amyloidosis with review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;N&#46; Zhang"
                            1 => "X&#46;Y&#46; Xue"
                            2 => "N&#46; Wang"
                            3 => "J&#46;X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3892/ol.2012.923"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oncol Lett"
                        "fecha" => "2012"
                        "volumen" => "4"
                        "paginaInicial" => "1366"
                        "paginaFinal" => "1370"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23205137"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transbronchial needle aspiration in the diagnosis of mediastinal amyloidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "V&#46; Leiro-Fernandez"
                            1 => "M&#46; Botana-Rial"
                            2 => "C&#46; Represas"
                            3 => "A&#46; Fernandez-Villar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2010.148510"
                      "Revista" => array:5 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2011"
                        "volumen" => "66"
                        "paginaInicial" => "543"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20947897"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fine-needle aspiration cytology of amyloid associated with nonneoplastic and malignant lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;E&#46; Halliday"
                            1 => "J&#46;F&#46; Silverman"
                            2 => "J&#46;L&#46; Finley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diagn Cytopathol"
                        "fecha" => "1998"
                        "volumen" => "18"
                        "paginaInicial" => "270"
                        "paginaFinal" => "275"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9557261"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extraskeletal Ewing&#39;s sarcoma presenting with multifocal intrathoracic mass lesions associated with mediastinal shift"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Kuzucu"
                            1 => "H&#46;S&#46; Erkal"
                            2 => "O&#46; Soysal"
                            3 => "M&#46; Serin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2005.03.116"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2006"
                        "volumen" => "81"
                        "paginaInicial" => "1487"
                        "paginaFinal" => "1488"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16564299"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extraskeletal Ewing&#39;s sarcoma presenting as a mediastinal mass"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Halliday"
                            1 => "S&#46;Y&#46; Soon"
                            2 => "H&#46; Monaghan"
                            3 => "W&#46;S&#46; Walker"
                            4 => "V&#46; Zamvar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2010.01.083"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2010"
                        "volumen" => "90"
                        "paginaInicial" => "1016"
                        "paginaFinal" => "1017"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20732541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of primary mediastinal Ewing&#39;s sarcoma&#47;primitive neuroectodermal tumor presenting with initial compression of superior vena cava"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Reali"
                            1 => "G&#46; Mortellaro"
                            2 => "S&#46; Allis"
                            3 => "E&#46; Trevisiol"
                            4 => "S&#46;M&#46; Anglesio"
                            5 => "S&#46; Bartoncini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/1817-1737.109834"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Med"
                        "fecha" => "2013"
                        "volumen" => "8"
                        "paginaInicial" => "121"
                        "paginaFinal" => "123"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23741276"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extraskeletal Ewing&#39;s sarcoma family of tumours in adults&#58; analysis of 57 patients from a single institution"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; El Weshi"
                            1 => "A&#46; Allam"
                            2 => "D&#46; Ajarim"
                            3 => "F&#46; Al Dayel"
                            4 => "R&#46; Pant"
                            5 => "S&#46; Bazarbashi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Oncol &#40;R Coll Radiol&#41;"
                        "fecha" => "2010"
                        "volumen" => "22"
                        "paginaInicial" => "374"
                        "paginaFinal" => "381"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surgically treated pulmonary inflammatory pseudotumor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Omasa"
                            1 => "T&#46; Kobayashi"
                            2 => "Y&#46; Takahashi"
                            3 => "J&#46; Tamada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Jpn J Thorac Cardiovasc Surg"
                        "fecha" => "2002"
                        "volumen" => "50"
                        "paginaInicial" => "305"
                        "paginaFinal" => "308"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12166272"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammatory pseudotumors of the lung"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Cerfolio"
                            1 => "M&#46;S&#46; Allen"
                            2 => "A&#46;G&#46; Nascimento"
                            3 => "C&#46; Deschamps"
                            4 => "V&#46;F&#46; Trastek"
                            5 => "D&#46;L&#46; Miller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1999"
                        "volumen" => "67"
                        "paginaInicial" => "933"
                        "paginaFinal" => "936"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10320231"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammatory pseudotumor&#58; a diagnostic dilemma in cytopathology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;A&#46; Hosler"
                            1 => "D&#46;M&#46; Steinberg"
                            2 => "S&#46; Sheth"
                            3 => "U&#46;M&#46; Hamper"
                            4 => "Y&#46;S&#46; Erozan"
                            5 => "S&#46;Z&#46; Ali"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/dc.20113"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diagn Cytopathol"
                        "fecha" => "2004"
                        "volumen" => "31"
                        "paginaInicial" => "267"
                        "paginaFinal" => "270"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15452903"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transthoracic fine-needle aspiration cytology of inflammatory pseudotumor&#44; fibrohistiocytic type&#58; a case report with immunohistochemical studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Bakhos"
                            1 => "E&#46;M&#46; Wojcik"
                            2 => "M&#46;C&#46; Olson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diagn Cytopathol"
                        "fecha" => "1998"
                        "volumen" => "19"
                        "paginaInicial" => "216"
                        "paginaFinal" => "220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9740999"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy&#58; a multicentre study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Navani"
                            1 => "P&#46;L&#46; Molyneaux"
                            2 => "R&#46;A&#46; Breen"
                            3 => "D&#46;W&#46; Connell"
                            4 => "A&#46; Jepson"
                            5 => "M&#46; Nankivell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thoraxjnl-2011-200063"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2011"
                        "volumen" => "66"
                        "paginaInicial" => "889"
                        "paginaFinal" => "893"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21813622"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of Nocardia asteroides infection in a patient with HIV&#47;AIDS diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration &#40;EBUS-TBNA&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Fujikura"
                            1 => "Y&#46; Kouzaki"
                            2 => "S&#46; Ohta"
                            3 => "Y&#46; Hara"
                            4 => "K&#46; Mikita"
                            5 => "T&#46; Maeda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Intern Med"
                        "fecha" => "2012"
                        "volumen" => "51"
                        "paginaInicial" => "1413"
                        "paginaFinal" => "1417"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22687853"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Complications associated with endobronchial ultrasound-guided transbronchial needle aspiration&#58; a nationwide survey by the Japan Society for Respiratory Endoscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Asano"
                            1 => "M&#46; Aoe"
                            2 => "Y&#46; Ohsaki"
                            3 => "Y&#46; Okada"
                            4 => "S&#46; Sasada"
                            5 => "S&#46; Sato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1465-9921-14-50"
                      "Revista" => array:5 [
                        "tituloSerie" => "Respir Res"
                        "fecha" => "2013"
                        "volumen" => "14"
                        "paginaInicial" => "50"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23663438"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/25310437/0000002400000005/v1_201810040621/S2531043718300187/v1_201810040621/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "75942"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case series"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/25310437/0000002400000005/v1_201810040621/S2531043718300187/v1_201810040621/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043718300187?idApp=UINPBA00004E"
]

Article information

ISSN: 25310437
Original language: English

DOI:10.1016/j.pulmoe.2017.12.004

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	11	8	19
2024 October	68	36	104
2024 September	75	34	109
2024 August	92	43	135
2024 July	76	39	115
2024 June	67	51	118
2024 May	84	35	119
2024 April	70	44	114
2024 March	54	28	82
2024 February	55	33	88
2024 January	49	28	77
2023 December	64	29	93
2023 November	52	52	104
2023 October	39	42	81
2023 September	68	33	101
2023 August	52	20	72
2023 July	45	30	75
2023 June	44	20	64
2023 May	68	29	97
2023 April	50	20	70
2023 March	88	37	125
2023 February	96	34	130
2023 January	57	26	83
2022 December	70	44	114
2022 November	76	40	116
2022 October	92	54	146
2022 September	44	40	84
2022 August	70	35	105
2022 July	66	68	134
2022 June	38	49	87
2022 May	53	34	87
2022 April	44	36	80
2022 March	63	57	120
2022 February	51	43	94
2022 January	63	50	113
2021 December	70	46	116
2021 November	48	38	86
2021 October	70	89	159
2021 September	59	39	98
2021 August	66	32	98
2021 July	55	26	81
2021 June	47	28	75
2021 May	43	30	73
2021 April	102	85	187
2021 March	58	43	101
2021 February	29	25	54
2021 January	71	27	98
2020 December	32	14	46
2020 November	53	19	72
2020 October	35	29	64
2020 September	49	41	90
2020 August	84	21	105
2020 July	54	28	82
2020 June	45	33	78
2020 May	76	28	104
2020 April	55	11	66
2020 March	84	27	111
2020 February	52	20	72
2020 January	56	27	83
2019 December	88	23	111
2019 November	47	24	71
2019 October	70	34	104
2019 September	66	23	89
2019 August	140	28	168
2019 July	143	38	181
2019 June	126	27	153
2019 May	148	30	178
2019 April	99	45	144
2019 March	115	38	153
2019 February	123	29	152
2019 January	114	45	159
2018 December	49	21	70
2018 November	2	0	2

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter