array:24 [
  "pii" => "S2531043721001951"
  "issn" => "25310437"
  "doi" => "10.1016/j.pulmoe.2021.07.010"
  "estado" => "S300"
  "fechaPublicacion" => "2022-01-01"
  "aid" => "1671"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "edi"
  "cita" => "Pulmonol. 2022;28:4-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2531043721001513"
    "issn" => "25310437"
    "doi" => "10.1016/j.pulmoe.2021.07.003"
    "estado" => "S300"
    "fechaPublicacion" => "2022-01-01"
    "aid" => "1647"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "fla"
    "cita" => "Pulmonol. 2022;28:6-12"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "First clinical evaluation of the QIAreach<span class="elsevierStyleSup">TM</span> QuantiFERON-TB for tuberculosis infection and active pulmonary disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "6"
          "paginaFinal" => "12"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0001"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2497
              "Ancho" => 3333
              "Tamanyo" => 239638
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "alt0004"
              "detalle" => "Fig&#46; "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Distribution plot and correlation analysis using plasma IFN-&#947; values &#40;uncorrected and corrected TB2 values&#41; versus TTR for positive samples &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;41 active TB patients&#41;</p> <p id="spara002" class="elsevierStyleSimplePara elsevierViewall">1 &#8211; uncorrected values&#59; 2&#8211; corrected IFN-&#947; values&#59; 3&#8211; natural logarithm converted uncorrected values&#59; 4&#8211; natural logarithm converted corrected IFN-&#947; values</p> <p id="spara003" class="elsevierStyleSimplePara elsevierViewall">Fig&#46; 1&#46;1A&#58; Six samples with IFN-&#947; levels &#40;uncorrected TB2 values&#41; between 0&#46;46-0&#46;77 IU&#47;mL &#40;median&#58; 0&#46;75 IU&#47;mL&#41; and time to result of 1200 s&#46;</p> <p id="spara004" class="elsevierStyleSimplePara elsevierViewall">Fig&#46; 1&#46;2A Corrected TB2 values ranging between 0&#46;36 and 0&#46;68 IU&#47;mL &#40;median&#58; 0&#46;555 IU&#47;mL&#41;</p> <p id="spara005" class="elsevierStyleSimplePara elsevierViewall">Fig&#46; 1&#46;1B and 1&#46;2B&#58; Six samples with IFN-&#947; levels &#62;10 IU&#47;mL &#40;uncorrected and correctedTB2 values&#41; and time to result between 215-305 s &#40;median&#58; 245 s&#41;&#46; Data transformation of TTR and IFN-&#947; of uncorrected and corrected TB2 values to a natural logarithmic scale showed a significantly high correlation &#40;<span class="elsevierStyleItalic">r</span>&#160;&#61;&#160;-0&#46;913&#44; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001 and <span class="elsevierStyleItalic">r</span>&#160;&#61;&#160;-0&#46;918&#44; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#44; respectively&#41; between IFN-&#947; levels and TTR by linear regression analysis &#40;Fig&#46; 1&#46;3 and 1&#46;4&#41;&#46; Corrected IFN-&#947; &#40;Fig&#46; 1&#46;2&#41; means IFN-&#947; levels with Nil subtraction&#46; IFN-&#947;&#58; interferon-&#947;&#59; TB&#58; tuberculosis&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "K&#46; Fukushima, K&#46; Akagi, A&#46; Kondo, T&#46; Kubo, N&#46; Sakamoto, H&#46; Mukae"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "K&#46;"
              "apellidos" => "Fukushima"
            ]
            1 => array:2 [
              "nombre" => "K&#46;"
              "apellidos" => "Akagi"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Kondo"
            ]
            3 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Kubo"
            ]
            4 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Sakamoto"
            ]
            5 => array:2 [
              "nombre" => "H&#46;"
              "apellidos" => "Mukae"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043721001513?idApp=UINPBA00004E"
    "url" => "/25310437/0000002800000001/v1_202201060713/S2531043721001513/v1_202201060713/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2531043721001240"
    "issn" => "25310437"
    "doi" => "10.1016/j.pulmoe.2021.05.011"
    "estado" => "S300"
    "fechaPublicacion" => "2022-01-01"
    "aid" => "1636"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Pulmonol. 2022;28:1-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Comment</span>"
      "titulo" => "The COVID-19 impact on the scientific production on the 25 main death causes according to world region"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1"
          "paginaFinal" => "3"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0001"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2393
              "Ancho" => 3000
              "Tamanyo" => 467806
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "alt0001"
              "detalle" => "Fig&#46; "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">The COVID-19 Impact on the Scientific Production on the 25 Main Death Causes according to World In Data&#46; Available from&#58; <span class="elsevierStyleInterRef" id="interref0001" href="https://ourworldindata.org/causes-of-death">https&#58;&#47;&#47;ourworldindata&#46;org&#47;causes-of-death</span>&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Felipe Eduardo Valencise, Matheus Negri Boschiero, Camila Vantini Capasso Palamim, Fernando Augusto Lima Marson"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Felipe Eduardo"
              "apellidos" => "Valencise"
            ]
            1 => array:2 [
              "nombre" => "Matheus Negri"
              "apellidos" => "Boschiero"
            ]
            2 => array:2 [
              "nombre" => "Camila Vantini Capasso"
              "apellidos" => "Palamim"
            ]
            3 => array:2 [
              "nombre" => "Fernando Augusto Lima"
              "apellidos" => "Marson"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043721001240?idApp=UINPBA00004E"
    "url" => "/25310437/0000002800000001/v1_202201060713/S2531043721001240/v1_202201060713/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
    "titulo" => "Making IGRA testing easier&#58; First performance report of QIAreach QFT for tuberculosis infection diagnosis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "4"
        "paginaFinal" => "5"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "P&#46; Miotto, D&#46; Goletti, L&#46; Petrone"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "P&#46;"
            "apellidos" => "Miotto"
            "email" => array:1 [
              0 => "miotto.paolo@hsr.it"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0001"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0001"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Goletti"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0002"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Petrone"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0002"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Emerging Bacterial Pathogens Unit&#44; Div&#46; of Immunology&#44; Transplantation and Infectious Diseases&#44; IRCCS San Raffaele Scientific Institute&#44; Milano&#44; Italy"
            "etiqueta" => "a"
            "identificador" => "aff0001"
          ]
          1 => array:3 [
            "entidad" => "Translational Research Unit&#44; National Institute for Infectious Diseases &#8220;Lazzaro Spallanzani&#8221;-IRCCS&#44; Rome&#44; Italy"
            "etiqueta" => "b"
            "identificador" => "aff0002"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0001"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author at&#58; Emerging Bacterial Pathogens Unit&#44; Div&#46; of Immunology&#44; Transplantation and Infectious Diseases&#44; IRCCS San Raffaele Scientific Institute&#44; Dibit 2&#44; Building San Gabriele 1&#44; Via Olgettina&#44; 60&#44; 20132 Milano&#44; Italy&#46;"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0001" class="elsevierStylePara elsevierViewall">Tuberculosis &#40;TB&#41;&#44; with around 1&#46;4 million deaths&#44; is one of the most important leading killer for infectious diseases in the world&#46; Moreover&#44; a quarter of the world population is estimated to live with TB infection &#40;TBI&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> TBI is considered the reservoir of active TB&#44; therefore&#44; diagnosing and treating TBI is a crucial component of the End TB Strategy to achieve TB control&#46;<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a> So far&#44; the diagnosis of TBI is based on tuberculin skin test and on interferon &#40;IFN&#41;-&#947; release assays &#40;IGRAs&#41; such as T-SPOT&#46; TB and Quantiferon-TB Plus &#40;QFT-Plus&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a> However&#44; costs&#44; complexity&#44; and supply chain requirements hamper the implementation of current tests for TBI in decentralized settings&#46; Therefore&#44; there is an urgent need for accelerating the scale-up of such assays to inform test-and-treat algorithms for TBI&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a></p><p id="para0002" class="elsevierStylePara elsevierViewall">The QIAreach QFT test is a novel and simplified version of QFT-Plus&#46; Indeed&#44; it uses a single tube corresponding to the TB2 tube of the QFT-Plus&#46; However&#44; unlike QFT-Plus&#44; the test provides a qualitative result through a fluorescence lateral flow reader&#44; which is transportable&#44; easy to use and does not need highly trained personnel&#46;<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a> The assay time to result &#40;TTR&#41; is around 20 minutes&#46; Therefore&#44; the QIAreach QFT test has the potentials to be a point-of-care test&#46;</p><p id="para0003" class="elsevierStylePara elsevierViewall">The paper of Fukushima et al<a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a> aimed to evaluate the accuracy of the QIAreach QFT test for the detection of TBI compared to the commercial QFT-Plus test in both immunocompetent and immunocompromised individuals&#46; The authors evaluate the tests&#8217; clinical performance in patients with active TB&#44; used as a surrogate for TBI&#46; Compared to QFT-Plus&#44; which was used as reference standard&#44; QIAreach QFT showed a 99&#37; overall concordance and an optimal accuracy with 100&#37; sensitivity and 98&#37; specificity&#44; similar to QFT-Plus 4&#46; Interestingly&#44; QIAreach QFT also scored positive in samples with IFN-&#947; level falling in the so-called uncertainty zone of the QFT-Plus&#46;<a class="elsevierStyleCrossRef" href="#bib0008"><span class="elsevierStyleSup">8</span></a> IFN- &#947; level inversely correlated with TTR&#44; suggesting that the TTR may be used as a surrogate marker for the IFN-&#947; concentrations&#46; The QIAreach QFT test also scored positive in individuals with CD4 counts &#60;200 cells&#47;&#181;l&#44; thus showing potential for immunocompromised individuals&#46;</p><p id="para0004" class="elsevierStylePara elsevierViewall">Multicenter studies are needed to validate these results&#44; and to evaluate the QIAreach in immunocompromised individuals&#46; Moreover&#44; data on precision&#44; repeatability and reproducibility&#44; as well as costs analyses are needed to fully understand the potential of this platform&#46; However&#44; these optimal pilot performances&#44; together with the technical advantages of the test &#40;a single 1 mL of blood is needed&#41;&#44; the short TTR&#44; the portability and the multipurpose design of the platform allowing for diagnosing relevant diseases other than TB&#44;<a class="elsevierStyleCrossRef" href="#bib0009"><span class="elsevierStyleSup">9</span></a> make the QIAreach QFT test a promising tool for TBI screening in peripheral settings for easier identification of people eligible for TB preventive therapy&#46; This tool may be useful for TBI screening based on the new suggestions proposed by the WHO&#44; and could support contact investigation to early identify individuals at risk for acquiring TBI also in high TB prevalence countries&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">10</span></a></p><p id="para0005" class="elsevierStylePara elsevierViewall">The further development and availability of tests for predicting the risk of progression from TBI to active disease will complete the portfolio for maximizing the impact of TB preventive treatment strategies&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2021-07-29"
    "fechaAceptado" => "2021-07-29"
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec1"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0001"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "WHO&#46; TB REPORT 2020&#46; <a target="_blank" href="https://www.who.int/publications/i/item/9789240013131">https&#58;&#47;&#47;www who int&#47;publications&#47;i&#47;item&#47;9789240013131</a> &#40;2020&#41;&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0002"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The global burden of latent tuberculosis infection&#58; a re-estimation using mathematical modelling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "RM Houben"
                            1 => "PJ Dodd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pmed.1001976"
                      "Revista" => array:4 [
                        "tituloSerie" => "PLoS Med"
                        "fecha" => "2016"
                        "volumen" => "13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27327646"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0003"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Implementing the End TB Strategy&#58; the essentials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "WHO"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2015"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;www&#46;who&#46;int&#47;tb&#47;publications&#47;2015&#47;The&#95;Essentials&#95;to&#95;End&#95;TB&#47;en&#47;"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0004"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "QuantiFERON TB Gold Plus for the diagnosis of tuberculosis&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G Sotgiu"
                            1 => "L Saderi"
                            2 => "E Petruccioli"
                            3 => "S Aliberti"
                            4 => "A Piana"
                            5 => "L Petrone"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jinf.2019.08.018"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect"
                        "fecha" => "2019"
                        "volumen" => "79"
                        "paginaInicial" => "444"
                        "paginaFinal" => "453"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31473271"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Framework for the evaluation of new tests for tuberculosis infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "WHO"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2020"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;www&#46;who&#46;int&#47;publications&#47;i&#47;item&#47;9789240007185"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0006"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tests for tuberculosis infection&#58; landscape analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y Hamada"
                            1 => "DM Cirillo"
                            2 => "A Matteelli"
                            3 => "A Penn-Nicholson"
                            4 => "MX Rangaka"
                            5 => "M Ruhwald"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/13993003.00711-2017"
                      "Revista" => array:3 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2021"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29025888"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0007"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "First clinical evaluation of the QIAreachTM QuantiFERON-TB for tuberculosis infection and active pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K Fukushima"
                            1 => "K Akagi"
                            2 => "A Kondo"
                            3 => "T Kubo"
                            4 => "N Sakamoto"
                            5 => "H Mukae"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Pulmonology"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0008"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic accuracy of early secretory antigenic target-6-free interferon-gamma release assay compared to QuantiFERON-TB gold in- tube"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E Nemes"
                            1 => "D Abrahams"
                            2 => "TJ Scriba"
                            3 => "F Ratangee"
                            4 => "A Keyser"
                            5 => "L Makhethe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/cid/ciz034"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2019"
                        "volumen" => "69"
                        "paginaInicial" => "1724"
                        "paginaFinal" => "1730"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30668657"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0009"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of SARS-CoV-2 total antibody detection via a lateral flow nanoparticle fluorescence immunoassay"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M Sibai"
                            1 => "D Solis"
                            2 => "K R&#246;ltgen"
                            3 => "BA Stevens"
                            4 => "KO Mfuh"
                            5 => "MK Sahoo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "J Clin Virol"
                        "fecha" => "2021"
                        "volumen" => "139"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Implementing contact tracing for tuberculosis in Kyrgyz Republic and risk factors for positivity using QuantiFERON-TB Gold plus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C Corbett"
                            1 => "A Kulzhabaeva"
                            2 => "T Toichkina"
                            3 => "G Kalmambetova"
                            4 => "S Ahmedov"
                            5 => "U Antonenka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12879-020-05465-x"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Infect Dis"
                        "fecha" => "2020"
                        "volumen" => "20"
                        "paginaInicial" => "746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33046016"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack579687"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="para0007" class="elsevierStylePara elsevierViewall">The work was supported by the Italian Ministry of Health&#44; Ricerca Corrente&#44; Linea 4&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/25310437/0000002800000001/v1_202201060713/S2531043721001951/v1_202201060713/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "73042"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Editorial"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/25310437/0000002800000001/v1_202201060713/S2531043721001951/v1_202201060713/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043721001951?idApp=UINPBA00004E"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Editorial
Making IGRA testing easier: First performance report of QIAreach QFT for tuberculosis infection diagnosis
P. Miottoa,
Corresponding author
miotto.paolo@hsr.it

Corresponding author at: Emerging Bacterial Pathogens Unit, Div. of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Dibit 2, Building San Gabriele 1, Via Olgettina, 60, 20132 Milano, Italy.
, D. Golettib, L. Petroneb
a Emerging Bacterial Pathogens Unit, Div. of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milano, Italy
b Translational Research Unit, National Institute for Infectious Diseases “Lazzaro Spallanzani”-IRCCS, Rome, Italy
Read
4266
Times
was read the article
1515
Total PDF
2751
Total HTML
Share statistics
 array:24 [
  "pii" => "S2531043721001951"
  "issn" => "25310437"
  "doi" => "10.1016/j.pulmoe.2021.07.010"
  "estado" => "S300"
  "fechaPublicacion" => "2022-01-01"
  "aid" => "1671"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "edi"
  "cita" => "Pulmonol. 2022;28:4-5"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2531043721001513"
    "issn" => "25310437"
    "doi" => "10.1016/j.pulmoe.2021.07.003"
    "estado" => "S300"
    "fechaPublicacion" => "2022-01-01"
    "aid" => "1647"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "fla"
    "cita" => "Pulmonol. 2022;28:6-12"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "First clinical evaluation of the QIAreach<span class="elsevierStyleSup">TM</span> QuantiFERON-TB for tuberculosis infection and active pulmonary disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "6"
          "paginaFinal" => "12"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0001"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2497
              "Ancho" => 3333
              "Tamanyo" => 239638
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "alt0004"
              "detalle" => "Fig&#46; "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Distribution plot and correlation analysis using plasma IFN-&#947; values &#40;uncorrected and corrected TB2 values&#41; versus TTR for positive samples &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;41 active TB patients&#41;</p> <p id="spara002" class="elsevierStyleSimplePara elsevierViewall">1 &#8211; uncorrected values&#59; 2&#8211; corrected IFN-&#947; values&#59; 3&#8211; natural logarithm converted uncorrected values&#59; 4&#8211; natural logarithm converted corrected IFN-&#947; values</p> <p id="spara003" class="elsevierStyleSimplePara elsevierViewall">Fig&#46; 1&#46;1A&#58; Six samples with IFN-&#947; levels &#40;uncorrected TB2 values&#41; between 0&#46;46-0&#46;77 IU&#47;mL &#40;median&#58; 0&#46;75 IU&#47;mL&#41; and time to result of 1200 s&#46;</p> <p id="spara004" class="elsevierStyleSimplePara elsevierViewall">Fig&#46; 1&#46;2A Corrected TB2 values ranging between 0&#46;36 and 0&#46;68 IU&#47;mL &#40;median&#58; 0&#46;555 IU&#47;mL&#41;</p> <p id="spara005" class="elsevierStyleSimplePara elsevierViewall">Fig&#46; 1&#46;1B and 1&#46;2B&#58; Six samples with IFN-&#947; levels &#62;10 IU&#47;mL &#40;uncorrected and correctedTB2 values&#41; and time to result between 215-305 s &#40;median&#58; 245 s&#41;&#46; Data transformation of TTR and IFN-&#947; of uncorrected and corrected TB2 values to a natural logarithmic scale showed a significantly high correlation &#40;<span class="elsevierStyleItalic">r</span>&#160;&#61;&#160;-0&#46;913&#44; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001 and <span class="elsevierStyleItalic">r</span>&#160;&#61;&#160;-0&#46;918&#44; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#44; respectively&#41; between IFN-&#947; levels and TTR by linear regression analysis &#40;Fig&#46; 1&#46;3 and 1&#46;4&#41;&#46; Corrected IFN-&#947; &#40;Fig&#46; 1&#46;2&#41; means IFN-&#947; levels with Nil subtraction&#46; IFN-&#947;&#58; interferon-&#947;&#59; TB&#58; tuberculosis&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "K&#46; Fukushima, K&#46; Akagi, A&#46; Kondo, T&#46; Kubo, N&#46; Sakamoto, H&#46; Mukae"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "K&#46;"
              "apellidos" => "Fukushima"
            ]
            1 => array:2 [
              "nombre" => "K&#46;"
              "apellidos" => "Akagi"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Kondo"
            ]
            3 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Kubo"
            ]
            4 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Sakamoto"
            ]
            5 => array:2 [
              "nombre" => "H&#46;"
              "apellidos" => "Mukae"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043721001513?idApp=UINPBA00004E"
    "url" => "/25310437/0000002800000001/v1_202201060713/S2531043721001513/v1_202201060713/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2531043721001240"
    "issn" => "25310437"
    "doi" => "10.1016/j.pulmoe.2021.05.011"
    "estado" => "S300"
    "fechaPublicacion" => "2022-01-01"
    "aid" => "1636"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "dis"
    "cita" => "Pulmonol. 2022;28:1-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Comment</span>"
      "titulo" => "The COVID-19 impact on the scientific production on the 25 main death causes according to world region"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1"
          "paginaFinal" => "3"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0001"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2393
              "Ancho" => 3000
              "Tamanyo" => 467806
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "alt0001"
              "detalle" => "Fig&#46; "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">The COVID-19 Impact on the Scientific Production on the 25 Main Death Causes according to World In Data&#46; Available from&#58; <span class="elsevierStyleInterRef" id="interref0001" href="https://ourworldindata.org/causes-of-death">https&#58;&#47;&#47;ourworldindata&#46;org&#47;causes-of-death</span>&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Felipe Eduardo Valencise, Matheus Negri Boschiero, Camila Vantini Capasso Palamim, Fernando Augusto Lima Marson"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Felipe Eduardo"
              "apellidos" => "Valencise"
            ]
            1 => array:2 [
              "nombre" => "Matheus Negri"
              "apellidos" => "Boschiero"
            ]
            2 => array:2 [
              "nombre" => "Camila Vantini Capasso"
              "apellidos" => "Palamim"
            ]
            3 => array:2 [
              "nombre" => "Fernando Augusto Lima"
              "apellidos" => "Marson"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043721001240?idApp=UINPBA00004E"
    "url" => "/25310437/0000002800000001/v1_202201060713/S2531043721001240/v1_202201060713/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
    "titulo" => "Making IGRA testing easier&#58; First performance report of QIAreach QFT for tuberculosis infection diagnosis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "4"
        "paginaFinal" => "5"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "P&#46; Miotto, D&#46; Goletti, L&#46; Petrone"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "P&#46;"
            "apellidos" => "Miotto"
            "email" => array:1 [
              0 => "miotto.paolo@hsr.it"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0001"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0001"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Goletti"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0002"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Petrone"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0002"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Emerging Bacterial Pathogens Unit&#44; Div&#46; of Immunology&#44; Transplantation and Infectious Diseases&#44; IRCCS San Raffaele Scientific Institute&#44; Milano&#44; Italy"
            "etiqueta" => "a"
            "identificador" => "aff0001"
          ]
          1 => array:3 [
            "entidad" => "Translational Research Unit&#44; National Institute for Infectious Diseases &#8220;Lazzaro Spallanzani&#8221;-IRCCS&#44; Rome&#44; Italy"
            "etiqueta" => "b"
            "identificador" => "aff0002"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0001"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author at&#58; Emerging Bacterial Pathogens Unit&#44; Div&#46; of Immunology&#44; Transplantation and Infectious Diseases&#44; IRCCS San Raffaele Scientific Institute&#44; Dibit 2&#44; Building San Gabriele 1&#44; Via Olgettina&#44; 60&#44; 20132 Milano&#44; Italy&#46;"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0001" class="elsevierStylePara elsevierViewall">Tuberculosis &#40;TB&#41;&#44; with around 1&#46;4 million deaths&#44; is one of the most important leading killer for infectious diseases in the world&#46; Moreover&#44; a quarter of the world population is estimated to live with TB infection &#40;TBI&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> TBI is considered the reservoir of active TB&#44; therefore&#44; diagnosing and treating TBI is a crucial component of the End TB Strategy to achieve TB control&#46;<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a> So far&#44; the diagnosis of TBI is based on tuberculin skin test and on interferon &#40;IFN&#41;-&#947; release assays &#40;IGRAs&#41; such as T-SPOT&#46; TB and Quantiferon-TB Plus &#40;QFT-Plus&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a> However&#44; costs&#44; complexity&#44; and supply chain requirements hamper the implementation of current tests for TBI in decentralized settings&#46; Therefore&#44; there is an urgent need for accelerating the scale-up of such assays to inform test-and-treat algorithms for TBI&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a></p><p id="para0002" class="elsevierStylePara elsevierViewall">The QIAreach QFT test is a novel and simplified version of QFT-Plus&#46; Indeed&#44; it uses a single tube corresponding to the TB2 tube of the QFT-Plus&#46; However&#44; unlike QFT-Plus&#44; the test provides a qualitative result through a fluorescence lateral flow reader&#44; which is transportable&#44; easy to use and does not need highly trained personnel&#46;<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a> The assay time to result &#40;TTR&#41; is around 20 minutes&#46; Therefore&#44; the QIAreach QFT test has the potentials to be a point-of-care test&#46;</p><p id="para0003" class="elsevierStylePara elsevierViewall">The paper of Fukushima et al<a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a> aimed to evaluate the accuracy of the QIAreach QFT test for the detection of TBI compared to the commercial QFT-Plus test in both immunocompetent and immunocompromised individuals&#46; The authors evaluate the tests&#8217; clinical performance in patients with active TB&#44; used as a surrogate for TBI&#46; Compared to QFT-Plus&#44; which was used as reference standard&#44; QIAreach QFT showed a 99&#37; overall concordance and an optimal accuracy with 100&#37; sensitivity and 98&#37; specificity&#44; similar to QFT-Plus 4&#46; Interestingly&#44; QIAreach QFT also scored positive in samples with IFN-&#947; level falling in the so-called uncertainty zone of the QFT-Plus&#46;<a class="elsevierStyleCrossRef" href="#bib0008"><span class="elsevierStyleSup">8</span></a> IFN- &#947; level inversely correlated with TTR&#44; suggesting that the TTR may be used as a surrogate marker for the IFN-&#947; concentrations&#46; The QIAreach QFT test also scored positive in individuals with CD4 counts &#60;200 cells&#47;&#181;l&#44; thus showing potential for immunocompromised individuals&#46;</p><p id="para0004" class="elsevierStylePara elsevierViewall">Multicenter studies are needed to validate these results&#44; and to evaluate the QIAreach in immunocompromised individuals&#46; Moreover&#44; data on precision&#44; repeatability and reproducibility&#44; as well as costs analyses are needed to fully understand the potential of this platform&#46; However&#44; these optimal pilot performances&#44; together with the technical advantages of the test &#40;a single 1 mL of blood is needed&#41;&#44; the short TTR&#44; the portability and the multipurpose design of the platform allowing for diagnosing relevant diseases other than TB&#44;<a class="elsevierStyleCrossRef" href="#bib0009"><span class="elsevierStyleSup">9</span></a> make the QIAreach QFT test a promising tool for TBI screening in peripheral settings for easier identification of people eligible for TB preventive therapy&#46; This tool may be useful for TBI screening based on the new suggestions proposed by the WHO&#44; and could support contact investigation to early identify individuals at risk for acquiring TBI also in high TB prevalence countries&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">10</span></a></p><p id="para0005" class="elsevierStylePara elsevierViewall">The further development and availability of tests for predicting the risk of progression from TBI to active disease will complete the portfolio for maximizing the impact of TB preventive treatment strategies&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2021-07-29"
    "fechaAceptado" => "2021-07-29"
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec1"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0001"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "WHO&#46; TB REPORT 2020&#46; <a target="_blank" href="https://www.who.int/publications/i/item/9789240013131">https&#58;&#47;&#47;www who int&#47;publications&#47;i&#47;item&#47;9789240013131</a> &#40;2020&#41;&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0002"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The global burden of latent tuberculosis infection&#58; a re-estimation using mathematical modelling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "RM Houben"
                            1 => "PJ Dodd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pmed.1001976"
                      "Revista" => array:4 [
                        "tituloSerie" => "PLoS Med"
                        "fecha" => "2016"
                        "volumen" => "13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27327646"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0003"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Implementing the End TB Strategy&#58; the essentials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "WHO"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2015"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;www&#46;who&#46;int&#47;tb&#47;publications&#47;2015&#47;The&#95;Essentials&#95;to&#95;End&#95;TB&#47;en&#47;"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0004"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "QuantiFERON TB Gold Plus for the diagnosis of tuberculosis&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G Sotgiu"
                            1 => "L Saderi"
                            2 => "E Petruccioli"
                            3 => "S Aliberti"
                            4 => "A Piana"
                            5 => "L Petrone"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jinf.2019.08.018"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect"
                        "fecha" => "2019"
                        "volumen" => "79"
                        "paginaInicial" => "444"
                        "paginaFinal" => "453"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31473271"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Framework for the evaluation of new tests for tuberculosis infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "WHO"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2020"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;www&#46;who&#46;int&#47;publications&#47;i&#47;item&#47;9789240007185"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0006"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tests for tuberculosis infection&#58; landscape analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y Hamada"
                            1 => "DM Cirillo"
                            2 => "A Matteelli"
                            3 => "A Penn-Nicholson"
                            4 => "MX Rangaka"
                            5 => "M Ruhwald"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/13993003.00711-2017"
                      "Revista" => array:3 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2021"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29025888"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0007"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "First clinical evaluation of the QIAreachTM QuantiFERON-TB for tuberculosis infection and active pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K Fukushima"
                            1 => "K Akagi"
                            2 => "A Kondo"
                            3 => "T Kubo"
                            4 => "N Sakamoto"
                            5 => "H Mukae"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Pulmonology"
                        "fecha" => "2021"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0008"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic accuracy of early secretory antigenic target-6-free interferon-gamma release assay compared to QuantiFERON-TB gold in- tube"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E Nemes"
                            1 => "D Abrahams"
                            2 => "TJ Scriba"
                            3 => "F Ratangee"
                            4 => "A Keyser"
                            5 => "L Makhethe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/cid/ciz034"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2019"
                        "volumen" => "69"
                        "paginaInicial" => "1724"
                        "paginaFinal" => "1730"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30668657"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0009"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of SARS-CoV-2 total antibody detection via a lateral flow nanoparticle fluorescence immunoassay"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M Sibai"
                            1 => "D Solis"
                            2 => "K R&#246;ltgen"
                            3 => "BA Stevens"
                            4 => "KO Mfuh"
                            5 => "MK Sahoo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "J Clin Virol"
                        "fecha" => "2021"
                        "volumen" => "139"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Implementing contact tracing for tuberculosis in Kyrgyz Republic and risk factors for positivity using QuantiFERON-TB Gold plus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C Corbett"
                            1 => "A Kulzhabaeva"
                            2 => "T Toichkina"
                            3 => "G Kalmambetova"
                            4 => "S Ahmedov"
                            5 => "U Antonenka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12879-020-05465-x"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Infect Dis"
                        "fecha" => "2020"
                        "volumen" => "20"
                        "paginaInicial" => "746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33046016"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack579687"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="para0007" class="elsevierStylePara elsevierViewall">The work was supported by the Italian Ministry of Health&#44; Ricerca Corrente&#44; Linea 4&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/25310437/0000002800000001/v1_202201060713/S2531043721001951/v1_202201060713/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "73042"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Editorial"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/25310437/0000002800000001/v1_202201060713/S2531043721001951/v1_202201060713/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043721001951?idApp=UINPBA00004E"
]
Article information
ISSN: 25310437
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 7 7 14
2024 October 32 36 68
2024 September 54 36 90
2024 August 47 34 81
2024 July 55 32 87
2024 June 43 17 60
2024 May 48 30 78
2024 April 35 39 74
2024 March 31 26 57
2024 February 53 18 71
2024 January 61 23 84
2023 December 43 23 66
2023 November 81 47 128
2023 October 55 31 86
2023 September 46 36 82
2023 August 38 19 57
2023 July 46 33 79
2023 June 36 23 59
2023 May 87 35 122
2023 April 55 22 77
2023 March 129 28 157
2023 February 96 80 176
2023 January 52 28 80
2022 December 70 28 98
2022 November 95 50 145
2022 October 125 47 172
2022 September 85 56 141
2022 August 146 57 203
2022 July 132 61 193
2022 June 95 43 138
2022 May 88 57 145
2022 April 70 47 117
2022 March 70 64 134
2022 February 128 69 197
2022 January 209 93 302
2021 December 63 49 112
2021 November 139 91 230
2021 October 6 0 6
Show all

Follow this link to access the full text of the article

Pulmonology

Are you a health professional able to prescribe or dispense drugs?