Original article
Alpha-1 antitrypsin deficiency and Pi*S and Pi*Z SERPINA1 variants are associated with asthma exacerbations
Elena Martín-Gonzáleza, José M. Hernández-Pérezb,c, José A. Pérez Péreza,d, Javier Pérez-Garcíaa, Esther Herrera-Luisa, Ruperto González-Péreze,f, Orelvis González-Gonzálezg, Elena Mederos-Luise, Inmaculada Sánchez-Machíne, Paloma Poza-Guedese,f, Olaia Sardónh,i, Paula Corcuerah, María J. Cruzj,k, Francisco J. González-Barcalal, Carlos Martínez-Riverak,m, Joaquim Mullolk,n, Xavier Muñozj,k, José M. Olaguibelk,o, Vicente Plazak,p, Santiago Quircek,q..., Antonio Valerok,r, Joaquín Sastrek,s, Javier Korta-Muruah, Victoria del Pozok,t, Fabián Lorenzo-Díaza,d, Jesús Villark,u, María Pino-Yanesa,k,v,
, Mario A. González-Carracedoa,d,
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a Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), 38200 La Laguna, Tenerife, Spain
b Department of Respiratory Medicine, Hospital Universitario de N.S de Candelaria, 38010 Santa Cruz de Tenerife, Spain
c Respiratory Medicine, Hospital Universitario de La Palma, 38713 Breña Alta, Santa Cruz de Tenerife, Spain
d Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain
e Allergy Department, Hospital Universitario de Canarias, 38320 La Laguna, Tenerife, Spain
f Severe Asthma Unit, Allergy Department, Hospital Universitario de Canarias, 38320 La Laguna, Spain
g Hospital Universitario de La Palma, 38713 Breña Alta, Santa Cruz de Tenerife, Spain
h Division of Pediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastián, Spain
i Department of Pediatrics, University of the Basque Country (UPV/EHU), San Sebastián, Spain
j Department of Respiratory Medicine, Hospital Vall d'Hebron, Barcelona, Spain
k CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
l Department of Respiratory Medicine, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, La Coruña, Spain
m Department of Respiratory Medicine, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
n Rhinology Unit & Smell Clinic, ENT Department, Clinical and Experimental Respiratory Immunoallergy (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
o Department of Allergy, Hospital Universitario de Navarra, Pamplona, Navarra, Spain
p Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain
q Department of Allergy, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain
r Allergy Unit & Severe Asthma Unit, Pneumonology and Allergy Department, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
s Department of Allergy, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
t Department of Immunology, Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
u Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain
v Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna (ULL), San Cristóbal de La Laguna, Tenerife, Spain
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