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</span><a href="&#35;bib20" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">6</span></a></p><p class="elsevierStylePara">The Portuguese National Program for Asthma Control conducted by the Directorate-General of Health between 2005 and 2010&#44; aimed to increase the proportion of asthma patients with controlled disease&#44; and to decrease the personal and community burden of the disease&#46;</p><p class="elsevierStylePara">At the end of this program&#44; in 2010&#44; we conducted the first Portuguese National Asthma Survey &#8211; <span class="elsevierStyleItalic">Inqu&#233;rito Nacional sobre Asma</span> &#40;INAsma&#41;&#44; which consisted of two phases&#46; In the first phase&#44; aiming to evaluate asthma prevalence&#44; we estimated that 7&#37; of the Portuguese population had current asthma&#46;<a href="&#35;bib21" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a> In the second phase we focused on asthma patients addressing disease control&#46;</p><p class="elsevierStylePara">We aim to measure asthma control using a structure-questionnaire and patient self-perception of asthma-control in the Portuguese National Asthma Survey &#40;INAsma&#41; and to study the relation of asthma control with asthma-related quality of life &#40;ARQoL&#41;&#46;</p><a name="sec0010" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStylePara">The INAsma was a cross-sectional&#44; nationwide&#44; telephone interview study&#46; Sample size calculations details have been previously reported&#46;<a href="&#35;bib21" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a> All the participants identified with possible asthma in the first phase of the survey were eligible for participation in the second phase&#46; Detailed information is provided in the Supplementary Material&#46; The study was approved by the Hospital Ethics Committee of <span class="elsevierStyleItalic">Hospital de S&#227;o Jo&#227;o &#40;Porto&#44; Portugal&#41;</span>&#46;</p><p class="elsevierStylePara">Current asthma was defined as self-report of asthma and one of the following&#58; at least one medical appointment due to asthma in the last 12 months&#59; 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IBM Company&#44; Chicago&#44; US&#41;&#46; Categorical variables were described with absolute frequencies&#44; proportions and 95&#37; Confidence Interval &#40;95&#37; CI&#41; and continuous variables were described with measures of central tendency and dispersion as appropriate&#46; Correlation between CARAT and mini-AQLQ scores was tested with Pearson&#39;s Correlation Coefficient&#44; with a <span class="elsevierStyleItalic">p</span>-value of &#60;0&#46;05 considered as statistically significant&#46;</p><a name="sec0015" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStylePara">Of the 707 participants identified with possible asthma in the Phase 1&#44; 559 agreed to participate in Phase 2&#44; from which 405 had current asthma as described in the online supplement &#40;Fig&#46; S1&#41;&#46; Sufficient data to define asthma control were available for 364 patients&#46; Participants&#8217; characteristics are summarized in <a href="&#35;t0005" class="elsevierStyleCrossRefs">Table 1</a>&#46;</p><p class="elsevierStylePara">Table 1&#46; Socio-demographic characteristics of the participants with classification for asthma control by asthma control status and patient perception of control and asthma related quality of life&#46;</p><a name="t0005" class="elsevierStyleCrossRefs"></a><p class="elsevierStylePara"></p><table><tr align="left"><td>&#160;</td><td>Total &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;364&#41;</td><td colspan="2">Controlled asthma</td><td colspan="2">Patient perception of control</td><td colspan="2">ARQoL cut-off value</td></tr><tr align="left"><td>&#160;</td><td>&#160;</td><td>Yes &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;207&#41;</td><td>No &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;157&#41;</td><td>Controlled &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;338&#41;</td><td>Non-controlled &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;21&#41;</td><td>Above &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;188&#41;</td><td>Below &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;89&#41;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">Sex&#44; 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<span class="elsevierStyleItalic">n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>&#60;9 years</td><td>240 &#40;65&#46;9&#41;</td><td>120 &#40;50&#46;0&#41;</td><td>120 &#40;50&#46;0&#41;</td><td>220 &#40;92&#46;4&#41;</td><td>18 &#40;7&#46;6&#41;</td><td>92 &#40;57&#46;5&#41;</td><td>68 &#40;42&#46;5&#41;</td></tr><tr align="left"><td>9&#8211;12 years</td><td>83 &#40;22&#46;8&#41;</td><td>57 &#40;68&#46;7&#41;</td><td>26 &#40;31&#46;3&#41;</td><td>80 &#40;98&#46;8&#41;</td><td>1 &#40;1&#46;2&#41;</td><td>60 &#40;78&#46;9&#41;</td><td>16 &#40;21&#46;1&#41;</td></tr><tr align="left"><td>&#62;12 years</td><td>41 &#40;11&#46;3&#41;</td><td>30 &#40;73&#46;2&#41;</td><td>11 &#40;26&#46;8&#41;</td><td>38 &#40;95&#46;0&#41;</td><td>2 &#40;5&#46;0&#41;</td><td>36 &#40;87&#46;8&#41;</td><td>5 &#40;12&#46;2&#41;</td></tr><tr align="left"><td colspan="8">&#160;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">SES</span><span class="elsevierStyleSup">b</span> &#44; <span class="elsevierStyleItalic">n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>Low</td><td>59 &#40;16&#46;3&#41;</td><td>18 &#40;30&#46;5&#41;</td><td>41 &#40;69&#46;5&#41;</td><td>51 &#40;87&#46;9&#41;</td><td>7 &#40;5&#46;9&#41;</td><td>29 &#40;49&#46;2&#41;</td><td>30 &#40;50&#46;8&#41;</td></tr><tr align="left"><td>Medium low</td><td>222 &#40;61&#46;2&#41;</td><td>127 &#40;57&#46;2&#41;</td><td>95 &#40;42&#46;8&#41;</td><td>211 &#40;95&#46;9&#41;</td><td>9 &#40;4&#46;1&#41;</td><td>116 &#40;69&#46;5&#41;</td><td>51 &#40;30&#46;5&#41;</td></tr><tr align="left"><td>Medium high</td><td>49 &#40;13&#46;5&#41;</td><td>35 &#40;71&#46;4&#41;</td><td>14 &#40;28&#46;6&#41;</td><td>44 &#40;91&#46;7&#41;</td><td>4 &#40;8&#46;3&#41;</td><td>27 &#40;84&#46;8&#41;</td><td>5 &#40;15&#46;6&#41;</td></tr><tr align="left"><td>High</td><td>33 &#40;9&#46;1&#41;</td><td>27 &#40;81&#46;8&#41;</td><td>6 &#40;18&#46;2&#41;</td><td>31 &#40;96&#46;9&#41;</td><td>1 &#40;3&#46;1&#41;</td><td>15 &#40;83&#46;3&#41;</td><td>3 &#40;16&#46;7&#41;</td></tr><tr align="left"><td colspan="8">&#160;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">Smoking status&#44; n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>Non-smoker</td><td>274 &#40;75&#46;3&#41;</td><td>153 &#40;55&#46;8&#41;</td><td>121 &#40;44&#46;2&#41;</td><td>255 &#40;93&#46;8&#41;</td><td>17 &#40;6&#46;3&#41;</td><td>121 &#40;64&#46;0&#41;</td><td>68 &#40;36&#46;0&#41;</td></tr><tr align="left"><td>Ex-smoker</td><td>53 &#40;14&#46;6&#41;</td><td>33 &#40;62&#46;3&#41;</td><td>20 &#40;37&#46;7&#41;</td><td>46 &#40;92&#46;0&#41;</td><td>4 &#40;8&#46;0&#41;</td><td>39 &#40;73&#46;6&#41;</td><td>14 &#40;26&#46;4&#41;</td></tr><tr align="left"><td>Current smoker</td><td>37 &#40;10&#46;2&#41;</td><td>21 &#40;56&#46;8&#41;</td><td>16 &#40;43&#46;2&#41;</td><td>37 &#40;100&#46;0&#41;</td><td>0 &#40;0&#46;0&#41;</td><td>28 &#40;80&#46;0&#41;</td><td>7 &#40;20&#46;0&#41;</td></tr><tr align="left"><td colspan="8">&#160;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">Controlled asthma&#44; n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>Yes</td><td>207 &#40;56&#46;9&#41;</td><td>&#8211;</td><td>&#8211;</td><td>201 &#40;98&#46;5&#41;</td><td>3 &#40;1&#46;5&#41;</td><td>137 &#40;92&#46;6&#41;</td><td>11 &#40;7&#46;4&#41;</td></tr><tr align="left"><td>No</td><td>157 &#40;43&#46;1&#41;</td><td>&#8211;</td><td>&#8211;</td><td>137 &#40;88&#46;4&#41;</td><td>18 &#40;85&#46;7&#41;</td><td>51 &#40;39&#46;5&#41;</td><td>78 &#40;60&#46;5&#41;</td></tr><tr align="left"><td colspan="8">&#160;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">Patient perception of control&#44; n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>Controlled</td><td>338 &#40;94&#46;2&#41;</td><td>201 &#40;59&#46;5&#41;</td><td>137 &#40;40&#46;5&#41;</td><td>&#8211;</td><td>&#8211;</td><td>181 &#40;70&#46;7&#41;</td><td>75 &#40;29&#46;3&#41;</td></tr><tr align="left"><td>Not controlled</td><td>21 &#40;5&#46;8&#41;</td><td>3 &#40;14&#46;3&#41;</td><td>18 &#40;85&#46;7&#41;</td><td>&#8211;</td><td>&#8211;</td><td>3 &#40;17&#46;6&#41;</td><td>14 &#40;82&#46;4&#41;</td></tr></table><p class="elsevierStylePara">Asthma Related Quality of Life &#40;ARQoL&#41; cut-off value of 5&#46;4&#46;<br></br></p><p class="elsevierStylePara">a A total of 60 &#40;2&#46;7&#37;&#41; participants were preschoolers &#40;not shown&#41; &#8211; Data retrieved from 1st phase of INAsma&#46;<br></br>b Socioeconomic Status was categorized in high &#40;A social class&#41;&#44; medium high &#40;B social class&#41;&#44; medium low &#40;C social classes&#41; and low &#40;D social class&#41; based on occupation and school education of the person who contributes more for the household income &#8211; Data retrieved from 1st phase of INAsma&#46;<br></br></p><p class="elsevierStylePara">According to the patients&#8217; answers to CARAT&#44; the most frequent symptoms were related to upper airways with 24&#46;9&#37; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;90&#41; and 21&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;78&#41; of the patients answering &#8220;Always&#8221;&#44; to sneezing and itchy nose&#44; respectively &#40;Fig&#46; S2&#41;&#46; The less common symptom reported was nocturnal awakening with 69&#46;5&#37; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;253&#41; of the patients answering &#8220;Never&#8221;&#46;</p><p class="elsevierStylePara">Asthma was controlled in 56&#46;9&#37; &#91;95&#37;CI&#44; 51&#46;8&#8211;62&#46;0&#93; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;207&#41; of the patients &#40;<a href="&#35;t0005" class="elsevierStyleCrossRefs">Table 1</a>&#41;&#46; Regarding patient self-perception of control&#44; 94&#37; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;338&#41; reported having their asthma controlled &#40;<a href="&#35;t0005" class="elsevierStyleCrossRefs">Table 1</a>&#41;&#46; Among the non-controlled patients 88&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;137&#41; perceived their asthma as controlled &#40;<a href="&#35;t0005" class="elsevierStyleCrossRefs">Table 1</a>&#44; Fig&#46; S3&#41;&#46;</p><p class="elsevierStylePara">Controlled patients had higher mini-AQLQ scores than the non-controlled &#40;median&#44; P25&#8211;P75&#59; 6&#46;6&#44; 6&#46;0&#8211;6&#46;9 and 4&#46;9&#44; 3&#46;7&#8211;5&#46;7&#44; respectively&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41; &#40;<a href="&#35;f0020" class="elsevierStyleCrossRefs">Figure 1</a>A&#41;&#46; A significant positive correlation between CARAT and mini-AQLQ scores was observed &#40;<span class="elsevierStyleItalic">r</span>&#160;&#61;&#160;0&#46;706&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#44; <a href="&#35;f0020" class="elsevierStyleCrossRefs">Figure 1</a>B&#41;&#46;</p><a name="f0020" class="elsevierStyleCrossRefs"></a><p class="elsevierStylePara"><img src="320v21n04-90433950fig1.jpg" alt="Relationship between CARAT and mini-AQLQ scores &#40;&#60;i&#62;n&#60;&#47;i&#62;&#160;&#61;&#160;274&#41;&#59; &#40;A&#41; ARQoL by asthma control groups&#59; Scatterplots show the correlation between &#40;B&#41; CARAT global score and ARQoL&#59; &#40;C&#41; CARAT superior airways subscore and ARQoL&#59; &#40;D&#41; CARAT inferior airways subscore and ARQoL&#46; In A the horizontal line represents the Mini-AQLQ cut-off of 5&#46;4 based on previous study&#59;&#60;cross-ref&#62;&#60;sup&#62;11&#60;&#47;sup&#62;&#60;&#47;cross-ref&#62; NCA&#58; non-controlled asthma&#59; CA&#58; Controlled asthma&#46; In &#40;B&#44; C and D&#41; the vertical lines represent the Mini-AQLQ cut-off of 5&#46;4&#60;cross-ref&#62;&#60;sup&#62;11&#60;&#47;sup&#62;&#60;&#47;cross-ref&#62; and the horizontal lines represent the CARAT cut-offs&#59;&#60;cross-ref&#62;&#60;sup&#62;9&#60;&#47;sup&#62;&#60;&#47;cross-ref&#62; &#40;B&#41; global score cut-off of 24&#59; &#40;C&#41; superior airways subscore cut-off of 8 and &#40;D&#41; the CARAT inferior subscore cut-off of 16&#46; The scatterplots are divided into four quadrants&#44; the inferior left corresponds to participants with non-controlled disease and more impairments and the upper right to participants with controlled disease and less impairments&#46;"></img></p><p class="elsevierStylePara">Figure 1&#46; Relationship between CARAT and mini-AQLQ scores &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;274&#41;&#59; &#40;A&#41; ARQoL by asthma control groups&#59; Scatterplots show the correlation between &#40;B&#41; CARAT global score and ARQoL&#59; &#40;C&#41; CARAT superior airways subscore and ARQoL&#59; &#40;D&#41; CARAT inferior airways subscore and ARQoL&#46; In A the horizontal line represents the Mini-AQLQ cut-off of 5&#46;4 based on previous study&#59;  <span class="elsevierStyleSup">11</span>  NCA&#58; non-controlled asthma&#59; CA&#58; Controlled asthma&#46; In &#40;B&#44; C and D&#41; the vertical lines represent the Mini-AQLQ cut-off of 5&#46;4  <span class="elsevierStyleSup">11</span>  and the horizontal lines represent the CARAT cut-offs&#59;  <span class="elsevierStyleSup">9</span>  &#40;B&#41; global score cut-off of 24&#59; &#40;C&#41; superior airways subscore cut-off of 8 and &#40;D&#41; the CARAT inferior subscore cut-off of 16&#46; The scatterplots are divided into four quadrants&#44; the inferior left corresponds to participants with non-controlled disease and more impairments and the upper right to participants with controlled disease and less impairments&#46;</p><a name="sec0020" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Discussion</span><p class="elsevierStylePara">We report the first nationwide results on asthma control in Portugal with more than half &#40;57&#37;&#41; of the patients presenting controlled asthma&#46; A significant positive correlation was found between CARAT and mini-AQLQ&#44; indicating that patients with controlled asthma had significant better ARQoL comparing to patients with non-controlled asthma&#46; However&#44; most patients &#40;88&#37;&#41; with non-controlled asthma perceived their asthma as controlled&#46;</p><p class="elsevierStylePara">The proportion of asthma control was in accordance with recent studies in other countries&#46;<a href="&#35;bib18" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a> In 2010&#44; the European National Health and Wellness Survey<a href="&#35;bib19" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">5</span></a> estimated a global proportion of non-controlled asthma of 53&#46;5&#37; across five European countries&#46; Similarly&#44; the International Asthma Patient Insight Research &#40;INSPIRE&#41; study<a href="&#35;bib18" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a> found a worldwide proportion of non-controlled asthma of 51&#37;&#46; In Portugal&#44; a study of asthma patients from one Allergy unit concluded that 57&#37; had partially or complete asthma control when assessed with ACT&#46;<a href="&#35;bib26" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">12</span></a></p><p class="elsevierStylePara">A strong positive correlation was observed between asthma control assessed by CARAT and ARQoL assessed by Mini-AQLQ&#46; This correlation was similar to previous reports using other asthma control questionnaires<a href="&#35;bib25" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">11</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib27" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">13</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib28" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">14</span></a> but had not been reported with CARAT questionnaire&#46;</p><p class="elsevierStylePara">Most of the participants with non-controlled asthma perceived their disease as controlled&#46; This is very similar to the data from the Asthma Insights and Reality in Europe survey&#46;<a href="&#35;bib17" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a> Also in the INSPIRE study&#44;<a href="&#35;bib18" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a> patient perception of asthma control was strikingly different from that based on symptoms assessment&#46; These data suggest that patients&#44; especially those with poor control&#44; continue to have very low expectations regarding asthma outcomes&#46; Clinical studies are warranted on the relation between asthma control and patient-self perception of control&#46;</p><p class="elsevierStylePara">The main strength of the present study is that INAsma is the first Portuguese study to include patients from the general population from all municipalities and all age groups&#46;<a href="&#35;bib21" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a> Some limitations are inherent to a landline telephone-based interview study&#44; especially with the recent shift from landline telephones to cellphones&#46; Other limitation is the potential for confusion as the definition of control may have been influenced by the rhinitis subscore&#46; However&#44; we compared the results of patients with and without associated rhinitis and there were no differences in the proportion of patients with controlled asthma&#44; in perceptions of asthma control and in the correlation between asthma control and ARQoL &#40;data not shown&#41;&#46; Moreover&#44; the CARAT superior airways subscore seems not to have affected the correlation between CARAT total score and miniARQLQ &#40;<a href="&#35;f0020" class="elsevierStyleCrossRefs">Figure 1</a>C&#41;&#46;</p><p class="elsevierStylePara">In conclusion&#44; more than half of the Portuguese asthma patients have their disease controlled and these have significantly better asthma-related quality of life&#46; Poor perception of control seems to be an obstacle to achieving better disease control as almost 9 out of 10 patients with non-controlled disease had poor perception of their asthma control&#46; The objective assessment of asthma control using validated tools may help patients to increase their expectations regarding asthma outcomes&#46;</p><a name="sec0025" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Ethical disclosures</span><a name="sec0030" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Protection of human and animal subjects</span><p class="elsevierStylePara">The authors declare that no experiments were performed on humans or animals for this study&#46;</p><a name="sec0035" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Confidentiality of data</span><p class="elsevierStylePara">The authors declare that no patient data appear in this article&#46;</p><a name="sec0040" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Right to privacy and informed consent</span><p class="elsevierStylePara">The authors declare that no patient data appear in this article&#46;</p><a name="sec0045" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p class="elsevierStylePara">The authors have no conflicts of interest to declare&#46;</p><p class="elsevierStylePara">Acknowledgements</p><p class="elsevierStylePara">The Portuguese National Asthma Survey &#8211; <span class="elsevierStyleItalic">Inqu&#233;rito Nacional sobre Asma</span> &#40;INAsma&#41; was conducted by the Center for Health Technology and Services Research &#40;CINTESIS&#41; in collaboration with <span class="elsevierStyleItalic">Sociedade Portuguesa de Pneumologia</span>&#44; by appointment of the Portuguese Health Directorate&#46;</p><p class="elsevierStylePara">The work presented in this short communication was partially funded by FEDER funds through COMPETE &#40;<span class="elsevierStyleItalic">Programa Operacional Factores de Competitividade</span>&#41; and by National funds through a FCT &#40;<span class="elsevierStyleItalic">Funda&#231;&#227;o para a Ci&#234;ncia e a Tecnologia</span>&#41; project with reference &#8220;PTDC&#47;SAU-SAP&#47;119192&#47;2010&#8221;&#46;</p><a name="sec0050" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Appendix A&#46; Supplementary data</span><p class="elsevierStylePara">Supplementary material associated with this article can be found in the online version available at <a href="http&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppneu&#46;2014&#46;08&#46;001" class="elsevierStyleCrossRefs">http&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppneu&#46;2014&#46;08&#46;001</a>&#46;</p><a name="sec0055" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Appendix A&#46; Supplementary data</span><p class="elsevierStylePara"><a name="f0005" class="elsevierStyleCrossRefs"></a></p><p class="elsevierStylePara"><img src="320v21n04-90433950fig1.jpg" alt="Participants Flowchart&#46; From 559 participants 405 had current asthma and 207 had their asthma controlled&#46;"></img></p><p class="elsevierStylePara">Supplementary Fig&#46; S1&#46; Participants Flowchart&#46; From 559 participants 405 had current asthma and 207 had their asthma controlled&#46;</p><a name="f0010" class="elsevierStyleCrossRefs"></a><p class="elsevierStylePara"><img src="320v21n04-90433950fig2.jpg" alt="Answers to CARAT questionnaire&#46; Questions 1&#8211;9&#58; dark blue &#8220;Never&#8221;&#59; yellow &#8220;Up to 2 days per week&#8221;&#59; orange &#8220;More than 2 days per week&#8221;&#59; red &#8220;Almost every day or every day&#8221;&#46; Question 10&#58; light blue &#8220;Not taking medication&#8221;&#59; dark blue &#8220;Never&#8221;&#59; orange &#8220;Less than 7 days&#8221;&#59; red &#8220;7 or more days&#8221;&#46;"></img></p><p class="elsevierStylePara">Supplementary Fig&#46; S2&#46; Answers to CARAT questionnaire&#46; Questions 1&#8211;9&#58; dark blue &#8220;Never&#8221;&#59; yellow &#8220;Up to 2 days per week&#8221;&#59; orange &#8220;More than 2 days per week&#8221;&#59; red &#8220;Almost every day or every day&#8221;&#46; Question 10&#58; light blue &#8220;Not taking medication&#8221;&#59; dark blue &#8220;Never&#8221;&#59; orange &#8220;Less than 7 days&#8221;&#59; red &#8220;7 or more days&#8221;&#46;</p><a name="f0015" class="elsevierStyleCrossRefs"></a><p class="elsevierStylePara"><img src="320v21n04-90433950fig3.jpg" alt="Perceived asthma control by asthma control status&#46; From the 359 participants who answered to the question &#8220;Did you feel that your asthma was well controlled&#63;&#8221;&#44; 155 had non-controlled asthma and 204 had their asthma controlled&#44; based on CARAT scores&#46;"></img></p><p class="elsevierStylePara">Supplementary Fig&#46; S3&#46; Perceived asthma control by asthma control status&#46; From the 359 participants who answered to the question &#8220;Did you feel that your asthma was well controlled&#63;&#8221;&#44; 155 had non-controlled asthma and 204 had their asthma controlled&#44; based on CARAT scores&#46;</p><p class="elsevierStylePara"><elsevierMultimedia href="320v21n04-90433950mmc4.pdf"></elsevierMultimedia></p><p class="elsevierStylePara">Received 2 May 2014 <br></br>Accepted 19 August 2014 </p><p class="elsevierStylePara">Corresponding author&#46; jfonseca&#64;med&#46;up&#46;pt</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><br/><p class="elsevierStylePara">We aimed &#40;1&#41; to measure asthma control using a structure-questionnaire and patient self-perception of asthma-control in the Portuguese National Asthma Survey &#40;INAsma&#41; and &#40;2&#41; to study the relationship between asthma control and asthma-related quality of life&#46;</p><span class="elsevierStyleSectionTitle">Methods</span><br/><p class="elsevierStylePara">We analyze data of asthma patients from a cross-sectional&#44; nationwide telephone interview study &#8211; INAsma&#46; Controlled asthma was defined as CARAT global score &#62;24 or CARAT lower airways score &#8805;16&#46; Mini-AQLQ was used to measure quality of life&#46;</p><span class="elsevierStyleSectionTitle">Results</span><br/><p class="elsevierStylePara">Two hundred and seven &#40;56&#46;9&#37; &#91;95&#37;CI&#58; 51&#46;8&#8211;62&#46;0&#93;&#41; of the 364 patients had controlled asthma&#46; Most patients with non-controlled asthma &#40;88&#37;&#41; perceived their disease as controlled&#46; Patients with controlled asthma presented higher mini-AQLQ scores &#40;median&#44; P25&#8211;P75&#59; 6&#46;6&#44; 6&#46;0&#8211;6&#46;9&#41; than those with non-controlled asthma &#40;4&#46;9&#44; 3&#46;7&#8211;5&#46;7&#41; &#40;<span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41; and a significant positive correlation between CARAT and mini-AQLQ scores was observed &#40;<span class="elsevierStyleItalic">r</span>&#160;&#61;&#160;0&#46;706&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41;&#46;</p><span class="elsevierStyleSectionTitle">Conclusion</span><br/><p class="elsevierStylePara">More than half of the Portuguese patients presented controlled asthma and showed significantly better asthma-related quality of life&#46; Almost 9 out of 10 patients with non-controlled disease have poor perception of their asthma control&#44; which may hinder them from seeking better asthma control&#46;</p>"
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Asthma control in the Portuguese National Asthma Survey
A.. Sá-Sousaa, R.. Amarala, M.. Morais-Almeidab,c, L.. Araújod,e,f, L.F.. Azevedoa,e, A.. Bugalho-Almeidab,g, J.. Bousqueth,i, J.A.. Fonsecaa,
,c,e,f
a Center for Research in Health Technologies and Information Systems – CINTESIS, Universidade do Porto, Porto, Portugal
b Allergy and Clinical Immunology Department, Hospital CUF-Descobertas, Lisboa, Portugal
c Sociedade Portuguesa de Alergologia e Imunologia Clínica, Lisbon, Portugal
d Immunology Department, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
e Health Information and Decision Sciences Department – CIDES, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
f Allergy Unit, Instituto CUF Porto e Hospital CUF Porto, Porto, Portugal
g Comissão de Acompanhamento do Programa Nacional de Controlo da Asma, Lisbon, Portugal
h Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, Montpellier, France
i Centre de recherche en Epidémiologie et Santé des Populations – CESP Inserm U1018, Villejuif, France
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    "textoCompleto" => "<a name="sec0005" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStylePara">Proper asthma therapy and education reduces the socioeconomic burden of asthma and improves patients&#8217; quality of life&#46;<a href="&#35;bib15" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">1</span></a> However&#44; the proportion of patients achieving asthma control remains low worldwide without substantial improvement in recent years&#46;<a href="&#35;bib16" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">2</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib17" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib18" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib19" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">5</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib20" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">6</span></a></p><p class="elsevierStylePara">The Portuguese National Program for Asthma Control conducted by the Directorate-General of Health between 2005 and 2010&#44; aimed to increase the proportion of asthma patients with controlled disease&#44; and to decrease the personal and community burden of the disease&#46;</p><p class="elsevierStylePara">At the end of this program&#44; in 2010&#44; we conducted the first Portuguese National Asthma Survey &#8211; <span class="elsevierStyleItalic">Inqu&#233;rito Nacional sobre Asma</span> &#40;INAsma&#41;&#44; which consisted of two phases&#46; In the first phase&#44; aiming to evaluate asthma prevalence&#44; we estimated that 7&#37; of the Portuguese population had current asthma&#46;<a href="&#35;bib21" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a> In the second phase we focused on asthma patients addressing disease control&#46;</p><p class="elsevierStylePara">We aim to measure asthma control using a structure-questionnaire and patient self-perception of asthma-control in the Portuguese National Asthma Survey &#40;INAsma&#41; and to study the relation of asthma control with asthma-related quality of life &#40;ARQoL&#41;&#46;</p><a name="sec0010" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStylePara">The INAsma was a cross-sectional&#44; nationwide&#44; telephone interview study&#46; Sample size calculations details have been previously reported&#46;<a href="&#35;bib21" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a> All the participants identified with possible asthma in the first phase of the survey were eligible for participation in the second phase&#46; Detailed information is provided in the Supplementary Material&#46; The study was approved by the Hospital Ethics Committee of <span class="elsevierStyleItalic">Hospital de S&#227;o Jo&#227;o &#40;Porto&#44; Portugal&#41;</span>&#46;</p><p class="elsevierStylePara">Current asthma was defined as self-report of asthma and one of the following&#58; at least one medical appointment due to asthma in the last 12 months&#59; current use of asthma medication&#59; asthma symptoms in the last 12 months &#40;wheeze&#44; cough&#44; breathlessness or sputum production without a cold or respiratory infection&#41;&#46;</p><p class="elsevierStylePara">Asthma control was defined based on Control of Allergic Rhinitis and Asthma Test &#40;CARAT&#41; scores&#46;<a href="&#35;bib22" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">8</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib23" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">9</span></a> Asthma was considered controlled for CARAT global score above 24 or CARAT lower airways score of 16 or above&#46; Self-perception of asthma control was evaluated by the answer to the question &#8220;Do you believe your asthma was well controlled in the last 4 weeks&#63;&#8221;&#46; Additional questions were included assessing socio-educational variables&#46;</p><p class="elsevierStylePara">ARQoL was measured by mini-Asthma Quality of Life Questionnaire &#40;mini-AQLQ&#41;<a href="&#35;bib24" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">10</span></a> with a cut-off value of 5&#46;4 set according to a previous study in northern Portugal&#46;<a href="&#35;bib25" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">11</span></a></p><p class="elsevierStylePara">Statistical analyses were performed using IBM SPSS Statistics v21 &#40;2012 SPSS Inc&#46;&#44; IBM Company&#44; Chicago&#44; US&#41;&#46; Categorical variables were described with absolute frequencies&#44; proportions and 95&#37; Confidence Interval &#40;95&#37; CI&#41; and continuous variables were described with measures of central tendency and dispersion as appropriate&#46; Correlation between CARAT and mini-AQLQ scores was tested with Pearson&#39;s Correlation Coefficient&#44; with a <span class="elsevierStyleItalic">p</span>-value of &#60;0&#46;05 considered as statistically significant&#46;</p><a name="sec0015" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStylePara">Of the 707 participants identified with possible asthma in the Phase 1&#44; 559 agreed to participate in Phase 2&#44; from which 405 had current asthma as described in the online supplement &#40;Fig&#46; S1&#41;&#46; Sufficient data to define asthma control were available for 364 patients&#46; Participants&#8217; characteristics are summarized in <a href="&#35;t0005" class="elsevierStyleCrossRefs">Table 1</a>&#46;</p><p class="elsevierStylePara">Table 1&#46; Socio-demographic characteristics of the participants with classification for asthma control by asthma control status and patient perception of control and asthma related quality of life&#46;</p><a name="t0005" class="elsevierStyleCrossRefs"></a><p class="elsevierStylePara"></p><table><tr align="left"><td>&#160;</td><td>Total &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;364&#41;</td><td colspan="2">Controlled asthma</td><td colspan="2">Patient perception of control</td><td colspan="2">ARQoL cut-off value</td></tr><tr align="left"><td>&#160;</td><td>&#160;</td><td>Yes &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;207&#41;</td><td>No &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;157&#41;</td><td>Controlled &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;338&#41;</td><td>Non-controlled &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;21&#41;</td><td>Above &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;188&#41;</td><td>Below &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;89&#41;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">Sex&#44; n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>Male</td><td>155 &#40;42&#46;6&#41;</td><td>111 &#40;71&#46;6&#41;</td><td>44 &#40;28&#46;4&#41;</td><td>146 &#40;96&#46;1&#41;</td><td>6 &#40;3&#46;9&#41;</td><td>79 &#40;81&#46;4&#41;</td><td>18 &#40;18&#46;6&#41;</td></tr><tr align="left"><td>Female</td><td>209 &#40;57&#46;4&#41;</td><td>96 &#40;45&#46;9&#41;</td><td>113 &#40;54&#46;1&#41;</td><td>192 &#40;92&#46;8&#41;</td><td>15 &#40;7&#46;2&#41;</td><td>109 &#40;60&#46;6&#41;</td><td>71 &#40;39&#46;4&#41;</td></tr><tr align="left"><td colspan="8">&#160;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">Age groups&#44; n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>&#60;18 years old</td><td>87 &#40;23&#46;9&#41;</td><td>59 &#40;67&#46;8&#41;</td><td>28 &#40;32&#46;2&#41;</td><td>82 &#40;96&#46;0&#41;</td><td>4 &#40;4&#46;7&#41;</td><td>0 &#40;0&#46;0&#41;</td><td>0 &#40;0&#46;0&#41;</td></tr><tr align="left"><td>18&#8211;64 years old</td><td>177 &#40;48&#46;6&#41;</td><td>112 &#40;63&#46;3&#41;</td><td>65 &#40;36&#46;7&#41;</td><td>168 &#40;96&#46;0&#41;</td><td>7 &#40;4&#46;0&#41;</td><td>132 &#40;74&#46;6&#41;</td><td>45 &#40;25&#46;4&#41;</td></tr><tr align="left"><td>&#62;64 years old</td><td>100 &#40;27&#46;5&#41;</td><td>36 &#40;6&#46;0&#41;</td><td>64 &#40;64&#46;0&#41;</td><td>88 &#40;89&#46;8&#41;</td><td>10 &#40;10&#46;2&#41;</td><td>56 &#40;56&#46;0&#41;</td><td>44 &#40;44&#46;0&#41;</td></tr><tr align="left"><td colspan="8">&#160;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">Education level</span><span class="elsevierStyleSup">a</span> &#44; <span class="elsevierStyleItalic">n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>&#60;9 years</td><td>240 &#40;65&#46;9&#41;</td><td>120 &#40;50&#46;0&#41;</td><td>120 &#40;50&#46;0&#41;</td><td>220 &#40;92&#46;4&#41;</td><td>18 &#40;7&#46;6&#41;</td><td>92 &#40;57&#46;5&#41;</td><td>68 &#40;42&#46;5&#41;</td></tr><tr align="left"><td>9&#8211;12 years</td><td>83 &#40;22&#46;8&#41;</td><td>57 &#40;68&#46;7&#41;</td><td>26 &#40;31&#46;3&#41;</td><td>80 &#40;98&#46;8&#41;</td><td>1 &#40;1&#46;2&#41;</td><td>60 &#40;78&#46;9&#41;</td><td>16 &#40;21&#46;1&#41;</td></tr><tr align="left"><td>&#62;12 years</td><td>41 &#40;11&#46;3&#41;</td><td>30 &#40;73&#46;2&#41;</td><td>11 &#40;26&#46;8&#41;</td><td>38 &#40;95&#46;0&#41;</td><td>2 &#40;5&#46;0&#41;</td><td>36 &#40;87&#46;8&#41;</td><td>5 &#40;12&#46;2&#41;</td></tr><tr align="left"><td colspan="8">&#160;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">SES</span><span class="elsevierStyleSup">b</span> &#44; <span class="elsevierStyleItalic">n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>Low</td><td>59 &#40;16&#46;3&#41;</td><td>18 &#40;30&#46;5&#41;</td><td>41 &#40;69&#46;5&#41;</td><td>51 &#40;87&#46;9&#41;</td><td>7 &#40;5&#46;9&#41;</td><td>29 &#40;49&#46;2&#41;</td><td>30 &#40;50&#46;8&#41;</td></tr><tr align="left"><td>Medium low</td><td>222 &#40;61&#46;2&#41;</td><td>127 &#40;57&#46;2&#41;</td><td>95 &#40;42&#46;8&#41;</td><td>211 &#40;95&#46;9&#41;</td><td>9 &#40;4&#46;1&#41;</td><td>116 &#40;69&#46;5&#41;</td><td>51 &#40;30&#46;5&#41;</td></tr><tr align="left"><td>Medium high</td><td>49 &#40;13&#46;5&#41;</td><td>35 &#40;71&#46;4&#41;</td><td>14 &#40;28&#46;6&#41;</td><td>44 &#40;91&#46;7&#41;</td><td>4 &#40;8&#46;3&#41;</td><td>27 &#40;84&#46;8&#41;</td><td>5 &#40;15&#46;6&#41;</td></tr><tr align="left"><td>High</td><td>33 &#40;9&#46;1&#41;</td><td>27 &#40;81&#46;8&#41;</td><td>6 &#40;18&#46;2&#41;</td><td>31 &#40;96&#46;9&#41;</td><td>1 &#40;3&#46;1&#41;</td><td>15 &#40;83&#46;3&#41;</td><td>3 &#40;16&#46;7&#41;</td></tr><tr align="left"><td colspan="8">&#160;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">Smoking status&#44; n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>Non-smoker</td><td>274 &#40;75&#46;3&#41;</td><td>153 &#40;55&#46;8&#41;</td><td>121 &#40;44&#46;2&#41;</td><td>255 &#40;93&#46;8&#41;</td><td>17 &#40;6&#46;3&#41;</td><td>121 &#40;64&#46;0&#41;</td><td>68 &#40;36&#46;0&#41;</td></tr><tr align="left"><td>Ex-smoker</td><td>53 &#40;14&#46;6&#41;</td><td>33 &#40;62&#46;3&#41;</td><td>20 &#40;37&#46;7&#41;</td><td>46 &#40;92&#46;0&#41;</td><td>4 &#40;8&#46;0&#41;</td><td>39 &#40;73&#46;6&#41;</td><td>14 &#40;26&#46;4&#41;</td></tr><tr align="left"><td>Current smoker</td><td>37 &#40;10&#46;2&#41;</td><td>21 &#40;56&#46;8&#41;</td><td>16 &#40;43&#46;2&#41;</td><td>37 &#40;100&#46;0&#41;</td><td>0 &#40;0&#46;0&#41;</td><td>28 &#40;80&#46;0&#41;</td><td>7 &#40;20&#46;0&#41;</td></tr><tr align="left"><td colspan="8">&#160;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">Controlled asthma&#44; n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>Yes</td><td>207 &#40;56&#46;9&#41;</td><td>&#8211;</td><td>&#8211;</td><td>201 &#40;98&#46;5&#41;</td><td>3 &#40;1&#46;5&#41;</td><td>137 &#40;92&#46;6&#41;</td><td>11 &#40;7&#46;4&#41;</td></tr><tr align="left"><td>No</td><td>157 &#40;43&#46;1&#41;</td><td>&#8211;</td><td>&#8211;</td><td>137 &#40;88&#46;4&#41;</td><td>18 &#40;85&#46;7&#41;</td><td>51 &#40;39&#46;5&#41;</td><td>78 &#40;60&#46;5&#41;</td></tr><tr align="left"><td colspan="8">&#160;</td></tr><tr align="left"><td colspan="8"><span class="elsevierStyleItalic">Patient perception of control&#44; n &#40;&#37;&#41;</span></td></tr><tr align="left"><td>Controlled</td><td>338 &#40;94&#46;2&#41;</td><td>201 &#40;59&#46;5&#41;</td><td>137 &#40;40&#46;5&#41;</td><td>&#8211;</td><td>&#8211;</td><td>181 &#40;70&#46;7&#41;</td><td>75 &#40;29&#46;3&#41;</td></tr><tr align="left"><td>Not controlled</td><td>21 &#40;5&#46;8&#41;</td><td>3 &#40;14&#46;3&#41;</td><td>18 &#40;85&#46;7&#41;</td><td>&#8211;</td><td>&#8211;</td><td>3 &#40;17&#46;6&#41;</td><td>14 &#40;82&#46;4&#41;</td></tr></table><p class="elsevierStylePara">Asthma Related Quality of Life &#40;ARQoL&#41; cut-off value of 5&#46;4&#46;<br></br></p><p class="elsevierStylePara">a A total of 60 &#40;2&#46;7&#37;&#41; participants were preschoolers &#40;not shown&#41; &#8211; Data retrieved from 1st phase of INAsma&#46;<br></br>b Socioeconomic Status was categorized in high &#40;A social class&#41;&#44; medium high &#40;B social class&#41;&#44; medium low &#40;C social classes&#41; and low &#40;D social class&#41; based on occupation and school education of the person who contributes more for the household income &#8211; Data retrieved from 1st phase of INAsma&#46;<br></br></p><p class="elsevierStylePara">According to the patients&#8217; answers to CARAT&#44; the most frequent symptoms were related to upper airways with 24&#46;9&#37; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;90&#41; and 21&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;78&#41; of the patients answering &#8220;Always&#8221;&#44; to sneezing and itchy nose&#44; respectively &#40;Fig&#46; S2&#41;&#46; The less common symptom reported was nocturnal awakening with 69&#46;5&#37; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;253&#41; of the patients answering &#8220;Never&#8221;&#46;</p><p class="elsevierStylePara">Asthma was controlled in 56&#46;9&#37; &#91;95&#37;CI&#44; 51&#46;8&#8211;62&#46;0&#93; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;207&#41; of the patients &#40;<a href="&#35;t0005" class="elsevierStyleCrossRefs">Table 1</a>&#41;&#46; Regarding patient self-perception of control&#44; 94&#37; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;338&#41; reported having their asthma controlled &#40;<a href="&#35;t0005" class="elsevierStyleCrossRefs">Table 1</a>&#41;&#46; Among the non-controlled patients 88&#46;4&#37; &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;137&#41; perceived their asthma as controlled &#40;<a href="&#35;t0005" class="elsevierStyleCrossRefs">Table 1</a>&#44; Fig&#46; S3&#41;&#46;</p><p class="elsevierStylePara">Controlled patients had higher mini-AQLQ scores than the non-controlled &#40;median&#44; P25&#8211;P75&#59; 6&#46;6&#44; 6&#46;0&#8211;6&#46;9 and 4&#46;9&#44; 3&#46;7&#8211;5&#46;7&#44; respectively&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41; &#40;<a href="&#35;f0020" class="elsevierStyleCrossRefs">Figure 1</a>A&#41;&#46; A significant positive correlation between CARAT and mini-AQLQ scores was observed &#40;<span class="elsevierStyleItalic">r</span>&#160;&#61;&#160;0&#46;706&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#44; <a href="&#35;f0020" class="elsevierStyleCrossRefs">Figure 1</a>B&#41;&#46;</p><a name="f0020" class="elsevierStyleCrossRefs"></a><p class="elsevierStylePara"><img src="320v21n04-90433950fig1.jpg" alt="Relationship between CARAT and mini-AQLQ scores &#40;&#60;i&#62;n&#60;&#47;i&#62;&#160;&#61;&#160;274&#41;&#59; &#40;A&#41; ARQoL by asthma control groups&#59; Scatterplots show the correlation between &#40;B&#41; CARAT global score and ARQoL&#59; &#40;C&#41; CARAT superior airways subscore and ARQoL&#59; &#40;D&#41; CARAT inferior airways subscore and ARQoL&#46; In A the horizontal line represents the Mini-AQLQ cut-off of 5&#46;4 based on previous study&#59;&#60;cross-ref&#62;&#60;sup&#62;11&#60;&#47;sup&#62;&#60;&#47;cross-ref&#62; NCA&#58; non-controlled asthma&#59; CA&#58; Controlled asthma&#46; In &#40;B&#44; C and D&#41; the vertical lines represent the Mini-AQLQ cut-off of 5&#46;4&#60;cross-ref&#62;&#60;sup&#62;11&#60;&#47;sup&#62;&#60;&#47;cross-ref&#62; and the horizontal lines represent the CARAT cut-offs&#59;&#60;cross-ref&#62;&#60;sup&#62;9&#60;&#47;sup&#62;&#60;&#47;cross-ref&#62; &#40;B&#41; global score cut-off of 24&#59; &#40;C&#41; superior airways subscore cut-off of 8 and &#40;D&#41; the CARAT inferior subscore cut-off of 16&#46; The scatterplots are divided into four quadrants&#44; the inferior left corresponds to participants with non-controlled disease and more impairments and the upper right to participants with controlled disease and less impairments&#46;"></img></p><p class="elsevierStylePara">Figure 1&#46; Relationship between CARAT and mini-AQLQ scores &#40;<span class="elsevierStyleItalic">n</span>&#160;&#61;&#160;274&#41;&#59; &#40;A&#41; ARQoL by asthma control groups&#59; Scatterplots show the correlation between &#40;B&#41; CARAT global score and ARQoL&#59; &#40;C&#41; CARAT superior airways subscore and ARQoL&#59; &#40;D&#41; CARAT inferior airways subscore and ARQoL&#46; In A the horizontal line represents the Mini-AQLQ cut-off of 5&#46;4 based on previous study&#59;  <span class="elsevierStyleSup">11</span>  NCA&#58; non-controlled asthma&#59; CA&#58; Controlled asthma&#46; In &#40;B&#44; C and D&#41; the vertical lines represent the Mini-AQLQ cut-off of 5&#46;4  <span class="elsevierStyleSup">11</span>  and the horizontal lines represent the CARAT cut-offs&#59;  <span class="elsevierStyleSup">9</span>  &#40;B&#41; global score cut-off of 24&#59; &#40;C&#41; superior airways subscore cut-off of 8 and &#40;D&#41; the CARAT inferior subscore cut-off of 16&#46; The scatterplots are divided into four quadrants&#44; the inferior left corresponds to participants with non-controlled disease and more impairments and the upper right to participants with controlled disease and less impairments&#46;</p><a name="sec0020" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Discussion</span><p class="elsevierStylePara">We report the first nationwide results on asthma control in Portugal with more than half &#40;57&#37;&#41; of the patients presenting controlled asthma&#46; A significant positive correlation was found between CARAT and mini-AQLQ&#44; indicating that patients with controlled asthma had significant better ARQoL comparing to patients with non-controlled asthma&#46; However&#44; most patients &#40;88&#37;&#41; with non-controlled asthma perceived their asthma as controlled&#46;</p><p class="elsevierStylePara">The proportion of asthma control was in accordance with recent studies in other countries&#46;<a href="&#35;bib18" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a> In 2010&#44; the European National Health and Wellness Survey<a href="&#35;bib19" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">5</span></a> estimated a global proportion of non-controlled asthma of 53&#46;5&#37; across five European countries&#46; Similarly&#44; the International Asthma Patient Insight Research &#40;INSPIRE&#41; study<a href="&#35;bib18" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a> found a worldwide proportion of non-controlled asthma of 51&#37;&#46; In Portugal&#44; a study of asthma patients from one Allergy unit concluded that 57&#37; had partially or complete asthma control when assessed with ACT&#46;<a href="&#35;bib26" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">12</span></a></p><p class="elsevierStylePara">A strong positive correlation was observed between asthma control assessed by CARAT and ARQoL assessed by Mini-AQLQ&#46; This correlation was similar to previous reports using other asthma control questionnaires<a href="&#35;bib25" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">11</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib27" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">13</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib28" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">14</span></a> but had not been reported with CARAT questionnaire&#46;</p><p class="elsevierStylePara">Most of the participants with non-controlled asthma perceived their disease as controlled&#46; This is very similar to the data from the Asthma Insights and Reality in Europe survey&#46;<a href="&#35;bib17" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a> Also in the INSPIRE study&#44;<a href="&#35;bib18" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a> patient perception of asthma control was strikingly different from that based on symptoms assessment&#46; These data suggest that patients&#44; especially those with poor control&#44; continue to have very low expectations regarding asthma outcomes&#46; Clinical studies are warranted on the relation between asthma control and patient-self perception of control&#46;</p><p class="elsevierStylePara">The main strength of the present study is that INAsma is the first Portuguese study to include patients from the general population from all municipalities and all age groups&#46;<a href="&#35;bib21" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a> Some limitations are inherent to a landline telephone-based interview study&#44; especially with the recent shift from landline telephones to cellphones&#46; Other limitation is the potential for confusion as the definition of control may have been influenced by the rhinitis subscore&#46; However&#44; we compared the results of patients with and without associated rhinitis and there were no differences in the proportion of patients with controlled asthma&#44; in perceptions of asthma control and in the correlation between asthma control and ARQoL &#40;data not shown&#41;&#46; Moreover&#44; the CARAT superior airways subscore seems not to have affected the correlation between CARAT total score and miniARQLQ &#40;<a href="&#35;f0020" class="elsevierStyleCrossRefs">Figure 1</a>C&#41;&#46;</p><p class="elsevierStylePara">In conclusion&#44; more than half of the Portuguese asthma patients have their disease controlled and these have significantly better asthma-related quality of life&#46; Poor perception of control seems to be an obstacle to achieving better disease control as almost 9 out of 10 patients with non-controlled disease had poor perception of their asthma control&#46; The objective assessment of asthma control using validated tools may help patients to increase their expectations regarding asthma outcomes&#46;</p><a name="sec0025" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Ethical disclosures</span><a name="sec0030" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Protection of human and animal subjects</span><p class="elsevierStylePara">The authors declare that no experiments were performed on humans or animals for this study&#46;</p><a name="sec0035" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Confidentiality of data</span><p class="elsevierStylePara">The authors declare that no patient data appear in this article&#46;</p><a name="sec0040" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Right to privacy and informed consent</span><p class="elsevierStylePara">The authors declare that no patient data appear in this article&#46;</p><a name="sec0045" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p class="elsevierStylePara">The authors have no conflicts of interest to declare&#46;</p><p class="elsevierStylePara">Acknowledgements</p><p class="elsevierStylePara">The Portuguese National Asthma Survey &#8211; <span class="elsevierStyleItalic">Inqu&#233;rito Nacional sobre Asma</span> &#40;INAsma&#41; was conducted by the Center for Health Technology and Services Research &#40;CINTESIS&#41; in collaboration with <span class="elsevierStyleItalic">Sociedade Portuguesa de Pneumologia</span>&#44; by appointment of the Portuguese Health Directorate&#46;</p><p class="elsevierStylePara">The work presented in this short communication was partially funded by FEDER funds through COMPETE &#40;<span class="elsevierStyleItalic">Programa Operacional Factores de Competitividade</span>&#41; and by National funds through a FCT &#40;<span class="elsevierStyleItalic">Funda&#231;&#227;o para a Ci&#234;ncia e a Tecnologia</span>&#41; project with reference &#8220;PTDC&#47;SAU-SAP&#47;119192&#47;2010&#8221;&#46;</p><a name="sec0050" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Appendix A&#46; Supplementary data</span><p class="elsevierStylePara">Supplementary material associated with this article can be found in the online version available at <a href="http&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppneu&#46;2014&#46;08&#46;001" class="elsevierStyleCrossRefs">http&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppneu&#46;2014&#46;08&#46;001</a>&#46;</p><a name="sec0055" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Appendix A&#46; Supplementary data</span><p class="elsevierStylePara"><a name="f0005" class="elsevierStyleCrossRefs"></a></p><p class="elsevierStylePara"><img src="320v21n04-90433950fig1.jpg" alt="Participants Flowchart&#46; From 559 participants 405 had current asthma and 207 had their asthma controlled&#46;"></img></p><p class="elsevierStylePara">Supplementary Fig&#46; S1&#46; Participants Flowchart&#46; From 559 participants 405 had current asthma and 207 had their asthma controlled&#46;</p><a name="f0010" class="elsevierStyleCrossRefs"></a><p class="elsevierStylePara"><img src="320v21n04-90433950fig2.jpg" alt="Answers to CARAT questionnaire&#46; Questions 1&#8211;9&#58; dark blue &#8220;Never&#8221;&#59; yellow &#8220;Up to 2 days per week&#8221;&#59; orange &#8220;More than 2 days per week&#8221;&#59; red &#8220;Almost every day or every day&#8221;&#46; Question 10&#58; light blue &#8220;Not taking medication&#8221;&#59; dark blue &#8220;Never&#8221;&#59; orange &#8220;Less than 7 days&#8221;&#59; red &#8220;7 or more days&#8221;&#46;"></img></p><p class="elsevierStylePara">Supplementary Fig&#46; S2&#46; Answers to CARAT questionnaire&#46; Questions 1&#8211;9&#58; dark blue &#8220;Never&#8221;&#59; yellow &#8220;Up to 2 days per week&#8221;&#59; orange &#8220;More than 2 days per week&#8221;&#59; red &#8220;Almost every day or every day&#8221;&#46; Question 10&#58; light blue &#8220;Not taking medication&#8221;&#59; dark blue &#8220;Never&#8221;&#59; orange &#8220;Less than 7 days&#8221;&#59; red &#8220;7 or more days&#8221;&#46;</p><a name="f0015" class="elsevierStyleCrossRefs"></a><p class="elsevierStylePara"><img src="320v21n04-90433950fig3.jpg" alt="Perceived asthma control by asthma control status&#46; From the 359 participants who answered to the question &#8220;Did you feel that your asthma was well controlled&#63;&#8221;&#44; 155 had non-controlled asthma and 204 had their asthma controlled&#44; based on CARAT scores&#46;"></img></p><p class="elsevierStylePara">Supplementary Fig&#46; S3&#46; Perceived asthma control by asthma control status&#46; From the 359 participants who answered to the question &#8220;Did you feel that your asthma was well controlled&#63;&#8221;&#44; 155 had non-controlled asthma and 204 had their asthma controlled&#44; based on CARAT scores&#46;</p><p class="elsevierStylePara"><elsevierMultimedia href="320v21n04-90433950mmc4.pdf"></elsevierMultimedia></p><p class="elsevierStylePara">Received 2 May 2014 <br></br>Accepted 19 August 2014 </p><p class="elsevierStylePara">Corresponding author&#46; jfonseca&#64;med&#46;up&#46;pt</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><br/><p class="elsevierStylePara">We aimed &#40;1&#41; to measure asthma control using a structure-questionnaire and patient self-perception of asthma-control in the Portuguese National Asthma Survey &#40;INAsma&#41; and &#40;2&#41; to study the relationship between asthma control and asthma-related quality of life&#46;</p><span class="elsevierStyleSectionTitle">Methods</span><br/><p class="elsevierStylePara">We analyze data of asthma patients from a cross-sectional&#44; nationwide telephone interview study &#8211; INAsma&#46; Controlled asthma was defined as CARAT global score &#62;24 or CARAT lower airways score &#8805;16&#46; Mini-AQLQ was used to measure quality of life&#46;</p><span class="elsevierStyleSectionTitle">Results</span><br/><p class="elsevierStylePara">Two hundred and seven &#40;56&#46;9&#37; &#91;95&#37;CI&#58; 51&#46;8&#8211;62&#46;0&#93;&#41; of the 364 patients had controlled asthma&#46; Most patients with non-controlled asthma &#40;88&#37;&#41; perceived their disease as controlled&#46; Patients with controlled asthma presented higher mini-AQLQ scores &#40;median&#44; P25&#8211;P75&#59; 6&#46;6&#44; 6&#46;0&#8211;6&#46;9&#41; than those with non-controlled asthma &#40;4&#46;9&#44; 3&#46;7&#8211;5&#46;7&#41; &#40;<span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41; and a significant positive correlation between CARAT and mini-AQLQ scores was observed &#40;<span class="elsevierStyleItalic">r</span>&#160;&#61;&#160;0&#46;706&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41;&#46;</p><span class="elsevierStyleSectionTitle">Conclusion</span><br/><p class="elsevierStylePara">More than half of the Portuguese patients presented controlled asthma and showed significantly better asthma-related quality of life&#46; Almost 9 out of 10 patients with non-controlled disease have poor perception of their asthma control&#44; which may hinder them from seeking better asthma control&#46;</p>"
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