array:21 [
  "pii" => "X0873215915856087"
  "issn" => "08732159"
  "doi" => "10.1016/j.rppnen.2014.09.006"
  "estado" => "S300"
  "fechaPublicacion" => "2015-01-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Pneumol. 2015;21:3-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4854
    "formatos" => array:3 [
      "EPUB" => 275
      "HTML" => 3638
      "PDF" => 941
    ]
  ]
  "itemSiguiente" => array:16 [
    "pii" => "X0873215915856095"
    "issn" => "08732159"
    "doi" => "10.1016/j.rppnen.2014.06.009"
    "estado" => "S300"
    "fechaPublicacion" => "2015-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2015;21:5-10"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6466
      "formatos" => array:3 [
        "EPUB" => 247
        "HTML" => 5126
        "PDF" => 1093
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "Bronchiectasis: A retrospective study of clinical and aetiological investigation in a general respiratory department"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "5"
          "paginaFinal" => "10"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "420v21n01-90385609fig1.jpg"
              "Alto" => 1088
              "Ancho" => 1526
              "Tamanyo" => 211021
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Aetiological investigation. AAT, ¿1-antitrypsin."
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A. Amorim, J. Bento, A.P. Vaz, I. Gomes, J. de Gracia, V. Hespanhol, A. Marques"
          "autores" => array:7 [
            0 => array:2 [
              "Iniciales" => "A."
              "apellidos" => "Amorim"
            ]
            1 => array:2 [
              "Iniciales" => "J."
              "apellidos" => "Bento"
            ]
            2 => array:2 [
              "Iniciales" => "A.P."
              "apellidos" => "Vaz"
            ]
            3 => array:2 [
              "Iniciales" => "I."
              "apellidos" => "Gomes"
            ]
            4 => array:2 [
              "Iniciales" => "J."
              "apellidos" => "de Gracia"
            ]
            5 => array:2 [
              "Iniciales" => "V."
              "apellidos" => "Hespanhol"
            ]
            6 => array:2 [
              "Iniciales" => "A."
              "apellidos" => "Marques"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915856095?idApp=UINPBA00004E"
    "url" => "/08732159/0000002100000001/v0_201604141151/X0873215915856095/v0_201604141151/en/main.assets"
  ]
  "itemAnterior" => array:16 [
    "pii" => "X0873215915856079"
    "issn" => "08732159"
    "doi" => "10.1016/j.rppnen.2014.12.001"
    "estado" => "S300"
    "fechaPublicacion" => "2015-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2015;21:1-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3043
      "formatos" => array:3 [
        "EPUB" => 242
        "HTML" => 1932
        "PDF" => 869
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "titulo" => "Lung transplantation in Portugal"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1"
          "paginaFinal" => "2"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J. Fragata"
          "autores" => array:1 [
            0 => array:2 [
              "Iniciales" => "J."
              "apellidos" => "Fragata"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915856079?idApp=UINPBA00004E"
    "url" => "/08732159/0000002100000001/v0_201604141151/X0873215915856079/v0_201604141151/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:18 [
      "pii" => "S2173511515000822"
      "issn" => "21735115"
      "doi" => "10.1016/j.rppnen.2015.03.004"
      "estado" => "S300"
      "fechaPublicacion" => "2015-05-01"
      "aid" => "1055"
      "copyright" => "Sociedade Portuguesa de Pneumologia"
      "documento" => "simple-article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "err"
      "cita" => "Rev Port Pneumol. 2015;21:171"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1484
        "formatos" => array:3 [
          "EPUB" => 234
          "HTML" => 762
          "PDF" => 488
        ]
      ]
      "en" => array:9 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Erratum</span>"
        "titulo" => "Erratum to &#8220;The future of lung transplantation&#8221;"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:1 [
            "paginaInicial" => "171"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46;M&#46; Borro"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "J&#46;M&#46;"
                "apellidos" => "Borro"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511515000822?idApp=UINPBA00004E"
      "url" => "/21735115/0000002100000003/v2_201505070217/S2173511515000822/v2_201505070217/en/main.assets"
    ]
  ]
  "en" => array:9 [
    "idiomaDefecto" => true
    "titulo" => "The future of lung transplantation"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "3"
        "paginaFinal" => "4"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "J.M. Borro"
        "autores" => array:1 [
          0 => array:4 [
            "Iniciales" => "J.M."
            "apellidos" => "Borro"
            "email" => array:1 [
              0 => "jbormat&#64;sergas&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "University of A Coruña, Xubias de Arriba 84, 15006 A Coruña, Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Department of Thoracic Surgery and Lung Transplantation, University Hospital of A Coruña, Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara">The first lung transplantation was performed 50 years ago&#44; in 1963&#44; in Jackson&#44; Mississippi<a href="&#35;bib1" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">1</span></a> and the first long-term survivals were achieved 25 years ago<a href="&#35;bib2" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">2</span></a>&#46; Currently&#44; lung transplantation has been established as an effective therapy for a group of selected patients with advanced-stage lung diseases&#44; when other therapeutic options are no longer useful and there is no other alternative therapy&#46;</p><p class="elsevierStylePara">Present status of lung transplantation is clearly favorable&#44; with an increasing number of transplantation procedures being performed both globally and at a national level&#44; along with a gradually improving short- and long-term survival&#46;</p><p class="elsevierStylePara">Various factors will have a significant impact on the development of lung transplantation in next years</p><p class="elsevierStylePara">Regarding receptors selection&#44; absolute contraindications &#40;hepatitis C&#44; HIV&#44; renal or liver failure&#41; will mostly become relative contraindications in selected cases in the latest revision of ISHLT that is about to be issued&#46; This is particularly true for hepatitis C and HIV&#59; in such patients an appropriate selection of suitable cases and the use of novel antiviral therapies have shown favorable mid-term results<a href="&#35;bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a>&#46; Furthermore&#44; combined transplantation allows an acceptable survival to be achieved in selected patients with renal and liver failure<a href="&#35;bib4" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib5" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">5</span></a>&#46;</p><p class="elsevierStylePara">Age of receptor is now considered in a more flexible way<a href="&#35;bib6" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">6</span></a> and will possibly be no longer a contraindication&#46; Therefore&#44; ethically appropriate decisions will be taken based on comorbidities or measurable factors such as quality of life&#44; physical exercise tolerance or brain functioning tests&#46;</p><p class="elsevierStylePara">Regarding main diseases to be treated by transplantation&#44; other alternative therapies aim at reducing the amount of candidates to transplantation&#44; because this must always be the last therapeutic option&#46; Recent results from studies of pirfenidone<a href="&#35;bib7" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a> in pulmonary fibrosis have shown a potential reduction of the number of patients eligible for transplantation or a prolonged time to transplantation&#46; Several surgical or bronchoscopic procedures for lung volume reduction could also postpone transplantation in emphysema<a href="&#35;bib8" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">8</span></a>&#46; Even more interestingly&#44; recent investigations on cystic fibrosis therapy<a href="&#35;bib9" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">9</span></a> could result in a change of the disease course&#44; as has already happened in patients with PPH<a href="&#35;bib10" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">10</span></a>&#46;</p><p class="elsevierStylePara">A better use of available donors is one of the most important factors helping lung transplantation to cover currently existing needs<a href="&#35;bib11" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">11</span></a>&#46; Thus&#44; an improved care of donors is providing more and better donors and has allowed using some suboptimal donors&#59; nevertheless&#44; the decision to accept a suboptimal donor should always ensure a survival similar to the usual one<a href="&#35;bib12" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">12</span></a>&#46; Donation in asystole has shown similar survival results&#44; and is now a reality that should increase in the future after asystole method is established in most medium-size towns&#46;</p><p class="elsevierStylePara">The most important development in the near future could probably be <span class="elsevierStyleItalic">ex vivo</span> preservation allowing an appropriate assessment of donor organs to be carried out and prolonging ischemia time to 12 or more hours&#44; while donor lungs are treated for neurogenic edema&#44; mild contusions&#44; and even some types of pulmonary infections<a href="&#35;bib13" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">13</span></a>&#46; The use of various <span class="elsevierStyleItalic">ex vivo</span> systems being currently tested&#44; along with the creation of specific donor lung therapy units&#44; will probably transform the future of lung donation&#46;</p><p class="elsevierStylePara">In the long-term&#44; one of the most attractive proposals could be the development of engineered bio-synthetic lungs&#44; by means of growing epithelial and endothelial cells on a decellularized lung skeleton&#44; thus allowing an appropriate ventilation&#44; perfusion&#44; and gas exchange<a href="&#35;bib14" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">14</span></a>&#46;</p><p class="elsevierStylePara">In conclusion&#44; lung transplantation is having a consistent development with current lines for research being mainly focused on improving the use of potential donors and treating chronic rejection&#44; still the main problems for lung transplantation development&#46;</p><hr></hr><p class="elsevierStylePara">&#9734; Please cite this article as&#58; Borro J&#46;M&#46; The future of lung transplantation&#46; Rev Port Pneumol&#46; 2015&#59;21&#58;3&#8211;4&#46;</p>"
    "pdfFichero" => "320v21n01a90385609pdf001.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:14 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Autotransplantation and homo transplantation: further studies. J Thorac Cardiovasc Surg. 1963; 46:606&#x002D;15."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Autotransplantation and homo transplantation&#58; further studies&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Hardy JD"
                            1 => "Eraslam S"
                            2 => "Dalton ML&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg. "
                        "fecha" => "1963"
                        "volumen" => "46"
                        "paginaInicial" => "606"
                        "paginaFinal" => "615"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14087734"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Lung Transplant Group Unilateral lung transplantation for pulmonary fibrosis. New Eng J Med. 1986; 314:1140&#x002D;5."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Lung Transplant Group Unilateral lung transplantation for pulmonary fibrosis&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Toronto&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198605013141802"
                      "Revista" => array:6 [
                        "tituloSerie" => "New Eng J Med. "
                        "fecha" => "1986"
                        "volumen" => "314"
                        "paginaInicial" => "1140"
                        "paginaFinal" => "1145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3515192"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Outcomes after lung transplantation and practices of lung transplant programs in the United States regarding hepatitis C seropositive recipients. Transplantattion. 2011; 91:1293."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Outcomes after lung transplantation and practices of lung transplant programs in the United States regarding hepatitis C seropositive recipients&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Fong TL"
                            1 => "Cho YW"
                            2 => "Hou L"
                            3 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Transplantattion. "
                        "fecha" => "2011"
                        "volumen" => "91"
                        "paginaInicial" => "1293"
                        "itemHostRev" => array:3 [
                          "pii" => "S2213260014702267"
                          "estado" => "S300"
                          "issn" => "22132600"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Simultaneous thoracic and abdominal transplantation: can we justify two organs for one recipient?. Am J Transplant. 2013; 13:1806&#x002D;16."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Simultaneous thoracic and abdominal transplantation&#58; can we justify two organs for one recipient&#63;&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Wolf JH"
                            1 => "Sulewski ME"
                            2 => "Cassuto JR"
                            3 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ajt.12291"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant. "
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "1806"
                        "paginaFinal" => "1816"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23718142"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Long&#x002D;term success of combined kidney&#x002D;lung transplantation in a patient with cystic fibrosis. Arch Bronconeumol. 2013; 49:272&#x002D;4."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Long-term success of combined kidney-lung transplantation in a patient with cystic fibrosis&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Borro JM"
                            1 => "Rama P"
                            2 => "Rey T"
                            3 => "Fern&#225;ndez-Rivera C&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arbres.2012.10.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol. "
                        "fecha" => "2013"
                        "volumen" => "49"
                        "paginaInicial" => "272"
                        "paginaFinal" => "274"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23427867"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Lung transplantation in patients 70 years old or older: have outcomes changed after implementation of the lung allocation score?. J Thorac Cardiovasc Surg. 2012; 144:1133&#x002D;8."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Lung transplantation in patients 70 years old or older&#58; have outcomes changed after implementation of the lung allocation score&#63;&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Kilic A1"
                            1 => "Merlo CA"
                            2 => "Conte JV"
                            3 => "Shah AS&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jtcvs.2012.07.080"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg. "
                        "fecha" => "2012"
                        "volumen" => "144"
                        "paginaInicial" => "1133"
                        "paginaFinal" => "1138"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22944081"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S2213260014702917"
                          "estado" => "S300"
                          "issn" => "22132600"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Pirfenidone: an update on clinical trial data and insights from everyday practice. Eur Respir Rev. 2014; 23:111&#x002D;7."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Pirfenidone&#58; an update on clinical trial data and insights from everyday practice&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Kreuter M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09059180.00008513"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir Rev. "
                        "fecha" => "2014"
                        "volumen" => "23"
                        "paginaInicial" => "111"
                        "paginaFinal" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24591668"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Update in chronic obstructive pulmonary disease 2013. Am J Respir Crit Care Med. 2014; 189:1337&#x002D;44."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Update in chronic obstructive pulmonary disease 2013&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Barreiro E1"
                            1 => "Criner GJ&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201402-0245UP"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med. "
                        "fecha" => "2014"
                        "volumen" => "189"
                        "paginaInicial" => "1337"
                        "paginaFinal" => "1344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24881938"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Update in cystic fibrosis 2013. Am J Respir Crit Care Med. 2014; 189:1181&#x002D;6."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Update in cystic fibrosis 2013&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Jain M"
                            1 => "Goss CH&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201402-0203UP"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Respir Crit Care Med. "
                        "fecha" => "2014"
                        "volumen" => "189"
                        "paginaInicial" => "1181"
                        "paginaFinal" => "1186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24832742"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S2213260014702917"
                          "estado" => "S300"
                          "issn" => "22132600"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Pulmonary Arterial Hypertension in Adults: Novel Drugs and Catheter Ablation Techniques Show Promise? Systematic Review on Pharmacotherapy and Interventional Strategies. Biomed Res Int. 2014; 2014:7438."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Pulmonary Arterial Hypertension in Adults&#58; Novel Drugs and Catheter Ablation Techniques Show Promise&#63; Systematic Review on Pharmacotherapy and Interventional Strategies&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Rosanio S"
                            1 => "Pelliccia F"
                            2 => "Gaudio"
                            3 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Biomed Res Int. "
                        "fecha" => "2014"
                        "volumen" => "2014"
                        "paginaInicial" => "7438"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "New methods to facilitate lung transplantation. Lancet. 2012; 24:1799&#x002D;801."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "New methods to facilitate lung transplantation&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Borro JM&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet. "
                        "fecha" => "2012"
                        "volumen" => "24"
                        "paginaInicial" => "1799"
                        "paginaFinal" => "1801"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Standard criteria for lung donors and considerations regarding extended&#x002D;criteria. Lancet Respir Med. 2013; 1:318&#x002D;22."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Standard criteria for lung donors and considerations regarding extended-criteria&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Munshi L"
                            1 => "Keshavjee S"
                            2 => "Cypel M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2213-2600(12)70064-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Respir Med. "
                        "fecha" => "2013"
                        "volumen" => "1"
                        "paginaInicial" => "318"
                        "paginaFinal" => "322"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24429157"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Technique for Prolonged Normothermic Ex Vivo Lung Perfusion. J Heart Lung Transplant. 2008; 27:1319&#x002D;25."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Technique for Prolonged Normothermic Ex Vivo Lung Perfusion&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Cypel M"
                            1 => "Keshavjee S&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.healun.2008.09.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Heart Lung Transplant. "
                        "fecha" => "2008"
                        "volumen" => "27"
                        "paginaInicial" => "1319"
                        "paginaFinal" => "1325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19059112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Regeneration and orthotopic transplantation of a bioartificial lung. Harald Nature Medicine. 2010; 16:927&#x002D;33."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Regeneration and orthotopic transplantation of a bioartificial lung&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Ott C"
                            1 => "Clippinger HC"
                            2 => "Conrad BC"
                            3 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Harald Nature Medicine. "
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "927"
                        "paginaFinal" => "933"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08732159/0000002100000001/v0_201604141151/X0873215915856087/v0_201604141151/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "50822"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Editorial"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08732159/0000002100000001/v0_201604141151/X0873215915856087/v0_201604141151/en/320v21n01a90385609pdf001.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915856087?idApp=UINPBA00004E"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

The future of lung transplantation
J.M.. Borroa,b
a University of A Coruña, Xubias de Arriba 84, 15006 A Coruña, Spain
b Department of Thoracic Surgery and Lung Transplantation, University Hospital of A Coruña, Spain
Read
9232
Times
was read the article
2490
Total PDF
6742
Total HTML
Share statistics
 array:21 [
  "pii" => "X0873215915856087"
  "issn" => "08732159"
  "doi" => "10.1016/j.rppnen.2014.09.006"
  "estado" => "S300"
  "fechaPublicacion" => "2015-01-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Pneumol. 2015;21:3-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4854
    "formatos" => array:3 [
      "EPUB" => 275
      "HTML" => 3638
      "PDF" => 941
    ]
  ]
  "itemSiguiente" => array:16 [
    "pii" => "X0873215915856095"
    "issn" => "08732159"
    "doi" => "10.1016/j.rppnen.2014.06.009"
    "estado" => "S300"
    "fechaPublicacion" => "2015-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2015;21:5-10"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6466
      "formatos" => array:3 [
        "EPUB" => 247
        "HTML" => 5126
        "PDF" => 1093
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "Bronchiectasis&#58; A retrospective study of clinical and aetiological investigation in a general respiratory department"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "5"
          "paginaFinal" => "10"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier Espa&#241;a"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "420v21n01-90385609fig1.jpg"
              "Alto" => 1088
              "Ancho" => 1526
              "Tamanyo" => 211021
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Aetiological investigation&#46; AAT&#44; &#191;1-antitrypsin&#46;"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A. Amorim, J. Bento, A.P. Vaz, I. Gomes, J. de Gracia, V. Hespanhol, A. Marques"
          "autores" => array:7 [
            0 => array:2 [
              "Iniciales" => "A."
              "apellidos" => "Amorim"
            ]
            1 => array:2 [
              "Iniciales" => "J."
              "apellidos" => "Bento"
            ]
            2 => array:2 [
              "Iniciales" => "A.P."
              "apellidos" => "Vaz"
            ]
            3 => array:2 [
              "Iniciales" => "I."
              "apellidos" => "Gomes"
            ]
            4 => array:2 [
              "Iniciales" => "J."
              "apellidos" => "de Gracia"
            ]
            5 => array:2 [
              "Iniciales" => "V."
              "apellidos" => "Hespanhol"
            ]
            6 => array:2 [
              "Iniciales" => "A."
              "apellidos" => "Marques"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915856095?idApp=UINPBA00004E"
    "url" => "/08732159/0000002100000001/v0_201604141151/X0873215915856095/v0_201604141151/en/main.assets"
  ]
  "itemAnterior" => array:16 [
    "pii" => "X0873215915856079"
    "issn" => "08732159"
    "doi" => "10.1016/j.rppnen.2014.12.001"
    "estado" => "S300"
    "fechaPublicacion" => "2015-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2015;21:1-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3043
      "formatos" => array:3 [
        "EPUB" => 242
        "HTML" => 1932
        "PDF" => 869
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "titulo" => "Lung transplantation in Portugal"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "1"
          "paginaFinal" => "2"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J. Fragata"
          "autores" => array:1 [
            0 => array:2 [
              "Iniciales" => "J."
              "apellidos" => "Fragata"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915856079?idApp=UINPBA00004E"
    "url" => "/08732159/0000002100000001/v0_201604141151/X0873215915856079/v0_201604141151/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:18 [
      "pii" => "S2173511515000822"
      "issn" => "21735115"
      "doi" => "10.1016/j.rppnen.2015.03.004"
      "estado" => "S300"
      "fechaPublicacion" => "2015-05-01"
      "aid" => "1055"
      "copyright" => "Sociedade Portuguesa de Pneumologia"
      "documento" => "simple-article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "err"
      "cita" => "Rev Port Pneumol. 2015;21:171"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 1484
        "formatos" => array:3 [
          "EPUB" => 234
          "HTML" => 762
          "PDF" => 488
        ]
      ]
      "en" => array:9 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Erratum</span>"
        "titulo" => "Erratum to &#8220;The future of lung transplantation&#8221;"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:1 [
            "paginaInicial" => "171"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46;M&#46; Borro"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "J&#46;M&#46;"
                "apellidos" => "Borro"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511515000822?idApp=UINPBA00004E"
      "url" => "/21735115/0000002100000003/v2_201505070217/S2173511515000822/v2_201505070217/en/main.assets"
    ]
  ]
  "en" => array:9 [
    "idiomaDefecto" => true
    "titulo" => "The future of lung transplantation"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "3"
        "paginaFinal" => "4"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "J.M. Borro"
        "autores" => array:1 [
          0 => array:4 [
            "Iniciales" => "J.M."
            "apellidos" => "Borro"
            "email" => array:1 [
              0 => "jbormat&#64;sergas&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "University of A Coruña, Xubias de Arriba 84, 15006 A Coruña, Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Department of Thoracic Surgery and Lung Transplantation, University Hospital of A Coruña, Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara">The first lung transplantation was performed 50 years ago&#44; in 1963&#44; in Jackson&#44; Mississippi<a href="&#35;bib1" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">1</span></a> and the first long-term survivals were achieved 25 years ago<a href="&#35;bib2" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">2</span></a>&#46; Currently&#44; lung transplantation has been established as an effective therapy for a group of selected patients with advanced-stage lung diseases&#44; when other therapeutic options are no longer useful and there is no other alternative therapy&#46;</p><p class="elsevierStylePara">Present status of lung transplantation is clearly favorable&#44; with an increasing number of transplantation procedures being performed both globally and at a national level&#44; along with a gradually improving short- and long-term survival&#46;</p><p class="elsevierStylePara">Various factors will have a significant impact on the development of lung transplantation in next years</p><p class="elsevierStylePara">Regarding receptors selection&#44; absolute contraindications &#40;hepatitis C&#44; HIV&#44; renal or liver failure&#41; will mostly become relative contraindications in selected cases in the latest revision of ISHLT that is about to be issued&#46; This is particularly true for hepatitis C and HIV&#59; in such patients an appropriate selection of suitable cases and the use of novel antiviral therapies have shown favorable mid-term results<a href="&#35;bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a>&#46; Furthermore&#44; combined transplantation allows an acceptable survival to be achieved in selected patients with renal and liver failure<a href="&#35;bib4" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib5" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">5</span></a>&#46;</p><p class="elsevierStylePara">Age of receptor is now considered in a more flexible way<a href="&#35;bib6" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">6</span></a> and will possibly be no longer a contraindication&#46; Therefore&#44; ethically appropriate decisions will be taken based on comorbidities or measurable factors such as quality of life&#44; physical exercise tolerance or brain functioning tests&#46;</p><p class="elsevierStylePara">Regarding main diseases to be treated by transplantation&#44; other alternative therapies aim at reducing the amount of candidates to transplantation&#44; because this must always be the last therapeutic option&#46; Recent results from studies of pirfenidone<a href="&#35;bib7" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a> in pulmonary fibrosis have shown a potential reduction of the number of patients eligible for transplantation or a prolonged time to transplantation&#46; Several surgical or bronchoscopic procedures for lung volume reduction could also postpone transplantation in emphysema<a href="&#35;bib8" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">8</span></a>&#46; Even more interestingly&#44; recent investigations on cystic fibrosis therapy<a href="&#35;bib9" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">9</span></a> could result in a change of the disease course&#44; as has already happened in patients with PPH<a href="&#35;bib10" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">10</span></a>&#46;</p><p class="elsevierStylePara">A better use of available donors is one of the most important factors helping lung transplantation to cover currently existing needs<a href="&#35;bib11" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">11</span></a>&#46; Thus&#44; an improved care of donors is providing more and better donors and has allowed using some suboptimal donors&#59; nevertheless&#44; the decision to accept a suboptimal donor should always ensure a survival similar to the usual one<a href="&#35;bib12" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">12</span></a>&#46; Donation in asystole has shown similar survival results&#44; and is now a reality that should increase in the future after asystole method is established in most medium-size towns&#46;</p><p class="elsevierStylePara">The most important development in the near future could probably be <span class="elsevierStyleItalic">ex vivo</span> preservation allowing an appropriate assessment of donor organs to be carried out and prolonging ischemia time to 12 or more hours&#44; while donor lungs are treated for neurogenic edema&#44; mild contusions&#44; and even some types of pulmonary infections<a href="&#35;bib13" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">13</span></a>&#46; The use of various <span class="elsevierStyleItalic">ex vivo</span> systems being currently tested&#44; along with the creation of specific donor lung therapy units&#44; will probably transform the future of lung donation&#46;</p><p class="elsevierStylePara">In the long-term&#44; one of the most attractive proposals could be the development of engineered bio-synthetic lungs&#44; by means of growing epithelial and endothelial cells on a decellularized lung skeleton&#44; thus allowing an appropriate ventilation&#44; perfusion&#44; and gas exchange<a href="&#35;bib14" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">14</span></a>&#46;</p><p class="elsevierStylePara">In conclusion&#44; lung transplantation is having a consistent development with current lines for research being mainly focused on improving the use of potential donors and treating chronic rejection&#44; still the main problems for lung transplantation development&#46;</p><hr></hr><p class="elsevierStylePara">&#9734; Please cite this article as&#58; Borro J&#46;M&#46; The future of lung transplantation&#46; Rev Port Pneumol&#46; 2015&#59;21&#58;3&#8211;4&#46;</p>"
    "pdfFichero" => "320v21n01a90385609pdf001.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:14 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Autotransplantation and homo transplantation: further studies. J Thorac Cardiovasc Surg. 1963; 46:606&#x002D;15."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Autotransplantation and homo transplantation&#58; further studies&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Hardy JD"
                            1 => "Eraslam S"
                            2 => "Dalton ML&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg. "
                        "fecha" => "1963"
                        "volumen" => "46"
                        "paginaInicial" => "606"
                        "paginaFinal" => "615"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14087734"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Lung Transplant Group Unilateral lung transplantation for pulmonary fibrosis. New Eng J Med. 1986; 314:1140&#x002D;5."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Lung Transplant Group Unilateral lung transplantation for pulmonary fibrosis&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Toronto&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198605013141802"
                      "Revista" => array:6 [
                        "tituloSerie" => "New Eng J Med. "
                        "fecha" => "1986"
                        "volumen" => "314"
                        "paginaInicial" => "1140"
                        "paginaFinal" => "1145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3515192"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Outcomes after lung transplantation and practices of lung transplant programs in the United States regarding hepatitis C seropositive recipients. Transplantattion. 2011; 91:1293."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Outcomes after lung transplantation and practices of lung transplant programs in the United States regarding hepatitis C seropositive recipients&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Fong TL"
                            1 => "Cho YW"
                            2 => "Hou L"
                            3 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Transplantattion. "
                        "fecha" => "2011"
                        "volumen" => "91"
                        "paginaInicial" => "1293"
                        "itemHostRev" => array:3 [
                          "pii" => "S2213260014702267"
                          "estado" => "S300"
                          "issn" => "22132600"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Simultaneous thoracic and abdominal transplantation: can we justify two organs for one recipient?. Am J Transplant. 2013; 13:1806&#x002D;16."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Simultaneous thoracic and abdominal transplantation&#58; can we justify two organs for one recipient&#63;&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Wolf JH"
                            1 => "Sulewski ME"
                            2 => "Cassuto JR"
                            3 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ajt.12291"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant. "
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "1806"
                        "paginaFinal" => "1816"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23718142"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Long&#x002D;term success of combined kidney&#x002D;lung transplantation in a patient with cystic fibrosis. Arch Bronconeumol. 2013; 49:272&#x002D;4."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Long-term success of combined kidney-lung transplantation in a patient with cystic fibrosis&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Borro JM"
                            1 => "Rama P"
                            2 => "Rey T"
                            3 => "Fern&#225;ndez-Rivera C&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arbres.2012.10.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol. "
                        "fecha" => "2013"
                        "volumen" => "49"
                        "paginaInicial" => "272"
                        "paginaFinal" => "274"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23427867"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Lung transplantation in patients 70 years old or older: have outcomes changed after implementation of the lung allocation score?. J Thorac Cardiovasc Surg. 2012; 144:1133&#x002D;8."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Lung transplantation in patients 70 years old or older&#58; have outcomes changed after implementation of the lung allocation score&#63;&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Kilic A1"
                            1 => "Merlo CA"
                            2 => "Conte JV"
                            3 => "Shah AS&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jtcvs.2012.07.080"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg. "
                        "fecha" => "2012"
                        "volumen" => "144"
                        "paginaInicial" => "1133"
                        "paginaFinal" => "1138"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22944081"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S2213260014702917"
                          "estado" => "S300"
                          "issn" => "22132600"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Pirfenidone: an update on clinical trial data and insights from everyday practice. Eur Respir Rev. 2014; 23:111&#x002D;7."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Pirfenidone&#58; an update on clinical trial data and insights from everyday practice&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Kreuter M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09059180.00008513"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir Rev. "
                        "fecha" => "2014"
                        "volumen" => "23"
                        "paginaInicial" => "111"
                        "paginaFinal" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24591668"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Update in chronic obstructive pulmonary disease 2013. Am J Respir Crit Care Med. 2014; 189:1337&#x002D;44."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Update in chronic obstructive pulmonary disease 2013&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Barreiro E1"
                            1 => "Criner GJ&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201402-0245UP"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med. "
                        "fecha" => "2014"
                        "volumen" => "189"
                        "paginaInicial" => "1337"
                        "paginaFinal" => "1344"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24881938"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Update in cystic fibrosis 2013. Am J Respir Crit Care Med. 2014; 189:1181&#x002D;6."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Update in cystic fibrosis 2013&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Jain M"
                            1 => "Goss CH&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201402-0203UP"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Respir Crit Care Med. "
                        "fecha" => "2014"
                        "volumen" => "189"
                        "paginaInicial" => "1181"
                        "paginaFinal" => "1186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24832742"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S2213260014702917"
                          "estado" => "S300"
                          "issn" => "22132600"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Pulmonary Arterial Hypertension in Adults: Novel Drugs and Catheter Ablation Techniques Show Promise? Systematic Review on Pharmacotherapy and Interventional Strategies. Biomed Res Int. 2014; 2014:7438."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Pulmonary Arterial Hypertension in Adults&#58; Novel Drugs and Catheter Ablation Techniques Show Promise&#63; Systematic Review on Pharmacotherapy and Interventional Strategies&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Rosanio S"
                            1 => "Pelliccia F"
                            2 => "Gaudio"
                            3 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Biomed Res Int. "
                        "fecha" => "2014"
                        "volumen" => "2014"
                        "paginaInicial" => "7438"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "New methods to facilitate lung transplantation. Lancet. 2012; 24:1799&#x002D;801."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "New methods to facilitate lung transplantation&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Borro JM&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet. "
                        "fecha" => "2012"
                        "volumen" => "24"
                        "paginaInicial" => "1799"
                        "paginaFinal" => "1801"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Standard criteria for lung donors and considerations regarding extended&#x002D;criteria. Lancet Respir Med. 2013; 1:318&#x002D;22."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Standard criteria for lung donors and considerations regarding extended-criteria&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Munshi L"
                            1 => "Keshavjee S"
                            2 => "Cypel M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2213-2600(12)70064-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Respir Med. "
                        "fecha" => "2013"
                        "volumen" => "1"
                        "paginaInicial" => "318"
                        "paginaFinal" => "322"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24429157"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Technique for Prolonged Normothermic Ex Vivo Lung Perfusion. J Heart Lung Transplant. 2008; 27:1319&#x002D;25."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Technique for Prolonged Normothermic Ex Vivo Lung Perfusion&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Cypel M"
                            1 => "Keshavjee S&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.healun.2008.09.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Heart Lung Transplant. "
                        "fecha" => "2008"
                        "volumen" => "27"
                        "paginaInicial" => "1319"
                        "paginaFinal" => "1325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19059112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Regeneration and orthotopic transplantation of a bioartificial lung. Harald Nature Medicine. 2010; 16:927&#x002D;33."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Regeneration and orthotopic transplantation of a bioartificial lung&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Ott C"
                            1 => "Clippinger HC"
                            2 => "Conrad BC"
                            3 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Harald Nature Medicine. "
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "927"
                        "paginaFinal" => "933"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08732159/0000002100000001/v0_201604141151/X0873215915856087/v0_201604141151/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "50822"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Editorial"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08732159/0000002100000001/v0_201604141151/X0873215915856087/v0_201604141151/en/320v21n01a90385609pdf001.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915856087?idApp=UINPBA00004E"
]
Article information
ISSN: 08732159
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 8 5 13
2024 October 53 29 82
2024 September 50 19 69
2024 August 62 39 101
2024 July 47 41 88
2024 June 56 23 79
2024 May 52 35 87
2024 April 55 32 87
2024 March 48 24 72
2024 February 58 15 73
2024 January 55 28 83
2023 December 42 26 68
2023 November 43 37 80
2023 October 45 30 75
2023 September 42 27 69
2023 August 37 26 63
2023 July 42 32 74
2023 June 40 19 59
2023 May 55 30 85
2023 April 59 13 72
2023 March 120 15 135
2023 February 49 22 71
2023 January 28 28 56
2022 December 58 23 81
2022 November 59 34 93
2022 October 75 45 120
2022 September 38 27 65
2022 August 40 51 91
2022 July 47 52 99
2022 June 41 34 75
2022 May 41 40 81
2022 April 42 25 67
2022 March 47 40 87
2022 February 41 43 84
2022 January 44 30 74
2021 December 34 38 72
2021 November 33 26 59
2021 October 43 38 81
2021 September 31 31 62
2021 August 44 24 68
2021 July 39 25 64
2021 June 36 27 63
2021 May 55 27 82
2021 April 135 61 196
2021 March 75 14 89
2021 February 63 10 73
2021 January 48 16 64
2020 December 48 10 58
2020 November 44 16 60
2020 October 46 15 61
2020 September 58 30 88
2020 August 54 22 76
2020 July 110 20 130
2020 June 99 17 116
2020 May 106 21 127
2020 April 84 9 93
2020 March 81 12 93
2020 February 70 14 84
2020 January 73 17 90
2019 December 76 21 97
2019 November 86 14 100
2019 October 81 24 105
2019 September 84 21 105
2019 August 174 14 188
2019 July 175 10 185
2019 June 194 10 204
2019 May 184 22 206
2019 April 152 21 173
2019 March 247 18 265
2019 February 212 10 222
2019 January 180 28 208
2018 December 101 5 106
2018 November 32 2 34
2018 October 53 14 67
2018 September 29 5 34
2018 August 39 24 63
2018 July 47 22 69
2018 June 55 17 72
2018 May 91 22 113
2018 April 73 15 88
2018 March 68 15 83
2018 February 35 11 46
2018 January 51 20 71
2017 December 57 11 68
2017 November 25 20 45
2017 October 14 17 31
2017 September 25 16 41
2017 August 19 18 37
2017 July 21 16 37
2017 June 28 17 45
2017 May 27 16 43
2017 April 11 6 17
2017 March 11 4 15
2017 February 7 6 13
2017 January 10 10 20
2016 December 14 14 28
2016 November 8 7 15
2016 October 7 1 8
2016 September 5 1 6
2016 August 3 3 6
2016 July 4 8 12
2016 June 9 3 12
2016 May 6 6 12
2016 April 41 1 42
2016 March 54 36 90
2016 February 49 27 76
2016 January 42 25 67
2015 December 49 24 73
2015 November 39 5 44
2015 October 47 15 62
2015 September 34 18 52
2015 August 31 13 44
2015 July 25 7 32
2015 June 26 6 32
2015 May 32 12 44
2015 April 49 40 89
2015 March 95 35 130
2015 February 71 62 133
Show all

Follow this link to access the full text of the article

Pulmonology

Are you a health professional able to prescribe or dispense drugs?