array:21 [
  "pii" => "X0873215915933025"
  "issn" => "08732159"
  "doi" => "10.1016/j.rppnen.2015.02.002"
  "estado" => "S300"
  "fechaPublicacion" => "2015-03-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Pneumol. 2015;21:53-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4846
    "formatos" => array:3 [
      "EPUB" => 262
      "HTML" => 3021
      "PDF" => 1563
    ]
  ]
  "itemSiguiente" => array:16 [
    "pii" => "X0873215915933033"
    "issn" => "08732159"
    "doi" => "10.1016/j.rppnen.2014.07.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-03-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2015;21:55-60"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5395
      "formatos" => array:3 [
        "EPUB" => 260
        "HTML" => 3951
        "PDF" => 1184
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "Obstructive sleep apnea and diabetes mellitus"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "55"
          "paginaFinal" => "60"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "320v21n02-90393303fig1.jpg"
              "Alto" => 939
              "Ancho" => 1621
              "Tamanyo" => 157359
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Graph 1. Glycemic control in type 2 DM and apnea¿hypopnea index."
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jorge Vale, Paula Manuel, Eurico Oliveira, Ana Rita Oliveira, Eloisa Silva, Vitor Melo, Marta Sousa, João Carlos Alexandre, Isabel Gil, Amparo Sanchez, Edite Nascimento, António Simões Torres"
          "autores" => array:12 [
            0 => array:2 [
              "nombre" => "Jorge"
              "apellidos" => "Vale"
            ]
            1 => array:2 [
              "nombre" => "Paula"
              "apellidos" => "Manuel"
            ]
            2 => array:2 [
              "nombre" => "Eurico"
              "apellidos" => "Oliveira"
            ]
            3 => array:2 [
              "nombre" => "Ana Rita"
              "apellidos" => "Oliveira"
            ]
            4 => array:2 [
              "nombre" => "Eloisa"
              "apellidos" => "Silva"
            ]
            5 => array:2 [
              "nombre" => "Vitor"
              "apellidos" => "Melo"
            ]
            6 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Sousa"
            ]
            7 => array:2 [
              "nombre" => "João Carlos"
              "apellidos" => "Alexandre"
            ]
            8 => array:2 [
              "nombre" => "Isabel"
              "apellidos" => "Gil"
            ]
            9 => array:2 [
              "nombre" => "Amparo"
              "apellidos" => "Sanchez"
            ]
            10 => array:2 [
              "nombre" => "Edite"
              "apellidos" => "Nascimento"
            ]
            11 => array:2 [
              "nombre" => "António Simões"
              "apellidos" => "Torres"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915933033?idApp=UINPBA00004E"
    "url" => "/08732159/0000002100000002/v0_201604141148/X0873215915933033/v0_201604141148/en/main.assets"
  ]
  "itemAnterior" => array:16 [
    "pii" => "X0873215915933017"
    "issn" => "08732159"
    "doi" => "10.1016/j.rppnen.2015.02.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-03-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2015;21:51-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3116
      "formatos" => array:3 [
        "EPUB" => 261
        "HTML" => 1957
        "PDF" => 898
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "titulo" => "What we have done so far and what we can achieve (II)"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "51"
          "paginaFinal" => "52"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "320v21n02-90393301fig1.jpg"
              "Alto" => 1389
              "Ancho" => 1489
              "Tamanyo" => 152850
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Evolution of visits and pages consulted in the PJP webpage over the past three years."
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915933017?idApp=UINPBA00004E"
    "url" => "/08732159/0000002100000002/v0_201604141148/X0873215915933017/v0_201604141148/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:19 [
      "pii" => "S217351151500024X"
      "issn" => "21735115"
      "doi" => "10.1016/j.rppnen.2014.07.005"
      "estado" => "S300"
      "fechaPublicacion" => "2015-03-01"
      "aid" => "1028"
      "copyright" => "Sociedade Portuguesa de Pneumologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Rev Port Pneumol. 2015;21:55-60"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 2006
        "formatos" => array:3 [
          "EPUB" => 237
          "HTML" => 1129
          "PDF" => 640
        ]
      ]
      "en" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
        "titulo" => "Obstructive sleep apnea and diabetes mellitus"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "55"
            "paginaFinal" => "60"
          ]
        ]
        "contieneResumen" => array:1 [
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Graph 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 939
                "Ancho" => 1621
                "Tamanyo" => 66394
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Glycemic control in type 2 DM and apnea&#8211;hypopnea index&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jorge Vale, Paula Manuel, Eurico Oliveira, Ana Rita Oliveira, Eloisa Silva, Vitor Melo, Marta Sousa, Jo&#227;o Carlos Alexandre, Isabel Gil, Amparo Sanchez, Edite Nascimento, Ant&#243;nio Sim&#245;es Torres"
            "autores" => array:12 [
              0 => array:2 [
                "nombre" => "Jorge"
                "apellidos" => "Vale"
              ]
              1 => array:2 [
                "nombre" => "Paula"
                "apellidos" => "Manuel"
              ]
              2 => array:2 [
                "nombre" => "Eurico"
                "apellidos" => "Oliveira"
              ]
              3 => array:2 [
                "nombre" => "Ana Rita"
                "apellidos" => "Oliveira"
              ]
              4 => array:2 [
                "nombre" => "Eloisa"
                "apellidos" => "Silva"
              ]
              5 => array:2 [
                "nombre" => "Vitor"
                "apellidos" => "Melo"
              ]
              6 => array:2 [
                "nombre" => "Marta"
                "apellidos" => "Sousa"
              ]
              7 => array:2 [
                "nombre" => "Jo&#227;o Carlos"
                "apellidos" => "Alexandre"
              ]
              8 => array:2 [
                "nombre" => "Isabel"
                "apellidos" => "Gil"
              ]
              9 => array:2 [
                "nombre" => "Amparo"
                "apellidos" => "Sanchez"
              ]
              10 => array:2 [
                "nombre" => "Edite"
                "apellidos" => "Nascimento"
              ]
              11 => array:2 [
                "nombre" => "Ant&#243;nio Sim&#245;es"
                "apellidos" => "Torres"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217351151500024X?idApp=UINPBA00004E"
      "url" => "/21735115/0000002100000002/v2_201503100122/S217351151500024X/v2_201503100122/en/main.assets"
    ]
  ]
  "en" => array:9 [
    "idiomaDefecto" => true
    "titulo" => "Type I diabetes&#58; a new risk factor for obstructive sleep apnea"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "53"
        "paginaFinal" => "54"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Geraldo Lorenzi-Filho, Luciano F&#46; Drager"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "Geraldo"
            "apellidos" => "Lorenzi-Filho"
            "email" => array:1 [
              0 => "geraldo&#46;lorenzi&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Luciano F&#46;"
            "apellidos" => "Drager"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Pulmonary Division, Sleep Laboratory; Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Hypertension Unit, Heart Institute (InCor), Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brasil"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
            "correspondencia" => "Corresponding author. geraldo.lorenzi@gmail.com"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara">Obstructive sleep apnea &#40;OSA&#41; is common in the general population but remains largely under recognized&#46;<a href="&#35;bib1" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">1</span></a> Risk factors for OSA include male gender&#44; obesity and increasing age&#46;<a href="&#35;bib1" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib2" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">2</span></a> There is growing evidence that OSA may cause several consequences including not only poor sleep quality and excessive daytime sleepiness but also contribute to detrimental cardiometabolic consequences&#46;<a href="&#35;bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib4" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a> Therefore&#44; recognizing populations that are at increased risk should help to detect OSA&#46; In the present number of the Portuguese Journal of Pulmonology&#44; Vale and colleagues provide novel evidence suggesting that type I diabetes is strongly associated with OSA&#46;<a href="&#35;bib5" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">5</span></a> The authors used portable monitoring to evaluate the presence of sleep disordered breathing among 46 adults with diabetes&#44; divided in 23 with type I and 23 type II diabetes&#46; Because OSA and type II diabetes share several common risk factors such as obesity&#44; it is not surprising that OSA was extremely frequent in this population&#46; This finding is therefore in line with several studies and point out to the low levels of OSA recognition among patients with type 2 diabetes&#46;<a href="&#35;bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a> Vale and colleagues took a step forward and showed a similar high frequency of OSA among adult patients with type I diabetes as compared with those with type II diabetes&#46; Despite the fact that the patients with type I were not particularly obese &#40;mean body mass index of 28&#160;kg&#47;m<span class="elsevierStyleSup">2</span>&#41; and were in fact much younger than those with type II diabetes &#40;mean age of 39 vs 62 years old&#44; respectively&#41; the frequency of OSA was similar among the two groups and ranged from 26 to 70&#37; depending of the apnea hypopnea index criterion for OSA definition&#46; The study is therefore in line with recent evidence pointing out that not only type II diabetes&#44; but also type I diabetes is associated with a high prevalence of OSA&#46;<a href="&#35;bib6" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib7" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a> Another important message of the study of Vale and colleagues was that there was no association between OSA and complaints of excessive daytime sleepiness among patients with diabetes&#46; In contrast to patients referred to sleep laboratories&#44; among consecutive patients with cardiovascular diseases such as hypertension as well among those with metabolic syndrome and diabetes&#44; the association between OSA and excessive daytime sleepiness is very poor or non- existent&#46;<a href="&#35;bib4" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib8" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">8</span></a> This raises one important question&#58; What is the real significance of an altered sleep study among patients with no overt symptoms&#63; The current working hypothesis is that OSA is more than a common condition but when present contributes to poor cardiovascular and metabolic outcome&#46;<a href="&#35;bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a> The primary mechanisms that are deleterious to the cardiovascular and metabolic system includes increased negative intrathoracic pressure during the efforts for breath against an occluded airway&#44; arousals from sleep and intermittent hypoxia&#46; There is growing evidence that these primary events that occur during sleep trigger a cascade of detrimental effects&#44; including increased sympathetic activity&#44; oxidative stress&#44; metabolic deregulation such as insulin resistance and lipid dysfunction&#44; endothelial dysfunction and accelerated atherosclerosis&#46;<a href="&#35;bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a> Consistent with the hypothesis that OSA may contribute to poor glicemic control&#44; Vale and colleagues found that the AHI was significantly lower and in the normal range among patients with type II diabetes and normal glycosylated hemoglobin &#40;HbA1c&#41; as compared to patients with type II diabetes and elevated HbA1C&#46; The serum level of HbA1C is known to reflect average glycemia over the preceding 2&#8211;3 months and therefore one possible conclusion is that OSA contributed to poor glicemic control&#46; The interpretation of such cross sectional data is&#44; however&#44; limited and the authors acknowledged that due to the relatively small sample they were under powered to correct for confounding variables&#46; There is some evidence that OSA treatment promotes better glucose control in type 2 diabetes&#46;<a href="&#35;bib9" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">9</span></a> Future randomized studies are necessary in order to evaluate whether treatment of OSA contributes to a better control of type I diabetes&#46; Another important aspect that the study of Vale and colleagues raises is the relationship between type I diabetes and sleep&#46; It must be stressed that type I diabetes and glicemic control may affect circadian rhythms&#44; sleep duration and quality of sleep&#46;<a href="&#35;bib10" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">10</span></a> Therefore the interaction of such factors may go far beyond OSA&#46; One attractive hypothesis is that diabetes may cause subtle alterations in the upper airway function&#46; Consistent with this hypothesis&#44; diabetes was recently associated with decreased nasal mucociliary function&#46;<a href="&#35;bib11" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">11</span></a> Although not directly related to OSA pathogenesis&#44; it raises the hypothesis that other functions such as upper airway neuro reflexes that are important to stabilize the upper airway during sleep are impaired among patients with long lasting type I diabetes&#46; Recent studies showed that OSA was independently associated with macrovascular complications&#44; retinopathy as well as cardiovascular autonomic neuropathy among patients with type I diabetes&#46;<a href="&#35;bib7" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib12" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">12</span></a> Therefore&#44; OSA could also be seen as a complication of diabetes&#46; Independent of the exact mechanism linking type I diabetes to OSA&#44; the study of Vale and colleagues contribute to the hypothesis that OSA should be actively searched not only among patients with type II diabetes but also among those with type I diabetes&#46;</p><p class="elsevierStylePara">Corresponding author&#46; geraldo&#46;lorenzi&#64;gmail&#46;com</p>"
    "pdfFichero" => "320v21n02a90393302pdf001.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:12 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study. Sleep Med. 2010; 11(5):441&#x002D;6."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Tufik S"
                            1 => "Santos-Silva R"
                            2 => "Taddei JA"
                            3 => "Bittencourt LR&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.sleep.2009.10.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep Med. "
                        "fecha" => "2010"
                        "volumen" => "11"
                        "paginaInicial" => "441"
                        "paginaFinal" => "446"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20362502"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Upper airway collapsibility is associated with obesity and hyoid position Sleep. 2014; 37(10):1673&#x002D;8."
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Genta PR"
                            1 => "Schorr F"
                            2 => "Eckert DJ"
                            3 => "Gebrim E"
                            4 => "Kayamori F"
                            5 => "Moriya HT"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5665/sleep.4078"
                      "Revista" => array:6 [
                        "tituloSerie" => "Upper airway collapsibility is associated with obesity and hyoid position Sleep. "
                        "fecha" => "2014"
                        "volumen" => "37"
                        "paginaInicial" => "1673"
                        "paginaFinal" => "1678"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25197805"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome. J Am Coll Cardiol. 2013; 62(7):569&#x002D;76."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Obstructive sleep apnea&#58; a cardiometabolic risk in obesity and the metabolic syndrome&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Drager LF"
                            1 => "Togeiro SM"
                            2 => "Polotsky VY"
                            3 => "Lorenzi-Filho G&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2013.05.045"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Coll Cardiol. "
                        "fecha" => "2013"
                        "volumen" => "62"
                        "paginaInicial" => "569"
                        "paginaFinal" => "576"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23770180"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673613626756"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Atherosclerosis. The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome. Atherosclerosis. 2010; 208(2):490&#x002D;5."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Atherosclerosis&#46; The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Drager LF"
                            1 => "Bortolotto LA"
                            2 => "Maki-Nunes C"
                            3 => "Trombetta IC"
                            4 => "Alves MJ"
                            5 => "Fraga RF"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2009.08.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis. "
                        "fecha" => "2010"
                        "volumen" => "208"
                        "paginaInicial" => "490"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19762024"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Vale J, Manuel P, Oliveira E, Oliveira AR, Silva E, Melo V, et al. Obstructive sleep apnea and diabetes mellitus. Rev Port Pneumol. http://dx.doi.org/10.1016/j.rppnen.2014.07.005."
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vale J&#44; Manuel P&#44; Oliveira E&#44; Oliveira AR&#44; Silva E&#44; Melo V&#44; et al&#46; Obstructive sleep apnea and diabetes mellitus&#46; Rev Port Pneumol&#46; http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppnen&#46;2014&#46;07&#46;005&#46;"
                      "idioma" => "pt"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "Vale J&#44; Manuel P&#44; Oliveira E&#44; Oliveira AR&#44; Silva E&#44; Melo V&#44; et al&#46; Obstructive sleep apnea and diabetes mellitus&#46; Rev Port Pneumol&#46; http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppnen&#46;2014&#46;07&#46;005&#46;"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "High prevalence of obstructive sleep apnoea syndrome in a Type 1 diabetic adult population: a pilot study. Diabet Med. 2010; 27(11):1328&#x002D;9."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "High prevalence of obstructive sleep apnoea syndrome in a Type 1 diabetic adult population&#58; a pilot study&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Borel AL"
                            1 => "Benhamou PY"
                            2 => "Baguet JP"
                            3 => "Halimi S"
                            4 => "Levy P"
                            5 => "Mallion JM"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1464-5491.2010.03096.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabet Med. "
                        "fecha" => "2010"
                        "volumen" => "27"
                        "paginaInicial" => "1328"
                        "paginaFinal" => "1329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20950392"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Obstructive sleep apnoea in people with Type 1 diabetes: prevalence and association with micro&#x002D; and macrovascular complications. Diabet Med. 2015; 32(1):90&#x002D;6."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Obstructive sleep apnoea in people with Type 1 diabetes&#58; prevalence and association with micro- and macrovascular complications&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Manin G"
                            1 => "Pons A"
                            2 => "Baltzinger P"
                            3 => "Moreau F"
                            4 => "Iamandi C"
                            5 => "Wilhelm JM"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dme.12582"
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabet Med. "
                        "fecha" => "2015"
                        "volumen" => "32"
                        "paginaInicial" => "90"
                        "paginaFinal" => "96"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25186832"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1098301512041320"
                          "estado" => "S300"
                          "issn" => "10983015"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Characteristics and predictors of obstructive sleep apnea in patients with systemic hypertension. Am J Cardiol. 2010; 105(8):1135&#x002D;9."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Characteristics and predictors of obstructive sleep apnea in patients with systemic hypertension&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Drager LF"
                            1 => "Genta PR"
                            2 => "Pedrosa RP"
                            3 => "Nerbass FB"
                            4 => "Gonzaga CC"
                            5 => "Krieger EM"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2009.12.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol. "
                        "fecha" => "2010"
                        "volumen" => "105"
                        "paginaInicial" => "1135"
                        "paginaFinal" => "1139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20381666"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea. Arch Intern Med. 2005; 165(4):447&#x002D;52."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Type 2 diabetes&#44; glycemic control&#44; and continuous positive airway pressure in obstructive sleep apnea&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Babu AR"
                            1 => "Herdegen J"
                            2 => "Fogelfeld L"
                            3 => "Shott S"
                            4 => "Mazzone T&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archinte.165.4.447"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med. "
                        "fecha" => "2005"
                        "volumen" => "165"
                        "paginaInicial" => "447"
                        "paginaFinal" => "452"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15738376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Type 1 Diabetes associated with sleep disorders. Sleep Science. 2009; 2(2):96&#x002D;8."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Type 1 Diabetes associated with sleep disorders&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Barone MTU"
                            1 => "Menna-Barreto L&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Sleep Science. "
                        "fecha" => "2009"
                        "volumen" => "2"
                        "paginaInicial" => "96"
                        "paginaFinal" => "98"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Aging, diabetes, and hypertension are associated with decreased nasal mucociliary clearance. Chest. 2013; 143(4):1091&#x002D;7."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Aging&#44; diabetes&#44; and hypertension are associated with decreased nasal mucociliary clearance&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "de Oliveira-Maul JP"
                            1 => "de Carvalho HB"
                            2 => "Miyuki Goto D"
                            3 => "Mendon&#231;a Maia R"
                            4 => "Fl&#243; C"
                            5 => "Barnab&#233; V"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.12-1183"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest. "
                        "fecha" => "2013"
                        "volumen" => "143"
                        "paginaInicial" => "1091"
                        "paginaFinal" => "1097"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23100111"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Front Endocrinol (Lausanne). Cardiovascular autonomic neuropathy contributes to sleep apnea in young and lean type 1 diabetes mellituspatients. Front Endocrinol (Lausanne). 2014; 5:119."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Front Endocrinol &#40;Lausanne&#41;&#46; Cardiovascular autonomic neuropathy contributes to sleep apnea in young and lean type 1 diabetes mellituspatients&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Janovsky CC"
                            1 => "Rolim LC"
                            2 => "de S&#225; JR"
                            3 => "Poyares D"
                            4 => "Tufik S"
                            5 => "Silva AB"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fendo.2014.00119"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Endocrinol (Lausanne). "
                        "fecha" => "2014"
                        "volumen" => "5"
                        "paginaInicial" => "119"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25157241"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08732159/0000002100000002/v0_201604141148/X0873215915933025/v0_201604141148/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "18132"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Editoriais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08732159/0000002100000002/v0_201604141148/X0873215915933025/v0_201604141148/en/320v21n02a90393302pdf001.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915933025?idApp=UINPBA00004E"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Type I diabetes: a new risk factor for obstructive sleep apnea
Geraldo Lorenzi-Filhoa,
Corresponding author
geraldo.lorenzi@gmail.com

Corresponding author. geraldo.lorenzi@gmail.com
, Luciano F. Dragerb
a Pulmonary Division, Sleep Laboratory; Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil
b Hypertension Unit, Heart Institute (InCor), Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brasil
Read
9380
Times
was read the article
3285
Total PDF
6095
Total HTML
Share statistics
 array:21 [
  "pii" => "X0873215915933025"
  "issn" => "08732159"
  "doi" => "10.1016/j.rppnen.2015.02.002"
  "estado" => "S300"
  "fechaPublicacion" => "2015-03-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Pneumol. 2015;21:53-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4846
    "formatos" => array:3 [
      "EPUB" => 262
      "HTML" => 3021
      "PDF" => 1563
    ]
  ]
  "itemSiguiente" => array:16 [
    "pii" => "X0873215915933033"
    "issn" => "08732159"
    "doi" => "10.1016/j.rppnen.2014.07.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-03-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2015;21:55-60"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5395
      "formatos" => array:3 [
        "EPUB" => 260
        "HTML" => 3951
        "PDF" => 1184
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "Obstructive sleep apnea and diabetes mellitus"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "55"
          "paginaFinal" => "60"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier Espa&#241;a"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "320v21n02-90393303fig1.jpg"
              "Alto" => 939
              "Ancho" => 1621
              "Tamanyo" => 157359
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Graph 1&#46; Glycemic control in type 2 DM and apnea&#191;hypopnea index&#46;"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jorge Vale, Paula Manuel, Eurico Oliveira, Ana Rita Oliveira, Eloisa Silva, Vitor Melo, Marta Sousa, Jo&#227;o Carlos Alexandre, Isabel Gil, Amparo Sanchez, Edite Nascimento, Ant&#243;nio Sim&#245;es Torres"
          "autores" => array:12 [
            0 => array:2 [
              "nombre" => "Jorge"
              "apellidos" => "Vale"
            ]
            1 => array:2 [
              "nombre" => "Paula"
              "apellidos" => "Manuel"
            ]
            2 => array:2 [
              "nombre" => "Eurico"
              "apellidos" => "Oliveira"
            ]
            3 => array:2 [
              "nombre" => "Ana Rita"
              "apellidos" => "Oliveira"
            ]
            4 => array:2 [
              "nombre" => "Eloisa"
              "apellidos" => "Silva"
            ]
            5 => array:2 [
              "nombre" => "Vitor"
              "apellidos" => "Melo"
            ]
            6 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Sousa"
            ]
            7 => array:2 [
              "nombre" => "Jo&#227;o Carlos"
              "apellidos" => "Alexandre"
            ]
            8 => array:2 [
              "nombre" => "Isabel"
              "apellidos" => "Gil"
            ]
            9 => array:2 [
              "nombre" => "Amparo"
              "apellidos" => "Sanchez"
            ]
            10 => array:2 [
              "nombre" => "Edite"
              "apellidos" => "Nascimento"
            ]
            11 => array:2 [
              "nombre" => "Ant&#243;nio Sim&#245;es"
              "apellidos" => "Torres"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915933033?idApp=UINPBA00004E"
    "url" => "/08732159/0000002100000002/v0_201604141148/X0873215915933033/v0_201604141148/en/main.assets"
  ]
  "itemAnterior" => array:16 [
    "pii" => "X0873215915933017"
    "issn" => "08732159"
    "doi" => "10.1016/j.rppnen.2015.02.005"
    "estado" => "S300"
    "fechaPublicacion" => "2015-03-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2015;21:51-2"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3116
      "formatos" => array:3 [
        "EPUB" => 261
        "HTML" => 1957
        "PDF" => 898
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "titulo" => "What we have done so far and what we can achieve &#40;II&#41;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "51"
          "paginaFinal" => "52"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier Espa&#241;a"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "320v21n02-90393301fig1.jpg"
              "Alto" => 1389
              "Ancho" => 1489
              "Tamanyo" => 152850
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Evolution of visits and pages consulted in the PJP webpage over the past three years&#46;"
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915933017?idApp=UINPBA00004E"
    "url" => "/08732159/0000002100000002/v0_201604141148/X0873215915933017/v0_201604141148/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:19 [
      "pii" => "S217351151500024X"
      "issn" => "21735115"
      "doi" => "10.1016/j.rppnen.2014.07.005"
      "estado" => "S300"
      "fechaPublicacion" => "2015-03-01"
      "aid" => "1028"
      "copyright" => "Sociedade Portuguesa de Pneumologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Rev Port Pneumol. 2015;21:55-60"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 2006
        "formatos" => array:3 [
          "EPUB" => 237
          "HTML" => 1129
          "PDF" => 640
        ]
      ]
      "en" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
        "titulo" => "Obstructive sleep apnea and diabetes mellitus"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "55"
            "paginaFinal" => "60"
          ]
        ]
        "contieneResumen" => array:1 [
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Graph 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 939
                "Ancho" => 1621
                "Tamanyo" => 66394
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Glycemic control in type 2 DM and apnea&#8211;hypopnea index&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jorge Vale, Paula Manuel, Eurico Oliveira, Ana Rita Oliveira, Eloisa Silva, Vitor Melo, Marta Sousa, Jo&#227;o Carlos Alexandre, Isabel Gil, Amparo Sanchez, Edite Nascimento, Ant&#243;nio Sim&#245;es Torres"
            "autores" => array:12 [
              0 => array:2 [
                "nombre" => "Jorge"
                "apellidos" => "Vale"
              ]
              1 => array:2 [
                "nombre" => "Paula"
                "apellidos" => "Manuel"
              ]
              2 => array:2 [
                "nombre" => "Eurico"
                "apellidos" => "Oliveira"
              ]
              3 => array:2 [
                "nombre" => "Ana Rita"
                "apellidos" => "Oliveira"
              ]
              4 => array:2 [
                "nombre" => "Eloisa"
                "apellidos" => "Silva"
              ]
              5 => array:2 [
                "nombre" => "Vitor"
                "apellidos" => "Melo"
              ]
              6 => array:2 [
                "nombre" => "Marta"
                "apellidos" => "Sousa"
              ]
              7 => array:2 [
                "nombre" => "Jo&#227;o Carlos"
                "apellidos" => "Alexandre"
              ]
              8 => array:2 [
                "nombre" => "Isabel"
                "apellidos" => "Gil"
              ]
              9 => array:2 [
                "nombre" => "Amparo"
                "apellidos" => "Sanchez"
              ]
              10 => array:2 [
                "nombre" => "Edite"
                "apellidos" => "Nascimento"
              ]
              11 => array:2 [
                "nombre" => "Ant&#243;nio Sim&#245;es"
                "apellidos" => "Torres"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217351151500024X?idApp=UINPBA00004E"
      "url" => "/21735115/0000002100000002/v2_201503100122/S217351151500024X/v2_201503100122/en/main.assets"
    ]
  ]
  "en" => array:9 [
    "idiomaDefecto" => true
    "titulo" => "Type I diabetes&#58; a new risk factor for obstructive sleep apnea"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "53"
        "paginaFinal" => "54"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Geraldo Lorenzi-Filho, Luciano F&#46; Drager"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "Geraldo"
            "apellidos" => "Lorenzi-Filho"
            "email" => array:1 [
              0 => "geraldo&#46;lorenzi&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Luciano F&#46;"
            "apellidos" => "Drager"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Pulmonary Division, Sleep Laboratory; Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Hypertension Unit, Heart Institute (InCor), Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brasil"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
            "correspondencia" => "Corresponding author. geraldo.lorenzi@gmail.com"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara">Obstructive sleep apnea &#40;OSA&#41; is common in the general population but remains largely under recognized&#46;<a href="&#35;bib1" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">1</span></a> Risk factors for OSA include male gender&#44; obesity and increasing age&#46;<a href="&#35;bib1" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib2" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">2</span></a> There is growing evidence that OSA may cause several consequences including not only poor sleep quality and excessive daytime sleepiness but also contribute to detrimental cardiometabolic consequences&#46;<a href="&#35;bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib4" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a> Therefore&#44; recognizing populations that are at increased risk should help to detect OSA&#46; In the present number of the Portuguese Journal of Pulmonology&#44; Vale and colleagues provide novel evidence suggesting that type I diabetes is strongly associated with OSA&#46;<a href="&#35;bib5" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">5</span></a> The authors used portable monitoring to evaluate the presence of sleep disordered breathing among 46 adults with diabetes&#44; divided in 23 with type I and 23 type II diabetes&#46; Because OSA and type II diabetes share several common risk factors such as obesity&#44; it is not surprising that OSA was extremely frequent in this population&#46; This finding is therefore in line with several studies and point out to the low levels of OSA recognition among patients with type 2 diabetes&#46;<a href="&#35;bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a> Vale and colleagues took a step forward and showed a similar high frequency of OSA among adult patients with type I diabetes as compared with those with type II diabetes&#46; Despite the fact that the patients with type I were not particularly obese &#40;mean body mass index of 28&#160;kg&#47;m<span class="elsevierStyleSup">2</span>&#41; and were in fact much younger than those with type II diabetes &#40;mean age of 39 vs 62 years old&#44; respectively&#41; the frequency of OSA was similar among the two groups and ranged from 26 to 70&#37; depending of the apnea hypopnea index criterion for OSA definition&#46; The study is therefore in line with recent evidence pointing out that not only type II diabetes&#44; but also type I diabetes is associated with a high prevalence of OSA&#46;<a href="&#35;bib6" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib7" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a> Another important message of the study of Vale and colleagues was that there was no association between OSA and complaints of excessive daytime sleepiness among patients with diabetes&#46; In contrast to patients referred to sleep laboratories&#44; among consecutive patients with cardiovascular diseases such as hypertension as well among those with metabolic syndrome and diabetes&#44; the association between OSA and excessive daytime sleepiness is very poor or non- existent&#46;<a href="&#35;bib4" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib8" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">8</span></a> This raises one important question&#58; What is the real significance of an altered sleep study among patients with no overt symptoms&#63; The current working hypothesis is that OSA is more than a common condition but when present contributes to poor cardiovascular and metabolic outcome&#46;<a href="&#35;bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a> The primary mechanisms that are deleterious to the cardiovascular and metabolic system includes increased negative intrathoracic pressure during the efforts for breath against an occluded airway&#44; arousals from sleep and intermittent hypoxia&#46; There is growing evidence that these primary events that occur during sleep trigger a cascade of detrimental effects&#44; including increased sympathetic activity&#44; oxidative stress&#44; metabolic deregulation such as insulin resistance and lipid dysfunction&#44; endothelial dysfunction and accelerated atherosclerosis&#46;<a href="&#35;bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a> Consistent with the hypothesis that OSA may contribute to poor glicemic control&#44; Vale and colleagues found that the AHI was significantly lower and in the normal range among patients with type II diabetes and normal glycosylated hemoglobin &#40;HbA1c&#41; as compared to patients with type II diabetes and elevated HbA1C&#46; The serum level of HbA1C is known to reflect average glycemia over the preceding 2&#8211;3 months and therefore one possible conclusion is that OSA contributed to poor glicemic control&#46; The interpretation of such cross sectional data is&#44; however&#44; limited and the authors acknowledged that due to the relatively small sample they were under powered to correct for confounding variables&#46; There is some evidence that OSA treatment promotes better glucose control in type 2 diabetes&#46;<a href="&#35;bib9" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">9</span></a> Future randomized studies are necessary in order to evaluate whether treatment of OSA contributes to a better control of type I diabetes&#46; Another important aspect that the study of Vale and colleagues raises is the relationship between type I diabetes and sleep&#46; It must be stressed that type I diabetes and glicemic control may affect circadian rhythms&#44; sleep duration and quality of sleep&#46;<a href="&#35;bib10" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">10</span></a> Therefore the interaction of such factors may go far beyond OSA&#46; One attractive hypothesis is that diabetes may cause subtle alterations in the upper airway function&#46; Consistent with this hypothesis&#44; diabetes was recently associated with decreased nasal mucociliary function&#46;<a href="&#35;bib11" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">11</span></a> Although not directly related to OSA pathogenesis&#44; it raises the hypothesis that other functions such as upper airway neuro reflexes that are important to stabilize the upper airway during sleep are impaired among patients with long lasting type I diabetes&#46; Recent studies showed that OSA was independently associated with macrovascular complications&#44; retinopathy as well as cardiovascular autonomic neuropathy among patients with type I diabetes&#46;<a href="&#35;bib7" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a><span class="elsevierStyleSup">&#44; </span><a href="&#35;bib12" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">12</span></a> Therefore&#44; OSA could also be seen as a complication of diabetes&#46; Independent of the exact mechanism linking type I diabetes to OSA&#44; the study of Vale and colleagues contribute to the hypothesis that OSA should be actively searched not only among patients with type II diabetes but also among those with type I diabetes&#46;</p><p class="elsevierStylePara">Corresponding author&#46; geraldo&#46;lorenzi&#64;gmail&#46;com</p>"
    "pdfFichero" => "320v21n02a90393302pdf001.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:12 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study. Sleep Med. 2010; 11(5):441&#x002D;6."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Tufik S"
                            1 => "Santos-Silva R"
                            2 => "Taddei JA"
                            3 => "Bittencourt LR&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.sleep.2009.10.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep Med. "
                        "fecha" => "2010"
                        "volumen" => "11"
                        "paginaInicial" => "441"
                        "paginaFinal" => "446"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20362502"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Upper airway collapsibility is associated with obesity and hyoid position Sleep. 2014; 37(10):1673&#x002D;8."
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Genta PR"
                            1 => "Schorr F"
                            2 => "Eckert DJ"
                            3 => "Gebrim E"
                            4 => "Kayamori F"
                            5 => "Moriya HT"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5665/sleep.4078"
                      "Revista" => array:6 [
                        "tituloSerie" => "Upper airway collapsibility is associated with obesity and hyoid position Sleep. "
                        "fecha" => "2014"
                        "volumen" => "37"
                        "paginaInicial" => "1673"
                        "paginaFinal" => "1678"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25197805"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome. J Am Coll Cardiol. 2013; 62(7):569&#x002D;76."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Obstructive sleep apnea&#58; a cardiometabolic risk in obesity and the metabolic syndrome&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Drager LF"
                            1 => "Togeiro SM"
                            2 => "Polotsky VY"
                            3 => "Lorenzi-Filho G&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2013.05.045"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Coll Cardiol. "
                        "fecha" => "2013"
                        "volumen" => "62"
                        "paginaInicial" => "569"
                        "paginaFinal" => "576"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23770180"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673613626756"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Atherosclerosis. The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome. Atherosclerosis. 2010; 208(2):490&#x002D;5."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Atherosclerosis&#46; The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Drager LF"
                            1 => "Bortolotto LA"
                            2 => "Maki-Nunes C"
                            3 => "Trombetta IC"
                            4 => "Alves MJ"
                            5 => "Fraga RF"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2009.08.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis. "
                        "fecha" => "2010"
                        "volumen" => "208"
                        "paginaInicial" => "490"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19762024"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Vale J, Manuel P, Oliveira E, Oliveira AR, Silva E, Melo V, et al. Obstructive sleep apnea and diabetes mellitus. Rev Port Pneumol. http://dx.doi.org/10.1016/j.rppnen.2014.07.005."
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vale J&#44; Manuel P&#44; Oliveira E&#44; Oliveira AR&#44; Silva E&#44; Melo V&#44; et al&#46; Obstructive sleep apnea and diabetes mellitus&#46; Rev Port Pneumol&#46; http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppnen&#46;2014&#46;07&#46;005&#46;"
                      "idioma" => "pt"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "Vale J&#44; Manuel P&#44; Oliveira E&#44; Oliveira AR&#44; Silva E&#44; Melo V&#44; et al&#46; Obstructive sleep apnea and diabetes mellitus&#46; Rev Port Pneumol&#46; http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppnen&#46;2014&#46;07&#46;005&#46;"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "High prevalence of obstructive sleep apnoea syndrome in a Type 1 diabetic adult population: a pilot study. Diabet Med. 2010; 27(11):1328&#x002D;9."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "High prevalence of obstructive sleep apnoea syndrome in a Type 1 diabetic adult population&#58; a pilot study&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Borel AL"
                            1 => "Benhamou PY"
                            2 => "Baguet JP"
                            3 => "Halimi S"
                            4 => "Levy P"
                            5 => "Mallion JM"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1464-5491.2010.03096.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabet Med. "
                        "fecha" => "2010"
                        "volumen" => "27"
                        "paginaInicial" => "1328"
                        "paginaFinal" => "1329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20950392"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Obstructive sleep apnoea in people with Type 1 diabetes: prevalence and association with micro&#x002D; and macrovascular complications. Diabet Med. 2015; 32(1):90&#x002D;6."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Obstructive sleep apnoea in people with Type 1 diabetes&#58; prevalence and association with micro- and macrovascular complications&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Manin G"
                            1 => "Pons A"
                            2 => "Baltzinger P"
                            3 => "Moreau F"
                            4 => "Iamandi C"
                            5 => "Wilhelm JM"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dme.12582"
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabet Med. "
                        "fecha" => "2015"
                        "volumen" => "32"
                        "paginaInicial" => "90"
                        "paginaFinal" => "96"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25186832"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1098301512041320"
                          "estado" => "S300"
                          "issn" => "10983015"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Characteristics and predictors of obstructive sleep apnea in patients with systemic hypertension. Am J Cardiol. 2010; 105(8):1135&#x002D;9."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Characteristics and predictors of obstructive sleep apnea in patients with systemic hypertension&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Drager LF"
                            1 => "Genta PR"
                            2 => "Pedrosa RP"
                            3 => "Nerbass FB"
                            4 => "Gonzaga CC"
                            5 => "Krieger EM"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2009.12.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol. "
                        "fecha" => "2010"
                        "volumen" => "105"
                        "paginaInicial" => "1135"
                        "paginaFinal" => "1139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20381666"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea. Arch Intern Med. 2005; 165(4):447&#x002D;52."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Type 2 diabetes&#44; glycemic control&#44; and continuous positive airway pressure in obstructive sleep apnea&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Babu AR"
                            1 => "Herdegen J"
                            2 => "Fogelfeld L"
                            3 => "Shott S"
                            4 => "Mazzone T&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archinte.165.4.447"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med. "
                        "fecha" => "2005"
                        "volumen" => "165"
                        "paginaInicial" => "447"
                        "paginaFinal" => "452"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15738376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Type 1 Diabetes associated with sleep disorders. Sleep Science. 2009; 2(2):96&#x002D;8."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Type 1 Diabetes associated with sleep disorders&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Barone MTU"
                            1 => "Menna-Barreto L&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Sleep Science. "
                        "fecha" => "2009"
                        "volumen" => "2"
                        "paginaInicial" => "96"
                        "paginaFinal" => "98"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Aging, diabetes, and hypertension are associated with decreased nasal mucociliary clearance. Chest. 2013; 143(4):1091&#x002D;7."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Aging&#44; diabetes&#44; and hypertension are associated with decreased nasal mucociliary clearance&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "de Oliveira-Maul JP"
                            1 => "de Carvalho HB"
                            2 => "Miyuki Goto D"
                            3 => "Mendon&#231;a Maia R"
                            4 => "Fl&#243; C"
                            5 => "Barnab&#233; V"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.12-1183"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest. "
                        "fecha" => "2013"
                        "volumen" => "143"
                        "paginaInicial" => "1091"
                        "paginaFinal" => "1097"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23100111"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Front Endocrinol (Lausanne). Cardiovascular autonomic neuropathy contributes to sleep apnea in young and lean type 1 diabetes mellituspatients. Front Endocrinol (Lausanne). 2014; 5:119."
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Front Endocrinol &#40;Lausanne&#41;&#46; Cardiovascular autonomic neuropathy contributes to sleep apnea in young and lean type 1 diabetes mellituspatients&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Janovsky CC"
                            1 => "Rolim LC"
                            2 => "de S&#225; JR"
                            3 => "Poyares D"
                            4 => "Tufik S"
                            5 => "Silva AB"
                            6 => "et-al&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fendo.2014.00119"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Endocrinol (Lausanne). "
                        "fecha" => "2014"
                        "volumen" => "5"
                        "paginaInicial" => "119"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25157241"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/08732159/0000002100000002/v0_201604141148/X0873215915933025/v0_201604141148/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "18132"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Editoriais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08732159/0000002100000002/v0_201604141148/X0873215915933025/v0_201604141148/en/320v21n02a90393302pdf001.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215915933025?idApp=UINPBA00004E"
]
Article information
ISSN: 08732159
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 13 3 16
2024 October 54 44 98
2024 September 44 48 92
2024 August 63 48 111
2024 July 52 37 89
2024 June 52 51 103
2024 May 58 34 92
2024 April 58 27 85
2024 March 47 27 74
2024 February 46 24 70
2024 January 50 28 78
2023 December 35 27 62
2023 November 40 27 67
2023 October 31 32 63
2023 September 32 33 65
2023 August 34 18 52
2023 July 37 30 67
2023 June 31 22 53
2023 May 55 25 80
2023 April 40 22 62
2023 March 75 17 92
2023 February 59 19 78
2023 January 34 17 51
2022 December 57 31 88
2022 November 75 40 115
2022 October 69 36 105
2022 September 36 30 66
2022 August 51 39 90
2022 July 46 47 93
2022 June 33 36 69
2022 May 40 45 85
2022 April 39 34 73
2022 March 36 36 72
2022 February 40 36 76
2022 January 39 33 72
2021 December 32 49 81
2021 November 37 31 68
2021 October 50 45 95
2021 September 43 33 76
2021 August 51 23 74
2021 July 38 18 56
2021 June 35 25 60
2021 May 37 18 55
2021 April 81 66 147
2021 March 68 27 95
2021 February 63 19 82
2021 January 45 23 68
2020 December 46 17 63
2020 November 62 18 80
2020 October 66 25 91
2020 September 66 27 93
2020 August 128 24 152
2020 July 125 19 144
2020 June 84 15 99
2020 May 101 20 121
2020 April 82 17 99
2020 March 91 44 135
2020 February 100 36 136
2020 January 119 16 135
2019 December 72 20 92
2019 November 66 25 91
2019 October 64 644 708
2019 September 76 21 97
2019 August 147 21 168
2019 July 123 27 150
2019 June 136 31 167
2019 May 148 24 172
2019 April 101 21 122
2019 March 142 21 163
2019 February 93 10 103
2019 January 117 33 150
2018 December 68 7 75
2018 November 26 1 27
2018 October 29 8 37
2018 September 22 9 31
2018 August 29 22 51
2018 July 35 18 53
2018 June 33 15 48
2018 May 48 20 68
2018 April 89 25 114
2018 March 75 18 93
2018 February 69 12 81
2018 January 59 12 71
2017 December 101 14 115
2017 November 36 13 49
2017 October 11 14 25
2017 September 23 19 42
2017 August 21 24 45
2017 July 17 8 25
2017 June 27 15 42
2017 May 20 11 31
2017 April 7 1 8
2017 March 14 6 20
2017 February 4 4 8
2017 January 6 7 13
2016 December 8 2 10
2016 November 6 3 9
2016 October 4 1 5
2016 September 3 0 3
2016 August 6 5 11
2016 July 5 13 18
2016 June 4 0 4
2016 May 0 15 15
2016 April 25 1 26
2016 March 33 16 49
2016 February 29 19 48
2016 January 29 12 41
2015 December 33 18 51
2015 November 27 9 36
2015 October 27 12 39
2015 September 32 11 43
2015 August 42 11 53
2015 July 35 6 41
2015 June 36 14 50
2015 May 52 18 70
2015 April 138 68 206
2015 March 116 72 188
Show all

Follow this link to access the full text of the article

Pulmonology

Are you a health professional able to prescribe or dispense drugs?