Limitations of evidence-based medicine
Read
1662
Timeswas read the article
727
Total PDF
935
Total HTML
Share statistics
array:20 [ "pii" => "X0873215916479419" "issn" => "08732159" "doi" => "10.1016/j.rppnen.2015.12.007" "estado" => "S300" "fechaPublicacion" => "2016-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2016;22:4-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 519 "formatos" => array:2 [ "HTML" => 319 "PDF" => 200 ] ] "itemSiguiente" => array:16 [ "pii" => "X0873215916479427" "issn" => "08732159" "doi" => "10.1016/j.rppnen.2015.08.005" "estado" => "S300" "fechaPublicacion" => "2016-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2016;22:6-10" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 574 "formatos" => array:2 [ "HTML" => 353 "PDF" => 221 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Overlap syndrome – Asthma and obstructive sleep apnea" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "6" "paginaFinal" => "10" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Madama, A. Silva, M.J. Matos" "autores" => array:3 [ 0 => array:2 [ "Iniciales" => "D." "apellidos" => "Madama" ] 1 => array:2 [ "Iniciales" => "A." "apellidos" => "Silva" ] 2 => array:2 [ "Iniciales" => "M.J." "apellidos" => "Matos" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215916479427?idApp=UINPBA00004E" "url" => "/08732159/0000002200000001/v0_201604141139/X0873215916479427/v0_201604141139/en/main.assets" ] "itemAnterior" => array:16 [ "pii" => "X0873215916479400" "issn" => "08732159" "doi" => "10.1016/j.rppnen.2015.12.006" "estado" => "S300" "fechaPublicacion" => "2016-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2016;22:1-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 699 "formatos" => array:2 [ "HTML" => 440 "PDF" => 259 ] ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "Obstructive sleep apnoea syndrome is an under-recognized cause of uncontrolled asthma across the life cycle" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1" "paginaFinal" => "3" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Bousquet, A.A. Cruz, C. Robalo-Cordeiro" "autores" => array:3 [ 0 => array:2 [ "Iniciales" => "J." "apellidos" => "Bousquet" ] 1 => array:2 [ "Iniciales" => "A.A." "apellidos" => "Cruz" ] 2 => array:2 [ "Iniciales" => "C." "apellidos" => "Robalo-Cordeiro" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215916479400?idApp=UINPBA00004E" "url" => "/08732159/0000002200000001/v0_201604141139/X0873215916479400/v0_201604141139/en/main.assets" ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Limitations of evidence-based medicine" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "4" "paginaFinal" => "5" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.R. Bach, M. Chiou" "autores" => array:2 [ 0 => array:4 [ "Iniciales" => "J.R." "apellidos" => "Bach" "email" => array:1 [ 0 => "bachjr@njms.rutgers.edu" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "Iniciales" => "M." "apellidos" => "Chiou" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ, USA" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "correspondencia" => "Corresponding author. bachjr@njms.rutgers.edu" ] ] ] ] "textoCompleto" => "<p class="elsevierStylePara">Today, EBM is the gold standard for validating treatments and is transforming medicine into a scientific discipline.<a href="#bib1" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">1</span></a> Despite ethical and logistical considerations associated with placebo controls,<a href="#bib2" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">2</span></a> there is an ever-growing reliance on randomized double-blind placebo-controlled (RDBPC) trials over observational studies and case series. However, the fact that EBM suggests that RDBPC trials are necessary for high quality treatment recommendations, whereas observational studies and case series receive only low quality ratings, merits further scrutiny.<a href="#bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">, </span><a href="#bib4" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">, </span><a href="#bib5" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">5</span></a></p><p class="elsevierStylePara">Sackett et al. define EBM as, “the conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients.”<a href="#bib5" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">5</span></a> Thus, even if a cited treatment is unsupported by a placebo-controlled trial but is still the “best available evidence,” then the treatment would still be supported by EBM. Unfortunately, Sackett and the Cochrane group go on to classify “no controls, case-series only” as Level V evidence that “…contain useful information about clinical course and prognosis but can only hint at efficacy.”<a href="#bib4" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">4</span></a> They further describe the quality of this evidence as low.<a href="#bib3" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">3</span></a> This can lead to errors of interpretation by clinicians who, at least in the field of pulmonary medicine, often justify their overlooking of new, beneficial, and even life-saving approaches because they do not consider the evidence supporting them to be high quality.</p><p class="elsevierStylePara">Interventions that replace the function of a vital organ (or, for that matter, any organ) cannot be placebo controlled. Such interventions can only be compared for secondary benefits or for their capacity to more effectively normalize physiological parameters. For instance, although invasive continuous tracheostomy mechanical ventilation and continuous noninvasive ventilatory support (CNVS) cohorts can be compared to each other for secondary benefits and untoward effects, in the absence of measurable vital capacity (VC), they cannot be matched with placebo controls any more than can parachute use be studied in this manner for skydivers.<a href="#bib6" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">6</span></a></p><p class="elsevierStylePara">Prolongation of survival by CNVS for patients with Duchenne muscular dystrophy and “…a mean [VC of] 176 ± 102 mL, or 3% of predicted normal, which is not compatible with survival without continuous ventilator support,”<a href="#bib7" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">7</span></a> has been known since 1979.<a href="#bib8" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">8</span></a> The same has been reported for amyotrophic lateral sclerosis patients with VCs as low as unmeasurable<a href="#bib9" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">9</span></a> and other neuromuscular disease populations with less than 2% of normal VC. Submissions of these papers consistently draw comments from reviewers that there was no control group, so nothing can be generalized from them. Reviewers have gone so far as to state that prolongation of life by a few months with use of sleep-only bi-level positive airway pressure that has been documented by controlled studies is high quality evidence, but prolonging life by as much as 60 years with CNVS is not because there were no controls.</p><p class="elsevierStylePara">Placebo controls also cannot be used when substituting for or restoring the function of any organ unless the intervention is so minimally effective that it is difficult to determine any positive treatment effect at all. For example, placebo is not possible and controlled trials were never performed for dialysis or renal organ transplantation, mechanical ventilator support, cochlear implants or hearing aids, prosthetic legs or arms, hip and knee replacements, or parachutes in the absence of wings.<a href="#bib6" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">6</span></a> Remarkably, this stark limitation has yet to be considered in the literature.</p><p class="elsevierStylePara">Besides mechanical ventilation, expiratory muscles must be supported or substituted for by alternately applying positive and negative pressures to the airways to generate effective cough flows to prevent episodes of acute respiratory failure, and if one is intubated, to avoid extubation failure. In this manner, mechanical insufflation-exsufflation (MIE) expulses airway debris. While the cough-enhancing effectiveness of different devices and techniques can be compared, such interventions cannot ethically be placebo controlled; yet, intensivists are reticent to use MIE, despite high rates of extubation failure in many patient populations.<a href="#bib10" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">10</span></a> Scrupulous adherence to Cochrane EBM criteria can, and do, result in studies<a href="#bib11" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">11</span></a> being discredited. Consequently, acute respiratory failure and resort to tracheotomy occur because there are no “high quality” RDBPC studies of CNVS or MIE.</p><p class="elsevierStylePara">Modern medicine evolves by minor EBM-supported improvements on major breakthroughs. As EBM establishes the efficacy and safety of new approaches, it is nonetheless crucial to understand its limitations. As long as there exists an expectation that all innovations be grounded in RDBPC trials, the institution of life-saving innovations may remain unsubstantiated. Sackett supports the use of both individual clinical expertise and best available evidence as “evidence-based,” but too many tend to forget this.<a href="#bib5" class="elsevierStyleCrossRefs"><span class="elsevierStyleSup">5</span></a> Indeed, some medical journals offer free publication of the latter but not for observational studies.</p><a name="sec0005" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Funding</span><p class="elsevierStylePara">There was no external funding available for this work.</p><a name="sec0010" class="elsevierStyleCrossRefs"></a><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p class="elsevierStylePara">The authors have no conflicts of interest to report.</p><hr></hr><p class="elsevierStylePara">☆ Over 100,000 British sailors died from scurvy between 1500 and 1850 despite the fact that James Lind performed a prospective placebo-controlled clinical trial in 1747, which demonstrated that provisioning ships with citrus fruit could prevent disease. In 1753, Lind published a 400-page evidence-based medicine (EBM) “A Treatise of the Scurvy,” but British doctors could not fathom how lemons might affect humoral imbalance, the prevailing paradigm of that era. As a result, the British College of Physicians ignored Lind''s findings and instructed the Admiralty to carry sulfuric acid solutions rather than fruit, and for the next 40 years, British sailors continued to die of scurvy.</p><p class="elsevierStylePara">Corresponding author. bachjr@njms.rutgers.edu</p>" "pdfFichero" => "320v22n01a90447941pdf001.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Should we reconsider the routine use of placebo controls in clinical research?. Trials. 2012; 13:44." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Should we reconsider the routine use of placebo controls in clinical research?." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Avins AL" 1 => "Cherkin DC" 2 => "Sherman KJ" 3 => "Goldberg H" 4 => "Pressman A." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1745-6215-13-44" "Revista" => array:5 [ "tituloSerie" => "Trials. " "fecha" => "2012" "volumen" => "13" "paginaInicial" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22540350" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Challenges and recommendations for placebo controls in randomized trials in physical and rehabilitation medicine: a report of the International Placebo Symposium Working Group. Am J Phys Med Rehab/Assoc Acad Physiatr. 2010; 89:160-72." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Challenges and recommendations for placebo controls in randomized trials in physical and rehabilitation medicine: a report of the International Placebo Symposium Working Group." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Fregni F" 1 => "Imamura M" 2 => "Chien HF" 3 => "Lew HL" 4 => "Boggio P" 5 => "Kaptchuk TJ" 6 => "et-al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Phys Med Rehab/Assoc Acad Physiatr. " "fecha" => "2010" "volumen" => "89" "paginaInicial" => "160" "paginaFinal" => "172" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "En: Higgins J.P.T., Green S., editors. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The cochrane collaboration. 2011. Available from <inter-ref>www.cochrane-handbook.org</inter-ref>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Rules of evidence and clinical recommendations on the use of antithrombotic agents. Chest. 1989; 95:2S-4S." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Rules of evidence and clinical recommendations on the use of antithrombotic agents." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Sackett DL." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest. " "fecha" => "1989" "volumen" => "95" "paginaInicial" => "2S" "paginaFinal" => "4S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2914516" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Evidence based medicine: what it is and what it isn’t. BMJ. 1996; 312:71." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Evidence based medicine: what it is and what it isn’t." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Sackett DL" 1 => "Rosenberg WMC" 2 => "Gray JAM" 3 => "Haynes RB" 4 => "Richardson WS." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "BMJ. " "fecha" => "1996" "volumen" => "312" "paginaInicial" => "71" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8555924" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials. BMJ. 2003; 327:1459-61." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Smith GCS" 1 => "Pell JP." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.327.7429.1459" "Revista" => array:6 [ "tituloSerie" => "BMJ. " "fecha" => "2003" "volumen" => "327" "paginaInicial" => "1459" "paginaFinal" => "1461" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14684649" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Duchenne muscular dystrophy: continuous noninvasive ventilatory support prolongs survival. Respir Care. 2011; 56:744-50." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Duchenne muscular dystrophy: continuous noninvasive ventilatory support prolongs survival." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Bach JR" 1 => "Martinez D." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4187/respcare.00831" "Revista" => array:6 [ "tituloSerie" => "Respir Care. " "fecha" => "2011" "volumen" => "56" "paginaInicial" => "744" "paginaFinal" => "750" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21333078" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Mechanical ventilation of patients with late stage Duchenne muscular dystrophy: management in the home. Arch Phys Med Rehabil. 1979; 60:289-92." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Mechanical ventilation of patients with late stage Duchenne muscular dystrophy: management in the home." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Alexander MA" 1 => "Johnson EW" 2 => "Petty J" 3 => "Stauch D." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Phys Med Rehabil. " "fecha" => "1979" "volumen" => "60" "paginaInicial" => "289" "paginaFinal" => "292" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/454124" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Amyotrophic lateral sclerosis: prolongation of life by noninvasive respiratory aids. Chest. 2002; 122:92-8." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Amyotrophic lateral sclerosis: prolongation of life by noninvasive respiratory aids." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Bach JR." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest. " "fecha" => "2002" "volumen" => "122" "paginaInicial" => "92" "paginaFinal" => "98" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12114343" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Decanulation of patients with severe respiratory muscle insufficiency: efficacy of mechanical insufflation-exsufflation. J Rehabil Med. 2014; 46:1037-41." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Decanulation of patients with severe respiratory muscle insufficiency: efficacy of mechanical insufflation-exsufflation." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Bach JR" 1 => "Saporito LR" 2 => "Shah HR" 3 => "Sinquee D." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/16501977-1874" "Revista" => array:6 [ "tituloSerie" => "J Rehabil Med. " "fecha" => "2014" "volumen" => "46" "paginaInicial" => "1037" "paginaFinal" => "1041" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25096928" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "The value of cough peak flow measurements in the assessment of extubation or decannulation readiness. Rev Port Pneumol (Engl Ed). 2015; 21:94-8." "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "The value of cough peak flow measurements in the assessment of extubation or decannulation readiness." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Winck JC" 1 => "LeBlanc C" 2 => "Soto JL" 3 => "Plano F." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Port Pneumol (Engl Ed). " "fecha" => "2015" "volumen" => "21" "paginaInicial" => "94" "paginaFinal" => "98" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/08732159/0000002200000001/v0_201604141139/X0873215916479419/v0_201604141139/en/main.assets" "Apartado" => array:4 [ "identificador" => "50811" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Editorials" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000002200000001/v0_201604141139/X0873215916479419/v0_201604141139/en/320v22n01a90447941pdf001.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0873215916479419?idApp=UINPBA00004E" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 7 | 15 |
| 2024 October | 36 | 26 | 62 |
| 2024 September | 52 | 22 | 74 |
| 2024 August | 56 | 38 | 94 |
| 2024 July | 51 | 29 | 80 |
| 2024 June | 61 | 34 | 95 |
| 2024 May | 49 | 31 | 80 |
| 2024 April | 35 | 31 | 66 |
| 2024 March | 30 | 21 | 51 |
| 2024 February | 29 | 31 | 60 |
| 2024 January | 26 | 22 | 48 |
| 2023 December | 14 | 28 | 42 |
| 2023 November | 18 | 31 | 49 |
| 2023 October | 23 | 35 | 58 |
| 2023 September | 23 | 35 | 58 |
| 2023 August | 12 | 12 | 24 |
| 2023 July | 14 | 22 | 36 |
| 2023 June | 22 | 23 | 45 |
| 2023 May | 57 | 49 | 106 |
| 2017 January | 1 | 0 | 1 |
| 2016 December | 1 | 0 | 1 |
| 2016 November | 1 | 0 | 1 |
| 2016 October | 2 | 0 | 2 |
| 2016 September | 4 | 0 | 4 |
| 2016 August | 4 | 0 | 4 |
| 2016 July | 1 | 2 | 3 |
| 2016 June | 2 | 0 | 2 |
| 2016 April | 27 | 9 | 36 |
| 2016 March | 117 | 59 | 176 |
| 2016 February | 159 | 130 | 289 |
Show all
