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Vol. 1. Issue 2.
Pages 129-137 (March - April 1995)
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Vol. 1. Issue 2.
Pages 129-137 (March - April 1995)
ARTIGO ORIGINAL
Open Access
Neoplasia do Pulmão associada à Tuberculose
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Jorge Dionísio, Margarida Cristóvão, Agostinho Costa, Maria José Melo
Sector de Oncologia Pneumológica, Serviço de Pneumológia 3 (Dir: Dr.a Maria de Lourdes Vilas-Boas), Hospital de Pulido Valente
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RESUMO

A tuberculose e o cancro do pulmão são duas entidades clínicas rustintas que podem aparecer em simultâneo, persistindo ainda muitas interrogações quanto à influência mútua de cada uma das entidades nosológicas.

Com o objectivo de avaliar a influência da tuberculose na sobrevida dos doentes com cancro do pulmão, procedemos a urn estudo retrospectivo de 81 doentes (70 homens e 11 mulheres) com este diagnóstico que foram divididos em três grupos: Grupo I, com antecedentes de tuberculose pulmonar (n=21), Grupo II, com tuberculose activa em simultâneo (n=9) e Grupo III, sem história de tuberculose (n=45).

Verificámos que não bavia diferenças significativas entre estes grupos no respeitante à distribuição por sexos, classes etárias, tipos histológicos, estadios anatómicos, terapêuticas efectuadas e resultados destas. Comparando as curvas de sobrevivência verificámos que o Grupo II apresentava uma sobrevida maior do que os restantes, embora estes resultados mereçam algumas reservas dado o pequeno número de doentes neste grupo.

Concluímos que a tuberculose não agrava o prognóstico da neoplasia do pulmão, sendo de referir que, na população estudada, a sobrevida dos doentes com tuberculose activa é maior do que a dos doentes com e sem antecedentes de tuberculose.

Palavras-chave:
Tuberculose
neoplasia do pulmão
sobrevida
SUMMARY

Tuberculosis and lung cancer are two different diseases which can occur simultaneously, questioning the casuality of the association.

To evaluate the influence of tuberculosis in the survival of patients with lung cancer, we reviewed the clinical records of patients with this disease, and divided them into three groups: group I with preceeding tuberculosis (n=21), group n with coexistent active tuberculosis (n=9) and group mwithout past or present tuberculosis (n=45).

We found no differences between the groups relating to sex, age, histological type, anatomic stagging, therapeutic approaches and their results.

Anallzing the survival rates, group U patients survived for a longer period than patients in other groups (however the overall number of patients is sparse).

We conclude that tuberculosis doesn’t worsen the prognosis of lung cancer and, in this particular group, the survival of patients with active tuberculosis is longer than that of the patients without tuberculosis.

Key-words:
Tuberculosis
lung cancer
survival
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BIBLIOGRAFIA
[1.]
C.H. Bayle.
Recherches sur Ia Phtisie Pulmonaire.
Gabon, (1810),
[2.]
J.M. Carey, A.E. Grear.
Bronchogenic carcinoma complicating pulmonary tuberculosis: A report of 8 cases and a review of 140 cases since 1932.
Ann Med Int, 49 (1958), pp. 161
[3.]
S.O. Greenberg, et al.
Coexistence of carcinoma and tuberculosis of the lung.
Am Rev Resp Dis, 90 (1964), pp. 67
[4.]
W. Tunnel, K.O.H. Yeong-Cheol, P.C. Adkin.
The dilemma of coincident active pulmonary tuberculosis and carcinoma of the lung.
The Journal of Thoracic and Cardiovascular Surgery, 62 (1971), pp. 563-567
[5.]
A. Gourjn, H. Lyons.
Concurrent pulmonary tuberculosis and bronchogenic carninoma. Experience in large municipal hospital.
NY State J Med, 74 (1974), pp. 2367-2371
[6.]
R. Steinitz.
Pulmonary tuberculosis and carcinoma of the lung. A survey from two populations – based disease registers.
Am Rev Resp Dis, 92 (1965), pp. 758-766
[7.]
D.G. Mc Quarie.
Tuberculosis and carcinoma of the lung.
Dis Chest, 54 (1968), pp. 29-34
[8.]
E.E. Cliffton.
B. Bit-Alkhas Irani – Pulmonary tuberculosis and cancer.
NY State J Med, 70 (1970), pp. 274-278
[9.]
M.G. Evaristo, A. Costa, C. Nunes, et al.
Associação da tuberculose pulmonar e carcinoma brônquico.
Arquivos da SPPR, V (1988), pp. 25-30
[10.]
L. Bonchek.
Diagnosis of lung cancer in tuberculosis patients Use of tuberculine skin test and serum protein electrophoresis.
Chest, 60 (1971), pp. 256-259
[11.]
Ming Ting Yoeh, W. Church, K.P. Ravikrishnan.
Lung carcinoma superimposed on pulmonary tuberculosis.
Radiology, 119 (1976), pp. 307-312
[12.]
R. Benoya, J. Polk, P. Raju, et al.
Concurrent pulmonary tuberculosis and pulmonary carcinoma.
Thorax, 26 (1971), pp. 384-386
[13.]
I.T.O. Masami, N. Kojiro, Toshiyuki Ikada, et al.
Increased proportions of peripheral blood γδ T cells in patients with pulmonary tuberculosis.
Chest, 102 (1992), pp. 195-197
[14.]
M. Munk, A. Gatrill, S. Kaufman.
Target cell lyses and IL2 secretion by γδ T lymphocites after activation with bacteria.
The Journal of Immunology, 145 (1990), pp. 2434-2439
[15.]
M. Feldman, A. Porgador, O. Mandeloim, D. Plaskin, L. Eisenbach.
Tumor Invasion and Metastasis: Immunotherapy via Gene Therapy.
pp. 67-82
[16.]
J. Monteiro, E. Teixeira.
Imunidade e Cancro.
pp. 49-61
[17.]
R. Raven.
The Theory and Practice of Oncology – Historical evolution and present principles.
The Parthenon Publishing Group pag, 325 (1990), pp. 327
[18.]
T.B. Nogueira, J. Maçanita, T.G. Villar.
Valor prognóstico da prova tuberculinica no cancro do pulmão.
Med Torac, (1980), pp. 185-193
[19.]
A. Bugalho De Almeida.
Imunoterapia.
pp. 129-133
[20.]
R. Matthay.
Immunoadjuvant Therapy for Lung Cancer. A critical review.
Clinics in Chest Med., 3 (1982), pp. 423-440
[21.]
A. Domingos, A. Costa, M. Cristovão, M.J. Melo.
Tymopentin in the treatment of non-small cell lung cancer (NSCLC) – Stage III – b/IV.
Lung Cancer, 7 (1991), pp. 150
[22.]
S. Rosenberg, M. Lotze, L. Mull, et al.
A progress report on the treatment of 157 patients with advanced cancer using lymphokine – activated Killer cell and Interleukin 2 alone.
N. Engl. J. Med., 316 (1987), pp. 889-897
[23.]
K. Rolston, P. Jones, V. Fainstein, et al.
Pulmonary disease caused by rapidly growing mycobacteria in patients with cancer.
Chest, 87 (1985), pp. 503-506
[24.]
J.R. Zvetina, N. Maliwan, W.E. Frederick, et al.
Mycobacterium Kansasii infection following primary pulmonary malignancy.
Chest, 102 (1992), pp. 1460-1463
[25.]
N. Nagata, Y. Nikaido, M. Kido, et al.
Terminal pulmonary infections in patients with lung cancer.
Chest, 103 (1993), pp. 1739-1742
[26.]
J.L. Sendón.
Cancer primitivo de pulmony tuberculosis pulmonar.
Rev Clin Esp, 116 (1970), pp. 363-368
[27.]
L. Fulkerson, G. Perlmutter, M. Zack, et al.
Radiotherapy in chest malignant tumors associated with pulmonary tuberculosis.
Radiology, 106 (1973), pp. 645-648
[28.]
L. Rumans.
Pulmonary mycobacteriosis and malignancy. Presumed activation by irradiation.
Cancer, 46 (1980), pp. 1581-1583
Copyright © 1995. Sociedade Portuguesa de Pneumologia/SPP
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