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RESUMO
Nos últimos 10 anos, o número de publicações sobre o óxido nítrico tem crescido de um modo exponencial, em várias áreas da Medicina.
O que torna esta molécula tão atractiva, no âmbito da Pneumologia e da Imunoalergologia, é a evidência crescente de que a sua medição no ar expirado possa traduzir, de urn modo não invasivo, o grau de inflamação existente em várias doenças pulmonares.
O presente artigo, pretende realçar a importância dada recentemente ao papel do óxido nítrico como marcador de inflamação em doenças respiratórias, incidindo especialmente sobre a asma, a doença pulmonar obstrutiva crónica, a fibrose quística, as bronquiectasias, as infecções respiratórias, a alveolite fibrosante e a sarcoidose.
REV PORT PNEUMOL 2000; VI (4): 309-318
Palavras-chave:
NO
Asma
Doença Pulmonar Obstrutiva Crónica
DPOC
Fibrose Quística
Bronquiectasias
Infecções respiratórias
Alveolite Fibrosante
Sarcoidose
ABSTRACT
In the last 10 years, the number of publications about nitric oxide has increased enormously, covering many fields of medicine.
What makes this molecule so attractive for pneumologists and immunoallergologists, is the growing evidence that exhaled nitric oxide measurements might reflect, in a non-invasive way, the status of inflammation in several respiratory diseases.
This paper draws the attention to the role of nitric oxide as a marker of inflammation in respiratory diseases, especially regarding asthma, chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis, respiratory Infections, fibrosing alveolitis and sarcoidosis.
REV PORT PNEUMOL 2000; VI (4): 309-318
Key-words:
NO
Asthma
Chronic Obstructive Pulmonary Disease
COPD
Cystic Fibrosis
Bronchiectasis
Respiratory infections
Fibrosing alveolitis
Sarcoidosis
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BIBLIOGRAFIA
[1.]
R.F. Furchgoti, N. Zawadski.
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcoline.
Nature, 288 (1980), pp. 373-376
[2.]
R.M.J. Palmer, A.G. Ferrjge, S. Moncada.
Nitric oxide release accounts for the biological activity of endotelium-derived relaxing factor.
Nature, 327 (1987), pp. 524-526
[3.]
L.E. Gustafsson, A. Leone, M. Persson, N. Wiklund, S. Moncada.
Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans.
Biochem Biophys Res Commun, 181 (1991), pp. 852-857
[4.]
K. Alving, E. Weimberg, J.M. Lundberg.
Increased amount of nitric oxide in exhaled air of asthmatics.
Eur Respir J, 6 (1993), pp. 1368-1370
[5.]
S.A. Kharitonov, D. Yates, R.A. Robbins, R. LoganSinclair, E.A. Shinebourne, P.J. Barnes.
Increased No in exhaled air of asthmatic patients.
Lancet, 343 (1994), pp. 133-135
[6.]
M.G. Person, O. Zetierstrom, V. Argenius, E. Ihre, L.E. Gustafsson.
Single-breath oxide measurements in asthmatic patients and smokers.
Lancet, 343 (1994), pp. 146-147
[7.]
A.F. Massaro, S. Mehta, C.M. Lilly, L. Kobzik, J.J. Reill, J.M. Drazen.
Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects.
Am J Respir Crit Care Med, 153 (1996), pp. 1510-1514
[8.]
S.A. Kharitonov, K.F. Chung, D. Evans, B.J. O’Connor, B.J. Barnes.
Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract.
Am J Respir Crit Care Med, 153 (1996), pp. 1773-1780
[9.]
R.A. Robbins, P.J. Barnes, D.R. Springal, et al.
Expression of inducible nitric oxide synthase in human bronchial epithelial cells.
Biochem Biophys Res Commun, 203 (1994), pp. 209-218
[10.]
S.A. Kharitonoy, D.A. Yates, K.F. Chung, P.J. Barnes.
Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients.
Am J Respir Crit Care Med, 153 (1996), pp. 454-457
[11.]
S.A. Kharitonoy, D.A. Yates, K.F. Chung, P.J. Barnes.
Changes in the dose of inhaled steroids affect exhaled nitric oxide levels in asthmatic patients.
Eur Respir J, 9 (1996), pp. 196-201
[12.]
S. Lim, A. Jatakanon, M. John, T. Gilbey, B.J. O’Connor, K.F. Chung, P.J. Barnes.
Effect of inhaled budesonide on lung function and airway inflammation.
Am J Respir Crit Care Med, 159 (1999), pp. 22-30
[13.]
E.L.J. Van Rensen, K.C.M. Straathof, M.A. Yeselic-Charvat, A.H. Zwinderman, E.H. Bel, P.J. Sterk.
Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils and exhaled nitric oxide levels in patients with asthma.
Thorax, 54 (1999), pp. 403-408
[14.]
D.A. Yates, S.A. Kharitonoy, P.J. Barnes.
Effect of short- and long-acting inhaled β2-agonists on exhaled nitric oxide in asthmatic patients.
Am J Respir Crit Care Med, 10 (1997), pp. 1483-1488
[15.]
L.A. Laitinen, A. Laitinen, T. Haahtela.
A comparative study of the effects of an inhaled corticosteroid. budesonide, and of a β2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma.
J Allergy Clin lmmunol, 90 (1992), pp. 32-42
[16.]
P.Y. Gardiner, C. Ward, H. Booth, A. Allison, D.J. Hendrick, E.H. Walters.
Effect of eight weeks of treatment with sahnetcrol on bronchoalveolar lavage inflammatory indices in asthmatics.
Am J Respir Crit Care Med, 150 (1994), pp. 1006-1011
[17.]
A. Jatakanon, S. Lim, S.A. Kharitonoy, K.F. Chung, P.J. Barnes.
Correlation between exhaled nitric oxide. sputum eosinophils and methacoline responsiveness in patients with mild asthma.
Thorax, 53 (1998), pp. 91-95
[18.]
N. Neuparth, P. Araujo Gonçalves, A. Bugalho de Almeida, P. Lopes da Mata, I. Caires, T. Gamboa, H. Carvalho, J.E. Rosado Pinto, A.B. Rendas.
A sensibilidade brônquica à metacolina é ummarcador da inflamação das vias aéreas na asma.
Rev Por Pneumol, 5 (1999), pp. C2
[19.]
P.J. Barnes, F.Y. Liew.
Nitric oxide and asthmatic inflammation.
Immunol Today, 16 (1995), pp. 128-130
[20.]
P.S. Sanders.
Nitric oxide in asthma. Pathogenic, Therapeutic, or diagnostic?.
Am J Respir Cell Mol Biol, 21 (1999), pp. 147-149
[21.]
R.A. Robbins, A.A. Floreani, S.C. Von Essen, J.H. Sisson, G.E. Hill, I. Rubinstein, R.G. Townley.
Measurement of exhaled nitric oxide by three different techniques.
Am J Respir Crit Care Med, 153 (1996), pp. 1631-1635
[22.]
S.R. Rutgers, D.S. Postma, T.H.W. Van der Mark, G.H. Koëter.
Nitric oxide in exhaled air in COPD.
Eur Respir J, 9 (1996), pp. 2537-2540
[23.]
W. Maziak, S. Loukides, S. Culpitt, P. Sullivan, S.A. Kharitonov, P.J. Barnes.
Exhaled nitric oxide in chronic obstructive pulmonary disease.
Am J Respir Crit Care Med, 157 (1998), pp. 998-1002
[24.]
S.R. Rutgers, R.J. Meijer, H.A.M. Kerstjens, T.H.W. Van Der Mark, G.H. Koëter, D.S. Postma.
Nitric oxide measured with single-breath and tidal-breathing methods in asthma and COPD.
Eur Respir J, 12 (1998), pp. 816-819
[25.]
L.P. Ho, J.A. Innes, A.P. Greening.
Exhaled nitric oxide is not elevated in the inflammatory airways diseases of cystic fibrosis and bronchiectasis.
Eur Respir J, 12 (1998), pp. 1290-1294
[26.]
J.O.N. Lundberg, S.L. Nordvall, E. Weitzberg, H. Kollberg, K. Alving.
Exhaled nitric oxide in paediatric asthma and cystic fibrosis.
Arch Dis Child, 75 (1996), pp. 323-326
[27.]
I.M. Balfour-Lynn, A. Lavarty, R. Dinwiddie.
Reduced upper airway nitric oxide in cystic fibrosis.
Arch Dis Child, 75 (1996), pp. 319-322
[28.]
J. Dötsch, S. Demirakça, H.G. Terbrack, G. Hols, W. Rascher, P.G. Kohl.
Airway nitric oxide in asthmatic children and patients with cystic fibrosis.
Eur Respir J, 9 (1996), pp. 2537-2540
[29.]
H. Grasemann, E. Michler, M. Wallot, F. Ratjen.
Decreased concentration of exhaled nitric oxide in patients with cystic fibrosis.
Pediatric Pulmonology, 24 (1997), pp. 173-177
[30.]
L.P. Ho, J.Á. Innes, A.P. Greening.
Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide.
Thorax, 53 (1998), pp. 680-684
[31.]
Q.H. Meng, D.R. Springall, A.E. Bishop, K. Morgan, T.J. Evans, S. Habib, D.C. Gruenert, K.M. Gyi, M.E. Hodson, M.H. Yacoub, J.M. Polak.
Lack of inducible nitric oxide synthase in bronchial epithelium: a possible mechanism of susceptibility to infection in cystic fibrosis.
J Pathol, 184 (1998), pp. 323-331
[32.]
L.O. Lewin, P.J. Byard, B.D. Davjes.
Effect of Pseudomonas cepacia colonisation on survival and pulmonary function of cystic fibrosis patients.
J Clin Epidemiol, 43 (1990), pp. 125-131
[33.]
A.W. Smith, J. Green, C.E. Eden, M.L. Watson.
Nitric oxide-induced potentiation of the killing of Burkholderia cepacia by reactive oxygen species: implications for cystic fibrosis.
J Med Microbiol, 48 (1999), pp. 419-423
[34.]
R.B. Dowling, R. Newton, A. Robichaud, P.J. Cole, P.J. Barnes, R. Wilson.
Effect of inhibition of nitric oxide synthase on Pseudomonas aeruginosa infection of respiratory mucosa in vitro.
Am J Respir Cell Mol Biol, 19 (1998), pp. 950-958
[35.]
H. Grasemann, I. Joannidis, R.P. Tomkiewicz, H. de Groot, B.K. Rubin, F. Ratjen.
Nitric oxide metabolites in cystic fibrosis lung disease.
Arch Dis Child, 78 (1998), pp. 49-53
[36.]
S.A. Kharitonov, A.U. Wells, B.J. O’Connor, D. Hanseell, P.J. Cole, P.J. Barnes.
Elevated levels of exhaled nitric oxide in bronchiectasis.
Am J Respir Crit Care Med, 151 (1995), pp. 1889-1893
[37.]
P. Silkoff, P.A. Maclean, A. Slutsky, H.G. Furlott, E. Hoffstein, S. Wakita, K.R. Chapman, J.P. Szalaj, N. Zamel.
Marked flow-dependence of exhaled nitric oxide using new technique to exclude nasal nitric oxide.
Am J Respir Crit Care Med, 155 (1997), pp. 260-267
[38.]
I. Caires, N. Neuparth, A.S. Rendas.
Controle do débuo expiratório na medição do óxido nitrico expirndo.
Rev Por Pneumol, 5 (1999), pp. C6
[39.]
S.R. Rutgers, T.H.W. Van der Mark, W. Coers, H. Moshage, W. Timens, H.F. Kauffman, G.H. Koeter, O.S. Postma.
Markers of nitric oxide metabolism in sputum and exhaled air are not increased in COPD.
Thorax, 54 (1999), pp. 576-580
[40.]
M. Corradi, M. Majori, G.C. Cacciani, G.F. Consigli, E. Demunari, A. Pesci.
Increased exhaled nitric oxide in patient with stable chronic obstructive pulmonury disease.
Thorax, 54 (1999), pp. 572-575
[41.]
P.J. Sterk, F.M. De Gouw, F.L.M. Ricciardolo, K.F. Rabe.
Exhaled nitric oxide in COPD: glancing through a smoke screen.
Thorax, 54 (1999), pp. 565-567
[42.]
S.A. Kharitonov, R.A. Robbins, D.A. Yates, V. Keatings, P.J. Barnes.
Acute and chronic effects of cigarette smoking on exhaled nitric oxide.
Am J Respir Crit Care Med, 152 (1995), pp. 609-612
[43.]
R.A. Robbins, T. Millatmal, K. Lassi, S. Rennard, D. Daughton.
Smoking cessution is associated with an increase in exhaled nitric oxcide.
Chest, 112 (1997), pp. 313-318
[44.]
J. Assreuy, F.Q. Cunha, F.Y. Lieew, S. Moncada.
Feedback inhibition of nitric oxide synthase by nitric oxide.
Br J Pharmacol, 108 (1993), pp. 833-837
[45.]
B. Jain, I. Lubinstein, R.A. Robbins, K.L. Leise, J.H. Sisson.
Modulation of airway epithelial cell ciliary beat frequency by nitric oxide.
Biochem Biophys Res Commun, 191 (1993), pp. 83-88
[46.]
C.H. Wang, C.Y. Liu, H.C. Lin, C.T. Yu, K.F. Chung, H.P. Kuo.
Increased exhaled nitric oxide in active pulmonary tuberculosis due to inducible No synthase upregulation in alveolar macrophages.
Eur Respir J, 11 (1998), pp. 809-815
[47.]
S.A. Kharjtonov, D.A. Yates, P.J. Barnes.
Increased nitric oxide in exhaled air of normal human subjects with upper respiratory infections.
Eur Respir J, 8 (1995), pp. 295-297
[48.]
H.W.F.M. De Gouw, K. Grünberg, R. Schot, E.C. Dick, P.J. Sterk.
Exhaled nitric oxide (NO) increases following experimental rhinovirus 16 (RV16) infection in asthmatic subjects in vivo.
Am J Respir Crit Care Med, 153 (1996), pp. A798
[49.]
P. Paredi, A.S. Kharitonov, S. Loukides, P. Pantelidis, R.M. Dubois, P.J. Barnes.
Exhaled nitric oxide: a marker for disease activity in cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis.
Chest, 115 (1999), pp. 1352-1356
[50.]
M.O. Loveless, C.R. Phillips, G.D. Giraud, W.E. Holden.
Decreased exhaled nitric oxide in subjects with HIV infection.
Thorax, 52 (1997), pp. 185-186
[51.]
O.M. O’Donnell, J. Moynihan, G.A. Finlay, Y.M. Keatings, C.M. O’connor, P. Mcloughun, M.X. Fitzgerald.
Exhaled nitric oxide and bronchoalveolar lavage nitrite/nitrate in active pulmonary sarcoidosis.
Am J Respir Crit Care Med, 156 (1997), pp. 1892-1896
[52.]
C.S. Reiss, T. Komatsu.
Does nitric oxide play a critical role in viral infections?.
J Virol, 72 (1998), pp. 1547-1551
[53.]
S.P. Sanders.
Asthma, viruses and nitric oxide.
Proc Soc Expl Biol Med, 220 (1999), pp. 123-132
[54.]
H.P. Kuo, C.H. Wang, K.S. Huang, H.C. Lin, C.T. Yu, C.Y. Liu, L.C. Lu.
Nitric oxide modulates interleukinl beta and tumor necrosis factor-alfa synthesis by alveolar macrophages in pulmonary tuberculosis.
Am J Respir Crit Care Med, 161 (2000), pp. 192-199
[55.]
J.S. Braun, R. Novak, G. Gao, P.J. Murray, J.L. Shenep.
Pneumolysin, a protein toxin of Streptococcus pneumoniae. induces nitric oxide production from macrophages.
Infect Immun, 67 (1999), pp. 3750-3756
[56.]
W.C. Tsai, R.M. Strieter, D.A. Zjsman, J.M. Wilkowski, K.A. Bucknell, G.H. Chen, T.J. Standiford.
Nitric oxide is required for effective innate immunity against Klebsiela pneumoniae.
Infect Immun, 65 (1997), pp. 1870-1875
[57.]
D. Saleh, P.J. Barnes, A. Giaid.
Increased production of potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis.
Am J Respir Crit Care Med, 155 (1997), pp. 1763-1769
[58.]
A.J. Fisher, Y.E. Gabba, T. Small, S. Doig, J.H. Dark, P.A. Corris.
Cross sectional study of exhaled nitric oxide levels following lung transplantation.
Thorax, 53 (1998), pp. 454-458
[59.]
K.C. Meyer, R.B. Love, J.J. Zimmerman.
The therapeutic potential of nitric oxide in lung transplantation.
Chest, 113 (1998), pp. 1360-1371
[61.]
S.A. Kharitonov, K. Alving, P.J. Barnes.
Exhaled and nasal nitric oxide measurement.s: recommendations.
Eur Respir J, 10 (1997), pp. 1683-1693
[62.]
P.J. Barnes, K. Alving, A.S. Kharjtonov, K. CheeseMan.
Exhaled markers in airway disease.
Eur Respir Rev, 9 (1999),
[63.]
P.J. Barnes, S.A. Kharitonov.
Exhaled nitric oxide: a new lung function test.
Thorax, 51 (1996), pp. 233-237
[64.]
P.J. Barnes.
Nitric oxide.
Asthma: basic mechanisms and clinical management, third, pp. 369-378
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