Journal Information
Vol. 16. Issue 1.
Pages 149-156 (January - February 2010)
Share
Share
Download PDF
More article options
Vol. 16. Issue 1.
Pages 149-156 (January - February 2010)
Full text access
Técnicas de dilatação broncoscópica e aplicação tópica de mitomicina C no tratamento da estenose traqueal pós-entubação – A propósito de dois casos clínicos
Bronchoscopic dilation techniques and topical application of mitomycin-C in the treatment of tracheal stenosis post intubation – two case reports
Visits
1010
Susana Ferreira1,5,
Corresponding author
susalvesferreira@gmail.com

Correspondência: Rua Conceição Fernandes – Vilar de Andorinho, 4430–502 Vila Nova de Gaia, Portugal, Telefone: 00351912767155.
, Carla Nogueira1,5, Ana Oliveira2,5, Sofia Neves2,5, José Almeida3,5, João Moura e Sá4,5, Parente Bárbara5
1 Interna Complementar de Pneumologia/Pulmonology resident
2 Assistente Hospitalar de Pneumologia/Pulmonology resident
3 Assistente Hospitalar Graduado de Pneumologia/Specialist, Pulmonology consultant
4 Chefe de Serviço de Pneumologia/Head, Pulmonology unit
5 Centro Hospitalar de Vila Nova de Gaia / Espinho EPE – Porto
This item has received
Article information
Resumo

A estenose traqueal surge na sequência de agressões à mucosa traqueal (isquémicas, traumáticas ou outras). O tratamento das estenoses traqueais continua a representar um desafio em termos de técnicas endoscópicas e cirurgia, apesar de todos os recentes avanços nesta área. O processo de cicatrização e a reestenose são as principais causas de falência terapêutica.

Os autores apresentam dois casos clínicos de doentes com estenose traqueal como consequência de entubação orotraqueal prolongada/traqueostomia, em que o tratamento foi bem sucedido com dilatação com broncoscopia rígida e laser, complementada por aplicação tópica de mitomicina C.

Palavras-chave:
Mitomicina C
estenoses traqueais
broncoscopia
terapêutica com laser
Abstract

Tracheal stenosis follows any injury to the airway mucosa, such as ischaemic, traumatic and other injuries.

The treatment of tracheal stenosis remains a challenging problem despite all the advances in endoscopic and surgical techniques. Scar formation and reestenosis are the main causes of treatment failure.

The authors present two cases of successful treatment of a tracheal stenosis after tracheal injury from prolonged oro-tracheal intubation / tracheostomy following dilatation with rigid broncoscope and laser therapy, associated with topical application of mitomycin C as an adjuvant treatment.

Key-words:
Mitomycin C
tracheal stenosis
bronchoscopy
laser therapy
Full text is only aviable in PDF
Bibliografia
[1]
R.E. Whited.
A prospective study of laryngotracheal sequelae in longterm intubation.
Laryngoscope, 94 (1984), pp. 367-377
[2]
S.K. Epstein.
Late complications of tracheostomy.
Respir Care, 50 (2005), pp. 542-549
[3]
R.D. Sue, I. Susanto.
Long-term complications of artificial airways.
Clin Chest Med, 24 (2003), pp. 457-471
[4]
J.L. Stauffer, D.E. Olson, T.L. Petty.
Complications and consequences of endotracheal intubation and tracheotomy. A prospective study of 150 critically ill adult patients.
Am J Med, 70 (1981), pp. 65-76
[5]
V.K. Anand, G. Alemar, E.T. Warren.
Surgical considerations in tracheal stenosis.
Laryngoscope, 102 (1992), pp. 237-243
[6]
M.K. Arola, M.V. Inberg, H. Puhakka.
Tracheal stenosis after tracheostomy and after oro-tracheal cuffed intubation.
Acta Chir Scand, 147 (1981), pp. 183-192
[7]
R.R. Lorenz.
Adult laryngotracheal stenosis: etiology and surgical management.
Curr Opin Otolaryngol Head Neck Surg, 11 (2003), pp. 467-472
[8]
A. Brichet, C. Verkindre, J. Dupont, M.L. Carlier, J. Darran.
Multidisciplinary approach to management of postintubation tracheal stenoses.
Eur Respir J, 13 (1999), pp. 888-893
[9]
E.J. Dollin, L.F. Strande, K. Tsuno, M.C. Santos.
Pharmacologic inhibition of collagen I in an experimental model of subglottic stenosis.
Ann Otol Rhinol Laryngol, 107 (1998), pp. 275-279
[10]
D.R. Ingrams, P. Ashton, J. Dhingra, R. Shah, S.M. Shapshay.
Slow-release 5-fluorouracil and triamcinolone reduces subglottic stenosis in a rabbit model.
Ann Otol Rhinol Laryngol, 109 (2000), pp. 422-424
[11]
A. Desmouliere, M. Redard, K. Darby, G. Gabbiani.
Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.
Am J Pathol, 146 (1995), pp. 56-66
[12]
R. Rahbar, S.M. Shapshay, G.B. Healy.
Mitomycin: effects on laryngeal and tracheal stenosis, benefits, and complications.
Ann Otol Rhinol Laryngol, 110 (2001), pp. 1-6
[13]
R. Rahbar, T.A. Valdez, S.M. Shapshay.
Preliminary results of intraoperative mitomycin C in the treatment and prevention of glottic and subglottic stenosis.
J Voice, 14 (2000), pp. 282-286
[14]
D.A. Lee, T.C. Lee, A.E. Cortes, S. Kitada.
Effects of mithramycin, mitomycin, daunorubicin, and bleomycin on human subconjunctival fibroblast attachment and proliferation.
Invest Ophthalmol Vis Sci, 31 (1990), pp. 2136-2144
[15]
P.T. Khaw, J.W. Doyle, M.B. Sherwood, I. Grierson, G.S. Schultz, S. McGorray.
Prolonged localized tissue effects from 5-minute exposure to fluorouracil and mitomycin C.
Arch Ophthalmol, 111 (1993), pp. 263-267
[16]
M. Tomsaz, Y. Palom.
The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity.
Pharmacol Ther, 76 (1997), pp. 73-87
[17]
N. Kunitomo, S. Mori.
Studies on the pterygium IV: a treatment of the pterygium by mitomycin-C instillation.
Acta Soc Ophthalmol Jpn, 67 (1963), pp. 601-607
[18]
J.E. Spector, J.A. Werkhaven, N.C. Spector, et al.
Preservation of function and histologic appearance in the injured glottis with topical mitomycin-C.
Laryngoscope, 109 (1999), pp. 1125-1129
[19]
J.E. Spector, J.A. Werkhaven, N.C. Spector, et al.
Prevention of anterior glottis reestenosis in a canine model with topical mitomycin-C.
Ann Otol Rhinol Laryngol, 110 (2001), pp. 1007-1010
[20]
C.G. Garret, J. Soto, J. Riddick, et al.
Effect of mitomycin-C on vocal fold healing in a canine model.
Ann Otol Rhinol Laryngol, 110 (2001), pp. 25-30
[21]
R. Eliashar, I. Eliachar, R. Esclamado, et al.
Can topical mitomyin-C prevent laryngotracheal stenosis?.
Laryngoscope, 109 (1999), pp. 1594-1600
[22]
A.J. Correa, L. Reinisch, D.L. Sanders, et al.
Inhibition of subglottic stenosis with mitomycin-C in the canine model.
Ann Otol Rhinol Laryngol, 108 (1999), pp. 1053-1060
[23]
R.F. Ward, M.M. April.
Mitomycin C in the treatment of tracheal cicatrix after tracheal reconstruction.
Int J Pediatr Otorhinolaryngol, 44 (1998), pp. 221-226
[24]
R. Rahbar, D. Jones, R. Nuss, D. Roberson, M. Kenna, T. McGill, et al.
The role of mytomicin in the prevention and treatment of scar formation in the pediatric aerodigestive tract.
Arch Otolaryngol Head Neck Surg, 128 (2002), pp. 401-406
[25]
A.C. Erard, P. Monnier, A. Spiliopoulos, L. Nicod.
Mytomicin C for control of recurrent bronchial stenosis: a case report.
Chest, 120 (2001), pp. 2103-2105
[26]
T.A. Valdez, S.M. Shapshay.
Idiophatic subglottic stenosis revisited.
Ann Otol Rhinol Laryngol, 111 (2002), pp. 690
[27]
I. Perepelitsyn, S.M. Shaphay.
Endoscopic treatment of laryngeal and tracheal stenosis – has mitomycin C improved the outcome?.
Otolaryngol Head Neck Surg, 131 (2004), pp. 16-20
[28]
C.B. Simpson, J.C. James.
The efficacy of mitomycin C in the treatment of laryngotracheal stenosis.
Laryngoscope, 116 (2006), pp. 1923-1925
[29]
S.A. Nouraei, A. Singh, A. Patel, et al.
Early endoscopic treatment of acute inflammatory airway lesions improves the outcome of post-intubation airway stenosis.
The Laryngoscope, 116 (2006), pp. 1417-1421
[30]
J.M. Schweinfurth.
Endoscopic treatment of severe tracheal stenosis.
Ann Otol Rhinol Laryngol, 115 (2006), pp. 30-34
[31]
C.J. Hartnick, B.E. Hartley, P.D. Lacy, et al.
Topical mitomycin C application after laryngotracheal reconstruction.
Arch Otolaryngol Head Neck Surg, 127 (2001), pp. 1260-1264
[32]
H.E. McCurdy, C.B. Simpson, et al.
Airway complications from topical Mitomicyn C.
Arch Otolaryngol Head Neck Surg, 133 (2005), pp. 831-835
Copyright © 2010. Sociedade Portuguesa de Pneumologia
Download PDF
Pulmonology
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?