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Vol. 16. Issue 1.
Pages 5-21 (January - February 2010)
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Vol. 16. Issue 1.
Pages 5-21 (January - February 2010)
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Tuberculosis – Risk of continued transmission in healthcare workers
Tuberculose – Risco de transmissão continuada em profissionais de saúde
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José Torres Costa1,2,3,
Corresponding author
zecatoco@sapo.pt

Correspondence to/Correspondência: Estrada de St.ª Luzia, n.° 269, 4900-408 Viana do Castelo, Portugal.
, Rui Silva1,2,3, Raul Sá1, Maria João Cardoso4, José Ferreira1, Carla Ribeiro1, Mário Miranda1,2,3, José Luís Plácido1,2
1 Serviço de Saúde Ocupacional, Hospital S. João, EPE – Porto/Occupational Health Unit, Hospital S. João, EPE – Porto, Portugal
2 Serviço de Imunoalergologia, Hospital S. João, EPE – Porto/Allergology and Clinical Immunology Unit, Hospital S. João, EPE – Porto, Portugal
3 Faculdade de Medicina, Universidade do Porto/Faculty of Medicine, Universidade do Porto, Portugal
4 Serviço de Patologia Clínica, Hospital S. João, EPE – Porto/Clinical Pathology Unit, Hospital S. João, EPE – Porto, Portugal
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Article information
Abstract
Introduction

Control of tuberculosis (TB) in healthcare workers requires an early recognition of contacts, the adoption of efficient protective measures and screening for cases of latent tuberculosis (TL) and recent TL.

Aims

Systematic screening for TB and TL in healthcare workers with contact with patients or other workers with TB and risk of contagion.

Material and methods

In a hospital with approximately 5400 workers 13 screenings were performed September 2007– December 2008 due to risk of continued TB. These consisted of clinical observation, tuberculin skin test (PT), Quantiferon®-TB Gold (QTF) test if PT ≥10mm and <15mm and chest X-ray. The diagnoses were performed according to the recommendations of the Portuguese Pulmonolgy Society (SPP).

Results

792 workers (563 ♂; 229 ♀) were included in the 13 screenings. Of these, 75 presented symptoms and 31 had radiology abnormalities. PT was performed in 490 workers, with results <10mm in 250, ≥10 and <15mm in 175 (QTF positive in 36) and ≥15mm in 65. Of the screened workers, 280 had a previous PT ≥15mm, and therefore it was not repeated. 1 case of active TB was diagnosed in a worker, as well as 408 cases of TL (51.5%) and 42 cases of recent TL (5.3%).

Conclusions

TB is considered an occupational disease in healthcare workers. The screening of contacts and TL cases is an important tool for an early diagnosis of active disease and for identifying the cases with higher risk of future disease.

Key-words:
Tuberculosis
latent tuberculosis
Mantoux
tuberculin skin test
interferon-gamma
healthcare workers
Resumo
Introdução

O controlo da tuberculose (TB) em profissionais de saúde passa pelo reconhecimento precoce dos contactos, adopção de medidas de protecção eficazes e despiste dos casos de tuberculose latente (TL) e latente recente.

Objectivos

Rastreio sistemático de TB e TL nos profissionais de saúde com contacto com doentes ou funcionários com TB e risco de contágio.

Material e métodos

Num hospital com aproximadamente 5400 funcionários, entre Setembro de 2007 e Dezembro de 2008, realizaram-se 13 rastreios de risco de TB continuada. Estes foram constituídos por observação clínica, realização de prova de tuberculina (PT), teste de Quantiferon®-TB Gold (QTF) se PT ≥10mm e <15mm e RX tórax. O diagnóstico foi efectuado de acordo com as recomendações da SPP.

Resultados

Nos 13 rastreios efectuados foram englobados 792 profissionais (563 ♀; 229 ♂). Destes, 75 apresentavam sintomas e 31 alterações radiológicas. A PT foi efectuada em 490 profissionais, sendo <10 mm em 250, ≥10 e <15mm em 175 (QTF positivo em 36) e ≥15mm em 65. Dos profissionais rastreados, 280 tinham PT anterior ≥15mm, pelo que não foi repetida. Durante o rastreio foi diagnosticado um caso de TB activa num profissional, 408 casos de TL (51,5%) e 42 de TL recente (5,3%).

Conclusões

A TB é considerada como doença profissional nos profissionais da saúde. O rastreio dos contactos e dos casos de TL é uma importante ferramenta para o diagnóstico precoce de doença activa e para a identificação dos casos de maior risco de doença futura.

Palavras-chave:
Tuberculose
tuberculose latente
Mantoux
prova de tuberculina
interferão-gama
profissionais de saúde
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Bibliography/Bibliografia
[1.]
K.A. Sepkowitz.
Tuberculosis and the health care worker: a historical perspective.
Ann Internal Med, 120 (1994), pp. 71-79
[2.]
D. Menzies, A. Fanning, L. Yuan, et al.
Tuberculosis among health care workers.
New Engl J Med, 332 (1995), pp. 92-98
[3.]
I. Baussano, M. Bugiani, A. Carosso, et al.
Risk of tuberculin conversion among healthcare workers and the adoption of preventive measures.
Occup Environ Med, 64 (2007), pp. 161-166
[4.]
World Health Organization.
Global Tuberculosis Control: Surveillance, Planning, Financing.
WHO Report, (2007),
[5.]
DGS, SVIG-TB, 2006. http://www.dgs.pt/upload/membro.id/ficheiros/i009162.pdf (acedida em 24 Fevereiro 2009).
[6.]
Ministério da Saúde e Direcção-Geral de Saúde 2004. Plano Nacional de Saúde 2004-2010: Mais saúde para todos. Direcção-Geral de Saúde, Lisboa.
[7.]
Decreto Regulamentar n.° 76/2007, de 17 de Julho de 2007. Diário da República, 17 Julho 2007 (n. 136), Série I – Ministério do Trabalho e da Solidariedade Social.
[8.]
S. Saleiro, A. Santos, O. Vidal, T. Carvalho, J. Torres Costa, J.A. Marques.
Tuberculose em profissionais de saúde de um serviço hospitalar.
Rev Port Pneumol, 13 (2007), pp. 789-799
[9.]
Institute of Medicine.
Tuberculosis in the workplace.
National Academy Press, (2001),
[10.]
D. Menzies, R. Joshi, M. Pai.
Risk of tuberculosis infection and disease associated with work in health care settings.
International Journal of Tuberculosis Lung Disease, 11 (2007), pp. 593-605
[11.]
M. Ratio, E. Tala.
Tuberculosis among health care workers during three recent decades.
Eur Respir J, 15 (2000), pp. 304-307
[12.]
Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings. Department of health and human services. Centers for Disease Control and Prevention, 2005.
[13.]
Ministério do Trabalho e da Segurança Social – Estatísticas Disponíveis – Doenças Profissionais. http://195.245.197.202/left.asp?02.21.03.07 (acedida em 24 de Fevereiro de 2009).
[14.]
Rastreio e tratamento de tuberculose em profissionais de saúde. Comissão para a Prevenção e Controlo da Tuberculose (CPCT) do Hospital de São João. Janeiro 2008 (intranet/HSJ).
[15.]
C.R. Horsburgh.
Priorities for the treatment of latent tuberculosis infection in the United States.
New Engl J Med, 350 (2004), pp. 2060-2067
[16.]
R. Duarte, J. Amado, H. Lucas, J.M. Sapage.
Tratamento da Tuberculose Latente – revisão das normas. Comissão de Trabalho de Tuberculose da Sociedade Portuguesa de Pneumologia.
Rev Port Pneumol, 13 (2007), pp. 397-406
[17.]
E. Vynnycky, P.E. Fine.
Lifetime risks, incubation period, and serial interval of tuberculosis.
Am J Epidemiol, 152 (2000), pp. 247-263
[18.]
Guidelines for using the QuantiFERON®-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. Department of health and human services. Centers for Disease Control and Prevention. Morbidity and Mortality Weekly Report 2005; 54 (No. RR-15):49-56.
[19.]
R. Duarte.
Teste tuberculínico. Como optimizar?.
Rev Port Pneumol, 15 (2009), pp. 295-304
[20.]
G. De Vries, M. Sebek, L. Van Weezenbeek.
Healthcare workers with tuberculosis infected during work.
Eur Resp J, 28 (2006), pp. 1216-1221
[21.]
Cunha J, Vieira C, Silva R, Torres Costa J. Eficácia da formação sobre riscos biológicos – transmissão via aérea – tuberculose, numa instituição hospitalar, comunicação oral no 7.° Congresso Nacional de Saúde Ocupacional, Póvoa de Varzim, Novembro de 2008.
[22.]
Ferreira JA, Silva R, Sá R, Miranda M, Plácido JL, Torres Costa J. Tuberculose em profissionais de saúde, comunicação oral no 7.° Congresso Nacional de Saúde Ocupacional, Póvoa de Varzim, Novembro de 2008.
[23.]
C. Whalen.
Diagnosis of latent tuberculosis infection.
JAMA, 293 (2005), pp. 2785-2787
[24.]
D. Menzies, M. Pai, G. Comstock.
Meta-analysis: Tests for the diagnosis of latent tuberculosis infection: Areas of uncertainty and recommmendations for research.
Ann Inter Med, 146 (2007), pp. 340-354
[25.]
D. Menzies.
Interpretation of repeated tuberculin tests Boosting, conversion, and reversion.
Am J Respir Crit Care Med, 159 (1999), pp. 15-21
[26.]
K. Ewer, J. Deeks, et al.
Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium infection in a school tuberculosis outbreak.
Lancet, 361 (2005), pp. 1168-1173
[27.]
P. Gokhale, J. Dogra.
Mycobacterium tuberculosis infection in health care workers in rural India: comparison of a whole-blood interferon gamma assay with tuberculin skin testing.
JAMA, 293 (2005), pp. 2746-2747
[28.]
Y.A. Kang, H. Lee, et al.
Discrepancy between the tuberculin skin test and the whole-blood interferon gamma assay for the diagnosis of latent tuberculosis infection in an intermediate tuberculosis-burden country.
JAMA, 293 (2005), pp. 2785-2787
[29.]
M. Pai, K. Gokhale, R. Joshi, et al.
Mycobacterium tuberculosis infection in health care workers in rural India. Comparison of a whole blood interferon gamma assay with tuberculin skin testing.
JAMA, 293 (2005), pp. 2746-2755
[30.]
J. Torres Costa, R. Sá, M.J. Cardoso, R. Silva, J. Ferreira, C. Ribeiro, M. Miranda, J.L. Plácido, Nienhaus.
Tuberculosis screening in Portuguese healthcare workers using the tuberculin skin test and the interferon-γ release assay.
Eur Respir J, 34 (2009), pp. 1423-1428
[31.]
U. Mack, G. Migliori, M. Sester, H. Rieder, C. Lange.
LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement.
Eur Respir J, 33 (2009), pp. 956-973
[32.]
R. Joshi, A.L. Reingold, D. Menzies, M. Pai.
Tuberculosis among health-care workers in low and middle-income countries: A systematic review.
[33.]
Khanna P, Nikolayevskyy V, Warburton F, et al. Rate of latent tuberculosis infection detected by occupational health screening of nurses new to a London teaching hospital. Infect Control Hosp Epidemiol 2009; 30 (in press).
[34]
Morbidity and Mortality Weekly Report 2000. Disponível em http://www.cdc.gov/mmwr.
[35.]
M.R. Reichler, R. Reves, S. Bur, et al.
Evaluation of investigations conducted to detect and prevent transmission of tuberculosis.
JAMA, 287 (2002), pp. 991-995
[36.]
Control and prevention of tuberculosis in the United Kingdom: code of practice 2000 Joint Tuberculosis Committee of the British Thoracic Society.
Thorax, 55 (2000), pp. 887-901
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