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RESUMO
Apreseotamos o caso clínico de um doente de 68 anos de idade, com glomerulonefrite rapidamente progressiva e hemorragia pulmonar, presença de anticorpos anti-citoplasma dos neutrófilos (padrão perinuclear com especificidade anti-mieloperoxidase), e anticorpos anti-cardiolipina. A histologia renal confirmou o diagnóstico de poliarterite microscópica. A propósito deste caso, são feitas algumas considerações sobre a utilidade dos auto-anticorpos no diagnóstico das diferentes formas de vasculite.
Palavras-chave:
Autoanticorpos
Antoantigénios
Endotélio Vascular
Mieloperoxidase
Neutrófilos
Serina proteinase
Vasculites
ABSRTRACT
We present the case report of a 68 year old man with rapidly progressive glomerulonephritis and pulmonary haemorrhage, with anti-neutrophil cytoplasmic auto-antibodies, perinuclear pattern with myeloperoxidase specifity, and anti-cardiolipin antibodies. Renal histology supported the diagnosis of microscopic polyarteritis. In reference to this case, some considerations regarding the usefullness of autoantibodies in different forms of vasculitis are made.
Key-Words:
Autoantibodies
Autoantiges
Endothelium
vascular
Myelope-roxidase
Neutrophils
Serine proteinase
Vasculitis
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