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Vol. 12. Issue 6.
Pages 709-714 (November - December 2006)
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Vol. 12. Issue 6.
Pages 709-714 (November - December 2006)
Artigo de Revisão\Revision Article
Open Access
Asma, polipose nasal e intolerância à aspirina – Uma tríade a recordar
Asthma, nasal polyposis and aspirin intolerance – A triad to remember
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Bárbara Seabra1, Raquel Duarte2, Raul César Sá3
1 Interna Complementar de Pneumologia, Centro Hospitalar Vila Nova de Gaia, Serviço de Pneumologia, Rua Conceição Fernandes, 4434-502 V. N. Gaia
2 Assistente Hospitalar de Pneumologia, Centro Hospitalar Vila Nova de Gaia, Serviço de Pneumologia, Rua Conceição Fernandes, 4434-502 V. N. Gaia
3 Director do Serviço de Pneumologia, Centro Hospitalar Vila Nova de Gaia, Serviço de Pneumologia, Rua Conceição Fernandes, 4434-502 V. N. Gaia
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Resumo

Apesar de reconhecida há mais de meio século, a tríade constituída por asma severa, polipose nasal e intolerância ao ácido acetilsalicílico a denominada asma induzida pela aspirina ou sindrome de Widal permanece francamente subdiagnosticada e insuficientemente tratada. De entre as principais razões para esta situação destacam-se o desconhecimento das suas características clínicas, a fisiopatologia e, por vezes, até a própria existência desta entidade.

O presente artigo pretende alertar a população médica para esta síndroma, ara as suas particularidades e para os cuidados específicos no seu tratamento, com vista a uma melhoria na prestação dos cuidados de saúde: O diagnóstico correcto é o primeiro passo no tratamento eficaz de qualquer patologia.

Rev Port Pneumol 2006; XII (6): 709-714

Palavras-chave:
Asma
polipose nasal
intolerância aspirina
síndroma de Widal
Keywords:
Asthma
nasal polyposis
aspirin intolerance
Widal syndrome
Abstract

Despite more than a half-century of recognition, the triad characterised by severe asthma, nasal polyposis and acetylsalicylic acid intolerance known as aspirin induced asthma or Widal’s triad remains markedly underdiagnosed and mistreated. A number of reasons may contribute to this situation with the lack of awareness of its clinical characteristics, pathophysiology and even sometimes of its’ actual existence the main ones.

This review article aims to alert physicians to this entity and its particularities in an attempt to improve healthcare. A correct diagnosis is the first step in the effective treatment of a disease.

Rev Port Pneumol 2006; XII (6): 709-714

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Bibliografia
[1.]
M.F. Widal, P. Abrami, J. Lermoyez.
Anaphylaxie et idiosyncrasie.
La Presse Médicale, Paris, 30 (1922), pp. 189-192
[2.]
G. Bochenek, K. Banska, Z. Szabo, E. Nizankowska, A. Szczeklik.
Diagnosis, Prevention and Treatment of Aspirin-Induced Asthma and Rhinitis.
Current Drug Targets – Inflammation & Allergy, 1 (2002), pp. 1-11
[3.]
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Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma.
J Allergy Clinical Immunology, 84 (1989), pp. 26-33
[4.]
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Aspirin and Asthma.
Chest, 118 (2000), pp. 1470-1476
[5.]
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Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin intolerant asthmatics.
Am J Respiratory Care Med, 157 (1998), pp. 11887-11896
[6.]
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The pivotal role of lipoxigenase products in the reaction of aspirin sensitive asthmatics to aspirin.
Am Rev Respiratory Dis, 148 (1993), pp. 1447
[7.]
J.M. Sweet, D.D. Stevenson, D.A. Mathison.
Long term effects of asthma desensitization – treatment of aspirin induced rhinosinusitis-asthma.
J Clin Immunol, 85 (1990), pp. 59
Copyright © 2006. Sociedade Portuguesa de Pneumologia/SPP
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