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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A esperan&#231;a de vida dos doentes com fibrose qu&#237;stica &#40;FQ&#41; tem vindo a aumentar&#44; sendo mais frequente a identifica&#231;&#227;o de osteoporose&#46; A patog&#233;nese de uma baixa densidade mineral &#243;ssea &#40;DMO&#41; na FQ parece ser multifactorial e o objectivo deste trabalho foi avaliar a preval&#234;ncia de baixa DMO num grupo de doentes com FQ e a sua correla&#231;&#227;o com outros par&#226;metros avaliados&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">O estudo incluiu 22 doentes com FQ com idades compreendidas entre os 14 e os 45 anos &#40;m&#233;dia 26&#44;3&#41;&#44; dois dos quais transplantados pulmonares&#46; A DMO foi avaliada por densitometria &#243;ssea ao n&#237;vel da coluna lombar e do colo do f&#233;mur&#46; Estes dados foram correlacionados com os valores s&#233;ricos de 25-hydroxivi-tamina D&#44; o IMC e o volume expirat&#243;rio m&#225;ximo for&#231;ado no primeiro segundo &#40;VEM&#41;&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Os valores da DMO &#40;<span class="elsevierStyleItalic">Z-score</span> e <span class="elsevierStyleItalic">T-scor</span>e&#41; variaram entre 0&#44;6 e -6 e entre 0&#44;5 e -6&#44;7&#44; respectivamente&#44; a n&#237;vel da coluna lombar e entre 0&#44;6 e -3&#44;9 e 0&#44;6 e -4&#44;1 a n&#237;vel do colo do f&#233;mur&#46; A m&#233;dia das concentra&#231;&#245;es s&#233;ricas de 25-&#40;OH&#41;D &#40;12&#44;57<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; encontrava-se no limite inferior da normalidade &#40;10-60<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; Em m&#233;dia os doentes n&#227;o apresentavam malnutri&#231;&#227;o mas os valores de IMC variam entre 15&#44;2 e 33&#44;7<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Relativamente &#224; fun&#231;&#227;o pulmonar&#44; 64&#37; dos doentes apresentavam VEM inferior a 80&#37; e&#44; destes&#44; quatro tinham valores inferiores a 40&#37;&#46; Foi encontrada uma correla&#231;&#227;o positiva entre valores baixos de DMO e VEM&#44; assim como entre valores de DMO e 25-OHD&#46; N&#227;o houve correla&#231;&#227;o linear entre IMC e DMO&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;5&#41;&#58; 625-634</span></p></span>"
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        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Patients with cystic fibrosis &#40;CF&#41; have an increasing life span and osteoporosis has become a more recognised problem in these patients&#46; The pathogenesis of low bone mineral density &#40;BMD&#41; in CF seems to be multifactorial and the aim of this study was to assess the prevalence of low BMD in a group of CF outpatients and to relate the findings with the variables studied&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">The study included 22 patients aged between 14 and 45 years &#40;mean age 26&#46;3&#41;&#46; Two of the subjects were lung transplant patients&#46; BMD was assessed by dualenergy X-ray absorptiometry &#40;DEXA&#41; at the lumbar spine &#40;LS&#41; and femoral neck &#40;FN&#41;&#46; This data was correlated with serum 25-hydroxy vitamin D &#40;25-OHD&#41; levels&#44; BMI and the forced expiratory volume in one second &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">BMD &#40;Z-score and T-score&#41; ranged from 0&#46;6 to -6 and from 0&#46;5 to -6&#46;7 at LS&#59; at FN the scores ranged from 0&#46;6 to -3&#46;9 and from 0&#46;6 to -4&#46;1&#46; The mean serum 25-OHD concentration &#40;12&#44;57<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; was at the low end of the normal range &#40;10-60<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; On average patients did not present with malnutrition&#44; however BMI ranged from 15&#46;2 to 33&#46;7<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Lung function status was assessed by FEV<span class="elsevierStyleInf">1</span>&#59; 64&#37; of patients had FEV<span class="elsevierStyleInf">1</span> below 80&#37; and within this group four patients had a FEV<span class="elsevierStyleInf">1</span> under 40&#37;&#46;</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">There was a positive correlation between low BMD and 25-OHD concentrations and also between BMD and FEV<span class="elsevierStyleInf">1</span>&#46; There was no linear correlation between BMD and BMI&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;5&#41;&#58; 625-634</span></p></span>"
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Vol. 14. Issue 5.
Pages 625-634 (September - October 2008)
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Vol. 14. Issue 5.
Pages 625-634 (September - October 2008)
Artigo Original/Original Article
Open Access
Avaliação da densidade mineral óssea em doentes com fibrose quística
Evaluation of bone mineral density in cystic fibrosis patients
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Jessica Cemlyn-Jones1, Fernanda Gamboa2, Mário Loureiro3, M. Fontes Baganha4
1 Interna Complementar de Pneumologia / Resident, specialist training in Pulmonology
2 Assistente Hospitalar de Pneumologia / Pulmonolgy consultant
3 Director do Serviço de Pneumologia dos HUC / Head, Pulmonologu Unit, HUC
4 Director do Departamento de Ciências Pneumológicas e Alergológicas dos HUC / Director, Department of Pulmonology and Allergology Sciences, HUC
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Resumo

A esperança de vida dos doentes com fibrose quística (FQ) tem vindo a aumentar, sendo mais frequente a identificação de osteoporose. A patogénese de uma baixa densidade mineral óssea (DMO) na FQ parece ser multifactorial e o objectivo deste trabalho foi avaliar a prevalência de baixa DMO num grupo de doentes com FQ e a sua correlação com outros parâmetros avaliados.

O estudo incluiu 22 doentes com FQ com idades compreendidas entre os 14 e os 45 anos (média 26,3), dois dos quais transplantados pulmonares. A DMO foi avaliada por densitometria óssea ao nível da coluna lombar e do colo do fémur. Estes dados foram correlacionados com os valores séricos de 25-hydroxivi-tamina D, o IMC e o volume expiratório máximo forçado no primeiro segundo (VEM).

Os valores da DMO (Z-score e T-score) variaram entre 0,6 e -6 e entre 0,5 e -6,7, respectivamente, a nível da coluna lombar e entre 0,6 e -3,9 e 0,6 e -4,1 a nível do colo do fémur. A média das concentrações séricas de 25-(OH)D (12,57ng/ml) encontrava-se no limite inferior da normalidade (10-60ng/ml). Em média os doentes não apresentavam malnutrição mas os valores de IMC variam entre 15,2 e 33,7kg/m2. Relativamente à função pulmonar, 64% dos doentes apresentavam VEM inferior a 80% e, destes, quatro tinham valores inferiores a 40%. Foi encontrada uma correlação positiva entre valores baixos de DMO e VEM, assim como entre valores de DMO e 25-OHD. Não houve correlação linear entre IMC e DMO.

Rev Port Pneumol 2008; XIV (5): 625-634

Palavras-chave:
Fibrose quística
densidade mineral óssea
vitamina D
Abstract

Patients with cystic fibrosis (CF) have an increasing life span and osteoporosis has become a more recognised problem in these patients. The pathogenesis of low bone mineral density (BMD) in CF seems to be multifactorial and the aim of this study was to assess the prevalence of low BMD in a group of CF outpatients and to relate the findings with the variables studied.

The study included 22 patients aged between 14 and 45 years (mean age 26.3). Two of the subjects were lung transplant patients. BMD was assessed by dualenergy X-ray absorptiometry (DEXA) at the lumbar spine (LS) and femoral neck (FN). This data was correlated with serum 25-hydroxy vitamin D (25-OHD) levels, BMI and the forced expiratory volume in one second (FEV1).

BMD (Z-score and T-score) ranged from 0.6 to -6 and from 0.5 to -6.7 at LS; at FN the scores ranged from 0.6 to -3.9 and from 0.6 to -4.1. The mean serum 25-OHD concentration (12,57ng/ml) was at the low end of the normal range (10-60ng/ml). On average patients did not present with malnutrition, however BMI ranged from 15.2 to 33.7kg/m2. Lung function status was assessed by FEV1; 64% of patients had FEV1 below 80% and within this group four patients had a FEV1 under 40%.

There was a positive correlation between low BMD and 25-OHD concentrations and also between BMD and FEV1. There was no linear correlation between BMD and BMI.

Rev Port Pneumol 2008; XIV (5): 625-634

Key-words:
Cystic fibrosis
bone mineral density
vitamin D
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Copyright © 2008. Sociedade Portuguesa de Pneumologia/SPP
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