array:24 [
  "pii" => "S2173511510700452"
  "issn" => "21735115"
  "doi" => "10.1016/S2173-5115(10)70045-2"
  "estado" => "S300"
  "fechaPublicacion" => "2010-05-01"
  "aid" => "70045"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2010"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Pneumol. 2010;16:391-405"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3651
    "formatos" => array:3 [
      "EPUB" => 245
      "HTML" => 2245
      "PDF" => 1161
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173511510700464"
    "issn" => "21735115"
    "doi" => "10.1016/S2173-5115(10)70046-4"
    "estado" => "S300"
    "fechaPublicacion" => "2010-05-01"
    "aid" => "70046"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2010;16:407-18"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3294
      "formatos" => array:3 [
        "EPUB" => 217
        "HTML" => 1803
        "PDF" => 1274
      ]
    ]
    "pt" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Eficácia e tolerabilidade de próteses na via aérea"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "407"
          "paginaFinal" => "418"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Efficacy and tolerability of airway stents"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Carla Valente, Alexandra Catarino, António Jorge Ferreira, Carlos Robalo Cordeiro, Mário Loureiro"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Carla"
              "apellidos" => "Valente"
            ]
            1 => array:2 [
              "nombre" => "Alexandra"
              "apellidos" => "Catarino"
            ]
            2 => array:2 [
              "nombre" => "António"
              "apellidos" => "Jorge Ferreira"
            ]
            3 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Robalo Cordeiro"
            ]
            4 => array:2 [
              "nombre" => "Mário"
              "apellidos" => "Loureiro"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511510700464?idApp=UINPBA00004E"
    "url" => "/21735115/0000001600000003/v1_201305151528/S2173511510700464/v1_201305151528/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173511510700440"
    "issn" => "21735115"
    "doi" => "10.1016/S2173-5115(10)70044-0"
    "estado" => "S300"
    "fechaPublicacion" => "2010-05-01"
    "aid" => "70044"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2010;16:369-89"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3324
      "formatos" => array:3 [
        "EPUB" => 212
        "HTML" => 1880
        "PDF" => 1232
      ]
    ]
    "pt" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Pneumonia organizativa – Experiência da consulta de um hospital central"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "369"
          "paginaFinal" => "389"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Organising pneumonia – the experience of an outpatient clinic of a central hospital"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M. Aguiar, M. Felizardo, A.C. Mendes, D. Moniz, R. Sotto-Mayor, A. Bugalho de Almeida"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "M."
              "apellidos" => "Aguiar"
            ]
            1 => array:2 [
              "nombre" => "M."
              "apellidos" => "Felizardo"
            ]
            2 => array:2 [
              "nombre" => "A.C."
              "apellidos" => "Mendes"
            ]
            3 => array:2 [
              "nombre" => "D."
              "apellidos" => "Moniz"
            ]
            4 => array:2 [
              "nombre" => "R."
              "apellidos" => "Sotto-Mayor"
            ]
            5 => array:2 [
              "nombre" => "A."
              "apellidos" => "Bugalho de Almeida"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511510700440?idApp=UINPBA00004E"
    "url" => "/21735115/0000001600000003/v1_201305151528/S2173511510700440/v1_201305151528/pt/main.assets"
  ]
  "pt" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Características clínicas de doentes com neoplasia do pulmão e neoplasias primárias síncronas ou metácronas com outras localizações"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "391"
        "paginaFinal" => "405"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Inês Vaz Luís, Rita Macedo, Encarnação Teixeira, Renato Sotto-Mayor, A Bugalho de Almeida"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Inês"
            "apellidos" => "Vaz Luís"
            "email" => array:1 [
              0 => "inesvazluis@gmail.com"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">6</span>"
                "identificador" => "aff0030"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Rita"
            "apellidos" => "Macedo"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">2</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">6</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Encarna&#231;&#227;o"
            "apellidos" => "Teixeira"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">3</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">6</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Renato"
            "apellidos" => "Sotto-Mayor"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">4</span>"
                "identificador" => "aff0020"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">6</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "A"
            "apellidos" => "Bugalho de Almeida"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">5</span>"
                "identificador" => "aff0025"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">6</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:6 [
          0 => array:3 [
            "entidad" => "Interna do Servi&#231;o de Oncologia M&#233;dica&#44; Hospital de Santa Maria &#40;HSM&#41; &#8211; Centro Hospitalar Lisboa Norte &#40;CHLN&#41;&#47;<span class="elsevierStyleItalic">Resident&#44; Medical Oncology Unit&#44; Hospital de Santa Maria &#40;HSM&#41;&#44; Centro Hospitalar Lisboa Norte &#40;CHLN&#41;</span>"
            "etiqueta" => "<span class="elsevierStyleSup">1</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Assistente Eventual de Pneumologia&#47;<span class="elsevierStyleItalic">Future Pulmonolgy Consultant</span>"
            "etiqueta" => "<span class="elsevierStyleSup">2</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Assistente Hospitalar Graduada de Pneumologia&#47;<span class="elsevierStyleItalic">Consultant&#44; Pulmonology Specialist</span>"
            "etiqueta" => "<span class="elsevierStyleSup">3</span>"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Chefe de Servi&#231;o de Pneumologia&#47;<span class="elsevierStyleItalic">Head&#44; Pulmonology Unit</span>"
            "etiqueta" => "<span class="elsevierStyleSup">4</span>"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Director de Servi&#231;o&#44; Professor da Faculdade de Medicina da Universidade de Lisboa&#47;Unit Director&#44; <span class="elsevierStyleItalic">Professor&#44; Medical School&#44; Universidade de Lisboa</span> Servi&#231;o de Pneumologia I&#44; HSM &#8211; CLHN&#44; Lisboa"
            "etiqueta" => "<span class="elsevierStyleSup">5</span>"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Centro onde o trabalho foi realizado&#47;<span class="elsevierStyleItalic">Work undertaken at</span>&#44; Servi&#231;o de Pneumologia I&#44; Hospital de Santa Maria&#47;Faculdade de Medicina de Lisboa&#44; Av&#46; Prof&#46; Egas Moniz&#44; 1643-035 Lisboa"
            "etiqueta" => "<span class="elsevierStyleSup">6</span>"
            "identificador" => "aff0030"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspond&#234;ncia&#47;Correspondence to Servi&#231;o de Oncologia M&#233;dica&#44; Hospital de Santa Maria&#47;Faculdade de Medicina de Lisboa&#44; Av&#46; Prof&#46; Egas Moniz&#44; 1643-035 Lisboa&#46; Telefone&#47;Telephone&#58; 21-7985257&#44; Telem&#243;vel&#47;Mobile&#58; 91-9129631&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Clinical characteristics of patients with lung cancer and metachronous or synchronous tumours with other locations"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2009-07-27"
    "fechaAceptado" => "2009-09-30"
    "PalabrasClave" => array:1 [
      "pt" => array:2 [
        0 => array:3 [
          "clase" => "keyword"
          "identificador" => "xpalclavsec160784"
          "palabras" => array:5 [
            0 => "Multiple cancers"
            1 => "metachronous cancer"
            2 => "synchronous cancer"
            3 => "lung cancer"
            4 => "follow-up"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec160785"
          "palabras" => array:5 [
            0 => "Neoplasias m&#250;ltiplas"
            1 => "neoplasia met&#225;crona"
            2 => "neoplasia s&#237;ncrona"
            3 => "neoplasia do pulm&#227;o"
            4 => "vigil&#226;ncia"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">O cancro do pulm&#227;o &#233; a causa mais comum de morte por doen&#231;a oncol&#243;gica&#46; Os doentes com diagn&#243;stico de neoplasia &#8211; qualquer que seja a localiza&#231;&#227;o &#8211; t&#234;m risco acrescido de desenvolver um segundo tumor&#46; Pretendeu-se caracterizar uma popula&#231;&#227;o com neopla- sia do pulm&#227;o e o diagn&#243;stico s&#237;ncrono ou met&#225;crono de tumor prim&#225;rio com outra localiza&#231;&#227;o&#46; Foi feito um estudo retrospectivo&#44; referente ao per&#237;odo de 2000&#8211;2007&#44; analisando-se os processos cl&#237;nicos de doentes seguidos na Unidade de Pneumologia Oncol&#243;gica do nosso hospital em que estavam referenciadas duas neoplasias&#46; Dos doentes seguidos na Unidade &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1046&#41; no per&#237;odo referido&#44; 4&#44;2&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>44&#41; tinham evid&#234;ncia de duas neoplasias&#46; A maioria &#40;88&#44;6&#37;&#41; dos doentes eram homens&#44; com idade m&#233;dia elevada &#40;70&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 anos&#41;&#46; Oitenta e seis por cento &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>38&#41; tinham h&#225;bitos tab&#225;gicos e 65&#44;4&#37; dos doentes com registo de hist&#243;ria familiar de neoplasia &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>26&#41; tinham hist&#243;ria familiar relevante &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#41;&#46; A doen&#231;a oncol&#243;gica manifestou-se em primeiro lugar na pr&#243;stata&#44; c&#243;lon&#44; cabe&#231;a e pesco&#231;o ou bexiga&#46; O cancro do pulm&#227;o foi em geral a segunda neoplasia&#46; O intervalo de tempo m&#233;dio entre a primeira e a segunda neoplasia foi de 62&#44;9&#177;64&#44;9 meses &#40;max&#58; 240&#44; min&#58; 0&#41;&#44; sendo que geralmente a segunda neoplasia foi detectada em est&#225;dio avan&#231;ado&#46; A sobreviv&#234;ncia m&#233;dia foi de 8&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;24 meses &#40;max&#58; 32&#59; min&#58; 1&#41;&#44; permanecendo vivos quatro doentes&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Os presentes dados levam-nos a sugerir vigil&#226;ncia cl&#237;nica prolongada em doentes com diagn&#243;stico pr&#233;vio de cancro&#46; Sugerimos um algoritmo que possibilite vigiar melhor estes doentes e estudo prospectivo para verificar se existem marcadores moleculares nesta popula&#231;&#227;o&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Lung cancer is the leading form of cancer death worldwide&#46; Cancer patients are at a high risk of developing a second cancer&#46; The present study attempts to determine the characteristics of a population with lung cancer diagnosed with another cancer&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We analysed records of patients from the Department of Lung Oncology of our hospital from 2000 to 2007 who were identified as having two or more tumours&#46; We found 4&#46;2&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>44&#41; multiple cancers among the registered cases &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1046&#41;&#44; 88&#46;6&#37; males&#44; &#40;high&#41; mean age 70&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10 years old&#46; About 86&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>38&#41; of the patients were smokers or ex-smokers&#46; From the patients with record of family history&#44; 65&#46;4&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#41; had relevant family history of cancer&#46; The majority of the first malignancy diagnosed was prostate&#44; colon&#44; head and neck and bladder&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Lung cancer was essentially the second malignancy&#46; The mean time lag between the two diagnoses was 62&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>64&#46;9 months &#40;max&#46; 240&#44; min&#46; 0&#41;&#44; with the second cancer usually detected at an advanced stage&#46; The mean survival of patients who had a second primary lung cancer was 8&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;24 months &#40;max&#46; 32&#44; min&#46; 1&#41;&#44; with four patients still surviving&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Our results suggest that extended follow-up is needed in these patients&#44; using screening strategies which follow international recommendations&#44; and with control of carcinogenic risk factors such as smoking&#46; We suggest a tailored risk algorithm and a further study to assess if there are particular molecular markers in these patients&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliografia&#47;Bibliography"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:23 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimates of cancer incidence ad mortality in Europe in 2006"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Ferlay"
                            1 => "P&#46; Autier"
                            2 => "M&#46; Boniol"
                            3 => "M&#46; Heanue"
                            4 => "M&#46; Colombet"
                            5 => "P&#46; Boyle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/annonc/mdl498"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Oncol"
                        "fecha" => "2007"
                        "volumen" => "18"
                        "paginaInicial" => "581"
                        "paginaFinal" => "592"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17287242"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer statistics&#44; 2008"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Jemal"
                            1 => "R&#46; Siegel"
                            2 => "E&#46; Ward"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "numero" => "2"
                        "paginaInicial" => "71"
                        "paginaFinal" => "96"
                        "itemHostRev" => array:3 [
                          "pii" => "S0300289611000548"
                          "estado" => "S300"
                          "issn" => "03002896"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "SEER Cancer statistics review 1975-2003"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Ries"
                            1 => "M&#46; Eisner"
                            2 => "C&#46; Kosary"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2006"
                        "editorial" => "National Cancer Institute"
                        "editorialLocalizacion" => "Bethesda"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Cancer survivors&#58; living longer&#44; and now better"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(04)17601-0"
                      "Revista" => array:7 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2004"
                        "volumen" => "364"
                        "numero" => "9452"
                        "paginaInicial" => "2153"
                        "paginaFinal" => "2154"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15610781"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term survival and competing causes of death in patients with early-stage Hodgkin&#8216;s disease treated at age 50 or younger"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;K&#46; Ng"
                            1 => "M&#46;P&#46; Bernardo"
                            2 => "E&#46; Weller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2002.08.021"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "numero" => "8"
                        "paginaInicial" => "2101"
                        "paginaFinal" => "2108"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11956271"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple primary malignancies involving lung cancer-clinical characteristics and prognosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46;Y&#46; Liu"
                            1 => "Y&#46;M&#46; Chen"
                            2 => "S&#46;H&#46; Yen"
                            3 => "C&#46;M&#46; Tsai"
                            4 => "R&#46;P&#46; Perng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Lung Cancer"
                        "fecha" => "2002"
                        "volumen" => "35"
                        "numero" => "2"
                        "paginaInicial" => "189"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11804692"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical features and prognosis of multiple primary tumors of lung combined with other organs-report of 281 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;Z&#46; Yi"
                            1 => "D&#46;C&#46; Zhang"
                            2 => "Y&#46;G&#46; Wang"
                            3 => "K&#46;L&#46; Sun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Ai Zheng"
                        "fecha" => "2006"
                        "volumen" => "25"
                        "numero" => "6"
                        "paginaInicial" => "731"
                        "paginaFinal" => "735"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16764770"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Therapy-associated solid tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46;B&#46; Travis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Acta Oncol"
                        "fecha" => "2002"
                        "volumen" => "41"
                        "numero" => "4"
                        "paginaInicial" => "323"
                        "paginaFinal" => "333"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12234023"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The epidemiology of second primary cancers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "L&#46;B&#46; Travis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1055-9965.EPI-06-0414"
                      "Revista" => array:7 [
                        "tituloSerie" => "Cancer Epidemiol Biomarkers Prev"
                        "fecha" => "2006"
                        "volumen" => "15"
                        "numero" => "11"
                        "paginaInicial" => "2020"
                        "paginaFinal" => "2026"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17057028"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple primary cancer&#58; an experience at the cancer institute hospital with special reference to colorectal cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Ueno"
                            1 => "T&#46; Muto"
                            2 => "M&#46; Oya"
                            3 => "H&#46; Ota"
                            4 => "K&#46; Azekura"
                            5 => "T&#46; Yamaguchi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10147-003-0322-z"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Clin Oncol"
                        "fecha" => "2003"
                        "volumen" => "8"
                        "numero" => "3"
                        "paginaInicial" => "162"
                        "paginaFinal" => "167"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12851840"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiological study of lung cancer in Portugal &#40;2000&#47;2002&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:4 [
                            0 => "B&#46; Parente"
                            1 => "H&#46; Queiroga"
                            2 => "E&#46; Teixeira"
                            3 => "R&#46; Sotto-Mayor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Port Pneumol"
                        "fecha" => "2007"
                        "volumen" => "13"
                        "numero" => "2"
                        "paginaInicial" => "255"
                        "paginaFinal" => "265"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17571453"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mortality in relation to smoking&#58; 20 years observations on male British doctors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Doll"
                            1 => "R&#46; Peto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1976"
                        "volumen" => "2"
                        "paginaInicial" => "1525"
                        "paginaFinal" => "1536"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/365289"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking and death&#58; the past 40 years and the next 40"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Peto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1994"
                        "volumen" => "309"
                        "paginaInicial" => "937"
                        "paginaFinal" => "939"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7950669"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "International Agency for Research on Cancer"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2004"
                        "editorial" => "IARC"
                        "editorialLocalizacion" => "Lyon France"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical cancer advances 2006&#58; major research advances in cancer treatment&#44; prevention and screening&#8211; a report from the American Society of Clinical Oncology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;F&#46; Ozols"
                            1 => "R&#46;S&#46; Herbst"
                            2 => "J&#46;L&#46; Colson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2007"
                        "volumen" => "21"
                        "numero" => "1"
                        "paginaInicial" => "146"
                        "paginaFinal" => "162"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer survivorship-genetic susceptibility and second primary cancers&#58; research strategies and recommendations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46;B&#46; Travis"
                            1 => "C&#46;S&#46; Rabkin"
                            2 => "L&#46;M&#46; Brown"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/jnci/djj001"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "2006"
                        "volumen" => "98"
                        "numero" => "1"
                        "paginaInicial" => "15"
                        "paginaFinal" => "25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16391368"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advisory Committee on Cancer Prevention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Recommendations on cancer screening in the European Union"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cancer"
                        "fecha" => "2000"
                        "volumen" => "36"
                        "paginaInicial" => "1473"
                        "paginaFinal" => "1478"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10930794"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary and preventive care&#58; Periodic assessments&#46; ACOG Committee Opinion 246"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "American College of Obstetricians and Gynecologists"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2000"
                        "editorial" => "FACOG"
                        "editorialLocalizacion" => "Washington&#44; DC"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Screening for colorectal&#44; breast&#44; and cervical cancer in the elderly&#58; a review of the evidence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;C&#46; Walter"
                            1 => "C&#46;L&#46; Lewis"
                            2 => "M&#46;B&#46; Barton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjmed.2005.01.063"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "2005"
                        "volumen" => "118"
                        "paginaInicial" => "1078"
                        "paginaFinal" => "1086"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16194635"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "U&#46;S&#46; Preventive Services Task Force&#46; Screening for colorectal cancer&#46; <a class="elsevierStyleInterRef" href="http://www.ahrq.gov/clinic/3rduspstf/colorectal.colorr.htm">www&#46;ahrq&#46;gov&#47;clinic&#47;3rduspstf&#47;colorectal&#46;colorr&#46;htm</a>&#46;"
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systematic review of baseline low-dose CT lung cancer screening"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Yau"
                            1 => "M&#46; Lock"
                            2 => "G&#46; Rodrigues"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.lungcan.2007.07.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lung Cancer"
                        "fecha" => "2007"
                        "volumen" => "58"
                        "paginaInicial" => "161"
                        "paginaFinal" => "170"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17723250"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "US Preventive Services Task Force&#46; Screening for cervical cancer&#58; recommendations and rationale&#46; Agency for Healthcare Research and Quality&#44; Rockville&#44; MD 2003&#46; Available at&#58; <a class="elsevierStyleInterRef" href="http://www.ahrq.gov/clinic/3rduspstf/cervcan/cervcanrr.pdf">www&#46;ahrq&#46;gov&#47;clinic&#47;3rduspstf&#47;cervcan&#47;cervcanrr&#46;pdf</a>&#46;"
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advisory Committee on Cancer Prevention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Recommendations on cancer screening in the European Union"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cancer"
                        "fecha" => "2000"
                        "volumen" => "36"
                        "paginaInicial" => "1473"
                        "paginaFinal" => "1478"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10930794"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/21735115/0000001600000003/v1_201305151528/S2173511510700452/v1_201305151528/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9667"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Artigo Original"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001600000003/v1_201305151528/S2173511510700452/v1_201305151528/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511510700452?idApp=UINPBA00004E"
]
Share
Journal Information
Vol. 16. Issue 3.
Pages 391-405 (May - June 2010)
Share
Share
Download PDF
More article options
Vol. 16. Issue 3.
Pages 391-405 (May - June 2010)
Full text access
Características clínicas de doentes com neoplasia do pulmão e neoplasias primárias síncronas ou metácronas com outras localizações
Clinical characteristics of patients with lung cancer and metachronous or synchronous tumours with other locations
Visits
958
Inês Vaz Luís1,6,
Corresponding author
inesvazluis@gmail.com

Correspondência/Correspondence to Serviço de Oncologia Médica, Hospital de Santa Maria/Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1643-035 Lisboa. Telefone/Telephone: 21-7985257, Telemóvel/Mobile: 91-9129631.
, Rita Macedo2,6, Encarnação Teixeira3,6, Renato Sotto-Mayor4,6, A Bugalho de Almeida5,6
1 Interna do Serviço de Oncologia Médica, Hospital de Santa Maria (HSM) – Centro Hospitalar Lisboa Norte (CHLN)/Resident, Medical Oncology Unit, Hospital de Santa Maria (HSM), Centro Hospitalar Lisboa Norte (CHLN)
2 Assistente Eventual de Pneumologia/Future Pulmonolgy Consultant
3 Assistente Hospitalar Graduada de Pneumologia/Consultant, Pulmonology Specialist
4 Chefe de Serviço de Pneumologia/Head, Pulmonology Unit
5 Director de Serviço, Professor da Faculdade de Medicina da Universidade de Lisboa/Unit Director, Professor, Medical School, Universidade de Lisboa Serviço de Pneumologia I, HSM – CLHN, Lisboa
6 Centro onde o trabalho foi realizado/Work undertaken at, Serviço de Pneumologia I, Hospital de Santa Maria/Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1643-035 Lisboa
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics
Resumo

O cancro do pulmão é a causa mais comum de morte por doença oncológica. Os doentes com diagnóstico de neoplasia – qualquer que seja a localização – têm risco acrescido de desenvolver um segundo tumor. Pretendeu-se caracterizar uma população com neopla- sia do pulmão e o diagnóstico síncrono ou metácrono de tumor primário com outra localização. Foi feito um estudo retrospectivo, referente ao período de 2000–2007, analisando-se os processos clínicos de doentes seguidos na Unidade de Pneumologia Oncológica do nosso hospital em que estavam referenciadas duas neoplasias. Dos doentes seguidos na Unidade (n=1046) no período referido, 4,2% (n=44) tinham evidência de duas neoplasias. A maioria (88,6%) dos doentes eram homens, com idade média elevada (70,1±10 anos). Oitenta e seis por cento (n=38) tinham hábitos tabágicos e 65,4% dos doentes com registo de história familiar de neoplasia (n=26) tinham história familiar relevante (n=17). A doença oncológica manifestou-se em primeiro lugar na próstata, cólon, cabeça e pescoço ou bexiga. O cancro do pulmão foi em geral a segunda neoplasia. O intervalo de tempo médio entre a primeira e a segunda neoplasia foi de 62,9±64,9 meses (max: 240, min: 0), sendo que geralmente a segunda neoplasia foi detectada em estádio avançado. A sobrevivência média foi de 8,6±8,24 meses (max: 32; min: 1), permanecendo vivos quatro doentes.

Os presentes dados levam-nos a sugerir vigilância clínica prolongada em doentes com diagnóstico prévio de cancro. Sugerimos um algoritmo que possibilite vigiar melhor estes doentes e estudo prospectivo para verificar se existem marcadores moleculares nesta população.

Keywords:
Multiple cancers
metachronous cancer
synchronous cancer
lung cancer
follow-up
Palavras-chave:
Neoplasias múltiplas
neoplasia metácrona
neoplasia síncrona
neoplasia do pulmão
vigilância
Abstract

Lung cancer is the leading form of cancer death worldwide. Cancer patients are at a high risk of developing a second cancer. The present study attempts to determine the characteristics of a population with lung cancer diagnosed with another cancer.

We analysed records of patients from the Department of Lung Oncology of our hospital from 2000 to 2007 who were identified as having two or more tumours. We found 4.2% (n=44) multiple cancers among the registered cases (n=1046), 88.6% males, (high) mean age 70.1±10 years old. About 86% (n=38) of the patients were smokers or ex-smokers. From the patients with record of family history, 65.4% (n=17) had relevant family history of cancer. The majority of the first malignancy diagnosed was prostate, colon, head and neck and bladder.

Lung cancer was essentially the second malignancy. The mean time lag between the two diagnoses was 62.9±64.9 months (max. 240, min. 0), with the second cancer usually detected at an advanced stage. The mean survival of patients who had a second primary lung cancer was 8.6±8.24 months (max. 32, min. 1), with four patients still surviving.

Our results suggest that extended follow-up is needed in these patients, using screening strategies which follow international recommendations, and with control of carcinogenic risk factors such as smoking. We suggest a tailored risk algorithm and a further study to assess if there are particular molecular markers in these patients.

Full text is only aviable in PDF
Bibliografia/Bibliography
[1.]
J. Ferlay, P. Autier, M. Boniol, M. Heanue, M. Colombet, P. Boyle.
Estimates of cancer incidence ad mortality in Europe in 2006.
Ann Oncol, 18 (2007), pp. 581-592
[2.]
A. Jemal, R. Siegel, E. Ward, et al.
Cancer statistics, 2008.
J Clin Oncol, 58 (2008), pp. 71-96
[3.]
L. Ries, M. Eisner, C. Kosary, et al.
SEER Cancer statistics review 1975-2003.
National Cancer Institute, (2006),
[4.]
Cancer survivors: living longer, and now better.
Lancet, 364 (2004), pp. 2153-2154
[5.]
A.K. Ng, M.P. Bernardo, E. Weller, et al.
Long-term survival and competing causes of death in patients with early-stage Hodgkin‘s disease treated at age 50 or younger.
J Clin Oncol, 20 (2002), pp. 2101-2108
[6.]
Y.Y. Liu, Y.M. Chen, S.H. Yen, C.M. Tsai, R.P. Perng.
Multiple primary malignancies involving lung cancer-clinical characteristics and prognosis.
Lung Cancer, 35 (2002), pp. 189-194
[7.]
S.Z. Yi, D.C. Zhang, Y.G. Wang, K.L. Sun.
Clinical features and prognosis of multiple primary tumors of lung combined with other organs-report of 281 cases.
Ai Zheng, 25 (2006), pp. 731-735
[8.]
L.B. Travis.
Therapy-associated solid tumors.
Acta Oncol, 41 (2002), pp. 323-333
[9.]
L.B. Travis.
The epidemiology of second primary cancers.
Cancer Epidemiol Biomarkers Prev, 15 (2006), pp. 2020-2026
[10.]
M. Ueno, T. Muto, M. Oya, H. Ota, K. Azekura, T. Yamaguchi.
Multiple primary cancer: an experience at the cancer institute hospital with special reference to colorectal cancer.
Int J Clin Oncol, 8 (2003), pp. 162-167
[11.]
B. Parente, H. Queiroga, E. Teixeira, R. Sotto-Mayor, et al.
Epidemiological study of lung cancer in Portugal (2000/2002).
Rev Port Pneumol, 13 (2007), pp. 255-265
[12.]
R. Doll, R. Peto.
Mortality in relation to smoking: 20 years observations on male British doctors.
BMJ, 2 (1976), pp. 1525-1536
[13.]
R. Peto.
Smoking and death: the past 40 years and the next 40.
BMJ, 309 (1994), pp. 937-939
[14.]
International Agency for Research on Cancer.
IARC, (2004),
[15.]
R.F. Ozols, R.S. Herbst, J.L. Colson, et al.
Clinical cancer advances 2006: major research advances in cancer treatment, prevention and screening– a report from the American Society of Clinical Oncology.
J Clin Oncol, 21 (2007), pp. 146-162
[16.]
L.B. Travis, C.S. Rabkin, L.M. Brown, et al.
Cancer survivorship-genetic susceptibility and second primary cancers: research strategies and recommendations.
J Natl Cancer Inst, 98 (2006), pp. 15-25
[17.]
Recommendations on cancer screening in the European Union.
Advisory Committee on Cancer Prevention.
Eur J Cancer, 36 (2000), pp. 1473-1478
[18.]
American College of Obstetricians and Gynecologists.
Primary and preventive care: Periodic assessments. ACOG Committee Opinion 246.
FACOG, (2000),
[19.]
L.C. Walter, C.L. Lewis, M.B. Barton.
Screening for colorectal, breast, and cervical cancer in the elderly: a review of the evidence.
Am J Med, 118 (2005), pp. 1078-1086
[20.]
U.S. Preventive Services Task Force. Screening for colorectal cancer. www.ahrq.gov/clinic/3rduspstf/colorectal.colorr.htm.
[21.]
G. Yau, M. Lock, G. Rodrigues.
Systematic review of baseline low-dose CT lung cancer screening.
Lung Cancer, 58 (2007), pp. 161-170
[22.]
US Preventive Services Task Force. Screening for cervical cancer: recommendations and rationale. Agency for Healthcare Research and Quality, Rockville, MD 2003. Available at: www.ahrq.gov/clinic/3rduspstf/cervcan/cervcanrr.pdf.
[23.]
Recommendations on cancer screening in the European Union.
Advisory Committee on Cancer Prevention.
Eur J Cancer, 36 (2000), pp. 1473-1478
Copyright © 2010. Sociedade Portuguesa de Pneumologia
Download PDF
Pulmonology
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?